Di-(2-Ethylhexyl) Phthalate and Microplastics Induced Neuronal Apoptosis through the PI3K/AKT Pathway and Mitochondrial Dysfunction

Subacute Cadmium Exposure Induces Necroptosis in Swine Lung via Influencing Th1/Th2 Balance

(2022) Wenyue Zhang et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Polystyrene nanoplastics induced cardiomyocyte apoptosis and myocardial inflammation in carp by promoting ROS production

(2022) Hao Wu et al.   FISH & SHELLFISH IMMUNOLOGY

Di-(2-ethyl hexyl) phthalate induced oxidative stress promotes microplastics mediated apoptosis and necroptosis in mice skeletal muscle by inhibiting PI3K/AKT/mTOR pathway

(2022) Xiaojing Liu et al.   TOXICOLOGY

Progranulin improves neural development via the PI3K/Akt/GSK-3β pathway in the cerebellum of a VPA-induced rat model of ASD

(2022) Lili Wang et al.   Translational Psychiatry

Long-term exposure of the Mediterranean mussels, Mytilus galloprovincialis to polyethylene terephthalate microfibers: Implication for reproductive and neurotoxic effects

(2022) Jin Soo Choi et al.   CHEMOSPHERE

High-fat diet aggravates prenatal low-dose DEHP exposure induced spermatogenesis disorder: Characterization of testicular metabolic patterns in mouse offspring

(2022) Yun Fan et al.   CHEMOSPHERE

Coupled Dynamic Material Flow, Multimedia Environmental Model, and Ecological Risk Analysis for Chemical Management: A Di(2-ethylhexhyl) Phthalate Case in China

(2022) Yunhan Cui et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Polystyrene nanoplastics exacerbated lipopolysaccharide‐induced necroptosis and inflammation via the ROS / MAPK pathway in mice spleen

(2022) Xinyu Tang et al.   ENVIRONMENTAL TOXICOLOGY

The decrease of selenoprotein K induced by selenium deficiency in diet improves apoptosis and cell progression block in chicken liver via the PTEN/PI3K/AKT pathway

(2022) Wenyue Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Polystyrene nanoplastics deteriorate LPS-modulated duodenal permeability and inflammation in mice via ROS drived-NF-κB/NLRP3 pathway

(2022) Yujiao He et al.   CHEMOSPHERE

Microplastics and di (2-ethylhexyl) phthalate synergistically induce apoptosis in mouse pancreas through the GRP78/CHOP/Bcl-2 pathway activated by oxidative stress

(2022) Yuqi Wang et al.   FOOD AND CHEMICAL TOXICOLOGY

Polystyrene nanoparticle exposure supports ROS-NLRP3 axis-dependent DNA-NET to promote liver inflammation

(2022) Qianru Chi et al.   JOURNAL OF HAZARDOUS MATERIALS

Detrimental Effects of Microplastic Exposure on Normal and Asthmatic Pulmonary Physiology

(2021) Kuo Lu et al.   JOURNAL OF HAZARDOUS MATERIALS

Protection of pancreatic β-cell by phosphocreatine through mitochondrial improvement via the regulation of dual AKT/IRS-1/GSK-3β and STAT3/Cyp-D signaling pathways

(2021) Hongyan Wang et al.   CELL BIOLOGY AND TOXICOLOGY

Mitochondrial Metal Ion Transport in Cell Metabolism and Disease

(2021) Xuan Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hydrogen sulfide exposure induces pyroptosis in the trachea of broilers via the regulatory effect of circRNA-17828/miR-6631-5p/DUSP6 crosstalk on ROS production

(2021) Nuan Song et al.   JOURNAL OF HAZARDOUS MATERIALS

Post COVID-19 pandemic: Biofragmentation and soil ecotoxicological effects of microplastics derived from face masks

(2021) Jin Il Kwak et al.   JOURNAL OF HAZARDOUS MATERIALS

Berberine and/or zinc protect against methotrexate-induced intestinal damage: Role of GSK-3β/NRF2 and JAK1/STAT-3 signaling pathways

(2021) Emad H.M. Hassanein et al.   LIFE SCIENCES

Microplastics in seawater and zooplankton: A case study from Terengganu estuary and offshore waters, Malaysia

