Sulforaphane prevents type 2 diabetes-induced nephropathy via AMPK-mediated activation of lipid metabolic pathways and Nrf2 antioxidative function

Epigenetics and epigenomics in diabetic kidney disease and metabolic memory

(2019) Mitsuo Kato et al.   Nature Reviews Nephrology

Nifedipine Modulates Renal Lipogenesis via the AMPK-SREBP Transcriptional Pathway

(2019) Yen-Chung Lin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sulforaphane ameliorates high-fat diet-induced spermatogenic deficiency in mice†

(2019) Yang Mu et al.   BIOLOGY OF REPRODUCTION

Extracellular Superoxide Dismutase Attenuates Renal Oxidative Stress Through the Activation of Adenosine Monophosphate-Activated Protein Kinase in Diabetic Nephropathy

(2018) Yu Ah Hong et al.   ANTIOXIDANTS & REDOX SIGNALING

Renin–angiotensin system inhibition ameliorates CCl4-induced liver fibrosis in mice through the inactivation of nuclear transcription factor kappa B

(2018) Sameh Saber et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

MiR-34a regulates mitochondrial content and fat ectopic deposition induced by resistin through the AMPK/PPARα pathway in HepG2 cells

(2018) Fengyun Wen et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The Adiponectin Receptor Agonist AdipoRon Ameliorates Diabetic Nephropathy in a Model of Type 2 Diabetes

(2018) Yaeni Kim et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Adiponectin receptor agonist AdipoRon decreased ceramide, and lipotoxicity, and ameliorated diabetic nephropathy

(2018) Sun Ryoung Choi et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Ginger Extract Ameliorates Obesity and Inflammation via Regulating MicroRNA-21/132 Expression and AMPK Activation in White Adipose Tissue

(2018) Seunghae Kim et al.   Nutrients

Lipid toxicity drives renal disease

(2017) Liesbet Lieben   Nature Reviews Nephrology

Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes

(2017) Annika S. Axelsson et al.   Science Translational Medicine

Nrf2 deficiency exacerbates ochratoxin A-induced toxicity in vitro and in vivo

(2017) Agnieszka Loboda et al.   TOXICOLOGY

Protectin DX ameliorates palmitate- or high-fat diet-induced insulin resistance and inflammation through an AMPK-PPARα-dependent pathway in mice

(2017) Tae Woo Jung et al.   Scientific Reports

Metformin exerts glucose-lowering action in high-fat fed mice via attenuating endotoxemia and enhancing insulin signaling

(2016) Zi-yu Zhou et al.   ACTA PHARMACOLOGICA SINICA

Novel protective mechanism of reducing renal cell damage in diabetes: Activation AMPK by AICAR increased NRF2/OGG1 proteins and reduced oxidative DNA damage

(2016) Samy L. Habib et al.   CELL CYCLE

Nrf2-mediated liver protection by esculentoside A against acetaminophen toxicity through the AMPK/Akt/GSK3β pathway

(2016) Lidong Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sulforaphane improves dysregulated metabolic profile and inhibits leptin-induced VSMC proliferation: Implications toward suppression of neointima formation after arterial injury in western diet-fed obese mice

(2016) Noha M. Shawky et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

TGF-β1/Smads and miR-21 in Renal Fibrosis and Inflammation

(2016) Agnieszka Loboda et al.   MEDIATORS OF INFLAMMATION

A pharmacological inhibitor of NLRP3 inflammasome prevents non-alcoholic fatty liver disease in a mouse model induced by high fat diet

(2016) Gabsik Yang et al.   Scientific Reports

Metallothionein plays a prominent role in the prevention of diabetic nephropathy by sulforaphane via up-regulation of Nrf2

(2015) Hao Wu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Magnolia Bioactive Constituent 4-O-Methylhonokiol Prevents the Impairment of Cardiac Insulin Signaling and the Cardiac Pathogenesis in High-Fat Diet-Induced Obese Mice

(2015) Zhiguo Zhang et al.   International Journal of Biological Sciences

Sulforaphane enhances temozolomide-induced apoptosis because of down-regulation of miR-21 via Wnt/β-catenin signaling in glioblastoma

(2015) FengMing Lan et al.   JOURNAL OF NEUROCHEMISTRY

AMPKα2 reduces renal epithelial transdifferentiation and inflammation after injury through interaction with CK2β

