TREM2 drives microglia response to amyloid-β via SYK-dependent and -independent pathways
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Title
TREM2 drives microglia response to amyloid-β via SYK-dependent and -independent pathways
Authors
Keywords
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Journal
CELL
Volume 185, Issue 22, Pages 4153-4169.e19
Publisher
Elsevier BV
Online
2022-10-27
DOI
10.1016/j.cell.2022.09.033
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Note: Only part of the references are listed.- Specification of CNS macrophage subsets occurs postnatally in defined niches
- (2022) Takahiro Masuda et al. NATURE
- Dissection of artifactual and confounding glial signatures by single-cell sequencing of mouse and human brain
- (2022) Samuel E. Marsh et al. NATURE NEUROSCIENCE
- Prior activation state shapes the microglia response to antihuman TREM2 in a mouse model of Alzheimer’s disease
- (2021) Daniel C. Ellwanger et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Microglia and Central Nervous System–Associated Macrophages—From Origin to Disease Modulation
- (2021) Marco Prinz et al. Annual Review of Immunology
- White matter aging drives microglial diversity
- (2021) Shima Safaiyan et al. NEURON
- Trem2 restrains the enhancement of tau accumulation and neurodegeneration by β-amyloid pathology
- (2021) Seung-Hye Lee et al. NEURON
- APOE immunotherapy reduces cerebral amyloid angiopathy and amyloid plaques while improving cerebrovascular function
- (2021) Monica Xiong et al. Science Translational Medicine
- Integrated analysis of multimodal single-cell data
- (2021) Yuhan Hao et al. CELL
- Microglia in Alzheimer's disease at single-cell level. Are there common patterns in humans and mice?
- (2021) Yun Chen et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Plaque-associated human microglia accumulate lipid droplets in a chimeric model of Alzheimer’s disease
- (2021) Christel Claes et al. Molecular Neurodegeneration
- Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease
- (2020) Yingyue Zhou et al. NATURE MEDICINE
- TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge
- (2020) Alicia A. Nugent et al. NEURON
- Trajectory-based differential expression analysis for single-cell sequencing data
- (2020) Koen Van den Berge et al. Nature Communications
- Early Fate Defines Microglia and Non-parenchymal Brain Macrophage Development
- (2020) Sebastian G. Utz et al. CELL
- TREM2 Modulation Remodels the Tumor Myeloid Landscape Enhancing Anti-PD-1 Immunotherapy
- (2020) Martina Molgora et al. CELL
- Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alzheimer’s disease model
- (2020) Shoutang Wang et al. JOURNAL OF EXPERIMENTAL MEDICINE
- muscat detects subpopulation-specific state transitions from multi-sample multi-condition single-cell transcriptomics data
- (2020) Helena L. Crowell et al. Nature Communications
- The Major Risk Factors for Alzheimer’s Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques
- (2019) Carlo Sala Frigerio et al. Cell Reports
- Comprehensive Integration of Single-Cell Data
- (2019) Tim Stuart et al. CELL
- Alzheimer Disease: An Update on Pathobiology and Treatment Strategies
- (2019) Justin M. Long et al. CELL
- Distinct Signaling Pathways Regulate TREM2 Phagocytic and NFκB Antagonistic Activities
- (2019) Hailan Yao et al. Frontiers in Cellular Neuroscience
- Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer’s disease model
- (2019) Elizabeth Spangenberg et al. Nature Communications
- Slingshot: cell lineage and pseudotime inference for single-cell transcriptomics
- (2018) Kelly Street et al. BMC GENOMICS
- Humanized TREM2 mice reveal microglia-intrinsic and -extrinsic effects of R47H polymorphism
- (2018) Wilbur M. Song et al. JOURNAL OF EXPERIMENTAL MEDICINE
- TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function
- (2018) Yingjun Zhao et al. NEURON
- Diverse Brain Myeloid Expression Profiles Reveal Distinct Microglial Activation States and Aspects of Alzheimer’s Disease Not Evident in Mouse Models
- (2018) Brad A. Friedman et al. Cell Reports
- TREM2 — a key player in microglial biology and Alzheimer disease
- (2018) Tyler K. Ulland et al. Nature Reviews Neurology
- Microglia and early brain development: An intimate journey
- (2018) Morgane S. Thion et al. SCIENCE
- The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases
- (2017) Susanne Krasemann et al. IMMUNITY
- A somatic mutation in erythro-myeloid progenitors causes neurodegenerative disease
- (2017) Elvira Mass et al. NATURE
- A new fate mapping system reveals context-dependent random or clonal expansion of microglia
- (2017) Tuan Leng Tay et al. NATURE NEUROSCIENCE
- Coupled Proliferation and Apoptosis Maintain the Rapid Turnover of Microglia in the Adult Brain
- (2017) Katharine Askew et al. Cell Reports
- Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution
- (2017) Hansruedi Mathys et al. Cell Reports
- Targeting microglia for the treatment of Alzheimer's Disease
- (2016) Paul D. Wes et al. GLIA
- TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques
- (2016) Yaming Wang et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Disease Progression-Dependent Effects of TREM2 Deficiency in a Mouse Model of Alzheimer's Disease
- (2016) Taylor R. Jay et al. JOURNAL OF NEUROSCIENCE
- Origin, fate and dynamics of macrophages at central nervous system interfaces
- (2016) Tobias Goldmann et al. NATURE IMMUNOLOGY
- TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy
- (2016) Peng Yuan et al. NEURON
- TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia
- (2016) Felix L. Yeh et al. NEURON
- TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model
- (2015) Yaming Wang et al. CELL
- Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2)
- (2015) Yuka Atagi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques
- (2015) Carlo Condello et al. Nature Communications
- Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors
- (2014) Elisa Gomez Perdiguero et al. NATURE
- A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation
- (2013) Tobias Goldmann et al. NATURE NEUROSCIENCE
- Motivational Disturbances and Effects of L-dopa Administration in Neurofibromatosis-1 Model Mice
- (2013) David F. Wozniak et al. PLoS One
- Neurotoxicity of Amyloid -Protein: Synaptic and Network Dysfunction
- (2013) L. Mucke et al. Cold Spring Harbor Perspectives in Medicine
- Biochemistry of Amyloid -Protein and Amyloid Deposits in Alzheimer Disease
- (2013) C. L. Masters et al. Cold Spring Harbor Perspectives in Medicine
- Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis
- (2012) Simon Yona et al. IMMUNITY
- A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells
- (2012) C. Schulz et al. SCIENCE
- Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages
- (2010) F. Ginhoux et al. SCIENCE
- TREM2- and DAP12-Dependent Activation of PI3K Requires DAP10 and Is Inhibited by SHIP1
- (2010) Q. Peng et al. Science Signaling
- The expanding roles of ITAM adapters FcRγ and DAP12 in myeloid cells
- (2009) Jessica A. Hamerman et al. IMMUNOLOGICAL REVIEWS
- DAP10- and DAP12-associated receptors in innate immunity
- (2008) Lewis L. Lanier IMMUNOLOGICAL REVIEWS
- Draper-dependent glial phagocytic activity is mediated by Src and Syk family kinase signalling
- (2008) Jennifer S. Ziegenfuss et al. NATURE
- Analysis of mouse LMIR5/CLM-7 as an activating receptor: differential regulation of LMIR5/CLM-7 in mouse versus human cells
- (2007) Y. Yamanishi et al. BLOOD
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