(2021) Zakaria Daoud Taha et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Polystyrene nanoplastics dysregulate lipid metabolism in murine macrophages in vitro

(2021) Ida Florance et al.   TOXICOLOGY

Brain energy failure in dementia syndromes: Opportunities and challenges for glucagon‐like peptide‐1 receptor agonists

(2021) Hussein N. Yassine et al.   Alzheimers & Dementia

Deoxynivalenol induces carp neutrophil apoptosis and necroptosis via CYP450s/ROS/PI3K/AKT pathway

(2021) Chang Ding et al.   AQUACULTURE

Polyethylene microplastics cooperate with Helicobacter pylori to promote gastric injury and inflammation in mice

(2021) Xiaohan Tong et al.   CHEMOSPHERE

Pig lung fibrosis is active in the subacute CdCl2 exposure model and exerts cumulative toxicity through the M1/M2 imbalance

(2021) Shi Xu et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Ingestion of Bis(2-ethylhexyl) phthalate (DEHP) during adolescence causes depressive-like behaviors through hypoactive glutamatergic signaling in the medial prefrontal cortex

(2021) Jae Soon Kang et al.   ENVIRONMENTAL POLLUTION

Quercetin antagonizes imidacloprid-induced mitochondrial apoptosis through PTEN/PI3K/AKT in grass carp hepatocytes

(2021) Zhiruo Miao et al.   ENVIRONMENTAL POLLUTION

Screening of Azadirachta indica phytoconstituents as GSK-3β inhibitor and its implication in neuroblastoma: molecular docking, molecular dynamics, MM-PBSA binding energy, and in-vitro study

(2021) Shivani Chandel et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Microplastics pollution and risk assessment in water bodies of two nature reserves in Jilin Province: Correlation analysis with the degree of human activity

(2021) Kai Yin et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Microglial phagocytosis of polystyrene microplastics results in immune alteration and apoptosis in vitro and in vivo

(2021) Wookbong Kwon et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Characteristics, Toxic Effects, and Analytical Methods of Microplastics in the Atmosphere

(2021) Huirong Yang et al.   Nanomaterials

Sinomenine ester derivative inhibits glioblastoma by inducing mitochondria-dependent apoptosis and autophagy by PI3K/AKT/mTOR and AMPK/mTOR pathway

(2021) Xiangjin Zheng et al.   Acta Pharmaceutica Sinica B

Effects and underlying cellular pathway involved in the impairment of the neurovascular unit following exposure of adult male mice to low doses of di(2-ethylhexyl) phthalate alone or in an environmental phthalate mixture

(2021) Delnia Ahmadpour et al.   ENVIRONMENTAL RESEARCH

Neuroregeneration: Regulation in Neurodegenerative Diseases and Aging

(2020) N. V. Bobkova et al.   BIOCHEMISTRY-MOSCOW

Mitochondrial fission in Huntington's disease mouse striatum disrupts ER-mitochondria contacts leading to disturbances in Ca2+ efflux and Reactive Oxygen Species (ROS) homeostasis

(2020) Marta Cherubini et al.   NEUROBIOLOGY OF DISEASE

Environmentally-relevant exposure to diethylhexyl phthalate (DEHP) alters regulation of double-strand break formation and crossover designation leading to germline dysfunction in Caenorhabditis elegans

(2020) Luciann Cuenca et al.   PLoS Genetics

IGF-1 Signalling Regulates Mitochondria Dynamics and Turnover through a Conserved GSK-3β–Nrf2–BNIP3 Pathway

(2020) Sarah Riis et al.   Cells

Antagonistic effect of selenium on lead-induced neutrophil apoptosis in chickens via miR-16-5p targeting of PiK3R1 and IGF1R

(2020) Kai Yin et al.   CHEMOSPHERE

Polydatin attenuates cadmium-induced oxidative stress via stimulating SOD activity and regulating mitochondrial function in Musca domestica larvae

(2020) Yuming Zhang et al.   CHEMOSPHERE

Sulforaphane prevents type 2 diabetes-induced nephropathy via AMPK-mediated activation of lipid metabolic pathways and Nrf2 antioxidative function

