Enzymatic Prenylation and Oxime Ligation for the Synthesis of Stable and Homogeneous Protein-Drug Conjugates for Targeted Therapy

Protein Prenylation: Enzymes, Therapeutics, and Biotechnology Applications

(2014) Charuta C. Palsuledesai et al.   ACS Chemical Biology

Antibody-Drug Conjugates: An Emerging Concept in Cancer Therapy

(2014) Ravi V. J. Chari et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enzyme-Mediated Site-Specific Bioconjugation of Metal Complexes to Proteins: Sortase-Mediated Coupling of Copper-64 to a Single-Chain Antibody

(2014) Brett M. Paterson et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A High-Affinity Protein Binder that Blocks the IL-6/STAT3 Signaling Pathway Effectively Suppresses Non–Small Cell Lung Cancer

(2014) Joong-jae Lee et al.   MOLECULAR THERAPY

Self-hydrolyzing maleimides improve the stability and pharmacological properties of antibody-drug conjugates

(2014) Robert P Lyon et al.   NATURE BIOTECHNOLOGY

Emerging classes of armed antibody therapeutics against cancer

(2014) Christian Hess et al.   MedChemComm

Orthogonal Assembly of a Designed Ankyrin Repeat Protein–Cytotoxin Conjugate with a Clickable Serum Albumin Module for Half-Life Extension

(2013) Manuel Simon et al.   BIOCONJUGATE CHEMISTRY

Oxime Ligation: A Chemoselective Click-Type Reaction for Accessing Multifunctional Biomolecular Constructs

(2013) Sébastien Ulrich et al.   CHEMISTRY-A EUROPEAN JOURNAL

Site-specific antibody drug conjugates for cancer therapy

(2013) Siler Panowski et al.   mAbs

Antibody Therapeutics in Cancer

(2013) M. X. Sliwkowski et al.   SCIENCE

Targeting the EGFR signaling pathway in cancer therapy

(2012) Parthasarathy Seshacharyulu et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Targeted drug delivery for cancer therapy: the other side of antibodies

(2012) Michael A Firer et al.   Journal of Hematology & Oncology

Design of a binding scaffold based on variable lymphocyte receptors of jawless vertebrates by module engineering

(2012) S.-C. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthesis of site-specific antibody-drug conjugates using unnatural amino acids

(2012) J. Y. Axup et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analysis of anticancer drugs: A review

(2011) Susanne Nussbaumer et al.   TALANTA

Site-Specific and Stoichiometric Modification of Antibodies by Bacterial Transglutaminase

(2010) Simone Jeger et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Expanded Utility of the β-Glucuronide Linker: ADCs That Deliver Phenolic Cytotoxic Agents

(2010) Scott C. Jeffrey et al.   ACS Medicinal Chemistry Letters

Aberrant trafficking of NSCLC-associated EGFR mutants through the endocytic recycling pathway promotes interaction with Src@

(2009) Byung Chung et al.   BMC CELL BIOLOGY

Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index

(2008) Jagath R Junutula et al.   NATURE BIOTECHNOLOGY