Synthesis and biological activity evaluation of 3-(hetero) arylideneindolin-2-ones as potential c-Src inhibitors

Tirbanibulin: First Approval

(2021) Anthony Markham et al.   DRUGS

A novel mode of inhibiting SRC improves drug efficacy and tolerability

(2021) Carolin Temps et al.   CANCER RESEARCH

Tirbanibulin Attenuates Pulmonary Fibrosis by Modulating Src/STAT3 Signaling

(2021) Xin Wang et al.   Frontiers in Pharmacology

A phase I, open-label, multicenter, first-in-human study of the safety, tolerability, pharmacokinetics, and antitumor activity of TPX-0022, a novel MET/CSF1R/SRC inhibitor, in patients with advanced solid tumors harboring genetic alterations in MET.

(2020) David S. Hong et al.   JOURNAL OF CLINICAL ONCOLOGY

Regulation of Src Family Kinases during Colorectal Cancer Development and Its Clinical Implications

(2020) Wook Jin   Cancers

c-Src and EGFR Inhibition in Molecular Cancer Therapy: What Else Can We Improve?

(2020) Stefania Belli et al.   Cancers

Structure and Characterization of a Covalent Inhibitor of Src Kinase

(2020) Deepak Gurbani et al.   Frontiers in Molecular Biosciences

Src Tyrosine Kinase Inhibitors: New Perspectives on Their Immune, Antiviral, and Senotherapeutic Potential

(2019) José Rivera-Torres et al.   Frontiers in Pharmacology

Challenging clinically unresponsive medullary thyroid cancer: Discovery and pharmacological activity of novel RET inhibitors

(2018) Valeria La Pietra et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Identification of new pyrrolo[2,3- d ]pyrimidines as Src tyrosine kinase inhibitors in vitro active against Glioblastoma

(2017) Francesca Musumeci et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

3-Arylidene-N-hydroxyoxindoles: A New Class of Compounds Endowed with Antitumor Activity

(2016) Loana Musso et al.   ChemMedChem

Novel roles of Src in cancer cell epithelial-to-mesenchymal transition, vascular permeability, microinvasion and metastasis

(2016) Ami Patel et al.   LIFE SCIENCES

Suppression of SRC Signaling Is Effective in Reducing Synergy between Glioblastoma and Stromal Cells

(2016) Alessia Calgani et al.   MOLECULAR CANCER THERAPEUTICS

Discovery of a Novel, Isothiazolonaphthoquinone-Based Small Molecule Activator of FOXO Nuclear-Cytoplasmic Shuttling

(2016) Bastien Cautain et al.   PLoS One

Synthesis of 5,6-dihydro-4H-benzo[d]isoxazol-7-one and 5,6-dihydro-4H-isoxazolo[5,4-c]pyridin-7-one Derivatives as Potential Hsp90 Inhibitors

(2015) Loana Musso et al.   Chemical Biology & Drug Design

N′-Alkylaminosulfonyl Analogues of 6-Fluorobenzylideneindolinones with Desirable Physicochemical Profiles and Potent Growth Inhibitory Activities on Hepatocellular Carcinoma

(2015) Xiao Chen et al.   ChemMedChem

Photoinduced Isomerization and Hepatoxicities of Semaxanib, Sunitinib and Related 3-Substituted Indolin-2-ones

(2015) Mun Hong Ngai et al.   ChemMedChem

SRC Family Kinase Inhibition Through a New Pyrazolo[3,4-d]Pyrimidine Derivative as a Feasible Approach for Glioblastoma Treatment

(2015) Elisa Ceccherini et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Design, Synthesis, and Characterization of 3-(Benzylidene)indolin-2-one Derivatives as Ligands for α-Synuclein Fibrils

(2015) Wenhua Chu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Vandetanib for the Treatment of Medullary Thyroid Carcinoma

(2014) Maryann R. Cooper et al.   ANNALS OF PHARMACOTHERAPY

Src signaling pathways in prostate cancer

(2014) Andreas Varkaris et al.   CANCER AND METASTASIS REVIEWS

4-Quinolone fused heterocyclic ring systems by intramolecular reactions of 4-quinolone-2-carboxamides

(2014) Raffaella Cincinelli et al.   TETRAHEDRON

Phosphorylation of unique domains of Src family kinases

(2014) Irene Amata et al.   Frontiers in Genetics

7-Azaindole-1-carboxamides as a new class of PARP-1 inhibitors

(2013) Raffaella Cincinelli et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Efficient Synthesis of 3,7-Diaryl-1,4-dihydro[1,2,4]triazolo[5,1-c][1,2,4]triazines

(2012) Sabrina Dallavalle et al.   SYNTHESIS-STUTTGART

Dasatinib: An Anti-Tumour Agent via Src Inhibition

(2011) Antonio Gnoni et al.   CURRENT DRUG TARGETS

Inhibition of γ-secretase by the CK1 inhibitor IC261 does not depend on CK1δ

(2010) Nicole Höttecke et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Inhibition of Src with AZD0530 Reveals the Src-Focal Adhesion Kinase Complex as a Novel Therapeutic Target in Papillary and Anaplastic Thyroid Cancer

(2009) Rebecca E. Schweppe et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Inhibition of Protein Kinase c-Src as a Therapeutic Approach for Cancer and Bone Metastases

(2008) Nadia Rucci et al.   Anti-Cancer Agents in Medicinal Chemistry

Synthesis, Modeling, and RET Protein Kinase Inhibitory Activity of 3- and 4-Substituted β-Carbolin-1-ones

(2008) Raffaella Cincinelli et al.   JOURNAL OF MEDICINAL CHEMISTRY