How Natalizumab Binds and Antagonizes α4Integrins

Antibodies for all: The case for genome-wide affinity reagents

(2012) Sachdev S. Sidhu   FEBS LETTERS

Crystal structure of α5β1 integrin ectodomain: Atomic details of the fibronectin receptor

(2012) Masamichi Nagae et al.   JOURNAL OF CELL BIOLOGY

Structural specializations of α4β7, an integrin that mediates rolling adhesion

(2012) Yamei Yu et al.   JOURNAL OF CELL BIOLOGY

Linking Crystallographic Model and Data Quality

(2012) P. A. Karplus et al.   SCIENCE

Integrin inside-out signaling and the immunological synapse

(2011) Timothy A Springer et al.   CURRENT OPINION IN CELL BIOLOGY

Regulation of integrin affinity on cell surfaces

(2011) Thomas Schürpf et al.   EMBO JOURNAL

Development and validation of immunoassays to quantify the half-antibody exchange of an IgG4 antibody, natalizumab (Tysabri®) with endogenous IgG4

(2011) Renée I. Shapiro et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Cost-effectiveness of natalizumab versus fingolimod for the treatment of relapsing multiple sclerosis

(2011) Ken O’Day et al.   JOURNAL OF MEDICAL ECONOMICS

Targeting leukocyte migration and adhesion in Crohn’s disease and ulcerative colitis

(2011) Saskia Thomas et al.   INFLAMMOPHARMACOLOGY

Requirement of open headpiece conformation for activation of leukocyte integrin  X 2

(2010) X. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Binding Specificity and Selective Antagonism of Vedolizumab, an Anti- 4 7 Integrin Therapeutic Antibody in Development for Inflammatory Bowel Diseases

(2009) D. Soler et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Efalizumab binding to the LFA-1  L I domain blocks ICAM-1 binding via steric hindrance

(2009) S. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

β1integrins differentially control extravasation of inflammatory cell subsets into the CNS during autoimmunity

(2009) Martina Bauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The cost effectiveness and budget impact of natalizumab for formulary inclusion

(2009) Justin Bakhshai et al.   JOURNAL OF MEDICAL ECONOMICS

Functional and Structural Stability of the Epidermal Growth Factor Receptor in Detergent Micelles and Phospholipid Nanodiscs†

(2008) Li-Zhi Mi et al.   BIOCHEMISTRY