Regulation of Src Family Kinases during Colorectal Cancer Development and Its Clinical Implications

IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling

(2019) Xia Sheng et al.   Nature Communications

High Glucose Concentrations Negatively Regulate the IGF1R/Src/ERK Axis through the MicroRNA-9 in Colorectal Cancer

(2019) Ya-Chun Chen et al.   Cells

Knockdown of IRE1ɑ suppresses metastatic potential of colon cancer cells through inhibiting FN1-Src/FAK-GTPases signaling

(2019) Yinghui Xie et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

CD44/CD133-Positive Colorectal Cancer Stem Cells are Sensitive to Trifluridine Exposure

(2019) Kenta Tsunekuni et al.   Scientific Reports

c‐Src promotes tumor progression through downregulation of microRNA‐129‐1‐3p

(2019) Daisuke Okuzaki et al.   CANCER SCIENCE

MicroRNA-137-mediated Src oncogenic signaling promotes cancer progression

(2018) Rie Kokuda et al.   GENES TO CELLS

Kinase inhibitors: the road ahead

(2018) Fleur M. Ferguson et al.   NATURE REVIEWS DRUG DISCOVERY

The molecular basis of JAK/STAT inhibition by SOCS1

(2018) Nicholas P. D. Liau et al.   Nature Communications

Investigation into Enhancing Capecitabine Efficacy in Colorectal Cancer by Inhibiting Focal Adhesion Kinase Signaling

(2018) JAE JUN SIM et al.   ANTICANCER RESEARCH

Randomized, double-blind, phase two study of ruxolitinib plus regorafenib in patients with relapsed/refractory metastatic colorectal cancer

(2018) David Fogelman et al.   Cancer Medicine

Exploration of the therapeutic aspects of Lck: A kinase target in inflammatory mediated pathological conditions

(2018) Pankaj Kumar Singh et al.   BIOMEDICINE & PHARMACOTHERAPY

Targeting PVR (CD155) and its receptors in anti-tumor therapy

(2018) Paola Kučan Brlić et al.   Cellular & Molecular Immunology

New insights into the mechanisms of epithelial–mesenchymal transition and implications for cancer

(2018) Anushka Dongre et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

T-LAK cell-originated protein kinase (TOPK): an emerging target for cancer-specific therapeutics

(2018) Katharine J. Herbert et al.   Cell Death & Disease

YAP promotes myogenic differentiation via the MEK5-ERK5 pathway

(2017) Ting-Huan Chen et al.   FASEB JOURNAL

Prognostic relevance of Src activation in stage II-III colon cancer

(2017) Julia Martínez-Pérez et al.   HUMAN PATHOLOGY

CD155 knockdown promotes apoptosis via AKT/Bcl-2/Bax in colon cancer cells

(2017) Qianqian Zheng et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Cytoplasmic Localization of RUNX3 via Histone Deacetylase-Mediated SRC Expression in Oxidative-Stressed Colon Cancer Cells

(2017) Kyoung Ah Kang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

EMT, CSCs, and drug resistance: the mechanistic link and clinical implications

(2017) Tsukasa Shibue et al.   Nature Reviews Clinical Oncology

Regorafenib as second-line therapy in hepatocellular carcinoma

(2017) Austin G. Duffy et al.   Nature Reviews Gastroenterology & Hepatology

The metastatic suppressor NDRG1 inhibits EMT, migration and invasion through interaction and promotion of caveolin-1 ubiquitylation in human colorectal cancer cells

(2017) L Mi et al.   ONCOGENE

YAP–IL-6ST autoregulatory loop activated on APC loss controls colonic tumorigenesis

(2017) Koji Taniguchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor Cell Invadopodia: Invasive Protrusions that Orchestrate Metastasis

(2017) Robert J. Eddy et al.   TRENDS IN CELL BIOLOGY

Elevated COX-2 Expression Promotes Angiogenesis Through EGFR/p38-MAPK/Sp1-Dependent Signalling in Pancreatic Cancer

(2017) Hai Hu et al.   Scientific Reports

Caspase-8 expression and its Src-dependent phosphorylation on Tyr380 promote cancer cell neoplastic transformation and resistance to anoikis

(2016) G. Fianco et al.   EXPERIMENTAL CELL RESEARCH

Claudin-1 promotes TNF-α-induced epithelial-mesenchymal transition and migration in colorectal adenocarcinoma cells

(2016) Ajaz A. Bhat et al.   EXPERIMENTAL CELL RESEARCH

Inhibition of c-Yes induces differentiation of HT-29 human colon cancer stem cells through midbody elongation

