Editorial Material
Cell Biology
Jinhyuk Choi, Fritz Cayabyab, Eiji Yoshihara
Summary: The study presents a method to convert human stomach-derived gastric stem cells into insulin-producing cells, offering an alternative approach for cell therapy in diabetes.
NATURE CELL BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Stepanka Benakova, Blanka Holendova, Lydie Plecita-Hlavata
Summary: Redox status plays a crucial role in determining the fate of beta-cells, requiring proper signaling for differentiation, proliferation, and insulin expression. Chronic pathological insults can lead to dysfunction and glucose intolerance in beta-cells, ultimately resulting in cell death.
Review
Biochemistry & Molecular Biology
Jiani Liang, Margot Chirikjian, Utpal B. Pajvani, Alberto Bartolome
Summary: The expression of MafA, a key transcription factor, is decreased in type 2 diabetes, leading to beta-cell dysfunction. Understanding the regulatory factors of MafA expression may help identify potential therapeutic targets for improving beta-cell function.
Review
Endocrinology & Metabolism
Shimon Efrat
Summary: Incomplete reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) may cause differentiation capacity heterogeneity. Epigenetic memory in BiPSCs predisposes them to enhanced differentiation into insulin-producing cells. Genome-wide analyses of open chromatin revealed differential sites and regulators of endodermal development enriched in BiPSCs, providing clues for improving differentiation efficiency of pluripotent stem cells.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Entomology
Dora M. Rajonhson, Chadchalerm Raksakoon, Anon Payakkapol, Sebastien Dujardin, Jean-Pierre Dujardin, Rutcharin Potiwat
Summary: A comparative study was conducted to assess the effectiveness of classifying Cimicidae using two methods: traditional morphometry and geometric morphometry. Both methods were found to be effective, but geometric morphometry provided better quality data for classification. The study recommends adopting this approach for future surveillance programs.
Article
Nutrition & Dietetics
Wenqian Gu, Camilla Christine Bundgaard Anker, Christine Bodelund Christiansen, Tilo Moede, Per-Olof Berggren, Kjeld Hermansen, Soren Gregersen, Per Bendix Jeppesen
Summary: The study found that islet beta cells suppress glucagon secretion from alpha cells via direct cell-to-cell contact during co-culture, leading to a significant decrease in glucagon secretion from the alpha cells. However, this effect did not impact insulin secretion from beta cells, and the distribution of cells in co-culture differed from the in vivo arrangement of beta and alpha cells in mouse islets.
Article
Multidisciplinary Sciences
Ami Watanabe, Anna Tanaka, Chizuko Koga, Masahito Matsumoto, Yasushi Okazaki, Tatsuya Kin, Atsushi Miyajima
Summary: Generating pancreatic beta cells from pluripotent stem cells is crucial for developing cell therapy for insulin-dependent diabetes, but the process often faces challenges such as instability and potential risk of tumorigenesis. By isolating beta cell precursors from late stage pancreatic endocrine progenitor cells, the tetraspanin family member CD82 has been identified as playing a key role in the efficient differentiation and function of beta cells. Knockdown or inhibition of CD82 expression also affects the maturation of EP cells into beta cells.
SCIENTIFIC REPORTS
(2021)
Article
Biology
Sevim Kahraman, Debasish Manna, Ercument Dirice, Basudeb Maji, Jonnell Small, Bridget K. Wagner, Amit Choudhary, Rohit N. Kulkarni
Summary: The reaction-based probe DA-ZP1 provides a sensitive method for imaging and purifying insulin-expressing cells like pancreatic beta-cells, derived from human pluripotent stem cells. It can be used for downstream applications such as functional studies, gene-expression, and cell-cell interaction analyses. Additionally, DA-ZP1 is capable of labeling engrafted human islets and endogenous mouse islets in vivo.
LIFE SCIENCE ALLIANCE
(2021)
Article
Computer Science, Software Engineering
Hao Zhong, Xiaoyin Wang, Hong Mei
Summary: Current static bug detection tools based on manual bug patterns have limitations in detecting all types of bugs. This study introduces a new approach, DePa, which extracts bug signatures from accurate partial-code analysis of bug fixes. Evaluation on 6,048 past bug fixes from four Apache projects demonstrates that DePa detected 27 unique previously unknown bugs, with three already confirmed and repaired by developers.
IEEE TRANSACTIONS ON SOFTWARE ENGINEERING
(2022)
Review
Biochemistry & Molecular Biology
Kristen M. Tummillo, Karsten R. O. Hazlett
Summary: Bioconjugation allows scientists to combine multiple functional elements into one biological unit, targeting specific sites or cell types to enhance response or activity. This targeted approach is particularly advantageous in cancer treatments, where delivering chemotherapies selectively can limit side effects and improve efficacy. Additionally, conjugation can help in treating bacterial infections more selectively and enhancing vaccine efficacy without compromising safety.
Article
Multidisciplinary Sciences
Ansarullah, Chirag Jain, Fataneh Fathi Far, Sarah Homberg, Katharina Wissmiller, Felizitas Grafin von Hahn, Aurelia Raducanu, Silvia Schirge, Michael Sterr, Sara Bilekova, Johanna Siehler, Julius Wiener, Lena Oppenlaender, Amir Morshedi, Aimee Bastidas-Ponce, Gustav Collden, Martin Irmler, Johannes Beckers, Annette Feuchtinger, Michal Grzybek, Christin Ahlbrecht, Regina Feederle, Oliver Plettenburg, Timo D. Mueller, Matthias Meier, Matthias H. Tschoep, Uenal Coskun, Heiko Lickert
Summary: The discovery of inceptor, an inhibitor of insulin receptor (INSR) and IGF1 receptor (IGF1R) signalling in mouse beta-cells, sheds light on a potential molecular target for INSR-IGF1R sensitization and diabetes therapy. The study shows that inceptor plays a role in shielding insulin-producing beta-cells from constitutive pathway activation, which could have implications for improving glucose tolerance in vivo.
Editorial Material
Immunology
Charles R. Schutt, Sho Yamasaki
Summary: In this study, it was discovered that the stress-induced lectin, intelectin-1, recruits pathogenic bacteria to the gut which worsens the symptoms of colitis. This research is significant for understanding the etiology and treatment of colitis.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Review
Cell Biology
Eric Kalo, Scott Read, Golo Ahlenstiel
Summary: This article reviews the concept of cell therapy for diabetes and explores various cell sources and their plasticity. It focuses on reprogramming pathways and transcriptional regulators that aim to generate functional insulin-producing cells.
Editorial Material
Cell Biology
Catherine Hall, Eunhee Choi
Summary: The study identified a new insulin inhibitory receptor, inceptor, which balances insulin signaling by promoting insulin receptor internalization, playing a crucial role in maintaining beta cell homeostasis.
Editorial Material
Cell Biology
Y. David Seo, Jennifer A. Wargo
Summary: Tintelnot et al. found that enrichment of indole-3-acetic acid (3-IAA), a tryptophan metabolite produced by gut microbiota, can predict the response of pancreatic adenocarcinoma to chemotherapy. Recapitulated in mouse models, 3-IAA represents a potential novel therapeutic approach for chemotherapy sensitization.
CELL REPORTS MEDICINE
(2023)
