Challenges for the application of EGFR-targeting peptide GE11 in tumor diagnosis and treatment

New repurposed rolapitant in nanovesicular systems for lung cancer treatment: Development, in-vitro assessment and in-vivo biodistribution study

(2022) Mohamed Fawzi Kabil et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Biodistribution and Activity of EGFR Targeted Polymeric Micelles Delivering a New Inhibitor of DNA Repair to Orthotopic Colorectal Cancer Xenografts with Metastasis

(2022) Igor Moura de Paiva et al.   MOLECULAR PHARMACEUTICS

Traditional and Computational Screening of Non-Toxic Peptides and Approaches to Improving Selectivity

(2022) Alberto A. Robles-Loaiza et al.   Pharmaceuticals

Artificial intelligence to deep learning: machine intelligence approach for drug discovery

(2021) Rohan Gupta et al.   MOLECULAR DIVERSITY

Targeting c-Myc to Overcome Acquired Resistance of EGFR Mutant NSCLC Cells to the Third-Generation EGFR Tyrosine Kinase Inhibitor, Osimertinib

(2021) Lei Zhu et al.   CANCER RESEARCH

Multifunctional Traceable Liposomes with Temperature-Triggered Drug Release and Neovasculature-Targeting Properties for Improved Cancer Chemotherapy

(2021) Eiji Yuba et al.   MOLECULAR PHARMACEUTICS

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

Obstacles and opportunities in a forward vision for cancer nanomedicine

(2021) Irene de Lázaro et al.   NATURE MATERIALS

Planning for tomorrow: global cancer incidence and the role of prevention 2020–2070

(2021) Isabelle Soerjomataram et al.   Nature Reviews Clinical Oncology

Chimeric virus-like particles (VLPs) designed from shrimp nodavirus (MrNV) capsid protein specifically target EGFR-positive human colorectal cancer cells

(2021) Khwanthana Grataitong et al.   Scientific Reports

Size-Dependent Internalization Efficiency of Macrophages from Adsorbed Nanoparticle-Based Monolayers

(2021) Tatiana Petithory et al.   Nanomaterials

EGFR in Cancer: Signaling Mechanisms, Drugs, and Acquired Resistance

(2021) Mary Luz Uribe et al.   Cancers

Preoperative Predictors of Prolonged Hospital Stay in Accelerated Rehabilitation for Patients Undergoing Orthopedic Surgery

(2021) Shu Huang et al.   BIOINORGANIC CHEMISTRY AND APPLICATIONS

Progress and Future Directions with Peptide-Drug Conjugates for Targeted Cancer Therapy

(2021) Jakob Lindberg et al.   MOLECULES

Globally Approved EGFR Inhibitors: Insights into Their Syntheses, Target Kinases, Biological Activities, Receptor Interactions, and Metabolism

(2021) Mohammed A. S. Abourehab et al.   MOLECULES

AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models

(2021) Mihaly Varadi et al.   NUCLEIC ACIDS RESEARCH

Novel Peptide Therapeutic Approaches for Cancer Treatment

(2021) Caroline M. Li et al.   Cells

Quantification of EGFR-HER2 Heterodimers in HER2-Overexpressing Breast Cancer Cells Using Liquid-Phase Electron Microscopy

(2021) Diana B. Peckys et al.   Cells

The role of JAK/STAT signaling pathway and its inhibitors in diseases

(2020) Ping Xin et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Comprehensive Evaluation of Fourteen Docking Programs on Protein–Peptide Complexes

(2020) Gaoqi Weng et al.   Journal of Chemical Theory and Computation

Synthesis and Analysis of 64Cu-Labeled GE11-Modified Polymeric Micellar Nanoparticles for EGFR-Targeted Molecular Imaging in a Colorectal Cancer Model

(2020) Igor Paiva et al.   MOLECULAR PHARMACEUTICS

Particle-Size-Dependent Delivery of Antitumoral miRNA Using Targeted Mesoporous Silica Nanoparticles

(2020) Lisa Haddick et al.   Pharmaceutics

Interrogation of Folic Acid-Functionalized Nanomedicines: The Regulatory Roles of Plasma Proteins Reexamined

(2020) Huan Wang et al.   ACS Nano

GE11 peptide-installed chimaeric polymersomes tailor-made for high-efficiency EGFR-targeted protein therapy of orthotopic hepatocellular carcinoma

(2020) Cheng Zhou et al.   Acta Biomaterialia

Clathrin‐mediated EGFR endocytosis as a potential therapeutic strategy for overcoming primary resistance of EGFR TKI in wild‐type EGFR non‐small cell lung cancer

(2020) Boyeon Kim et al.   Cancer Medicine

Synthesis, Microtubule-Binding Affinity, and Antiproliferative Activity of New Epothilone Analogs and of an EGFR-Targeted Epothilone-Peptide Conjugate

(2019) Fabienne Gaugaz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dual-targeted NIS polyplexes—a theranostic strategy toward tumors with heterogeneous receptor expression

(2019) Sarah Urnauer et al.   GENE THERAPY

Ivermectin reverses the drug resistance in cancer cells through EGFR/ERK/Akt/NF-κB pathway

(2019) Lu Jiang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Reimaging biological barriers affecting distribution and extravasation of PEG/peptide- modified liposomes in xenograft SMMC7721 tumor

(2019) Hailing Tang et al.   Acta Pharmaceutica Sinica B

Epidermal growth factor (EGF) triggers nuclear calcium signaling through the intranuclear phospholipase Cδ-4 (PLCδ4)

(2019) Marcelo Coutinho de Miranda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Real-Time Label-Free Targeting Assessment and in Vitro Characterization of Curcumin-Loaded Poly-lactic-co-glycolic Acid Nanoparticles for Oral Colon Targeting

(2019) Mohamed A. Akl et al.   ACS Omega

Multi-functional self-assembled nanoparticles for pVEGF-shRNA loading and anti-tumor targeted therapy

(2019) Sai Lu et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Influence of ligands property and particle size of gold nanoparticles on the protein adsorption and corresponding targeting ability

(2018) Wei Xiao et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

GE11-Directed Functional Polymersomal Doxorubicin as an Advanced Alternative to Clinical Liposomal Formulation for Ovarian Cancer Treatment

(2018) Yan Zou et al.   MOLECULAR PHARMACEUTICS

Exploring pitfalls of 64Cu-labeled EGFR-targeting peptide GE11 as a potential PET tracer

(2018) Franziska Striese et al.   AMINO ACIDS

Intra-Articular Formulation of GE11-PLGA Conjugate-Based NPs for Dexamethasone Selective Targeting—In Vitro Evaluation

(2018) Enrica Chiesa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Epidermal Growth Factor Receptor-Targeting Peptide Nanoparticles Simultaneously Deliver Gemcitabine and Olaparib To Treat Pancreatic Cancer with Breast Cancer 2 (BRCA2) Mutation

(2018) Chong Du et al.   ACS Nano

Distinction Between Active and Passive Targeting of Nanoparticles Dictate Their Overall Therapeutic Efficacy

(2018) Tristan D. Clemons et al.   LANGMUIR

68Ga-labelled NOTA-RGD-GE11 peptide for dual integrin and EGFR-targeted tumour imaging

(2018) Chien-Jen Chen et al.   NUCLEAR MEDICINE AND BIOLOGY

Modulation of Hypoxia-Induced Chemoresistance to Polymeric Micellar Cisplatin: The Effect of Ligand Modification of Micellar Carrier Versus Inhibition of the Mediators of Drug Resistance

(2018) Hoda Soleymani Abyaneh et al.   Pharmaceutics

Synthesis and biological evaluation of phthalocyanine-peptide conjugate for EGFR-targeted photodynamic therapy and bioimaging

(2018) Ligang Yu et al.   DYES AND PIGMENTS

GE11 peptide-conjugated nanoliposomes to enhance the combinational therapeutic efficacy of docetaxel and siRNA in laryngeal cancers

(2017) Wei-Wei Xu et al.   International Journal of Nanomedicine

Tumor-targeted pH/redox dual-sensitive unimolecular nanoparticles for efficient siRNA delivery

(2017) Guojun Chen et al.   JOURNAL OF CONTROLLED RELEASE

Interaction of phospholipase C with liposome: A conformation transition of the enzyme is critical and specific to liposome composition for burst hydrolysis and fusion in concert

(2017) Samir Kumar Patra et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

Enhanced EGFR Targeting Activity of Plasmonic Nanostructures with Engineered GE11 Peptide

(2017) Francesca Biscaglia et al.   Advanced Healthcare Materials

GE11 Peptide as an Active Targeting Agent in Antitumor Therapy: A Minireview

(2017) et al.   Pharmaceutics

Construction of Epidermal Growth Factor Receptor Peptide Magnetic Nanovesicles with Lipid Bilayers for Enhanced Capture of Liver Cancer Circulating Tumor Cells

(2016) Jian Ding et al.   ANALYTICAL CHEMISTRY

Development of self-assembling peptide nanovesicle with bilayers for enhanced EGFR-targeted drug and gene delivery

(2016) Xiaofei Liang et al.   BIOMATERIALS

Aminoflavone-loaded EGFR-targeted unimolecular micelle nanoparticles exhibit anti-cancer effects in triple negative breast cancer

(2016) Ashley M. Brinkman et al.   BIOMATERIALS

EGFR targeted thermosensitive liposomes: A novel multifunctional platform for simultaneous tumor targeted and stimulus responsive drug delivery

(2016) Azadeh Haeri et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

GE11 peptide modified and reduction-responsive hyaluronic acid-based nanoparticles induced higher efficacy of doxorubicin for breast carcinoma therapy

(2016) Danrong Hu et al.   International Journal of Nanomedicine

Design of smart GE11-PLGA/PEG-PLGA blend nanoparticulate platforms for parenteral administration of hydrophilic macromolecular drugs: synthesis, preparation and in vitro/ex vivo characterization

(2016) Barbara Colzani et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Cetuximab treatment alters the content of extracellular vesicles released from tumor cells

(2016) Susan M van Dommelen et al.   Nanomedicine

Enzymatic Prenylation and Oxime Ligation for the Synthesis of Stable and Homogeneous Protein-Drug Conjugates for Targeted Therapy

(2015) Joong-jae Lee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Design and biological activity of epidermal growth factor receptor-targeted peptide doxorubicin conjugate

(2015) Mingliang Fan et al.   BIOMEDICINE & PHARMACOTHERAPY

Incorporation of Peptides Targeting EGFR and FGFR1 into the Adenoviral Fiber Knob Domain and Their Evaluation as Targeted Cancer Therapies

(2015) Hanni Uusi-Kerttula et al.   HUMAN GENE THERAPY

Improving drug delivery to solid tumors: Priming the tumor microenvironment

(2015) Iftikhar Ali Khawar et al.   JOURNAL OF CONTROLLED RELEASE

Epidermal growth factor receptor-targeted peptide conjugated phospholipid micelles for doxorubicin delivery

(2015) Mingliang Fan et al.   JOURNAL OF DRUG TARGETING

Peptide-conjugated micelles as a targeting nanocarrier for gene delivery

(2015) Wen Jen Lin et al.   JOURNAL OF NANOPARTICLE RESEARCH

Dual-Targeted Polyplexes Based on Sequence-Defined Peptide-PEG-Oligoamino Amides

(2015) Petra Kos et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Peptide GE11–Polyethylene Glycol–Polyethylenimine for targeted gene delivery in laryngeal cancer

(2015) Henglei Ren et al.   MEDICAL ONCOLOGY

GE11-modified liposomes for non-small cell lung cancer targeting: preparation, ex vitro and in vivo evaluation

(2014) Da-Wei Chen et al.   International Journal of Nanomedicine

Effects of Surface Displayed Targeting Ligand GE11 on Liposome Distribution and Extravasation in Tumor

(2014) Hailing Tang et al.   MOLECULAR PHARMACEUTICS

Afatinib resistance in non-small cell lung cancer involves the PI3K/AKT and MAPK/ERK signalling pathways and epithelial-to-mesenchymal transition

(2014) Simona Coco et al.   Targeted Oncology

Structural Evaluation of EGFR Inhibition Mechanisms for Nanobodies/VHH Domains

(2013) Karl R. Schmitz et al.   STRUCTURE

PolyIC GE11 polyplex inhibits EGFR-overexpressing tumors

(2012) Galith Abourbeh et al.   IUBMB LIFE

Phthalocyanine–Peptide Conjugates for Epidermal Growth Factor Receptor Targeting

(2012) Benson G. Ongarora et al.   JOURNAL OF MEDICINAL CHEMISTRY

Tuning Nanoparticle Uptake: Live-Cell Imaging Reveals Two Distinct Endocytosis Mechanisms Mediated by Natural and Artificial EGFR Targeting Ligand

(2012) Frauke M. Mickler et al.   NANO LETTERS

Structures of Adnectin/Protein Complexes Reveal an Expanded Binding Footprint

(2012) Vidhyashankar Ramamurthy et al.   STRUCTURE

Disconnecting the Yin and Yang Relation of Epidermal Growth Factor Receptor (EGFR)-Mediated Delivery: A Fully Synthetic, EGFR-Targeted Gene Transfer System Avoiding Receptor Activation

(2011) A. Schäfer et al.   HUMAN GENE THERAPY

Peptide-directed HPMA copolymer-doxorubicin conjugates as targeted therapeutics for colorectal cancer

(2011) Eva Kopansky et al.   JOURNAL OF DRUG TARGETING

Epidermal Growth Factor Receptor-targeted 131I-therapy of Liver Cancer Following Systemic Delivery of the Sodium Iodide Symporter Gene

(2011) Kathrin Klutz et al.   MOLECULAR THERAPY

Structural Evidence for Loose Linkage between Ligand Binding and Kinase Activation in the Epidermal Growth Factor Receptor

(2010) C. Lu et al.   MOLECULAR AND CELLULAR BIOLOGY

Novel peptide ligand directs liposomes toward EGF-R high-expressing cancer cells in vitro and in vivo

(2009) Shuxian Song et al.   FASEB JOURNAL

Epidermal Growth Factor Receptor-Targeted Gelatin-Based Engineered Nanocarriers for DNA Delivery and Transfection in Human Pancreatic Cancer Cells

(2008) Padmaja Magadala et al.   AAPS Journal

Endocytic downregulation of ErbB receptors: mechanisms and relevance in cancer

(2008) Kirstine Roepstorff et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Peptide ligand-mediated liposome distribution and targeting to EGFR expressing tumor in vivo

(2008) Shuxian Song et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Structural Basis for EGF Receptor Inhibition by the Therapeutic Antibody IMC-11F8

(2008) Shiqing Li et al.   STRUCTURE