(2016) Jessica Jung et al.   Tissue Engineering and Regenerative Medicine

Regulation of paxillin-p130-PI3K-AKT signaling axis by Src and PTPRT impacts colon tumorigenesis

(2016) Yiqing Zhao et al.   Oncotarget

Phosphorylation of TOPK at Y74, Y272 by Src increases the stability of TOPK and promotes tumorigenesis of colon

(2016) Juanjuan Xiao et al.   Oncotarget

Mechanism of suppressors of cytokine signaling 1 inhibition of epithelial-mesenchymal transition signaling through ROS regulation in colon cancer cells: suppression of Src leading to thioredoxin up-regulation

(2016) Sung-Hoon Jung et al.   Oncotarget

SASH1 mediates sensitivity of breast cancer cells to chloropyramine and is associated with prognosis in breast cancer

(2016) Joshua T. Burgess et al.   Oncotarget

Inhibition of c-Yes induces differentiation of HT-29 human colon cancer stem cells through midbody elongation

(2016) Jessica Jung et al.   Tissue Engineering and Regenerative Medicine

Cell Transformation by PTP1B Truncated Mutants Found in Human Colon and Thyroid Tumors

(2016) Wenhan Mei et al.   PLoS One

Protease-activated receptors (PARs)—biology and role in cancer invasion and metastasis

(2015) Marek Z. Wojtukiewicz et al.   CANCER AND METASTASIS REVIEWS

IL13 Receptor  2 Signaling Requires a Scaffold Protein, FAM120A, to Activate the FAK and PI3K Pathways in Colon Cancer Metastasis

(2015) R. A. Bartolome et al.   CANCER RESEARCH

MicroRNA-27b suppresses tumor progression by regulating ARFGEF1 and focal adhesion signaling

(2015) Rei Matsuyama et al.   CANCER SCIENCE

ERBB4 is over-expressed in human colon cancer and enhances cellular transformation

(2015) Christopher S. Williams et al.   CARCINOGENESIS

Dynamic regulation of the cancer stem cell compartment by Cripto-1 in colorectal cancer

(2015) F Francescangeli et al.   CELL DEATH AND DIFFERENTIATION

Regulation of RPTPα-c-Src signalling pathway by miR-218

(2015) Xueping Lai et al.   FEBS Journal

SPROUTY-2 represses the epithelial phenotype of colon carcinoma cells via upregulation of ZEB1 mediated by ETS1 and miR-200/miR-150

(2015) A Barbáchano et al.   ONCOGENE

Polarized cell migration induces cancer type-specific CD133/integrin/Src/Akt/GSK3β/β-catenin signaling required for maintenance of cancer stem cell properties

(2015) Ying-Jhen Su et al.   Oncotarget

Acquired resistance to 5-fluorouracil via HSP90/Src-mediated increase in thymidylate synthase expression in colon cancer

(2015) Ji-Young Ahn et al.   Oncotarget

Folic acid inhibits COLO-205 colon cancer cell proliferation through activating the FRα/c-SRC/ERK1/2/NFκB/TP53 pathway: in vitro and in vivo studies

(2015) Chun-Ting Kuo et al.   Scientific Reports

Potentiation of Epidermal Growth Factor-Mediated Oncogenic Transformation by Sialidase NEU3 Leading to Src Activation

(2015) Koji Yamamoto et al.   PLoS One

Diacylglycerol kinase α promotes 3D cancer cell growth and limits drug sensitivity through functional interaction with Src

(2015) Pedro Torres-Ayuso et al.   Oncotarget

The tyrosine phosphatase PTPRO sensitizes colon cancer cells to anti-EGFR therapy through activation of SRC-mediated EGFR signaling

(2015) Layka Abbasi Asbagh et al.   Oncotarget

Bcl-2 stabilization by paxillin confers 5-fluorouracil resistance in colorectal cancer

(2014) D-W Wu et al.   CELL DEATH AND DIFFERENTIATION

Cetuximab-Induced MET Activation Acts as a Novel Resistance Mechanism in Colon Cancer Cells

(2014) Na Song et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Protein-tyrosine Phosphatase 4A3 (PTP4A3) Promotes Vascular Endothelial Growth Factor Signaling and Enables Endothelial Cell Motility

(2014) Mark W. Zimmerman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Eps8 controls Src- and FAK-dependent phenotypes in squamous carcinoma cells

(2014) C. Schoenherr et al.   JOURNAL OF CELL SCIENCE

Claudin-7 expression induces mesenchymal to epithelial transformation (MET) to inhibit colon tumorigenesis