(2020) Zhuo Li et al.   CLINICAL SCIENCE

PROTACs suppression of GSK-3β, a crucial kinase in neurodegenerative diseases

(2020) Xueyang Jiang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Activation of the ROS/HO-1/NQO1 signaling pathway contributes to the copper-induced oxidative stress and autophagy in duck renal tubular epithelial cells

(2020) Yukun Fang et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Chlorpyrifos induced oxidative stress to promote apoptosis and autophagy through the regulation of miR-19a-AMPK axis in common carp

(2019) Qiaojian Zhang et al.   FISH & SHELLFISH IMMUNOLOGY

Glutaredoxin 2 (GRX2) deficiency exacerbates high fat diet (HFD)-induced insulin resistance, inflammation and mitochondrial dysfunction in brain injury: A mechanism involving GSK-3β

(2019) Zhao Wohua et al.   BIOMEDICINE & PHARMACOTHERAPY

The interference of DEHP in precocious puberty of females mediated by the hypothalamic IGF-1/PI3K/Akt/mTOR signaling pathway

(2019) Pu Shao et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Flavonoid GL-V9 induces apoptosis and inhibits glycolysis of breast cancer via disrupting GSK-3β-modulated mitochondrial binding of HKII

(2019) Yongjian Guo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Di-(2-ethyl hexyl) phthalate induces necroptosis in chicken cardiomyocytes by triggering calcium overload

(2019) Yingying Zheng et al.   JOURNAL OF HAZARDOUS MATERIALS

Niacin Protects against Butyrate-Induced Apoptosis in Rumen Epithelial Cells

(2019) Dan Luo et al.   Oxidative Medicine and Cellular Longevity

Mitochondrial Oxidative Stress Impairs Energy Metabolism and Reduces Stress Resistance and Longevity of C. elegans

(2019) Benjamin Dilberger et al.   Oxidative Medicine and Cellular Longevity

SIK2 promotes reprogramming of glucose metabolism through PI3K/AKT/HIF-1α pathway and Drp1-mediated mitochondrial fission in ovarian cancer

(2019) Tian Gao et al.   CANCER LETTERS

Heavy-Metals-Mediated Phospholipids Scrambling by Human Phospholipid Scramblase 3: A Probable Role in Mitochondrial Apoptosis

(2019) Santosh Kumar Palanirajan et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Occurrence of microplastics in gastrointestinal tracts and gills of fish from Beibu Gulf, South China Sea

(2019) J. Bimali Koongolla et al.   ENVIRONMENTAL POLLUTION

Single and mixture toxicity of strobilurin and SDHI fungicides to Xenopus tropicalis embryos

(2018) Siyu Wu et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Biodegradation pathway of di-(2-ethylhexyl) phthalate by a novel Rhodococcus pyridinivorans XB and its bioaugmentation for remediation of DEHP contaminated soil

(2018) Hai-Ming Zhao et al.   SCIENCE OF THE TOTAL ENVIRONMENT

The mycotoxin phomoxanthone A disturbs the form and function of the inner mitochondrial membrane

(2018) Philip Böhler et al.   Cell Death & Disease

Examining the responses of the zebrafish (Danio rerio) gastrointestinal system to the suspected obesogen diethylhexyl phthalate

(2018) Amanda N. Buerger et al.   ENVIRONMENTAL POLLUTION

Etoposide induces pancreatic β-cells cytotoxicity via the JNK/ERK/GSK-3 signaling-mediated mitochondria-dependent apoptosis pathway

(2016) Kuan-I Lee et al.   TOXICOLOGY IN VITRO

Wnt Signaling Regulates Blood Pressure by Downregulating a GSK-3β–Mediated Pathway to Enhance Insulin Signaling in the Central Nervous System

(2015) Pei-Wen Cheng et al.   DIABETES

Oxidative stress response and Nrf2 signaling in aging

(2015) Hongqiao Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Glucokinase Activation Ameliorates ER Stress-Induced Apoptosis in Pancreatic  -Cells

(2013) J. Shirakawa et al.   DIABETES

Accumulation of Microplastic on Shorelines Woldwide: Sources and Sinks

(2011) Mark Anthony Browne et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY