Expansion of T memory stem cells with superior anti-tumor immunity by Urolithin A-induced mitophagy

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Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

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Urolithin A ameliorates experimental autoimmune encephalomyelitis by targeting aryl hydrocarbon receptor

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Immunomodulatory Role of Urolithin A on Metabolic Diseases

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Urolithin A improves muscle function by inducing mitophagy in muscular dystrophy

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An engineered IL-2 partial agonist promotes CD8+ T cell stemness

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Impact of the Natural Compound Urolithin A on Health, Disease, and Aging

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Enforced PGC-1α expression promotes CD8 T cell fitness, memory formation and antitumor immunity

(2020) Nina Dumauthioz et al.   Cellular & Molecular Immunology

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(2020) Giulia Parisi et al.   Nature Communications

Inhibiting the coregulator CoREST impairs Foxp3+ Treg function and promotes antitumor immunity

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Mitochondrial phosphatase PGAM5 modulates cellular senescence by regulating mitochondrial dynamics

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Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion

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MEK inhibition reprograms CD8+ T lymphocytes into memory stem cells with potent antitumor effects

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The NAD-Booster Nicotinamide Riboside Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance

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An increased autophagic flux contributes to the anti-inflammatory potential of urolithin A in macrophages

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Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis

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The gut microbiota urolithin metabotypes revisited: the human metabolism of ellagic acid is mainly determined by aging

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In vivo generation of human CD19‐CAR T cells results in B‐cell depletion and signs of cytokine release syndrome

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Cleaved PGAM5 is released from mitochondria depending on proteasome-mediated rupture of the outer mitochondrial membrane during mitophagy

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The Link between the Multiverse of Immune Microenvironments in Metastases and the Survival of Colorectal Cancer Patients

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T memory stem cells in health and disease

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Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming

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T Cell Factor 1-Expressing Memory-like CD8 + T Cells Sustain the Immune Response to Chronic Viral Infections

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The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction

(2016) Nicole E. Scharping et al.   IMMUNITY

BACH2 regulates CD8+ T cell differentiation by controlling access of AP-1 factors to enhancers

(2016) Rahul Roychoudhuri et al.   NATURE IMMUNOLOGY

Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

(2016) Dongryeol Ryu et al.   NATURE MEDICINE

Modulation of mTOR Signalling Triggers the Formation of Stem Cell-like Memory T Cells

(2016) Godehard Scholz et al.   EBioMedicine

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PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

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Differences in CD44 Surface Expression Levels and Function Discriminates IL-17 and IFN-γ Producing Helper T Cells

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(2014) Saravana Kumar Jaganathan   WORLD JOURNAL OF GASTROENTEROLOGY

Biological Significance of Urolithins, the Gut Microbial Ellagic Acid-Derived Metabolites: The Evidence So Far

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Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells

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