Prior activation state shapes the microglia response to antihuman TREM2 in a mouse model of Alzheimer’s disease
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Prior activation state shapes the microglia response to antihuman TREM2 in a mouse model of Alzheimer’s disease
Authors
Keywords
-
Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 118, Issue 3, Pages e2017742118
Publisher
Proceedings of the National Academy of Sciences
Online
2021-01-15
DOI
10.1073/pnas.2017742118
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer’s disease
- (2020) David Gate et al. NATURE
- Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease
- (2020) Yingyue Zhou et al. NATURE MEDICINE
- Trajectory-based differential expression analysis for single-cell sequencing data
- (2020) Koen Van den Berge et al. Nature Communications
- Enhancing protective microglial activities with a dual function TREM 2 antibody to the stalk region
- (2020) Kai Schlepckow et al. EMBO Molecular Medicine
- Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alzheimer’s disease model
- (2020) Shoutang Wang et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Alzheimer’s Patient Microglia Exhibit Enhanced Aging and Unique Transcriptional Activation
- (2020) Karpagam Srinivasan et al. Cell Reports
- Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk
- (2019) Iris E. Jansen et al. NATURE GENETICS
- Alzheimer Disease: An Update on Pathobiology and Treatment Strategies
- (2019) Justin M. Long et al. CELL
- TREM2-activating antibodies abrogate the negative pleiotropic effects of the Alzheimer’s disease variant TREM2R47Hon murine myeloid cell function
- (2018) Qingwen Cheng et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Humanized TREM2 mice reveal microglia-intrinsic and -extrinsic effects of R47H polymorphism
- (2018) Wilbur M. Song et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer’s Disease Models
- (2018) C.Y. Daniel Lee et al. NEURON
- TREM2 — a key player in microglial biology and Alzheimer disease
- (2018) Tyler K. Ulland et al. Nature Reviews Neurology
- The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases
- (2017) Susanne Krasemann et al. IMMUNITY
- Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution
- (2017) Hansruedi Mathys et al. Cell Reports
- The amyloid hypothesis of Alzheimer's disease at 25 years
- (2016) Dennis J Selkoe et al. EMBO Molecular Medicine
- TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques
- (2016) Yaming Wang et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Disease Progression-Dependent Effects of TREM2 Deficiency in a Mouse Model of Alzheimer's Disease
- (2016) Taylor R. Jay et al. JOURNAL OF NEUROSCIENCE
- TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy
- (2016) Peng Yuan et al. NEURON
- Alzheimer’s Disease Risk Genes and Mechanisms of Disease Pathogenesis
- (2015) Celeste M. Karch et al. BIOLOGICAL PSYCHIATRY
- TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model
- (2015) Yaming Wang et al. CELL
- Computational assignment of cell-cycle stage from single-cell transcriptome data
- (2015) Antonio Scialdone et al. METHODS
- Aβ reduction in BACE1 heterozygous null 5XFAD mice is associated with transgenic APP level
- (2015) Katherine R Sadleir et al. Molecular Neurodegeneration
- NR4A nuclear receptors are orphans but not lonesome
- (2014) Kondababu Kurakula et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- The Nuclear Receptor Nr4a1 Mediates Anti-Inflammatory Effects of Apoptotic Cells
- (2014) N. Ipseiz et al. JOURNAL OF IMMUNOLOGY
- IFN-Stimulated Gene LY6E in Monocytes Regulates the CD14/TLR4 Pathway but Inadequately Restrains the Hyperactivation of Monocytes during Chronic HIV-1 Infection
- (2014) Xuan Xu et al. JOURNAL OF IMMUNOLOGY
- Galantamine Slows Down Plaque Formation and Behavioral Decline in the 5XFAD Mouse Model of Alzheimer’s Disease
- (2014) Soumee Bhattacharya et al. PLoS One
- Sequential Proteolytic Processing of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) Protein by Ectodomain Shedding and γ-Secretase-dependent Intramembranous Cleavage
- (2013) Patrick Wunderlich et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Variant of TREM2 Associated with the Risk of Alzheimer's Disease
- (2012) Thorlakur Jonsson et al. NEW ENGLAND JOURNAL OF MEDICINE
- TREM2 Variants in Alzheimer's Disease
- (2012) Rita Guerreiro et al. NEW ENGLAND JOURNAL OF MEDICINE
- The transcription factor NR4A1 (Nur77) controls bone marrow differentiation and the survival of Ly6C− monocytes
- (2011) Richard N Hanna et al. NATURE IMMUNOLOGY
- Macrophage colony-stimulating factor induces the proliferation and survival of macrophages via a pathway involving DAP12 and β-catenin
- (2009) Karel Otero et al. NATURE IMMUNOLOGY
- Beta-Amyloid Deposition and the Aging Brain
- (2009) Karen M. Rodrigue et al. NEUROPSYCHOLOGY REVIEW
- The Immunological Genome Project: networks of gene expression in immune cells
- (2008) Tracy S P Heng et al. NATURE IMMUNOLOGY
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now