Site‐Specific Multi‐Functionalization of the Carrier Protein CRM 197 by Disulfide Rebridging for Conjugate Vaccine Development

Retaining the structural integrity of disulfide bonds in diphtheria toxoid carrier protein is crucial for the effectiveness of glycoconjugate vaccine candidates

(2022) Filippo Carboni et al.   Chemical Science

Emerging concepts in the science of vaccine adjuvants

(2021) Bali Pulendran et al.   NATURE REVIEWS DRUG DISCOVERY

SARS-CoV-2 RBD-Tetanus Toxoid Conjugate Vaccine Induces a Strong Neutralizing Immunity in Preclinical Studies

(2021) Yury Valdes-Balbin et al.   ACS Chemical Biology

Carbohydrate Conjugates in Vaccine Developments

(2020) Shuyao Lang et al.   Frontiers in Chemistry

Recent advances of thiol-selective bioconjugation reactions

(2020) Philipp Ochtrop et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Protein and Glycan Mimicry in HIV Vaccine Design

(2019) Gemma E. Seabright et al.   JOURNAL OF MOLECULAR BIOLOGY

Chemically engineered glycan-modified cancer vaccines to mobilize skin dendritic cells

(2019) Sanne Duinkerken et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Recent Advances in Toll Like Receptor-Targeting Glycoconjugate Vaccines

(2018) Qingjiang Li et al.   MOLECULES

Highly homogeneous antibody modification through optimisation of the synthesis and conjugation of functionalised dibromopyridazinediones

(2018) Calise Bahou et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Glycoconjugate vaccines: Principles and mechanisms

(2018) Rino Rappuoli   Science Translational Medicine

Bacterially derived synthetic mimetics of mammalian oligomannose prime antibody responses that neutralize HIV infectivity

(2017) Ralph Pantophlet et al.   Nature Communications

Cu-Catalyzed Click Reaction in Carbohydrate Chemistry

(2016) Vinod K. Tiwari et al.   CHEMICAL REVIEWS

Site-Selective Disulfide Modification of Proteins: Expanding Diversity beyond the Proteome

(2016) Seah Ling Kuan et al.   CHEMISTRY-A EUROPEAN JOURNAL

Strain-Promoted 1,3-Dipolar Cycloaddition of Cycloalkynes and Organic Azides

(2016) Jan Dommerholt et al.   Topics in Current Chemistry

Sugar-Protein Connectivity Impacts on the Immunogenicity of Site-SelectiveSalmonellaO-Antigen Glycoconjugate Vaccines

(2015) Giuseppe Stefanetti et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A plug-and-play approach to antibody-based therapeutics via a chemoselective dual click strategy

(2015) Antoine Maruani et al.   Nature Communications

The Imidazoquinoline Toll-Like Receptor-7/8 Agonist Hybrid-2 Potently Induces Cytokine Production by Human Newborn and Adult Leukocytes

(2015) Lakshmi Ganapathi et al.   PLoS One

Targeting C-type lectin receptors with multivalent carbohydrate ligands

(2013) Bernd Lepenies et al.   ADVANCED DRUG DELIVERY REVIEWS

Epitope Mapping of Monoclonal Antibodies using Synthetic Oligosaccharides Uncovers Novel Aspects of Immune Recognition of the Psl Exopolysaccharide ofPseudomonas aeruginosa

(2013) Huiqing Li et al.   CHEMISTRY-A EUROPEAN JOURNAL

Modern Subunit Vaccines: Development, Components, and Research Opportunities

(2013) Peter Michael Moyle et al.   ChemMedChem

Synthetic carbohydrate antigens for HIV vaccine design

(2013) Lai-Xi Wang   CURRENT OPINION IN CHEMICAL BIOLOGY

Beyond Empiricism: Informing Vaccine Development through Innate Immunity Research

(2012) Stuart M. Levitz et al.   CELL

Identification of broadly protective human antibodies toPseudomonas aeruginosaexopolysaccharide Psl by phenotypic screening

(2012) Antonio DiGiandomenico et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Biochemical and biological characteristics of cross-reacting material 197 (CRM197), a non-toxic mutant of diphtheria toxin: Use as a conjugation protein in vaccines and other potential clinical applications

(2011) Michael Bröker et al.   BIOLOGICALS

Bromopyridazinedione-mediated protein and peptide bioconjugation

(2011) Vijay Chudasama et al.   CHEMICAL COMMUNICATIONS

Immunological mechanisms of vaccination

(2011) Bali Pulendran et al.   NATURE IMMUNOLOGY

Immune recognition of tumor-associated mucin MUC1 is achieved by a fully synthetic aberrantly glycosylated MUC1 tripartite vaccine

(2011) V. Lakshminarayanan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Use of defined TLR ligands as adjuvants within human vaccines

(2010) Malcolm S. Duthie et al.   IMMUNOLOGICAL REVIEWS

Recent advances in carbohydrate-based vaccines

(2009) Marie-Lyn Hecht et al.   CURRENT OPINION IN CHEMICAL BIOLOGY