(2014) A A Bhat et al.   ONCOGENE

Epidermal Growth Factor Stimulates Nuclear Factor-κB Activation and Heme Oxygenase-1 Expression via c-Src, NADPH Oxidase, PI3K, and Akt in Human Colon Cancer Cells

(2014) Gi-Shih Lien et al.   PLoS One

Src Plays a Key Role in ADAM28 Expression in v- src –Transformed Epithelial Cells and Human Carcinoma Cells

(2013) Hitoshi Abe et al.   AMERICAN JOURNAL OF PATHOLOGY

FGFR4 Role in Epithelial-Mesenchymal Transition and Its Therapeutic Value in Colorectal Cancer

(2013) Alberto Peláez-García et al.   PLoS One

Src-Mediated Phosphorylation of the Tyrosine Phosphatase PRL-3 Is Required for PRL-3 Promotion of Rho Activation, Motility and Invasion

(2013) James J. Fiordalisi et al.   PLoS One

MiR-424/503-Mediated Rictor Upregulation Promotes Tumor Progression

(2013) Chitose Oneyama et al.   PLoS One

Maintenance of the stemness in CD44+ HCT-15 and HCT-116 human colon cancer cells requires miR-203 suppression

(2013) Sy-Yeuan Ju et al.   Stem Cell Research

Src-mediated aryl hydrocarbon and epidermal growth factor receptor cross talk stimulates colon cancer cell proliferation

(2012) Guofeng Xie et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Dual inhibition of αV integrins and Src kinase activity as a combination therapy strategy for colorectal cancer

(2012) Jingquan Jia et al.   ANTI-CANCER DRUGS

High Expression of IL-13 Receptor  2 in Colorectal Cancer Is Associated with Invasion, Liver Metastasis, and Poor Prognosis

(2012) R. Barderas et al.   CANCER RESEARCH

Claudin-1 expression confers resistance to anoikis in colon cancer cells in a Src-dependent manner

(2012) Amar B. Singh et al.   CARCINOGENESIS

β-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis

(2012) Joseph Rosenbluh et al.   CELL

Src tyrosine kinase inhibits apoptosis through the Erk1/2- dependent degradation of the death accelerator Bik

(2012) J Lopez et al.   CELL DEATH AND DIFFERENTIATION

Drugging Wnt signalling in cancer

(2012) Paul Polakis   EMBO JOURNAL

A crucial role for Nox 1 in redox-dependent regulation of Wnt-β-catenin signaling

(2012) Seheli Kajla et al.   FASEB JOURNAL

Protein Tyrosine Phosphatase   Phosphotyrosyl-789 Binds BCAR3 To Position Cas for Activation at Integrin-Mediated Focal Adhesions

(2012) G. Sun et al.   MOLECULAR AND CELLULAR BIOLOGY

Survival advantages conferred to colon cancer cells by E-selectin-induced activation of the PI3K-NFκB survival axis downstream of Death receptor-3

(2011) Nicolas Porquet et al.   BMC CANCER

Activation of serotonin receptors promotes microglial injury-induced motility but attenuates phagocytic activity

(2011) Grietje Krabbe et al.   BRAIN BEHAVIOR AND IMMUNITY

Twist1-Induced Invadopodia Formation Promotes Tumor Metastasis

(2011) Mark A. Eckert et al.   CANCER CELL

Activation of Src and transformation by an RPTPα splice mutant found in human tumours

(2011) Jian Huang et al.   EMBO JOURNAL

Direct reprogramming of stem cell properties in colon cancer cells by CD44

(2011) Ying-Jhen Su et al.   EMBO JOURNAL

MicroRNA-mediated upregulation of integrin-linked kinase promotes Src-induced tumor progression

(2011) C Oneyama et al.   ONCOGENE

Rack1 promotes epithelial cell–cell adhesion by regulating E-cadherin endocytosis

(2011) G Swaminathan et al.   ONCOGENE

Specific Oncogenic Activity of the Src-Family Tyrosine Kinase c-Yes in Colon Carcinoma Cells

(2011) Florence Sancier et al.   PLoS One

Curcumin enhances dasatinib-induced inhibition of growth and transformation of colon cancer cells

(2010) Jyoti Nautiyal et al.   INTERNATIONAL JOURNAL OF CANCER

ErbB4 promotes cyclooxygenase-2 expression and cell survival in colon epithelial cells

(2010) Mark R Frey et al.   LABORATORY INVESTIGATION

c-Src–Mediated Phosphorylation of NoxA1 and Tks4 Induces the Reactive Oxygen Species (ROS)–Dependent Formation of Functional Invadopodia in Human Colon Cancer Cells

(2010) Davide Gianni et al.   MOLECULAR BIOLOGY OF THE CELL

Sprouty-2 controls c-Met expression and metastatic potential of colon cancer cells: sprouty/c-Met upregulation in human colonic adenocarcinomas

(2010) C Holgren et al.   ONCOGENE

Substrate stiffness and the receptor-type tyrosine-protein phosphatase alpha regulate spreading of colon cancer cells through cytoskeletal contractility

(2010) D Krndija et al.   ONCOGENE

p140Cap dual regulation of E-cadherin/EGFR cross-talk and Ras signalling in tumour cell scatter and proliferation

(2010) L Damiano et al.   ONCOGENE

Hypoxia Activates the K-Ras Proto-Oncogene to Stimulate Angiogenesis and Inhibit Apoptosis in Colon Cancer Cells

(2010) Min Zeng et al.   PLoS One

Pseudopodium-enriched atypical kinase 1 regulates the cytoskeleton and cancer progression

(2010) Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cripto-1 Is a Cell Surface Marker for a Tumorigenic, Undifferentiated Subpopulation in Human Embryonal Carcinoma Cells

(2010) Kazuhide Watanabe et al.   STEM CELLS

Quantitative Phosphoproteomics Reveals a Cluster of Tyrosine Kinases That Mediates Src Invasive Activity in Advanced Colon Carcinoma Cells

(2009) C. Leroy et al.   CANCER RESEARCH

Synergistic Activity of the Src Family Kinase Inhibitor Dasatinib and Oxaliplatin in Colon Carcinoma Cells Is Mediated by Oxidative Stress

(2009) S. Kopetz et al.   CANCER RESEARCH

Plasma membrane-associated sialidase (NEU3) promotes formation of colonic aberrant crypt foci in azoxymethane-treated transgenic mice

(2009) Kazuhiro Shiozaki et al.   CANCER SCIENCE

Reversion-induced LIM interaction with Src reveals a novel Src inactivation cycle

(2009) Yongjun Zhang et al.   JOURNAL OF CELL BIOLOGY

NC2213: a novel methionine aminopeptidase 2 inhibitor in human colon cancer HT29 cells

(2009) Ponniah Selvakumar et al.   Molecular Cancer

Src kinases as therapeutic targets for cancer

(2009) Lori C. Kim et al.   Nature Reviews Clinical Oncology

Src family tyrosine kinases-driven colon cancer cell invasion is induced by Csk membrane delocalization

(2009) A Sirvent et al.   ONCOGENE

A novel pro-apoptotic function of RACK1: suppression of Src activity in the intrinsic and Akt pathways

(2009) V Mamidipudi et al.   ONCOGENE

Increased extracellular pressure enhances cancer cell integrin-binding affinity through phosphorylation of β1-integrin at threonine 788/789

(2008) David H. Craig et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Phosphorylated Caveolin-1 Regulates Rho/ROCK-Dependent Focal Adhesion Dynamics and Tumor Cell Migration and Invasion

(2008) B. Joshi et al.   CANCER RESEARCH

Focal adhesion kinase is not required for Src-induced formation of invadopodia in KM12C colon cancer cells and can interfere with their assembly

(2008) S VITALE et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Valproic acid enhances bosutinib cytotoxicity in colon cancer cells

(2008) Luca Mologni et al.   INTERNATIONAL JOURNAL OF CANCER

Aberrant expression of proteinase-activated receptor 4 promotes colon cancer cell proliferation through a persistent signaling that involves Src and ErbB-2 kinase

(2008) Valérie Gratio et al.   INTERNATIONAL JOURNAL OF CANCER

Colchicine inhibits pressure-induced tumor cell implantation within surgical wounds and enhances tumor-free survival in mice

(2008) David H. Craig et al.   JOURNAL OF CLINICAL INVESTIGATION

The Involvement of the Tyrosine Kinase c-Src in the Regulation of Reactive Oxygen Species Generation Mediated by NADPH Oxidase-1

(2008) Davide Gianni et al.   MOLECULAR BIOLOGY OF THE CELL

Ectopic expression of methionine aminopeptidase-2 causes cell transformation and stimulates proliferation

(2008) L A Tucker et al.   ONCOGENE

Correlation of tumor growth suppression and methionine aminopetidase-2 activity blockade using an orally active inhibitor

(2008) J. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caveolin-1-Mediated Expression and Secretion of Kallikrein 6 in Colon Cancer Cells

(2008) Rebecca S. Henkhaus et al.   NEOPLASIA

Nox1-dependent superoxide production controls colon adenocarcinoma cell migration

(2007) Amine Sadok et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH