Journal
ANALYTICAL CHEMISTRY
Volume 88, Issue 18, Pages 8997-9003Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.6b01443
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Funding
- National Natural Science Foundation of China [81572973, 81300321, 31271586]
- Fujian Provincial Natural Science Fund [2013J01369, 2014J01419]
- Biological Medicine Industry-University Research Project of Shanghai [12DZ1941702]
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Highly effective targeted tumor recognition via vectors is crucial for cancer detection In contrast to antibodies and proteins, peptides are direct targeting ligands with a low molecular weight. In the present study, a peptide magnetic nanovector platform containing a lipid bilayer was designed using a peptide amphiphile (PA) as a skeleton material in a controlled manner without surface modification. Fluorescein isothiocyanate-labeled epidermal growth factor receptor (EGFR) peptide nanoparticles (NPs) could specifically bind to EGFR-positive liver tumor cells. EGFR peptide magnetic vesicles (EPMVs) could efficiently recognize and separate hepatoma carcinoma cells from cell solutions and treated blood samples (ratio of magnetic EPMVs versus anti-EpCAM NPs: 3.5 +/- 0.29). Analysis of the circulating tumor cell (CTC) count in blood samples from 32 patients with liver cancer showed that EPMVs Could be effectively applied for CTC capture. Thus, this nanoscale, targeted cargo-packaging technology may be useful for designing cancer diagnostic systems.
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