Strain-Promoted 1,3-Dipolar Cycloaddition of Cycloalkynes and Organic Azides

Strain-Promoted Oxidation-Controlled Cyclooctyne–1,2-Quinone Cycloaddition (SPOCQ) for Fast and Activatable Protein Conjugation

(2015) Annika Borrmann et al.   BIOCONJUGATE CHEMISTRY

PYRROC: the first functionalized cycloalkyne that facilitates isomer-free generation of organic molecules by SPAAC

(2015) Corinna Gröst et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A Fast and Activatable Cross-Linking Strategy for Hydrogel Formation

(2014) Anika M. Jonker et al.   ADVANCED MATERIALS

New Generation of Bioorthogonally Applicable Fluorogenic Dyes with Visible Excitations and Large Stokes Shifts

(2014) András Herner et al.   BIOCONJUGATE CHEMISTRY

Production of Site-Specific Antibody–Drug Conjugates Using Optimized Non-Natural Amino Acids in a Cell-Free Expression System

(2014) Erik S. Zimmerman et al.   BIOCONJUGATE CHEMISTRY

4-Halogeno-sydnones for fast strain promoted cycloaddition with bicyclo-[6.1.0]-nonyne

(2014) Lucie Plougastel et al.   CHEMICAL COMMUNICATIONS

Synthesis of DIBAC analogues with excellent SPAAC rate constants

(2014) Marjoke F. Debets et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Imaging bacterial peptidoglycan with near-infrared fluorogenic azide probes

(2014) P. Shieh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Scalable Synthesis of Strained Cyclooctyne Derivatives

(2014) Alex Adronov et al.   SYNTHESIS-STUTTGART

Strain-promoted sydnone bicyclo-[6.1.0]-nonyne cycloaddition

(2014) Stephen Wallace et al.   Chemical Science

Highly accelerated inverse electron-demand cycloaddition of electron-deficient azides with aliphatic cyclooctynes

(2014) Jan Dommerholt et al.   Nature Communications

Thiacycloalkynes for Copper-Free Click Chemistry

(2012) Gabriela de Almeida et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Genetic Encoding of a Bicyclo[6.1.0]nonyne-Charged Amino Acid Enables Fast Cellular Protein Imaging by Metal-Free Ligation

(2012) Annika Borrmann et al.   CHEMBIOCHEM

Genetic Encoding of Bicyclononynes and trans-Cyclooctenes for Site-Specific Protein Labeling in Vitro and in Live Mammalian Cells via Rapid Fluorogenic Diels–Alder Reactions

(2012) Kathrin Lang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Polar Dibenzocyclooctynes for Selective Labeling of Extracellular Glycoconjugates of Living Cells

(2012) Frédéric Friscourt et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fluorogenic Azidofluoresceins for Biological Imaging

(2012) Peyton Shieh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of isoxazoles by hypervalent iodine-induced cycloaddition of nitrile oxides to alkynes

(2011) Anup M. Jawalekar et al.   CHEMICAL COMMUNICATIONS

Clicking 1,2,4,5-tetrazine and cyclooctynes with tunable reaction rates

(2011) Weixuan Chen et al.   CHEMICAL COMMUNICATIONS

A Non-Fluorinated Monobenzocyclooctyne for Rapid Copper-Free Click Reactions

(2011) Balázs R. Varga et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis of a Fluorogenic Cyclooctyne Activated by Cu-Free Click Chemistry

(2011) John C. Jewett et al.   ORGANIC LETTERS

Development and evaluation of new cyclooctynes for cell surface glycan imaging in cancer cells

(2011) Henning Stöckmann et al.   Chemical Science

Protein Modification by Strain-Promoted Alkyne-Nitrone Cycloaddition

(2010) Xinghai Ning et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Readily Accessible Bicyclononynes for Bioorthogonal Labeling and Three-Dimensional Imaging of Living Cells

(2010) Jan Dommerholt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Surface Functionalization Using Catalyst-Free Azide−Alkyne Cycloaddition

(2010) Alexander Kuzmin et al.   BIOCONJUGATE CHEMISTRY

Azide: A Unique Dipole for Metal-Free Bioorthogonal Ligations

(2010) Marjoke F. Debets et al.   CHEMBIOCHEM

Difluorobenzocyclooctyne: Synthesis, Reactivity, and Stabilization by β-Cyclodextrin

(2010) Ellen M. Sletten et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rapid Cu-Free Click Chemistry with Readily Synthesized Biarylazacyclooctynones

(2010) John C. Jewett et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Metal-Free Sequential [3 + 2]-Dipolar Cycloadditions using Cyclooctynes and 1,3-Dipoles of Different Reactivity

(2010) Brian C. Sanders et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nitrones as dipoles for rapid strain-promoted 1,3-dipolar cycloadditions with cyclooctynes

(2009) Craig S. McKay et al.   CHEMICAL COMMUNICATIONS

Aza-dibenzocyclooctynes for fast and efficient enzyme PEGylation via copper-free (3+2) cycloaddition

(2009) Marjoke F. Debets et al.   CHEMICAL COMMUNICATIONS

Fluorogenic click reaction

(2009) Céline Le Droumaguet et al.   CHEMICAL SOCIETY REVIEWS

Ring Strain Energy in the Cyclooctyl System. The Effect of Strain Energy on [3 + 2] Cycloaddition Reactions with Azides

(2009) Robert D. Bach   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Visualizing Metabolically Labeled Glycoconjugates of Living Cells by Copper-Free and Fast Huisgen Cycloadditions

(2008) Xinghai Ning et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Transition States of Strain-Promoted Metal-Free Click Chemistry:  1,3-Dipolar Cycloadditions of Phenyl Azide and Cyclooctynes

(2008) Daniel H. Ess et al.   ORGANIC LETTERS

A Hydrophilic Azacyclooctyne for Cu-Free Click Chemistry

(2008) Ellen M. Sletten et al.   ORGANIC LETTERS

A fluorogenic ‘click’ reaction of azidoanthracene derivatives

(2008) Fang Xie et al.   TETRAHEDRON