Four Decades After the Discovery of Regenerating Islet-Derived (Reg) Proteins: Current Understanding and Challenges

MicroRNA-7 directly targets Reg1 in pancreatic cells

(2019) Shawna Downing et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Crucial role of Reg I from acinar-like cell cluster touching with islets (ATLANTIS) on mitogenesis of beta cells in EMC virus-induced diabetic mice

(2018) Kaoru Aida et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Enteric Delivery of Regenerating Family Member 3 alpha Alters the Intestinal Microbiota and Controls Inflammation in Mice With Colitis

(2018) Marion Darnaud et al.   GASTROENTEROLOGY

REG3A overexpression suppresses gastric cancer cell invasion, proliferation and promotes apoptosis through PI3K/Akt signaling pathway

(2018) Yan-Song Qiu et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Survival signal REG3α prevents crypt apoptosis to control acute gastrointestinal graft-versus-host disease

(2018) Dongchang Zhao et al.   JOURNAL OF CLINICAL INVESTIGATION

Regenerating islet-derived 1α (REG-1α) protein increases tau phosphorylation in cell and animal models of tauopathies

(2018) Mireille Moussaed et al.   NEUROBIOLOGY OF DISEASE

Reg Gene Expression in Periosteum after Fracture and Its In Vitro Induction Triggered by IL-6

(2017) Yasuaki Tohma et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

LiteMol suite: interactive web-based visualization of large-scale macromolecular structure data

(2017) David Sehnal et al.   NATURE METHODS

Type 2 Diabetes Remission After Roux-en-Y Gastric Bypass: Evidence for Increased Expression of Jejunal Genes Encoding Regenerating Pancreatic Islet-Derived Proteins as a Potential Mechanism

(2017) Priscila Sala et al.   OBESITY SURGERY

DNA Methylation-Mediated Silencing of Regenerating Protein 1 Alpha (REG1A) Affects Gastric Cancer Prognosis

(2017) Yan-Song Qiu et al.   MEDICAL SCIENCE MONITOR

REG3β modifies cell tumor function by impairing extracellular vesicle uptake

(2017) Laia Bonjoch et al.   Scientific Reports

REG3β Plays a Key Role in IL17RA Protumoral Effect—Letter

(2016) Qing Li et al.   CANCER RESEARCH

REG3β Plays a Key Role in IL17RA Protumoral Effect—Response

(2016) Celine Loncle et al.   CANCER RESEARCH

Intestinal REG3 Lectins Protect against Alcoholic Steatohepatitis by Reducing Mucosa-Associated Microbiota and Preventing Bacterial Translocation

(2016) Lirui Wang et al.   Cell Host & Microbe

Prognostic role of regenerating gene-I in patients with stage-IV head and neck squamous cell carcinoma

(2016) Mohamed Aboshanif et al.   Diagnostic Pathology

Reg2 expression is required for pancreatic islet compensation in response to aging and high fat diet-induced obesity

(2016) Qing Li et al.   ENDOCRINOLOGY

Reg4+deep crypt secretory cells function as epithelial niche for Lgr5+stem cells in colon

(2016) Nobuo Sasaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reg-2, A Downstream Signaling Protein in the Ciliary Neurotrophic Factor Survival Pathway, Alleviates Experimental Autoimmune Encephalomyelitis

(2016) Hong Jiang et al.   Frontiers in Neuroanatomy

REG4 promotes peritoneal metastasis of gastric cancer through GPR37

(2016) Hexiao Wang et al.   Oncotarget

Reg proteins promote acinar-to-ductal metaplasia and act as novel diagnostic and prognostic markers in pancreatic ductal adenocarcinoma

(2016) Qing Li et al.   Oncotarget

Pancreatic cancer

(2016) Jorg Kleeff et al.   Nature Reviews Disease Primers

REG3A accelerates pancreatic cancer cell growth under IL-6-associated inflammatory condition: Involvement of a REG3A–JAK2/STAT3 positive feedback loop

(2015) Xiulan Liu et al.   CANCER LETTERS

IL17 Functions through the Novel REG3 -JAK2-STAT3 Inflammatory Pathway to Promote the Transition from Chronic Pancreatitis to Pancreatic Cancer

(2015) C. Loncle et al.   CANCER RESEARCH

Identification of a Three-Biomarker Panel in Urine for Early Detection of Pancreatic Adenocarcinoma

(2015) T. P. Radon et al.   CLINICAL CANCER RESEARCH

The pancreatic cancer secreted REG4 promotes macrophage polarization to M2 through EGFR/AKT/CREB pathway

(2015) XIUYING MA et al.   ONCOLOGY REPORTS

Effect of REG Iα protein on angiogenesis in gastric cancer tissues

(2015) KEN HARA et al.   ONCOLOGY REPORTS

REG4 is a transcriptional target of GATA6 and is essential for colorectal tumorigenesis

(2015) Yoshihiro Kawasaki et al.   Scientific Reports

Overexpression of Reg4, alone or combined with MMP-7 overexpression, is predictive of poor prognosis in colorectal cancer

(2014) XINGWU ZHU et al.   ONCOLOGY REPORTS

Distinct Cell Clusters Touching Islet Cells Induce Islet Cell Replication in Association with Over-Expression of Regenerating Gene (REG) Protein in Fulminant Type 1 Diabetes

(2014) Kaoru Aida et al.   PLoS One

HIP/PAP prevents excitotoxic neuronal death and promotes plasticity

(2014) Parthiv Haldipur et al.   Annals of Clinical and Translational Neurology

REG1A Expression Status Suggests Chemosensitivity Among Advanced Thoracic Esophageal Squamous Cell Carcinoma Patients Treated with Esophagectomy Followed by Adjuvant Chemotherapy

(2013) Yusuke Sato et al.   ANNALS OF SURGICAL ONCOLOGY

Reg3  Deficiency Impairs Pancreatic Tumor Growth by Skewing Macrophage Polarization

(2013) M. Gironella et al.   CANCER RESEARCH

REG gene expression in inflamed and healthy colon mucosa explored by in situ hybridisation

(2013) Atle van Beelen Granlund et al.   CELL AND TISSUE RESEARCH

Overexpression of regenerating gene Iα appears to reflect aberration of crypt cell compartmentalization in sessile serrated adenoma/polyps of the colon

(2013) Kentaro Okamoto et al.   Diagnostic Pathology

Cellular mechanisms underlying failed beta cell regeneration in offspring of protein-restricted pregnant mice

(2013) Aaron R Cox et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

N-terminal Cleaved Pancreatitis-associated Protein-III (PAP-III) Serves as a Scaffold for Neurites and Promotes Neurite Outgrowth

(2013) Hiroyuki Konishi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discrimination between Adenocarcinoma and Normal Pancreatic Ductal Fluid by Proteomic and Glycomic Analysis

(2013) Mindy Porterfield et al.   JOURNAL OF PROTEOME RESEARCH

Identification of Reg1 as a novel stellate cell activator in regenerating pancreas

(2013) Marc W. LaFonte et al.   JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS

Reg4-induced mitogenesis involves Akt-GSK3β-β-Catenin-TCF-4 signaling in human colorectal cancer

(2013) Kumar S Bishnupuri et al.   MOLECULAR CARCINOGENESIS

Antibacterial membrane attack by a pore-forming intestinal C-type lectin

(2013) Sohini Mukherjee et al.   NATURE

The Antimicrobial Protein REG3A Regulates Keratinocyte Proliferation and Differentiation after Skin Injury

(2012) Yuping Lai et al.   IMMUNITY

Intestinally Secreted C-Type Lectin Reg3b Attenuates Salmonellosis but Not Listeriosis in Mice

