BefA, a microbiota-secreted membrane disrupter, disseminates to the pancreas and increases β cell mass

From bugs to β cells

(2022) Jennifer Hampton Hill   SCIENCE

Maternal cecal microbiota transfer rescues early-life antibiotic-induced enhancement of type 1 diabetes in mice

(2021) Xue-Song Zhang et al.   Cell Host & Microbe

Solution Structure of the BPSL1445 Protein of Burkholderia pseudomallei Reveals the SYLF Domain Three-Dimensional Fold

(2021) Giacomo Quilici et al.   ACS Chemical Biology

Patterns of partnership: surveillance and mimicry in host-microbiota mutualisms

(2020) Travis J Wiles et al.   CURRENT OPINION IN MICROBIOLOGY

The architecture of the Gram-positive bacterial cell wall

(2020) L. Pasquina-Lemonche et al.   NATURE

Mechanistic Landscape of Membrane-Permeabilizing Peptides

(2019) Shantanu Guha et al.   CHEMICAL REVIEWS

Probiotic Studies in Neonatal Mice Using Gavage

(2019) Freddy Francis et al.   Jove-Journal of Visualized Experiments

Intestinal lysozyme liberates Nod1 ligands from microbes to direct insulin trafficking in pancreatic beta cells

(2019) Qin Zhang et al.   CELL RESEARCH

Tumor Microbiome Diversity and Composition Influence Pancreatic Cancer Outcomes

(2019) Erick Riquelme et al.   CELL

Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix

(2019) Dorothee Liebschner et al.   Acta Crystallographica Section D-Structural Biology

Lysosome-Rich Enterocytes Mediate Protein Absorption in the Vertebrate Gut

(2019) Jieun Park et al.   DEVELOPMENTAL CELL

Four Decades After the Discovery of Regenerating Islet-Derived (Reg) Proteins: Current Understanding and Challenges

(2019) Zijing Chen et al.   Frontiers in Cell and Developmental Biology

Strain-Level Analysis of Mother-to-Child Bacterial Transmission during the First Few Months of Life

(2018) Moran Yassour et al.   Cell Host & Microbe

Pancreatic β Cell Regeneration as a Possible Therapy for Diabetes

(2018) Cristina Aguayo-Mazzucato et al.   Cell Metabolism

The Pancreatic Cancer Microbiome Promotes Oncogenesis by Induction of Innate and Adaptive Immune Suppression

(2018) Smruti Pushalkar et al.   Cancer Discovery

Cellular mechanisms and signals that coordinate plasma membrane repair

(2018) Adam Horn et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The Microbiomes of Pancreatic and Duodenum Tissue Overlap and are Highly Subject Specific but Differ between Pancreatic Cancer and Non-Cancer Subjects

(2018) Erika Del Castillo et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Mechanisms protecting host cells against bacterial pore-forming toxins

(2018) Cláudia Brito et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A bacterial immunomodulatory protein with lipocalin-like domains facilitates host–bacteria mutualism in larval zebrafish

(2018) Annah S Rolig et al.   eLife

Age-dependent human β cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling

(2017) Chunhua Dai et al.   JOURNAL OF CLINICAL INVESTIGATION

Type 2 Diabetes Remission After Roux-en-Y Gastric Bypass: Evidence for Increased Expression of Jejunal Genes Encoding Regenerating Pancreatic Islet-Derived Proteins as a Potential Mechanism

(2017) Priscila Sala et al.   OBESITY SURGERY

Interhost dispersal alters microbiome assembly and can overwhelm host innate immunity in an experimental zebrafish model

(2017) Adam R. Burns et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The molecular and morphogenetic basis of pancreas organogenesis

(2017) Hjalte List Larsen et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Disruption of the plant-specific CFS1 gene impairs autophagosome turnover and triggers EDS1-dependent cell death

(2017) Arpaporn Sutipatanasomboon et al.   Scientific Reports

Intestinal REG3 Lectins Protect against Alcoholic Steatohepatitis by Reducing Mucosa-Associated Microbiota and Preventing Bacterial Translocation

(2016) Lirui Wang et al.   Cell Host & Microbe

Metabolites: messengers between the microbiota and the immune system

(2016) Maayan Levy et al.   GENES & DEVELOPMENT

Gut microbiome and liver diseases

(2016) Herbert Tilg et al.   GUT

MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets

(2016) Sudhir Kumar et al.   MOLECULAR BIOLOGY AND EVOLUTION

Cloche is a bHLH-PAS transcription factor that drives haemato-vascular specification

(2016) Sven Reischauer et al.   NATURE

CDD/SPARCLE: functional classification of proteins via subfamily domain architectures

(2016) Aron Marchler-Bauer et al.   NUCLEIC ACIDS RESEARCH

Antibiotics, birth mode, and diet shape microbiome maturation during early life

(2016) Nicholas A. Bokulich et al.   Science Translational Medicine

A conserved bacterial protein induces pancreatic beta cell expansion during zebrafish development

