The Imidazoquinoline Toll-Like Receptor-7/8 Agonist Hybrid-2 Potently Induces Cytokine Production by Human Newborn and Adult Leukocytes

Global, regional, and national age–sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013

(2015)   LANCET

A New Era of Targeting the Ancient Gatekeepers of the Immune System: Toll-Like Agonists in the Treatment of Allergic Rhinitis and Asthma

(2014) Zahra Aryan et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Determinants of Activity at Human Toll-like Receptors 7 and 8: Quantitative Structure–Activity Relationship (QSAR) of Diverse Heterocyclic Scaffolds

(2014) Euna Yoo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ontogeny of early life immunity

(2014) David J. Dowling et al.   TRENDS IN IMMUNOLOGY

Soluble Mediators Regulating Immunity in Early Life

(2014) Matthew Aaron Pettengill et al.   Frontiers in Immunology

TLR Agonists as Modulators of the Innate Immune Response and Their Potential as Agents Against Infectious Disease

(2014) Edin J. Mifsud et al.   Frontiers in Immunology

Role of Innate Immunity in Neonatal Infection

(2013) Alex Cuenca et al.   AMERICAN JOURNAL OF PERINATOLOGY

TLR agonists: our best frenemy in cancer immunotherapy

(2013) Sabina Kaczanowska et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Exquisite Selectivity for Human Toll-Like Receptor 8 in Substituted Furo[2,3-c]quinolines

(2013) Hari Prasad Kokatla et al.   JOURNAL OF MEDICINAL CHEMISTRY

Immunosuppressive CD71+ erythroid cells compromise neonatal host defence against infection

(2013) Shokrollah Elahi et al.   NATURE

The Ultra-Potent and Selective TLR8 Agonist VTX-294 Activates Human Newborn and Adult Leukocytes

(2013) David J. Dowling et al.   PLoS One

Structural Reorganization of the Toll-Like Receptor 8 Dimer Induced by Agonistic Ligands

(2013) H. Tanji et al.   SCIENCE

Newborn survival: a multi-country analysis of a decade of change

(2012) Joy E Lawn et al.   HEALTH POLICY AND PLANNING

Innate Immune Function by Toll-like Receptors: Distinct Responses in Newborns and the Elderly

(2012) Tobias R. Kollmann et al.   IMMUNITY

Imidazoquinoline Toll-like receptor 8 agonists activate human newborn monocytes and dendritic cells through adenosine-refractory and caspase-1–dependent pathways

(2012) Victoria J. Philbin et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Immunization of newborns with bacterial conjugate vaccines

(2012) Anita H.J. van den Biggelaar et al.   VACCINE

Immune response to vaccine adjuvants during the first year of life

(2012) Ofer Levy et al.   VACCINE

iMOSFLM: a new graphical interface for diffraction-image processing withMOSFLM

(2011) T. Geoff G. Battye et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Adenosine modulates Toll-like receptor function: basic mechanisms and translational opportunities

(2011) Melanie R Power Coombs et al.   Expert Review of Anti-Infective Therapy

Cytokine Signatures of Innate and Adaptive Immunity in 17DD Yellow Fever Vaccinated Children and Its Association With the Level of Neutralizing Antibody

(2011) M. Luiza-Silva et al.   JOURNAL OF INFECTIOUS DISEASES

Challenges in infant immunity: implications for responses to infection and vaccines

(2011) Mercy PrabhuDas et al.   NATURE IMMUNOLOGY

Immunological mechanisms of vaccination

(2011) Bali Pulendran et al.   NATURE IMMUNOLOGY

Comparative Analysis of Species-Specific Ligand Recognition in Toll-Like Receptor 8 Signaling: A Hypothesis

(2011) Rajiv Gandhi Govindaraj et al.   PLoS One

Development of Newborn and Infant Vaccines

(2011) G. Sanchez-Schmitz et al.   Science Translational Medicine

Syntheses of fluorescent imidazoquinoline conjugates as probes of Toll-like receptor 7

(2010) Nikunj M. Shukla et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Vaccine Adjuvants: Putting Innate Immunity to Work

(2010) Robert L. Coffman et al.   IMMUNITY

Use of defined TLR ligands as adjuvants within human vaccines

(2010) Malcolm S. Duthie et al.   IMMUNOLOGICAL REVIEWS

Structure−Activity Relationships in Human Toll-Like Receptor 7-Active Imidazoquinoline Analogues

(2010) Nikunj M. Shukla et al.   JOURNAL OF MEDICINAL CHEMISTRY

Expression of Toll-like receptors by neonatal leukocytes

(2010) Pallave Dasari et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

Molecular replacement withMOLREP

(2009) Alexei Vagin et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Neonatal Innate TLR-Mediated Responses Are Distinct from Those of Adults

(2009) T. R. Kollmann et al.   JOURNAL OF IMMUNOLOGY

Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans

(2008) Troy D Querec et al.   NATURE IMMUNOLOGY