Intestinal lysozyme liberates Nod1 ligands from microbes to direct insulin trafficking in pancreatic beta cells

Circulating NOD1 Activators and Hematopoietic NOD1 Contribute to Metabolic Inflammation and Insulin Resistance

(2017) Kenny L. Chan et al.   Cell Reports

Sensing of the microbiota by NOD1 in mesenchymal stromal cells regulates murine hematopoiesis

(2016) Chiaki Iwamura et al.   BLOOD

Inter-organ communication and regulation of beta cell function

(2016) Mehboob A. Hussain et al.   DIABETOLOGIA

LIM domain–binding 1 maintains the terminally differentiated state of pancreatic β cells

(2016) Benjamin N. Ediger et al.   JOURNAL OF CLINICAL INVESTIGATION

Acetate mediates a microbiome–brain–β-cell axis to promote metabolic syndrome

(2016) Rachel J. Perry et al.   NATURE

Nod2-mediated recognition of the microbiota is critical for mucosal adjuvant activity of cholera toxin

(2016) Donghyun Kim et al.   NATURE MEDICINE

Signals from the gut microbiota to distant organs in physiology and disease

(2016) Bjoern O Schroeder et al.   NATURE MEDICINE

A secreted bacterial peptidoglycan hydrolase enhances tolerance to enteric pathogens

(2016) K. J. Rangan et al.   SCIENCE

Rab1A mediates proinsulin to insulin conversion in β-cells by maintaining Golgi stability through interactions with golgin-84

(2016) Xiaojing Liu et al.   Protein & Cell

HID-1 is required for homotypic fusion of immature secretory granules during maturation

(2016) Wen Du et al.   eLife

A conserved bacterial protein induces pancreatic beta cell expansion during zebrafish development

(2016) Jennifer Hampton Hill et al.   eLife

IL-1 family members in the pathogenesis and treatment of metabolic disease: Focus on adipose tissue inflammation and insulin resistance

(2015) Dov B. Ballak et al.   CYTOKINE

New Role of Nod Proteins in Regulation of Intestinal Goblet Cell Response in the Context of Innate Host Defense in an Enteric Parasite Infection

(2015) Huaqing Wang et al.   INFECTION AND IMMUNITY

Commensal bacteria direct selective cargo sorting to promote symbiosis

(2015) Qin Zhang et al.   NATURE IMMUNOLOGY

Rab1A regulates anterograde melanosome transport by recruiting kinesin-1 to melanosomes through interaction with SKIP

(2015) Morié Ishida et al.   Scientific Reports

The Immune Receptor NOD1 and Kinase RIP2 Interact with Bacterial Peptidoglycan on Early Endosomes to Promote Autophagy and Inflammatory Signaling

(2014) Aaron T. Irving et al.   Cell Host & Microbe

The IRE1α-XBP1 pathway regulates metabolic stress-induced compensatory proliferation of pancreatic β-cells

(2014) Tongfu Xu et al.   CELL RESEARCH

Insight into Insulin Secretion from Transcriptome and Genetic Analysis of Insulin-Producing Cells of Drosophila

(2014) Jian Cao et al.   GENETICS

Bacterial Sensor Nod2 Prevents Inflammation of the Small Intestine by Restricting the Expansion of the Commensal Bacteroides vulgatus

(2014) Deepshika Ramanan et al.   IMMUNITY

NOD1 and NOD2: Signaling, Host Defense, and Inflammatory Disease

(2014) Roberta Caruso et al.   IMMUNITY

Endosomes are specialized platforms for bacterial sensing and NOD2 signalling

(2014) Norihiro Nakamura et al.   NATURE

Efficient genome modification by CRISPR-Cas9 nickase with minimal off-target effects

(2014) Bin Shen et al.   NATURE METHODS

Genetically Engineered Lactococcus lactis Protect against House Dust Mite Allergy in a BALB/c Mouse Model

(2014) Chunqing Ai et al.   PLoS One

Metabolome Response to Glucose in the β-Cell Line INS-1 832/13

(2013) Matthew A. Lorenz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional involvement of Rab1A in microtubule-dependent anterograde melanosome transport in melanocytes

(2012) M. Ishida et al.   JOURNAL OF CELL SCIENCE

NOD1 Activators Link Innate Immunity to Insulin Resistance

(2011) J. D. Schertzer et al.   DIABETES

Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment

(2011) Jacques Amar et al.   EMBO Molecular Medicine

Proteomic analysis of endocytic vesicles: Rab1a regulates motility of early endocytic vesicles

(2011) A. Mukhopadhyay et al.   JOURNAL OF CELL SCIENCE

Nod2 sensing of lysozyme-digested peptidoglycan promotes macrophage recruitment and clearance of S. pneumoniae colonization in mice

(2011) Kimberly M. Davis et al.   JOURNAL OF CLINICAL INVESTIGATION

Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis

(2011) Charles L. Bevins et al.   NATURE REVIEWS MICROBIOLOGY

Germ-free C57BL/6J mice are resistant to high-fat-diet-induced insulin resistance and have altered cholesterol metabolism

(2010) Sylvie Rabot et al.   FASEB JOURNAL

Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity

(2010) Thomas B Clarke et al.   NATURE MEDICINE

Quantification of pancreatic islet distribution in situ in mice

(2009) German Kilimnik et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Proteins Associated with Immunopurified Granules from a Model Pancreatic Islet β-Cell System: Proteomic Snapshot of an Endocrine Secretory Granule

(2008) Anthony J. R. Hickey et al.   JOURNAL OF PROTEOME RESEARCH

Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis

(2008) Djahida Bouskra et al.   NATURE