Engineering brain assembloids to interrogate human neural circuits

Fundamentals of the Development of Connectivity in the Human Fetal Brain in Late Gestation: From 24 Weeks Gestational Age to Term

(2021) Ivica Kostović et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Multi-lineage Human iPSC-Derived Platforms for Disease Modeling and Drug Discovery

(2020) Arun Sharma et al.   Cell Stem Cell

Variation of Human Neural Stem Cells Generating Organizer States In Vitro before Committing to Cortical Excitatory or Inhibitory Neuronal Fates

(2020) Nicola Micali et al.   Cell Reports

3D Brain Organoids: Studying Brain Development and Disease Outside the Embryo

(2020) Silvia Velasco et al.   Annual Review of Neuroscience

Variable Outcomes in Neural Differentiation of Human PSCs Arise from Intrinsic Differences in Developmental Signaling Pathways

(2020) Alessio Strano et al.   Cell Reports

Generation of Functional Human 3D Cortico-Motor Assembloids

(2020) Jimena Andersen et al.   CELL

Generation of human striatal organoids and cortico-striatal assembloids from human pluripotent stem cells

(2020) Yuki Miura et al.   NATURE BIOTECHNOLOGY

Differentiation and maturation of oligodendrocytes in human three-dimensional neural cultures

(2019) Rebecca M. Marton et al.   NATURE NEUROSCIENCE

hESC-Derived Thalamic Organoids Form Reciprocal Projections When Fused with Cortical Organoids

(2019) Yangfei Xiang et al.   Cell Stem Cell

Reconstruction of 1,000 Projection Neurons Reveals New Cell Types and Organization of Long-Range Connectivity in the Mouse Brain

(2019) Johan Winnubst et al.   CELL

Engineering of human brain organoids with a functional vascular-like system

(2019) Bilal Cakir et al.   NATURE METHODS

Generation and assembly of human brain region–specific three-dimensional cultures

(2018) Steven A. Sloan et al.   Nature Protocols

Chemical Landscape for Tissue Clearing Based on Hydrophilic Reagents

(2018) Kazuki Tainaka et al.   Cell Reports

Reliability of human cortical organoid generation

(2018) Se-Jin Yoon et al.   NATURE METHODS

Assembly of functionally integrated human forebrain spheroids

(2017) Fikri Birey et al.   NATURE

Fused cerebral organoids model interactions between brain regions

(2017) Joshua A Bagley et al.   NATURE METHODS

rAAV-compatible MiniPromoters for restricted expression in the brain and eye

(2016) Charles N. de Leeuw et al.   Molecular Brain

A deleterious Nav1.1 mutation selectively impairs telencephalic inhibitory neurons derived from Dravet Syndrome patients

(2016) Yishan Sun et al.   eLife

Modeling psychiatric disorders for developing effective treatments

(2015) Tobias Kaiser et al.   NATURE MEDICINE

Whole-Brain Imaging with Single-Cell Resolution Using Chemical Cocktails and Computational Analysis

(2014) Etsuo A. Susaki et al.   CELL

Independent optical excitation of distinct neural populations

(2014) Nathan C Klapoetke et al.   NATURE METHODS

Alteration in basal and depolarization induced transcriptional network in iPSC derived neurons from Timothy syndrome

(2014) Yuan Tian et al.   Genome Medicine

A simple tool to improve pluripotent stem cell differentiation

(2013) Sundari Chetty et al.   NATURE METHODS

Corticostriatal connectivity and its role in disease

(2013) Gordon M. G. Shepherd   NATURE REVIEWS NEUROSCIENCE

Power failure: why small sample size undermines the reliability of neuroscience

(2013) Katherine S. Button et al.   NATURE REVIEWS NEUROSCIENCE

Shank3 mutant mice display autistic-like behaviours and striatal dysfunction

(2011) João Peça et al.   NATURE

Using iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndrome

(2011) Sergiu P Paşca et al.   NATURE MEDICINE

Obsessive-compulsive disorder: beyond segregated cortico-striatal pathways

(2011) Mohammed R. Milad et al.   TRENDS IN COGNITIVE SCIENCES

Fluorescent pipettes for optically targeted patch-clamp recordings

(2010) Daisuke Ishikawa et al.   NEURAL NETWORKS