Genetic in vivo engineering of human T lymphocytes in mouse models

Receptor-mediated cell entry of paramyxoviruses: Mechanisms, and consequences for tropism and pathogenesis

(2020) Chanakha K. Navaratnarajah et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CD8-Specific Designed Ankyrin Repeat Proteins Improve Selective Gene Delivery into Human and Primate T Lymphocytes

(2020) Annika M. Frank et al.   HUMAN GENE THERAPY

In Vivo Generation of CAR T Cells Selectively in Human CD4+ Lymphocytes

(2020) Shiwani Agarwal et al.   MOLECULAR THERAPY

Humanized Mice Are Precious Tools for Preclinical Evaluation of CAR T and CAR NK Cell Therapies

(2020) Rana Mhaidly et al.   Cancers

Highly efficient and selective CAR-gene transfer using CD4- and CD8-targeted lentiviral vectors

(2019) Arezoo Jamali et al.   Molecular Therapy-Methods & Clinical Development

Multispecific anti-HIV duoCAR-T cells display broad in vitro antiviral activity and potent in vivo elimination of HIV-infected cells in a humanized mouse model

(2019) Kim Anthony-Gonda et al.   Science Translational Medicine

Humanized mice are precious tools for evaluation of hematopoietic gene therapies and preclinical modeling to move towards a clinical trial

(2019) Christian Brendel et al.   BIOCHEMICAL PHARMACOLOGY

Vectofusin-1 Improves Transduction of Primary Human Cells with Diverse Retroviral and Lentiviral Pseudotypes, Enabling Robust, Automated Closed-System Manufacturing

(2019) Constanze Radek et al.   HUMAN GENE THERAPY

CAR T Cells Beyond Cancer: Hope for Immunomodulatory Therapy of Infectious Diseases

(2019) Michelle Seif et al.   Frontiers in Immunology

In vivo generated human CAR T cells eradicate tumor cells

(2019) Shiwani Agarwal et al.   OncoImmunology

Optimized DNA electroporation for primary human T cell engineering

(2018) Zhang Zhang et al.   BMC BIOTECHNOLOGY

Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia

(2018) Joseph A. Fraietta et al.   NATURE MEDICINE

Chimeric Antigen Receptor Therapy

(2018) Carl H. June et al.   NEW ENGLAND JOURNAL OF MEDICINE

A library-based screening strategy for the identification of DARPins as ligands for receptor-targeted AAV and lentiviral vectors

(2018) Jessica Hartmann et al.   Molecular Therapy-Methods & Clinical Development

In vivo generation of human CD19‐CAR T cells results in B‐cell depletion and signs of cytokine release syndrome

(2018) Anett Pfeiffer et al.   EMBO Molecular Medicine

Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell

(2018) Marco Ruella et al.   NATURE MEDICINE

Surface-Engineered Lentiviral Vectors for Selective Gene Transfer into Subtypes of Lymphocytes

(2018) Annika M. Frank et al.   Molecular Therapy-Methods & Clinical Development

Analysis of parameters that affect human hematopoietic cell outputs in mutant c-kit-immunodeficient mice

(2017) Paul H. Miller et al.   EXPERIMENTAL HEMATOLOGY

In situ programming of leukaemia-specific T cells using synthetic DNA nanocarriers

(2017) Tyrel T. Smith et al.   Nature Nanotechnology

Engineering HIV-Specific Immunity with Chimeric Antigen Receptors

(2016) Scott G. Kitchen et al.   AIDS PATIENT CARE AND STDS

Propagating Humanized BLT Mice for the Study of Human Immunology and Immunotherapy

(2016) Drake J. Smith et al.   STEM CELLS AND DEVELOPMENT

Lentiviral vector interactions with the host cell

(2016) Chiara Borsotti et al.   Current Opinion in Virology

Receptor-Targeted Nipah Virus Glycoproteins Improve Cell-Type Selective Gene Delivery and Reveal a Preference for Membrane-Proximal Cell Attachment

