Blocking immune cell infiltration of the central nervous system to tame Neuroinflammation in Amyotrophic lateral sclerosis

Tumor Necrosis Factor Alpha in Amyotrophic Lateral Sclerosis: Friend or Foe?

(2021) Giulia Guidotti et al.   Cells

Non-neuronal cells in amyotrophic lateral sclerosis — from pathogenesis to biomarkers

(2021) Björn F. Vahsen et al.   Nature Reviews Neurology

The feeding behaviour of ALS mouse models is modulated by the Ca 2+ ‐activated KCa3.1 channels

(2021) Germana Cocozza et al.   BRITISH JOURNAL OF PHARMACOLOGY

CD4 + T cells contribute to neurodegeneration in Lewy body dementia

(2021) David Gate et al.   SCIENCE

CD8+ T-cells infiltrate Alzheimer’s disease brains and regulate neuronal- and synapse-related gene expression in APP-PS1 transgenic mice

(2020) M.S. Unger et al.   BRAIN BEHAVIOR AND IMMUNITY

Microglial physiological properties and interactions with synapses are altered at presymptomatic stages in a mouse model of Huntington’s disease pathology

(2020) Julie C. Savage et al.   Journal of Neuroinflammation

Natural killer cells modulate motor neuron-immune cell cross talk in models of Amyotrophic Lateral Sclerosis

(2020) Stefano Garofalo et al.   Nature Communications

The impact of regional astrocyte interferon-γ signaling during chronic autoimmunity: a novel role for the immunoproteasome

(2020) Brandon C. Smith et al.   Journal of Neuroinflammation

The role of natural killer cells in Parkinson’s disease

(2020) Rachael H. Earls et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

TDP-43 mediated blood-brain barrier permeability and leukocyte infiltration promote neurodegeneration in a low-grade systemic inflammation mouse model

(2020) Frank Zamudio et al.   Journal of Neuroinflammation

Modifying macrophages at the periphery has the capacity to change microglial reactivity and to extend ALS survival

(2020) Aude Chiot et al.   NATURE NEUROSCIENCE

Astrocyte Crosstalk in CNS Inflammation

(2020) Mathias Linnerbauer et al.   NEURON

The microglial component of amyotrophic lateral sclerosis

(2020) Benjamin E Clarke et al.   BRAIN

Cytotoxic CD8+T lymphocytes expressing ALS-causing SOD1 mutant selectively trigger death of spinal motoneurons

(2019) Emmanuelle Coque et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immune dysregulation in amyotrophic lateral sclerosis: mechanisms and emerging therapies

(2019) David R Beers et al.   LANCET NEUROLOGY

C9orf72 expansion within astrocytes reduces metabolic flexibility in amyotrophic lateral sclerosis

(2019) Scott P Allen et al.   BRAIN

Neurochemical regulation of the expression and function of glial fibrillary acidic protein in astrocytes

(2019) Dongyang Li et al.   GLIA

Ca 2+ -activated K + channels modulate microglia affecting motor neuron survival in hSOD1 G93A mice

(2018) Germana Cocozza et al.   BRAIN BEHAVIOR AND IMMUNITY

Inflammation in CNS neurodegenerative diseases

(2018) Jodie Stephenson et al.   IMMUNOLOGY

Microglia-mediated recovery from ALS-relevant motor neuron degeneration in a mouse model of TDP-43 proteinopathy

(2018) Krista J. Spiller et al.   NATURE NEUROSCIENCE

Counteracting roles of MHCI and CD8+ T cells in the peripheral and central nervous system of ALS SOD1G93A mice

(2018) Giovanni Nardo et al.   Molecular Neurodegeneration

Wildtype motoneurons, ALS-Linked SOD1 mutation and glutamate profoundly modify astrocyte metabolism and lactate shuttling

(2017) Blandine Madji Hounoum et al.   GLIA

Correlation of Peripheral Immunity With Rapid Amyotrophic Lateral Sclerosis Progression

(2017) Benjamin J. Murdock et al.   JAMA Neurology

Dark microglia: A new phenotype predominantly associated with pathological states

(2016) Kanchan Bisht et al.   GLIA

CD4 + T Cells and Neuroprotection: Relevance to Motoneuron Injury and Disease

(2015) Kathryn J. Jones et al.   Journal of Neuroimmune Pharmacology

Role of the innate and adaptive immune responses in the course of multiple sclerosis

(2015) Bernhard Hemmer et al.   LANCET NEUROLOGY

Glial fibrillary acidic protein: from intermediate filament assembly and gliosis to neurobiomarker

(2015) Zhihui Yang et al.   TRENDS IN NEUROSCIENCES

Astrocyte-Derived TGF-β1 Accelerates Disease Progression in ALS Mice by Interfering with the Neuroprotective Functions of Microglia and T Cells

(2015) Fumito Endo et al.   Cell Reports

A revision of the El Escorial criteria - 2015

(2015) Albert Ludolph et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Prevention of intestinal obstruction reveals progressive neurodegeneration in mutant TDP-43 (A315T) mice

(2014) Sarah Herdewyn et al.   Molecular Neurodegeneration

Microglia Induce Motor Neuron Death via the Classical NF-κB Pathway in Amyotrophic Lateral Sclerosis

(2014) Ashley E. Frakes et al.   NEURON

C57BL/6J congenic Prp-TDP43A315T mice develop progressive neurodegeneration in the myenteric plexus of the colon without exhibiting key features of ALS

(2013) Theo Hatzipetros et al.   BRAIN RESEARCH

How Natalizumab Binds and Antagonizes α4Integrins

(2013) Yamei Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Degeneration and impaired regeneration of gray matter oligodendrocytes in amyotrophic lateral sclerosis

(2013) Shin H Kang et al.   NATURE NEUROSCIENCE

Dysregulated microRNAs in amyotrophic lateral sclerosis microglia modulate genes linked to neuroinflammation

(2013) C Parisi et al.   Cell Death & Disease

A Neurodegeneration-Specific Gene-Expression Signature of Acutely Isolated Microglia from an Amyotrophic Lateral Sclerosis Mouse Model

(2013) Isaac M. Chiu et al.   Cell Reports

Impaired blood–brain/spinal cord barrier in ALS patients

(2012) Svitlana Garbuzova-Davis et al.   BRAIN RESEARCH

Regulatory T-lymphocytes mediate amyotrophic lateral sclerosis progression and survival

(2012) Jenny S. Henkel et al.   EMBO Molecular Medicine

Antibody to α4 integrin suppresses natural killer cells infiltration in central nervous system in experimental autoimmune encephalomyelitis

(2012) Yan Gan et al.   JOURNAL OF NEUROIMMUNOLOGY

Motor neuron impairment mediated by a sumoylated fragment of the glial glutamate transporter EAAT2

(2011) Emily Foran et al.   GLIA

Neuroinflammation in amyotrophic lateral sclerosis: role of glial activation in motor neuron disease

(2011) Thomas Philips et al.   LANCET NEUROLOGY

Astrocytes from familial and sporadic ALS patients are toxic to motor neurons

(2011) Amanda M Haidet-Phillips et al.   NATURE BIOTECHNOLOGY

Abnormal Changes in NKT Cells, the IGF-1 Axis, and Liver Pathology in an Animal Model of ALS

(2011) Arseny Finkelstein et al.   PLoS One

Neuroinflammation modulates distinct regional and temporal clinical responses in ALS mice

(2010) David R. Beers et al.   BRAIN BEHAVIOR AND IMMUNITY

Astrocyte loss of mutant SOD1 delays ALS disease onset and progression in G85R transgenic mice

(2010) L. Wang et al.   HUMAN MOLECULAR GENETICS

Interferon-γ Produced by Microglia and the Neuropeptide PACAP Have Opposite Effects on the Viability of Neural Progenitor Cells

(2010) Johanna Mäkelä et al.   PLoS One

TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration

(2009) I. Wegorzewska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA