Src signaling pathways in prostate cancer

Ligand-independent activation of MET through IGF-1/IGF-1R signaling

(2013) Andreas Varkaris et al.   INTERNATIONAL JOURNAL OF CANCER

A phase I trial of KX2-391, a novel non-ATP competitive substrate-pocket- directed SRC inhibitor, in patients with advanced malignancies

(2013) Aung Naing et al.   INVESTIGATIONAL NEW DRUGS

Prostate cancer progression after androgen deprivation therapy: mechanisms of castrate resistance and novel therapeutic approaches

(2013) T Karantanos et al.   ONCOGENE

Increased serum insulin-like growth factor-1 levels are associated with prolonged response to dasatinib-based regimens in metastatic prostate cancer

(2013) Farshid Dayyani et al.   PROSTATE

Spatiotemporal regulation of Src and its substrates at invadosomes

(2012) Lindsy R. Boateng et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Peptidomimetic Src/Pretubulin Inhibitor KX-01 Alone and in Combination with Paclitaxel Suppresses Growth, Metastasis in Human ER/PR/HER2-Negative Tumor Xenografts

(2012) M. Anbalagan et al.   MOLECULAR CANCER THERAPEUTICS

Bradykinin enhances cell migration in human prostate cancer cells through B2 receptor/PKCδ/c-Src dependent signaling pathway

(2012) Hsin-Shan Yu et al.   PROSTATE

Dasatinib combined with docetaxel for castration-resistant prostate cancer

(2011) John C. Araujo et al.   CANCER

Invadosome regulation by adhesion signaling

(2011) Olivier Destaing et al.   CURRENT OPINION IN CELL BIOLOGY

Thiazolyl N-benzyl-substituted acetamide derivatives: Synthesis, Src kinase inhibitory and anticancer activities

(2011) Asal Fallah-Tafti et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Ligand-dependent Corepressor Acts as a Novel Androgen Receptor Corepressor, Inhibits Prostate Cancer Growth, and Is Functionally Inactivated by the Src Protein Kinase

(2011) Mohammad Asim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Current Status of Src Inhibitors in Solid Tumor Malignancies

(2011) L. N. Puls et al.   ONCOLOGIST

Differential transformation capacity of Src family kinases during the initiation of prostate cancer

(2011) H. Cai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Once-daily Dasatinib: Expansion of Phase II Study Evaluating Safety and Efficacy of Dasatinib in Patients With Metastatic Castration-resistant Prostate Cancer

(2011) Evan Y. Yu et al.   UROLOGY

Shedding of RANKL by Tumor-Associated MT1-MMP Activates Src-Dependent Prostate Cancer Cell Migration

(2010) A. L. Sabbota et al.   CANCER RESEARCH

Invasive Prostate Carcinoma Driven by c-Src and Androgen Receptor Synergy

(2010) H. Cai et al.   CANCER RESEARCH

Src-mediated regulation of homotypic cell adhesion: implications for cancer progression and opportunities for therapeutic intervention

(2010) Anshu Wadhawan et al.   CANCER TREATMENT REVIEWS

Phase I Safety, Pharmacokinetics, and Inhibition of Src Activity Study of Saracatinib in Patients with Solid Tumors

(2010) J. Baselga et al.   CLINICAL CANCER RESEARCH

Oncogenic Src requires a wild-type counterpart to regulate invadopodia maturation

(2010) L. C. Kelley et al.   JOURNAL OF CELL SCIENCE

Associations of saposin C, Src, and androgen receptor upregulate the expression and function of androgen receptor in human prostate cancer cells

(2010) Yan Ding et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Myristoylation and Membrane Binding Regulate c-Src Stability and Kinase Activity

(2010) P. Patwardhan et al.   MOLECULAR AND CELLULAR BIOLOGY

SKI-606 (Bosutinib) Blocks Prostate Cancer Invasion, Growth, and Metastasis In vitro and In vivo through Regulation of Genes Involved in Cancer Growth and Skeletal Metastasis

(2010) S. A. Rabbani et al.   MOLECULAR CANCER THERAPEUTICS

Adherens junctions: from molecules to morphogenesis

(2010) Tony J. C. Harris et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Src family kinase/abl inhibitor dasatinib suppresses proliferation and enhances differentiation of osteoblasts

(2010) Y-C Lee et al.   ONCOGENE

Dasatinib inhibits site-specific tyrosine phosphorylation of androgen receptor by Ack1 and Src kinases

(2010) Y Liu et al.   ONCOGENE

A phase II trial of the Src-kinase inhibitor AZD0530 in patients with advanced castration-resistant prostate cancer: a California Cancer Consortium study

(2009) Primo N. Lara et al.   ANTI-CANCER DRUGS

Dasatinib inhibits the growth of prostate cancer in bone and provides additional protection from osteolysis

(2009) T Koreckij et al.   BRITISH JOURNAL OF CANCER

Phase II Study of Dasatinib in Patients with Metastatic Castration-Resistant Prostate Cancer

(2009) E. Y. Yu et al.   CLINICAL CANCER RESEARCH

Phase I Dose-Escalation and Pharmacokinetic Study of Dasatinib in Patients with Advanced Solid Tumors

(2009) G. D. Demetri et al.   CLINICAL CANCER RESEARCH

Src Family Kinase Activity Is Up-Regulated in Hormone-Refractory Prostate Cancer

(2009) O. Tatarov et al.   CLINICAL CANCER RESEARCH

Anti-androgens and androgen-depleting therapies in prostate cancer: new agents for an established target

(2009) Yu Chen et al.   LANCET ONCOLOGY

The Novel Adaptor Protein Tks4 (SH3PXD2B) Is Required for Functional Podosome Formation

(2009) Matthew D. Buschman et al.   MOLECULAR BIOLOGY OF THE CELL

Src-Induced Disassembly of Adherens Junctions Requires Localized Phosphorylation and Degradation of the Rac Activator Tiam1

(2009) Simon A. Woodcock et al.   MOLECULAR CELL

Src kinases as therapeutic targets for cancer

(2009) Lori C. Kim et al.   Nature Reviews Clinical Oncology

FYNis overexpressed in human prostate cancer

(2008) Edwin M. Posadas et al.   BJU INTERNATIONAL

Targeting Src Family Kinases Inhibits Growth and Lymph Node Metastases of Prostate Cancer in an Orthotopic Nude Mouse Model

(2008) S. I. Park et al.   CANCER RESEARCH

Src family kinases as mediators of endothelial permeability: effects on inflammation and metastasis

(2008) M. P. Kim et al.   CELL AND TISSUE RESEARCH

Targeting Src signaling in metastatic bone disease

(2008) John Araujo et al.   INTERNATIONAL JOURNAL OF CANCER

Src family kinase oncogenic potential and pathways in prostate cancer as revealed by AZD0530

(2008) Y-M Chang et al.   ONCOGENE

Src kinase potentiates androgen receptor transactivation function and invasion of androgen-independent prostate cancer C4-2 cells

(2008) M Asim et al.   ONCOGENE

Src family kinases: Regulation of their activities, levels and identification of new pathways

(2007) Evan Ingley   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Regulation of endothelial permeability by Src kinase signaling: Vascular leakage versus transcellular transport of drugs and macromolecules

(2007) Guochang Hu et al.   CHEMICO-BIOLOGICAL INTERACTIONS