(2012) Marleen T. J. van Ampting et al.   INFECTION AND IMMUNITY

The Expression Patterns of Reg IV Gene in Normal Rat Reproduction System

(2012) Fang Du et al.   Journal of Experimental Zoology Part A-Ecological Genetics and Physiology

Coordinated expression of REG4 and aldehyde dehydrogenase 1 regulating tumourigenic capacity of diffuse-type gastric carcinoma-initiating cells is inhibited by TGF-β

(2012) Yoko Katsuno et al.   JOURNAL OF PATHOLOGY

Reg IV Is a Direct Target of Intestinal Transcriptional Factor CDX2 in Gastric Cancer

(2012) Yutaka Naito et al.   PLoS One

Serum levels of pancreatic stone protein (PSP)/reg1A as an indicator of beta-cell apoptosis suggest an increased apoptosis rate in hepatocyte nuclear factor 1 alpha (HNF1A-MODY) carriers from the third decade of life onward

(2012) Siobhan Bacon et al.   BMC Endocrine Disorders

Pancreatic islet-specific overexpression of Reg3β protein induced the expression of pro-islet genes and protected the mice against streptozotocin-induced diabetes mellitus

(2011) Xiaoquan Xiong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Regenerating islet-derived 3-alpha is a biomarker of gastrointestinal graft-versus-host disease

(2011) J. L. M. Ferrara et al.   BLOOD

Expression of Pancreatitis-Associated Protein after Traumatic Brain Injury: A Mechanism Potentially Contributing to Neuroprotection in Human Brain

(2011) Pia März-Weiss et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Immunohistochemical Analysis of REG Iα Expression in Ulcerative Colitis-Associated Neoplastic Lesions

(2011) Hiroyuki Tanaka et al.   DIGESTION

Coordinated age-dependent and pancreatic-specific expression of mouseReg2Reg3α, andReg3βgenes

(2011) Ying Wang et al.   GROWTH FACTORS

Evaluation of REG4 for early diagnosis and prognosis of gastric cancer

(2011) Hou-Quan Tao et al.   HUMAN PATHOLOGY

Regenerating islet-derived family member, 4 modulates multiple receptor tyrosine kinases and mediators of drug resistance in cancer

(2011) Kathryn Vanderlaag et al.   INTERNATIONAL JOURNAL OF CANCER

Regenerating Islet-derived 1α (Reg-1α) Protein Is New Neuronal Secreted Factor That Stimulates Neurite Outgrowth via Exostosin Tumor-like 3 (EXTL3) Receptor

(2011) Isabelle Acquatella-Tran Van Ba et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteomic analysis of pancreatic juice for the identification of biomarkers of pancreatic cancer

(2011) Jeong Youp Park et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Expression analysis of the regenerating gene (Reg) family members Reg-IIIβ and Reg-IIIγ in the mouse during development

(2011) Sakiko Matsumoto et al.   JOURNAL OF COMPARATIVE NEUROLOGY

The expression of REG 1A and REG 1B is increased during acute amebic colitis

(2011) Kristine M. Peterson et al.   PARASITOLOGY INTERNATIONAL

The Antibacterial Lectin RegIII  Promotes the Spatial Segregation of Microbiota and Host in the Intestine

(2011) S. Vaishnava et al.   SCIENCE

Regenerating gene Iα is a biomarker for diagnosis and monitoring of celiac disease: a preliminary study

(2011) Raquel Planas et al.   Translational Research

Pancreatic acinar-specific overexpression of Reg2 gene offered no protection against either experimental diabetes or pancreatitis in mice

(2010) Bing Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Reg2 protects mouse insulinoma cells from streptozotocin-induced mitochondrial disruption and apoptosis

(2010) Lu Liu et al.   GROWTH FACTORS

Human hepatocarcinoma-intestine-pancreas/pancreatitis-associated protein cures fas-induced acute liver failure in mice by attenuating free-radical damage in injured livers

(2010) Nicolas Moniaux et al.   HEPATOLOGY

Circulating Reg1α Proteins and Autoantibodies to Reg1α Proteins as Biomarkers of β-Cell Regeneration and Damage in Type 1 Diabetes

(2010) E. Astorri et al.   HORMONE AND METABOLIC RESEARCH

Comparison of His and GST tagged versions of recombinant pancreatitis associated protein 2 in modulation of inflammatory responses

(2010) Domenico Viterbo et al.   INFLAMMATION RESEARCH

Upregulation of REG Iα accelerates tumor progression in pancreatic cancer with diabetes

(2010) Lin Zhou et al.   INTERNATIONAL JOURNAL OF CANCER

Human RegIV Protein Adopts a Typical C-Type Lectin Fold but Binds Mannan with Two Calcium-Independent Sites

(2010) Meng-Ru Ho et al.   JOURNAL OF MOLECULAR BIOLOGY

Involvement of the IL-22/REG Iα axis in ulcerative colitis

(2010) Akira Sekikawa et al.   LABORATORY INVESTIGATION

Intramuscular delivery of a naked DNA plasmid encoding proinsulin and pancreatic regenerating III protein ameliorates type 1 diabetes mellitus

(2010) Wen-Rui Hou et al.   PHARMACOLOGICAL RESEARCH

Molecular basis for peptidoglycan recognition by a bactericidal lectin

(2010) Rebecca E. Lehotzky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression of Reg Family Proteins in Embryonic Stem Cells and Its Modulation by Wnt/β-Catenin Signaling

(2010) Donghui Jing et al.   STEM CELLS AND DEVELOPMENT

Expression and localization of regenerating gene I in a rat liver regeneration model

(2009) Jingshu Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Reg IVenhances peritoneal metastasis in gastric carcinomas

(2009) H. Kuniyasu et al.   CELL PROLIFERATION

PAP1 signaling involves MAPK signal transduction

(2009) M. Ferrés-Masó et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Overexpression of Reg3α increases cell growth and the levels of cyclin D1 and CDK4 in insulinoma cells

(2009) Wei Cui et al.   GROWTH FACTORS

Serum olfactomedin 4 (GW112, hGC-1) in combination with Reg IV is a highly sensitive biomarker for gastric cancer patients

(2009) Naohide Oue et al.   INTERNATIONAL JOURNAL OF CANCER

The reg4 Gene, Amplified in the Early Stages of Pancreatic Cancer Development, Is a Promising Therapeutic Target

(2009) Aude Legoffic et al.   PLoS One

REG1A Expression is an Independent Factor Predictive of Poor Prognosis in Patients with Breast Cancer

(2008) Yasuhiro Sasaki et al.   ANNALS OF SURGICAL ONCOLOGY

Involvement of REG Iα protein in the regeneration of ductal epithelial cells in the minor salivary glands of patients with Sjögren's syndrome

(2008) T. Kimura et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

MicroRNA miR-7 is preferentially expressed in endocrine cells of the developing and adult human pancreas

(2008) Mayrin Correa-Medina et al.   GENE EXPRESSION PATTERNS

Pancreatic Reg I Binds MKP-1 and Regulates Cyclin D in Pancreatic-Derived Cells

(2008) Cathy M. Mueller et al.   JOURNAL OF SURGICAL RESEARCH

Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens

(2008) Yan Zheng et al.   NATURE MEDICINE

Pancreatic Regenerating Protein I in Chronic Pancreatitis and Aging

(2008) Martin Bluth et al.   PANCREAS

Deletion of the mouse RegIII  (Reg2) gene disrupts ciliary neurotrophic factor signaling and delays myelination of mouse cranial motor neurons

(2008) L. A. Tebar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative differential expression analysis reveals miR-7 as major islet microRNA

(2007) Valia Bravo-Egana et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

REG1A expression is an independent factor predictive of poor prognosis in patients with non-small cell lung cancer

(2007) Yoshihiro Minamiya et al.   LUNG CANCER