An integrated approach to identify environmental modulators of genetic risk factors for complex traits

Regulatory genomic circuitry of human disease loci by integrative epigenomics

(2021) Carles A. Boix et al.   NATURE

Functional dynamic genetic effects on gene regulation are specific to particular cell types and environmental conditions

(2021) Anthony S Findley et al.   eLife

Updating insights into rosiglitazone and cardiovascular risk through shared data: individual patient and summary level meta-analyses

(2020) Joshua D Wallach et al.   BMJ-British Medical Journal

FAM13A affects body fat distribution and adipocyte function

(2020) Mohsen Fathzadeh et al.   Nature Communications

Association of Statin Use With All-Cause and Cardiovascular Mortality in US Veterans 75 Years and Older

(2020) Ariela R. Orkaby et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Expanded encyclopaedias of DNA elements in the human and mouse genomes

(2020) Jill E. Moore et al.   NATURE

The GTEx Consortium atlas of genetic regulatory effects across human tissues

(2020)   SCIENCE

Where Are the Disease-Associated eQTLs?

(2020) Benjamin D. Umans et al.   TRENDS IN GENETICS

Predictive network modeling in human induced pluripotent stem cells identifies key driver genes for insulin responsiveness

(2020) Ivan Carcamo-Orive et al.   PLoS Computational Biology

Genetic effects on promoter usage are highly context-specific and contribute to complex traits

(2019) Kaur Alasoo et al.   eLife

Multi-dimensional Transcriptional Remodeling by Physiological Insulin In Vivo

(2019) Thiago M. Batista et al.   Cell Reports

TGFβ1 – A Novel Cause of Resistance to Bronchodilators in Asthma?

(2019) Michael A Wortley et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Effect of metformin on all-cause and cardiovascular mortality in patients with coronary artery diseases: a systematic review and an updated meta-analysis

(2019) Yechen Han et al.   Cardiovascular Diabetology

Landscape of stimulation-responsive chromatin across diverse human immune cells

(2019) Diego Calderon et al.   NATURE GENETICS

Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types

(2018) Hilary K. Finucane et al.   NATURE GENETICS

Role of Adiponectin in Central Nervous System Disorders

(2018) Jenna Bloemer et al.   NEURAL PLASTICITY

The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019

(2018) Annalisa Buniello et al.   NUCLEIC ACIDS RESEARCH

Leptin in depression: a potential therapeutic target

(2018) Tongtong Ge et al.   Cell Death & Disease

TGF-β in inflammatory bowel disease: a key regulator of immune cells, epithelium, and the intestinal microbiota

(2017) Sozaburo Ihara et al.   JOURNAL OF GASTROENTEROLOGY

Limited statistical evidence for shared genetic effects of eQTLs and autoimmune-disease-associated loci in three major immune-cell types

(2017) Sung Chun et al.   NATURE GENETICS

Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology

(2017) Manuel A Ferreira et al.   NATURE GENETICS

Allele-specific expression reveals interactions between genetic variation and environment

(2017) David A Knowles et al.   NATURE METHODS

Metformin effects on the heart and the cardiovascular system: A review of experimental and clinical data

(2017) L. Nesti et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

IGF-I and relation to growth in infancy and early childhood in very-low-birth-weight infants and term born infants

(2017) Miranda de Jong et al.   PLoS One

Genetic regulatory effects modified by immune activation contribute to autoimmune disease associations

(2017) Sarah Kim-Hellmuth et al.   Nature Communications

Colocalization of GWAS and eQTL Signals Detects Target Genes

(2016) Farhad Hormozdiari et al.   AMERICAN JOURNAL OF HUMAN GENETICS

FINEMAP: efficient variable selection using summary data from genome-wide association studies

(2016) Christian Benner et al.   BIOINFORMATICS

variancePartition: interpreting drivers of variation in complex gene expression studies

(2016) Gabriel E. Hoffman et al.   BMC BIOINFORMATICS

Genetic Ancestry and Natural Selection Drive Population Differences in Immune Responses to Pathogens

(2016) Yohann Nédélec et al.   CELL

Genetic Adaptation and Neandertal Admixture Shaped the Immune System of Human Populations

(2016) Hélène Quach et al.   CELL

High-throughput allele-specific expression across 250 environmental conditions

(2016) Gregory A. Moyerbrailean et al.   GENOME RESEARCH

An updated meta-analysis of transforming growth factor-β1 gene: Three well-characterized polymorphisms with asthma

(2016) Ying-shui Yao et al.   HUMAN IMMUNOLOGY

Interpretation of the evidence for the efficacy and safety of statin therapy

(2016) Rory Collins et al.   LANCET

Integrative approaches for large-scale transcriptome-wide association studies

(2016) Alexander Gusev et al.   NATURE GENETICS

The new NHGRI-EBI Catalog of published genome-wide association studies (GWAS Catalog)

(2016) Jacqueline MacArthur et al.   NUCLEIC ACIDS RESEARCH

Integrative analysis of 111 reference human epigenomes

(2015) Anshul Kundaje et al.   NATURE

A global reference for human genetic variation

(2015) Richard A. Gibbs et al.   NATURE

Partitioning heritability by functional annotation using genome-wide association summary statistics

(2015) Hilary K Finucane et al.   NATURE GENETICS

Plasma adiponectin levels in schizophrenia and role of second-generation antipsychotics: A meta-analysis

(2015) Francesco Bartoli et al.   PSYCHONEUROENDOCRINOLOGY

Partitioning Heritability of Regulatory and Cell-Type-Specific Variants across 11 Common Diseases

(2014) Alexander Gusev et al.   AMERICAN JOURNAL OF HUMAN GENETICS

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

Intersection of population variation and autoimmunity genetics in human T cell activation

(2014) C. J. Ye et al.   SCIENCE

Common Genetic Variants Modulate Pathogen-Sensing Responses in Human Dendritic Cells

(2014) M. N. Lee et al.   SCIENCE

Innate Immune Activity Conditions the Effect of Regulatory Variants upon Monocyte Gene Expression

(2014) B. P. Fairfax et al.   SCIENCE

Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics

(2014) Claudia Giambartolomei et al.   PLoS Genetics

Establishment of a human skeletal muscle-derived cell line: biochemical, cellular and electrophysiological characterization

(2013) Ori Rokach et al.   BIOCHEMICAL JOURNAL

Systematic evaluation of validated type 2 diabetes and glycaemic trait loci for association with insulin clearance

(2013) M. O. Goodarzi et al.   DIABETOLOGIA

Discovery and refinement of loci associated with lipid levels

(2013) Cristen J Willer et al.   NATURE GENETICS

Elevated levels of adiponectin and other cytokines in drug naïve, first episode schizophrenia patients with normal weight

(2013) Xueqin Song et al.   SCHIZOPHRENIA RESEARCH

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

(2012) Guangchuang Yu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Systematic Localization of Common Disease-Associated Variation in Regulatory DNA

(2012) M. T. Maurano et al.   SCIENCE

Hepatic metabolism of retinoids and disease associations

(2011) Yohei Shirakami et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Interactions between Glucocorticoid Treatment and Cis-Regulatory Polymorphisms Contribute to Cellular Response Phenotypes

(2011) Joseph C. Maranville et al.   PLoS Genetics

Pharmacogenetic interaction between dexamethasone and Cd36-deficient segment of spontaneously hypertensive rat chromosome 4 affects triacylglycerol and cholesterol distribution into lipoprotein fractions

(2010) Michaela Krupková et al.   Lipids in Health and Disease

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

(2010) Josée Dupuis et al.   NATURE GENETICS

The Sequence Alignment/Map format and SAMtools

(2009) H. Li et al.   BIOINFORMATICS

Screening for Partial Conjunction Hypotheses

(2008) Yoav Benjamini et al.   BIOMETRICS

ConsensusPathDB—a database for integrating human functional interaction networks

(2008) Atanas Kamburov et al.   NUCLEIC ACIDS RESEARCH

Human SGBS Cells – a Unique Tool for Studies of Human Fat Cell Biology

(2008) Pamela Fischer-Posovszky et al.   Obesity Facts