(2016) Ruben R. Bender et al.   PLoS Pathogens

Enhanced Reconstitution of Human Erythropoiesis and Thrombopoiesis in an Immunodeficient Mouse Model with Kit Wv Mutations

(2016) Ayano Yurino et al.   Stem Cell Reports

Exclusive Transduction of Human CD4+T Cells upon Systemic Delivery of CD4-Targeted Lentiviral Vectors

(2015) Qi Zhou et al.   JOURNAL OF IMMUNOLOGY

Gene therapy returns to centre stage

(2015) Luigi Naldini   NATURE

Receptor-targeted lentiviral vectors are exceptionally sensitive toward the biophysical properties of the displayed single-chain Fv

(2015) Thorsten Friedel et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Surface-Engineered Viral Vectors for Selective and Cell Type-Specific Gene Delivery

(2015) Christian J. Buchholz et al.   TRENDS IN BIOTECHNOLOGY

Nonirradiated NOD,B6.SCID Il2rγ−/− KitW41/W41 (NBSGW) Mice Support Multilineage Engraftment of Human Hematopoietic Cells

(2015) Brian E. McIntosh et al.   Stem Cell Reports

Closely related T-memory stem cells correlate with in vivo expansion of CAR.CD19-T cells and are preserved by IL-7 and IL-15

(2014) Y. Xu et al.   BLOOD

Kit Regulates HSC Engraftment across the Human-Mouse Species Barrier

(2014) Kadriye Nehir Cosgun et al.   Cell Stem Cell

Human Hemato-Lymphoid System Mice: Current Use and Future Potential for Medicine

(2013) Anthony Rongvaux et al.   Annual Review of Immunology

Human immune system development and survival of non-obese diabetic (NOD)-scid IL2rγnull(NSG) mice engrafted with human thymus and autologous haematopoietic stem cells

(2013) L. Covassin et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

The Receptor Attachment Function of Measles Virus Hemagglutinin Can Be Replaced with an Autonomous Protein That Binds Her2/neu While Maintaining Its Fusion-Helper Function

(2013) A. Rasbach et al.   JOURNAL OF VIROLOGY

T-cell receptor gene transfer exclusively to human CD8+ cells enhances tumor cell killing

(2012) Q. Zhou et al.   BLOOD

Development of Mature and Functional Human Myeloid Subsets in Hematopoietic Stem Cell-Engrafted NOD/SCID/IL2r KO Mice

(2012) S. Tanaka et al.   JOURNAL OF IMMUNOLOGY

New generation humanized mice for virus research: Comparative aspects and future prospects

(2012) Ramesh Akkina   VIROLOGY

DARPins: An Efficient Targeting Domain for Lentiviral Vectors

(2011) Robert C Münch et al.   MOLECULAR THERAPY

A simple, versatile and efficient method to genetically modify human monocyte-derived dendritic cells with HIV-1–derived lentiviral vectors

(2011) Grégory Berger et al.   Nature Protocols

Environmental risk assessment for medicinal products containing genetically modified organisms

(2009) B. Anliker et al.   Bundesgesundheitsblatt-Gesundheitsforschung-Gesundheitsschutz

Targeted Transduction via CD4 by a Lentiviral Vector Uses a Clathrin-Mediated Entry Pathway

(2009) M. Liang et al.   JOURNAL OF VIROLOGY

Cell Type-Specific Targeting with Surface-Engineered Lentiviral Vectors Co-displaying OKT3 Antibody and Fusogenic Molecule

(2009) Haiguang Yang et al.   PHARMACEUTICAL RESEARCH

IL-15 trans-presentation promotes human NK cell development and differentiation in vivo

(2008) Nicholas D. Huntington et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Targeted Cell Entry of Lentiviral Vectors

(2008) Sabrina Funke et al.   MOLECULAR THERAPY