Gut Metabolite Trimethylamine-N-Oxide in Atherosclerosis: From Mechanism to Therapy
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Gut Metabolite Trimethylamine-N-Oxide in Atherosclerosis: From Mechanism to Therapy
Authors
Keywords
-
Journal
Frontiers in Cardiovascular Medicine
Volume 8, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2021-11-30
DOI
10.3389/fcvm.2021.723886
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- NLRP3 inflammasome in cardiovascular diseases: Pathophysiological and pharmacological implications
- (2021) Carolina Pellegrini et al. MEDICINAL RESEARCH REVIEWS
- Hawthorn fruit extract reduced trimethylamine-N-oxide (TMAO)-exacerbated atherogenesis in mice via anti-inflammation and anti-oxidation
- (2021) Zouyan He et al. Nutrition & Metabolism
- Heart Disease and Stroke Statistics—2021 Update: A Report From the American Heart Association
- (2021) Salim S. Virani et al. CIRCULATION
- Association of Trimethylamine N-Oxide Levels and Calcification in Culprit Lesion Segments in Patients With ST-Segment–Elevation Myocardial Infarction Evaluated by Optical Coherence Tomography
- (2021) Jiannan Li et al. Frontiers in Cardiovascular Medicine
- Trimethylamine N-oxide induces osteogenic responses in human aortic valve interstitial cells in vitro and aggravates aortic valve lesions in mice
- (2021) Jiaying Li et al. CARDIOVASCULAR RESEARCH
- Vascular endothelial tissue factor contributes to trimethylamine N-oxide-enhanced arterial thrombosis
- (2021) Marco Witkowski et al. CARDIOVASCULAR RESEARCH
- Vascular Calcification Mechanisms: Updates and Renewed Insight into Signaling Pathways Involved in High Phosphate-Mediated Vascular Smooth Muscle Cell Calcification
- (2021) Nima Abbasian Biomedicines
- Quality consideration for the validation of urine TMA and TMAO measurement by nuclear magnetic resonance spectroscopy in Fish Odor Syndrome
- (2021) Charlotte Veyrat-Durebex et al. ANALYTICAL BIOCHEMISTRY
- Trimethylamine-N-Oxide Promotes Vascular Calcification Through Activation of NLRP3 (Nucleotide-Binding Domain, Leucine-Rich-Containing Family, Pyrin Domain-Containing-3) Inflammasome and NF-κB (Nuclear Factor κB) Signals
- (2020) Xiuli Zhang et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Protective Effect of Saponins-Enriched Fraction of Gynostemma pentaphyllum against High Choline-Induced Vascular Endothelial Dysfunction and Hepatic Damage in Mice
- (2020) Chengcheng Yang et al. BIOLOGICAL & PHARMACEUTICAL BULLETIN
- A Pilot Study on the Effects of l-Carnitine and Trimethylamine-N-Oxide on Platelet Mitochondrial DNA Methylation and CVD Biomarkers in Aged Women
- (2020) Laura Bordoni et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Long-Term Changes in Gut Microbial Metabolite Trimethylamine N-Oxide and Coronary Heart Disease Risk
- (2020) Yoriko Heianza et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Gut microbial taxa as potential predictive biomarkers for acute coronary syndrome and post-STEMI cardiovascular events
- (2020) Jing Gao et al. Scientific Reports
- Small molecule inhibition of gut microbial choline trimethylamine lyase activity alters host cholesterol and bile acid metabolism
- (2020) Preeti Pathak et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Plasma levels of trimethylamine-N-oxide can be increased with ‘healthy’ and ‘unhealthy’ diets and do not correlate with the extent of atherosclerosis but with plaque instability
- (2020) Yen Chin Koay et al. CARDIOVASCULAR RESEARCH
- Gut microbiota–dependent trimethylamine N-oxide and all-cause mortality: Findings from an updated systematic review and meta-analysis
- (2020) Mahdieh Abbasalizad Farhangi NUTRITION
- A link between inflammation and thrombosis in atherosclerotic cardiovascular diseases: Clinical and therapeutic implications
- (2020) Evangelos Oikonomou et al. ATHEROSCLEROSIS
- Too much TMAO and GVHD
- (2020) Eiko Hayase et al. BLOOD
- Effects of particulate matter on atherosclerosis: a link via high-density lipoprotein (HDL) functionality?
- (2020) Siri A. N. Holme et al. Particle and Fibre Toxicology
- Protective Effects of Black Raspberry (Rubus occidentalis) Extract against Hypercholesterolemia and Hepatic Inflammation in Rats Fed High-Fat and High-Choline Diets
- (2020) Taehwan Lim et al. Nutrients
- Next Generation Health Claims Based on Resilience: The Example of Whole-Grain Wheat
- (2020) Femke Hoevenaars et al. Nutrients
- Alisma orientalis Beverage Treats Atherosclerosis by Regulating Gut Microbiota in ApoE-/- Mice
- (2020) Boran Zhu et al. Frontiers in Pharmacology
- The role of gut microbiota metabolite trimethylamine N-oxide in functional impairment of bone marrow mesenchymal stem cells in osteoporosis disease
- (2020) Hao Lin et al. Annals of Translational Medicine
- CROT (Carnitine O-Octanoyltransferase) Is a Novel Contributing Factor in Vascular Calcification via Promoting Fatty Acid Metabolism and Mitochondrial Dysfunction
- (2020) Takehito Okui et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Choline Metabolism and Risk of Atrial Fibrillation and Heart Failure in the PREDIMED Study
- (2020) Christopher Papandreou et al. CLINICAL CHEMISTRY
- Macrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques
- (2020) Jeroen Baardman et al. Nature Communications
- Iron accumulation in macrophages promotes the formation of foam cells and development of atherosclerosis
- (2020) Jing Cai et al. Cell and Bioscience
- Trimethylamine N-Oxide Was Not Associated With 30-Day Left Ventricular Systolic Dysfunction in Patients With a First Anterior ST-Segment Elevation Myocardial Infarction After Primary Revascularization: A Sub-analysis From an Optical Coherence Tomography Registry
- (2020) Jinying Zhou et al. Frontiers in Cardiovascular Medicine
- Ginkgolide B treatment regulated intestinal flora to improve high-fat diet induced atherosclerosis in ApoE−/− mice
- (2020) Zhiyang Lv et al. BIOMEDICINE & PHARMACOTHERAPY
- Circulating trimethylamine N-oxide in association with diet and cardiometabolic biomarkers: an international pooled analysis
- (2020) Jae Jeong Yang et al. AMERICAN JOURNAL OF CLINICAL NUTRITION
- Plasma Trimethylamine N-Oxide as a Novel Biomarker for Plaque Rupture in Patients With ST-Segment–Elevation Myocardial Infarction
- (2019) Yu Tan et al. Circulation-Cardiovascular Interventions
- Statins for the Primary Prevention of Coronary Heart Disease
- (2019) Min Li et al. Biomed Research International
- Increased circulating trimethylamine N-oxide plays a contributory role in the development of endothelial dysfunction and hypertension in the RUPP rat model of preeclampsia
- (2019) Hui Chen et al. HYPERTENSION IN PREGNANCY
- Mean platelet volume and coronary plaque vulnerability: an optical coherence tomography study in patients with non-ST-elevation acute coronary syndrome
- (2019) Jun Wang et al. BMC Cardiovascular Disorders
- Precision Nutrition and the Microbiome, Part I: Current State of the Science
- (2019) Mills et al. Nutrients
- Carnitine Is Associated With Atherosclerotic Risk and Myocardial Infarction in HIV‐Infected Adults
- (2019) Arjun Sinha et al. Journal of the American Heart Association
- Hepatic Forkhead Box Protein A3 Regulates ApoA-I (Apolipoprotein A-I) Expression, Cholesterol Efflux, and Atherogenesis
- (2019) Yuanyuan Li et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Trimethylamine N-Oxide Binds and Activates PERK to Promote Metabolic Dysfunction
- (2019) Sifan Chen et al. Cell Metabolism
- Soluble RAGE attenuates AngII-induced endothelial hyperpermeability by disrupting HMGB1-mediated crosstalk between AT1R and RAGE
- (2019) Jisu Jeong et al. EXPERIMENTAL AND MOLECULAR MEDICINE
- Trimethylamine But Not Trimethylamine Oxide Increases With Age in Rat Plasma and Affects Smooth Muscle Cells Viability
- (2019) Kinga Jaworska et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- TMA, A Forgotten Uremic Toxin, but Not TMAO, Is Involved in Cardiovascular Pathology
- (2019) Kinga Jaworska et al. Toxins
- Association between plasma trimethylamine N-oxide and neoatherosclerosis in patients with very late stent thrombosis
- (2019) Yu Tan et al. CANADIAN JOURNAL OF CARDIOLOGY
- Fish Oil Is More Potent than Flaxseed Oil in Modulating Gut Microbiota and Reducing Trimethylamine-N-oxide-Exacerbated Atherogenesis
- (2019) Zouyan He et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Microbiota-derived Trimethylamine N-oxide Predicts Cardiovascular Risk After STEMI
- (2019) Yasushi Matsuzawa et al. Scientific Reports
- Tacrolimus reduces atherosclerotic plaque formation in ApoE-/- mice by inhibiting NLRP3 inflammatory corpuscles
- (2019) Xiao Li et al. Experimental and Therapeutic Medicine
- Gut Microbiota–Dependent TrimethylamineN-Oxide Predicts Risk of Cardiovascular Events in Patients With Stroke and Is Related to Proinflammatory Monocytes
- (2018) Arash Haghikia et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Increased circulating trimethylamine N-oxide contributes to endothelial dysfunction in a rat model of chronic kidney disease
- (2018) Tiejun Li et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Simultaneous determination of trimethylamine N -oxide, choline, betaine by UPLC–MS/MS in human plasma: An application in acute stroke patients
- (2018) Weibang Yu et al. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
- Inhibition of miR-29b suppresses MAPK signaling pathway through targeting SPRY1 in atherosclerosis
- (2018) Zhen Lu et al. VASCULAR PHARMACOLOGY
- Effects of sevoflurane pretreatment on the apoptosis of rat H9c2 cardiomyocytes and the expression of GRP78
- (2018) Zhongli Wang et al. Experimental and Therapeutic Medicine
- Gut microbiota derived metabolites in cardiovascular health and disease
- (2018) Zeneng Wang et al. Protein & Cell
- CHRONIC, LOW-DOSE TMAO TREATMENT REDUCES DIASTOLIC DYSFUNCTION AND HEART FIBROSIS IN HYPERTENSIVE RATS.
- (2018) Tomasz Huc et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Relation of Circulating Trimethylamine N-Oxide With Coronary Atherosclerotic Burden in Patients With ST-segment Elevation Myocardial Infarction
- (2018) Zhaoxue Sheng et al. AMERICAN JOURNAL OF CARDIOLOGY
- L-Carnitine Supplementation Increases Trimethylamine-N-Oxide but not Markers of Atherosclerosis in Healthy Aged Women
- (2018) Joanna J. Samulak et al. ANNALS OF NUTRITION AND METABOLISM
- l-Carnitine in omnivorous diets induces an atherogenic gut microbial pathway in humans
- (2018) Robert A. Koeth et al. JOURNAL OF CLINICAL INVESTIGATION
- Trimethylamine-N-oxide (TMAO)-induced atherosclerosis is associated with bile acid metabolism
- (2018) Lin Ding et al. Lipids in Health and Disease
- Dietary metabolism, the gut microbiome, and heart failure
- (2018) W. H. Wilson Tang et al. Nature Reviews Cardiology
- Gut microbiota-dependent trimethylamine N-oxide in acute coronary syndromes: a prognostic marker for incident cardiovascular events beyond traditional risk factors
- (2017) Xinmin S. Li et al. EUROPEAN HEART JOURNAL
- Gut microbe-generated metabolite trimethylamine-N-oxide as cardiovascular risk biomarker: a systematic review and dose-response meta-analysis
- (2017) Gabriele Giacomo Schiattarella et al. EUROPEAN HEART JOURNAL
- Significance of l -carnitine for human health
- (2017) María M. Adeva-Andany et al. IUBMB LIFE
- Trimethylamine‐N‐Oxide Induces Vascular Inflammation by Activating the NLRP3 Inflammasome Through the SIRT3‐SOD2‐mtROS Signaling Pathway
- (2017) Ming‐liang Chen et al. Journal of the American Heart Association
- L-Carnitine intake and high trimethylamine N-oxide plasma levels correlate with low aortic lesions in ApoE−/− transgenic mice expressing CETP
- (2016) Heidi L. Collins et al. ATHEROSCLEROSIS
- Trimethylamine N-oxide induces inflammation and endothelial dysfunction in human umbilical vein endothelial cells via activating ROS-TXNIP-NLRP3 inflammasome
- (2016) Xiaolei Sun et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk
- (2016) Weifei Zhu et al. CELL
- The Plot Thickens: Diet Microbe Interactions May Modulate Thrombosis Risk
- (2016) Ana Martínez-del Campo et al. Cell Metabolism
- Hepatotoxicity and endothelial dysfunction induced by high choline diet and the protective effects of phloretin in mice
- (2016) Daoyuan Ren et al. FOOD AND CHEMICAL TOXICOLOGY
- Role of gut microbiota in atherosclerosis
- (2016) Annika Lindskog Jonsson et al. Nature Reviews Cardiology
- Resveratrol Attenuates Trimethylamine- N -Oxide (TMAO)-Induced Atherosclerosis by Regulating TMAO Synthesis and Bile Acid Metabolism via Remodeling of the Gut Microbiota
- (2016) Ming-liang Chen et al. mBio
- Trimethylamine N‐Oxide Promotes Vascular Inflammation Through Signaling of Mitogen‐Activated Protein Kinase and Nuclear Factor‐κB
- (2016) Marcus M. Seldin et al. Journal of the American Heart Association
- Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis
- (2015) Zeneng Wang et al. CELL
- Basic mechanisms in endoplasmic reticulum stress and relation to cardiovascular diseases
- (2015) Erdi Sozen et al. FREE RADICAL BIOLOGY AND MEDICINE
- Trimethylamine-N-Oxide Treatment Induces Changes in the ATP-Binding Cassette Transporter A1 and Scavenger Receptor A1 in Murine Macrophage J774A.1 cells
- (2015) Abbas Mohammadi et al. INFLAMMATION
- ω-3 Fatty Acids and Cardiovascular Diseases: Effects, Mechanisms and Dietary Relevance
- (2015) Hanne Maehre et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Fish protein increases circulating levels of trimethylamine-N-oxide and accelerates aortic lesion formation in apoE null mice
- (2015) Narges Yazdekhasti et al. MOLECULAR NUTRITION & FOOD RESEARCH
- Flavin-containing monooxygenase 3 as a potential player in diabetes-associated atherosclerosis
- (2015) Ji Miao et al. Nature Communications
- Protective effects of tartary buckwheat flavonoids on high TMAO diet-induced vascular dysfunction and liver injury in mice
- (2015) Yuanyuan Hu et al. Food & Function
- Fish oil ameliorates trimethylamine N-oxide-exacerbated glucose intolerance in high-fat diet-fed mice
- (2015) Xiang Gao et al. Food & Function
- Association of Metabolic Syndrome with the Cardioankle Vascular Index in Asymptomatic Korean Population
- (2015) Su-Hyun Nam et al. Journal of Diabetes Research
- Transmission of Atherosclerosis Susceptibility with Gut Microbial Transplantation
- (2014) Jill C. Gregory et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Suppression of intestinal microbiota-dependent production of pro-atherogenic trimethylamine N-oxide by shifting L-carnitine microbial degradation
- (2014) Janis Kuka et al. LIFE SCIENCES
- Carnitine metabolism to trimethylamine by an unusual Rieske-type oxygenase from human microbiota
- (2014) Y. Zhu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Chemical Chaperones Mitigate Experimental Asthma by Attenuating Endoplasmic Reticulum Stress
- (2013) Lokesh Makhija et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- Consensus and Update on the Definition of On-Treatment Platelet Reactivity to Adenosine Diphosphate Associated With Ischemia and Bleeding
- (2013) Udaya S. Tantry et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis
- (2013) Robert A Koeth et al. NATURE MEDICINE
- Involvement of endoplasmic reticulum stress-associated apoptosis in a heart failure model induced by chronic myocardial ischemia
- (2011) Li INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease
- (2011) Zeneng Wang et al. NATURE
- Endoplasmic Reticulum Stress As a Therapeutic Target in Cardiovascular Disease
- (2010) Tetsuo Minamino et al. CIRCULATION RESEARCH
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started