Stem cell models for context-specific modeling in psychiatric disorders

Engineering brain assembloids to interrogate human neural circuits

(2022) Yuki Miura et al.   Nature Protocols

Predicted gene expression in ancestrally diverse populations leads to discovery of susceptibility loci for lifestyle and cardiometabolic traits

(2022) Heather M. Highland et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Massively parallel reporter perturbation assays uncover temporal regulatory architecture during neural differentiation

(2022) Anat Kreimer et al.   Nature Communications

Cell Type-Specific Predictive Models Perform Prioritization of Genes and Gene Sets Associated With Autism

(2021) Jinting Guan et al.   Frontiers in Genetics

powerEQTL: An R package and shiny application for sample size and power calculation of bulk tissue and single-cell eQTL analysis

(2021) Xianjun Dong et al.   BIOINFORMATICS

Sex differences in the human brain transcriptome of cases with schizophrenia

(2021) Gabriel E. Hoffman et al.   BIOLOGICAL PSYCHIATRY

Mendelian randomization integrating GWAS and eQTL data revealed genes pleiotropically associated with major depressive disorder

(2021) Huarong Yang et al.   Translational Psychiatry

A map of transcriptional heterogeneity and regulatory variation in human microglia

(2021) Adam M. H. Young et al.   NATURE GENETICS

Genome-wide CRISPRi/a screens in human neurons link lysosomal failure to ferroptosis

(2021) Ruilin Tian et al.   NATURE NEUROSCIENCE

Derivation and Molecular Characterization of a Morphological Subpopulation of Human iPSC Astrocytes Reveal a Potential Role in Schizophrenia and Clozapine Response

(2021) Ibrahim A Akkouh et al.   SCHIZOPHRENIA BULLETIN

Genome-wide CRISPR screen identifies protein pathways modulating tau protein levels in neurons

(2021) Carlos G. Sanchez et al.   Communications Biology

An integrated approach to identify environmental modulators of genetic risk factors for complex traits

(2021) Brunilda Balliu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Beyond the looking glass: recent advances in understanding the impact of environmental exposures on neuropsychiatric disease

(2020) Jonathan A. Hollander et al.   NEUROPSYCHOPHARMACOLOGY

Single-cell RNA-sequencing of differentiating iPS cells reveals dynamic genetic effects on gene expression

(2020) Anna S. E. Cuomo et al.   Nature Communications

Integrative QTL analysis of gene expression and chromatin accessibility identifies multi-tissue patterns of genetic regulation

(2020) Gregory R. Keele et al.   PLoS Genetics

Behavioral effects of multiple-dose oxytocin treatment in autism: a randomized, placebo-controlled trial with long-term follow-up

(2020) Sylvie Bernaerts et al.   Molecular Autism

Brain organoids: an ensemble of bioassays to investigate human neurodevelopment and disease

(2020) Jaydeep Sidhaye et al.   CELL DEATH AND DIFFERENTIATION

Quantifying genetic effects on disease mediated by assayed gene expression levels

(2020) Douglas W. Yao et al.   NATURE GENETICS

From GWAS to Function: Using Functional Genomics to Identify the Mechanisms Underlying Complex Diseases

(2020) Eddie Cano-Gamez et al.   Frontiers in Genetics

Molecular neuroanatomy of anorexia nervosa

(2020) Derek Howard et al.   Scientific Reports

Analysis of Genetically Regulated Gene Expression Identifies a Prefrontal PTSD Gene, SNRNP35, Specific to Military Cohorts

(2020) Laura M. Huckins et al.   Cell Reports

Neuronal defects in a human cellular model of 22q11.2 deletion syndrome

(2020) Themasap A. Khan et al.   NATURE MEDICINE

The impact of sex on gene expression across human tissues

(2020) Meritxell Oliva et al.   SCIENCE

Mendelian randomization integrating GWAS and mQTL data identified novel pleiotropic DNA methylation loci for neuropathology of Alzheimer’s disease

(2020) Di Liu et al.   NEUROBIOLOGY OF AGING

Massively parallel discovery of human-specific substitutions that alter enhancer activity

(2020) Severin Uebbing et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic effects on promoter usage are highly context-specific and contribute to complex traits

(2019) Kaur Alasoo et al.   eLife

Dysconnectivity of the medio-dorsal thalamic nucleus in drug-naïve first episode schizophrenia: diagnosis-specific or trans-diagnostic effect?

(2019) Qiyong Gong et al.   Translational Psychiatry

Direct cell reprogramming for tissue engineering and regenerative medicine

(2019) Alexander Grath et al.   Journal of Biological Engineering

Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions

(2019) David M. Howard et al.   NATURE NEUROSCIENCE

Gene expression imputation across multiple brain regions provides insights into schizophrenia risk

(2019) Laura M. Huckins et al.   NATURE GENETICS

Identification of common genetic risk variants for autism spectrum disorder

(2019) Jakob Grove et al.   NATURE GENETICS

Serotonin-induced hyperactivity in SSRI-resistant major depressive disorder patient-derived neurons

(2019) Krishna C. Vadodaria et al.   MOLECULAR PSYCHIATRY

hESC-Derived Thalamic Organoids Form Reciprocal Projections When Fused with Cortical Organoids

(2019) Yangfei Xiang et al.   Cell Stem Cell

OLIG2 Drives Abnormal Neurodevelopmental Phenotypes in Human iPSC-Based Organoid and Chimeric Mouse Models of Down Syndrome

(2019) Ranjie Xu et al.   Cell Stem Cell

Human 3D cellular model of hypoxic brain injury of prematurity

(2019) Anca M. Pașca et al.   NATURE MEDICINE

Influence of childhood trauma and brain-derived neurotrophic factor Val66Met polymorphism on posttraumatic stress symptoms and cortical thickness

(2019) Min Jin Jin et al.   Scientific Reports

Synergistic effects of common schizophrenia risk variants

(2019) Nadine Schrode et al.   NATURE GENETICS

CommonMind Consortium provides transcriptomic and epigenomic data for Schizophrenia and Bipolar Disorder

(2019) Gabriel E. Hoffman et al.   Scientific Data

Identification and Massively Parallel Characterization of Regulatory Elements Driving Neural Induction

(2019) Fumitaka Inoue et al.   Cell Stem Cell

Search-and-replace genome editing without double-strand breaks or donor DNA

(2019) Andrew V. Anzalone et al.   NATURE

Activity-by-contact model of enhancer–promoter regulation from thousands of CRISPR perturbations

(2019) Charles P. Fulco et al.   NATURE GENETICS

Brain cell type–specific enhancer–promoter interactome maps and disease-risk association

(2019) Alexi Nott et al.   SCIENCE

International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci

(2019) Caroline M. Nievergelt et al.   Nature Communications

Genome-wide identification of DNA methylation QTLs in whole blood highlights pathways for cardiovascular disease

(2019) Tianxiao Huan et al.   Nature Communications

Mechanisms of Sex Differences in Fear and Posttraumatic Stress Disorder

(2018) Teniel Sonya Ramikie et al.   BIOLOGICAL PSYCHIATRY

Using an atlas of gene regulation across 44 human tissues to inform complex disease- and trait-associated variation

(2018) Eric R. Gamazon et al.   NATURE GENETICS

Genetic identification of brain cell types underlying schizophrenia

(2018) Nathan G. Skene et al.   NATURE GENETICS

Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection

(2018) Antonio F. Pardiñas et al.   NATURE GENETICS

Generation of human brain region–specific organoids using a miniaturized spinning bioreactor

(2018) Xuyu Qian et al.   Nature Protocols

Transdifferentiation of human adult peripheral blood T cells into neurons

(2018) Koji Tanabe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Determining the genetic basis of anthracycline-cardiotoxicity by molecular response QTL mapping in induced cardiomyocytes

(2018) David A Knowles et al.   eLife

Rapid and efficient induction of functional astrocytes from human pluripotent stem cells

(2018) Isaac Canals et al.   NATURE METHODS

Induction of myelinating oligodendrocytes in human cortical spheroids

(2018) Mayur Madhavan et al.   NATURE METHODS

Genetic influences on eight psychiatric disorders based on family data of 4 408 646 full and half-siblings, and genetic data of 333 748 cases and controls

(2018) E. Pettersson et al.   PSYCHOLOGICAL MEDICINE

Development and validation of a simplified method to generate human microglia from pluripotent stem cells

(2018) Amanda McQuade et al.   Molecular Neurodegeneration

Microglia innately develop within cerebral organoids

(2018) Paul R. Ormel et al.   Nature Communications

Reactivation of hyperglycemia-induced hypocretin (HCRT) gene silencing by N-acetyl-d-mannosamine in the orexin neurons derived from human iPS cells

(2017) Koji Hayakawa et al.   Epigenetics

Context-specific effects of genetic variants associated with autoimmune disease

(2017) Iris H. Jonkers et al.   HUMAN MOLECULAR GENETICS

Multiplexed Engineering and Analysis of Combinatorial Enhancer Activity in Single Cells

(2017) Shiqi Xie et al.   MOLECULAR CELL

The thalamic reticular nucleus in schizophrenia and bipolar disorder: role of parvalbumin-expressing neuron networks and oxidative stress

(2017) P Steullet et al.   MOLECULAR PSYCHIATRY

Cannabis use and risk of schizophrenia: a Mendelian randomization study

(2017) J Vaucher et al.   MOLECULAR PSYCHIATRY

Cell diversity and network dynamics in photosensitive human brain organoids

(2017) Giorgia Quadrato et al.   NATURE

Genetic effects on gene expression across human tissues

(2017) François Aguet et al.   NATURE

Allele-specific expression reveals interactions between genetic variation and environment

(2017) David A Knowles et al.   NATURE METHODS

Generation of pure GABAergic neurons by transcription factor programming

(2017) Nan Yang et al.   NATURE METHODS

An xQTL map integrates the genetic architecture of the human brain's transcriptome and epigenome

(2017) Bernard Ng et al.   NATURE NEUROSCIENCE

The dopamine motive system: implications for drug and food addiction

(2017) Nora D. Volkow et al.   NATURE REVIEWS NEUROSCIENCE

The use of brain organoids to investigate neural development and disease

(2017) Elizabeth Di Lullo et al.   NATURE REVIEWS NEUROSCIENCE

Cortisol stress reactivity across psychiatric disorders: A systematic review and meta-analysis

(2017) Jelle V. Zorn et al.   PSYCHONEUROENDOCRINOLOGY

Transcriptional signatures of schizophrenia in hiPSC-derived NPCs and neurons are concordant with post-mortem adult brains

(2017) Gabriel E. Hoffman et al.   Nature Communications

Genetic regulatory effects modified by immune activation contribute to autoimmune disease associations

(2017) Sarah Kim-Hellmuth et al.   Nature Communications

Deciphering the genetic control of gene expression following Mycobacterium leprae antigen stimulation

(2017) Jérémy Manry et al.   PLoS Genetics

Modeling anorexia nervosa: transcriptional insights from human iPSC-derived neurons

(2017) P D Negraes et al.   Translational Psychiatry

Interleukin-6 in Schizophrenia—Is There a Therapeutic Relevance?

(2017) Milica Milovan Borovcanin et al.   Frontiers in Psychiatry

Disentangling the Role of Astrocytes in Alcohol Use Disorder

(2016) Louise Adermark et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Genetic Adaptation and Neandertal Admixture Shaped the Immune System of Human Populations

(2016) Hélène Quach et al.   CELL

Direct Identification of Hundreds of Expression-Modulating Variants using a Multiplexed Reporter Assay

(2016) Ryan Tewhey et al.   CELL

Midbrain-like Organoids from Human Pluripotent Stem Cells Contain Functional Dopaminergic and Neuromelanin-Producing Neurons

(2016) Junghyun Jo et al.   Cell Stem Cell

Zika Virus Depletes Neural Progenitors in Human Cerebral Organoids through Activation of the Innate Immune Receptor TLR3

(2016) Jason Dang et al.   Cell Stem Cell

Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage

(2016) Alexis C. Komor et al.   NATURE

Identification of context-dependent expression quantitative trait loci in whole blood

(2016) Daria V Zhernakova et al.   NATURE GENETICS

Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets

(2016) Zhihong Zhu et al.   NATURE GENETICS

Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen

(2016) Miao Xu et al.   NATURE MEDICINE

Meta-analysis of the Association Between the Level of Cannabis Use and Risk of Psychosis

(2016) Arianna Marconi et al.   SCHIZOPHRENIA BULLETIN

Cerebral Organoids Recapitulate Epigenomic Signatures of the Human Fetal Brain

(2016) Chongyuan Luo et al.   Cell Reports

Insight into Genotype-Phenotype Associations through eQTL Mapping in Multiple Cell Types in Health and Immune-Mediated Disease

(2016) James E. Peters et al.   PLoS Genetics

Maintenance of age in human neurons generated by microRNA-based neuronal conversion of fibroblasts

(2016) Christine J Huh et al.   eLife

FOXG1-Dependent Dysregulation of GABA/Glutamate Neuron Differentiation in Autism Spectrum Disorders

(2015) Jessica Mariani et al.   CELL

Alcohol Elicits Functional and Structural Plasticity Selectively in Dopamine D1 Receptor-Expressing Neurons of the Dorsomedial Striatum

(2015) Jun Wang et al.   JOURNAL OF NEUROSCIENCE

Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder

(2015) Jerome Mertens et al.   NATURE

Discovery of cancer drug targets by CRISPR-Cas9 screening of protein domains

(2015) Junwei Shi et al.   NATURE BIOTECHNOLOGY

Generation of serotonin neurons from human pluripotent stem cells

(2015) Jianfeng Lu et al.   NATURE BIOTECHNOLOGY

Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers

(2015) Isaac B Hilton et al.   NATURE BIOTECHNOLOGY

The role of regulatory variation in complex traits and disease

(2015) Frank W. Albert et al.   NATURE REVIEWS GENETICS

Genetic Differences in the Immediate Transcriptome Response to Stress Predict Risk-Related Brain Function and Psychiatric Disorders

(2015) Janine Arloth et al.   NEURON

The Genetics of Stress-Related Disorders: PTSD, Depression and Anxiety Disorders

(2015) Jordan W Smoller   NEUROPSYCHOPHARMACOLOGY

Human cerebral organoids recapitulate gene expression programs of fetal neocortex development

(2015) J. Gray Camp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Self-Organization of Polarized Cerebellar Tissue in 3D Culture of Human Pluripotent Stem Cells

(2015) Keiko Muguruma et al.   Cell Reports

Host Genetic Variation Influences Gene Expression Response to Rhinovirus Infection

(2015) Minal Çalışkan et al.   PLoS Genetics

Targeting glutamate uptake to treat alcohol use disorders

(2015) P.S.S. Rao et al.   Frontiers in Neuroscience

Interaction between stress and the BDNFVal66Met polymorphism in depression: a systematic review and meta-analysis

(2014) Georgina M Hosang et al.   BMC Medicine

Synaptic dysregulation in a human iPS cell model of mental disorders

(2014) Zhexing Wen et al.   NATURE

Intersection of population variation and autoimmunity genetics in human T cell activation

(2014) C. J. Ye et al.   SCIENCE

Common Genetic Variants Modulate Pathogen-Sensing Responses in Human Dendritic Cells

(2014) M. N. Lee et al.   SCIENCE

Innate Immune Activity Conditions the Effect of Regulatory Variants upon Monocyte Gene Expression

(2014) B. P. Fairfax et al.   SCIENCE

Transcripts involved in calcium signaling and telencephalic neuronal fate are altered in induced pluripotent stem cells from bipolar disorder patients

(2014) H M Chen et al.   Translational Psychiatry

Glia and immune cell signaling in bipolar disorder: insights from neuropharmacology and molecular imaging to clinical application

(2014) C C Watkins et al.   Translational Psychiatry

Sex- and age-interacting eQTLs in human complex diseases

(2013) Chen Yao et al.   HUMAN MOLECULAR GENETICS

A statin-dependent QTL for GATM expression is associated with statin-induced myopathy

(2013) Lara M. Mangravite et al.   NATURE

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

The Genotype-Tissue Expression (GTEx) project

(2013) John Lonsdale et al.   NATURE GENETICS

CRISPR interference (CRISPRi) for sequence-specific control of gene expression

(2013) Matthew H Larson et al.   Nature Protocols

Rapid Single-Step Induction of Functional Neurons from Human Pluripotent Stem Cells

(2013) Yingsha Zhang et al.   NEURON

Systematic Localization of Common Disease-Associated Variation in Regulatory DNA

(2012) M. T. Maurano et al.   SCIENCE

Unraveling the Regulatory Mechanisms Underlying Tissue-Dependent Genetic Variation of Gene Expression

(2012) Jingyuan Fu et al.   PLoS Genetics

Altered resting-state functional connectivity of thalamus in earthquake-induced posttraumatic stress disorder: A functional magnetic resonance imaging study

(2011) Yan Yin et al.   BRAIN RESEARCH

Childhood abuse, the BDNF-Val66Met polymorphism and adult psychotic-like experiences

(2011) Silvia Alemany et al.   BRITISH JOURNAL OF PSYCHIATRY

GABAergic interneuron origin of schizophrenia pathophysiology

(2011) Kazu Nakazawa et al.   NEUROPHARMACOLOGY

Direct conversion of human fibroblasts to dopaminergic neurons

(2011) U. Pfisterer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interactions between Glucocorticoid Treatment and Cis-Regulatory Polymorphisms Contribute to Cellular Response Phenotypes

(2011) Joseph C. Maranville et al.   PLoS Genetics

Stressful life events and the brain-derived neurotrophic factor gene in bipolar disorder

(2010) Georgina M. Hosang et al.   JOURNAL OF AFFECTIVE DISORDERS

Direct conversion of fibroblasts to functional neurons by defined factors

(2010) Thomas Vierbuchen et al.   NATURE