(2016) Jennifer Hampton Hill et al.   eLife

Function and interactions of the Ysc84/SH3yl1 family of actin- and lipid-binding proteins

(2015) Agnieszka N. Urbanek et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Cathelicidin Antimicrobial Peptide: A Novel Regulator of Islet Function, Islet Regeneration, and Selected Gut Bacteria

(2015) Lynley D. Pound et al.   DIABETES

Antimicrobial Defense of the Intestine

(2015) Sohini Mukherjee et al.   IMMUNITY

The I-TASSER Suite: protein structure and function prediction

(2015) Jianyi Yang et al.   NATURE METHODS

First quantitative high-throughput screen in zebrafish identifies novel pathways for increasing pancreatic β-cell mass

(2015) Guangliang Wang et al.   eLife

Spatial and Temporal Features of the Growth of a Bacterial Species Colonizing the Zebrafish Gut

(2014) Matthew Jemielita et al.   mBio

Antibacterial membrane attack by a pore-forming intestinal C-type lectin

(2013) Sohini Mukherjee et al.   NATURE

Analysis Tool Web Services from the EMBL-EBI

(2013) Hamish McWilliam et al.   NUCLEIC ACIDS RESEARCH

Biophysical characterization of higher plant Rubisco activase

(2012) J. Nathan Henderson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Zebrafish sox9b is crucial for hepatopancreatic duct development and pancreatic endocrine cell regeneration

(2012) Isabelle Manfroid et al.   DEVELOPMENTAL BIOLOGY

Neonatal β Cell Development in Mice and Humans Is Regulated by Calcineurin/NFAT

(2012) William R. Goodyer et al.   DEVELOPMENTAL CELL

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Linking Crystallographic Model and Data Quality

(2012) P. A. Karplus et al.   SCIENCE

Dendroscope 3: An Interactive Tool for Rooted Phylogenetic Trees and Networks

(2012) Daniel H. Huson et al.   SYSTEMATIC BIOLOGY

Chemical Methods to Induce Beta-Cell Proliferation

(2012) Amedeo Vetere et al.   International Journal of Endocrinology

Serum levels of pancreatic stone protein (PSP)/reg1A as an indicator of beta-cell apoptosis suggest an increased apoptosis rate in hepatocyte nuclear factor 1 alpha (HNF1A-MODY) carriers from the third decade of life onward

(2012) Siobhan Bacon et al.   BMC Endocrine Disorders

sox9b Is a Key Regulator of Pancreaticobiliary Ductal System Development

(2012) Marion Delous et al.   PLoS Genetics

Toll-like receptor 4 (TLR4) expression in human and murine pancreatic beta-cells affects cell viability and insulin homeostasis

(2011) Humberto M Garay-Malpartida et al.   BMC IMMUNOLOGY

Visualizing digestive organ morphology and function using differential fatty acid metabolism in live zebrafish

(2011) Juliana Debrito Carten et al.   DEVELOPMENTAL BIOLOGY

SH3YL1 regulates dorsal ruffle formation by a novel phosphoinositide-binding domain

(2011) Junya Hasegawa et al.   JOURNAL OF CELL BIOLOGY

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

(2011) F. Sievers et al.   Molecular Systems Biology

The Antibacterial Lectin RegIII  Promotes the Spatial Segregation of Microbiota and Host in the Intestine

(2011) S. Vaishnava et al.   SCIENCE

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Circulating Reg1α Proteins and Autoantibodies to Reg1α Proteins as Biomarkers of β-Cell Regeneration and Damage in Type 1 Diabetes

(2010) E. Astorri et al.   HORMONE AND METABOLIC RESEARCH

I-TASSER: a unified platform for automated protein structure and function prediction

(2010) Ambrish Roy et al.   Nature Protocols

A new bioinformatics analysis tools framework at EMBL-EBI

(2010) M. Goujon et al.   NUCLEIC ACIDS RESEARCH

Predicting melting temperature directly from protein sequences

(2009) Tienhsiung Ku et al.   COMPUTATIONAL BIOLOGY AND CHEMISTRY

The WASP Homologue Las17 Activates the Novel Actin-regulatory Activity of Ysc84 to Promote Endocytosis in Yeast

(2009) Alastair S. Robertson et al.   MOLECULAR BIOLOGY OF THE CELL

Islet Formation during the Neonatal Development in Mice

(2009) Kevin Miller et al.   PLoS One

Bayesian Modeling of the Yeast SH3 Domain Interactome Predicts Spatiotemporal Dynamics of Endocytosis Proteins

(2009) Raffi Tonikian et al.   PLOS BIOLOGY

Use of Zebrafish to Probe the Divergent Virulence Potentials and Toxin Requirements of Extraintestinal Pathogenic Escherichia coli

(2009) Travis J. Wiles et al.   PLoS Pathogens

I-TASSER server for protein 3D structure prediction

(2008) Yang Zhang   BMC BIOINFORMATICS