(2015) Shulan Qiu et al.   JOURNAL OF PATHOLOGY

Gastrodin Ameliorates Oxidative Stress and Proinflammatory Response in Nonalcoholic Fatty Liver Disease through the AMPK/Nrf2 Pathway

(2015) Li-Li Qu et al.   PHYTOTHERAPY RESEARCH

Sulforaphane reduction of testicular apoptotic cell death in diabetic mice is associated with the upregulation of Nrf2 expression and function

(2014) Yonggang Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Zinc is essential for the transcription function of Nrf2 in human renal tubule cellsin vitroand mouse kidneyin vivounder the diabetic condition

(2014) Bing Li et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Sulforaphane prevents the development of cardiomyopathy in type 2 diabetic mice probably by reversing oxidative stress-induced inhibition of LKB1/AMPK pathway

(2014) Zhiguo Zhang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Ectopic lipid accumulation: A potential cause for metabolic disturbances and a contributor to the alteration of kidney function

(2013) Fitsum Guebre-Egziabher et al.   BIOCHIMIE

Adaptive Changes of the Insig1/SREBP1/SCD1 Set Point Help Adipose Tissue to Cope With Increased Storage Demands of Obesity

(2013) S. Carobbio et al.   DIABETES

Altered renal lipid metabolism and renal lipid accumulation in human diabetic nephropathy

(2013) Michal Herman-Edelstein et al.   JOURNAL OF LIPID RESEARCH

Prevention by sulforaphane of diabetic cardiomyopathy is associated with up-regulation of Nrf2 expression and transcription activation

(2013) Yang Bai et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Novel insights of dietary polyphenols and obesity

(2013) Shu Wang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Sulforaphane attenuates obesity by inhibiting adipogenesis and activating the AMPK pathway in obese mice

(2013) Kyeong-Mi Choi et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

MagnoliaExtract (BL153) Ameliorates Kidney Damage in a High Fat Diet-Induced Obesity Mouse Model

(2013) Wenpeng Cui et al.   Oxidative Medicine and Cellular Longevity

Potential therapeutic effects of the simultaneous targeting of the Nrf2 and NF-κB pathways in diabetic neuropathy

(2013) Veera Ganesh Yerra et al.   Redox Biology

Resveratrol prevents renal lipotoxicity and inhibits mesangial cell glucotoxicity in a manner dependent on the AMPK–SIRT1–PGC1α axis in db/db mice

(2012) M. Y. Kim et al.   DIABETOLOGIA

Prevention of Diabetic Nephropathy by Sulforaphane: Possible Role of Nrf2 Upregulation and Activation

(2012) Wenpeng Cui et al.   Oxidative Medicine and Cellular Longevity

Therapeutic Potential of Nrf2 Activators in Streptozotocin-Induced Diabetic Nephropathy

(2011) Hongting Zheng et al.   DIABETES

Metabolism and Tissue Distribution of Sulforaphane in Nrf2 Knockout and Wild-Type Mice

(2011) John D. Clarke et al.   PHARMACEUTICAL RESEARCH

The Protective Role of Nrf2 in Streptozotocin-Induced Diabetic Nephropathy

(2010) T. Jiang et al.   DIABETES

Inhibitory effects of honokiol on lipopolysaccharide-induced cellular responses and signaling events in human renal mesangial cells

(2010) Fang Wu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

CCR2 antagonism improves insulin resistance, lipid metabolism, and diabetic nephropathy in type 2 diabetic mice

(2010) Young Sun Kang et al.   KIDNEY INTERNATIONAL

Inhibition of synovial hyperplasia, rheumatoid T cell activation, and experimental arthritis in mice by sulforaphane, a naturally occurring isothiocyanate

(2009) Jin-Sun Kong et al.   ARTHRITIS AND RHEUMATISM

Inactivation of GSK-3  by Metallothionein Prevents Diabetes-Related Changes in Cardiac Energy Metabolism, Inflammation, Nitrosative Damage, and Remodeling

(2009) Y. Wang et al.   DIABETES

High-calorie diet partially ameliorates dysregulation of intrarenal lipid metabolism in remnant kidney

(2009) Hyun Ju Kim et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY