ERK1/2 in immune signalling

TPL-2 Inhibits IFN-β Expression via an ERK1/2-TCF-FOS Axis in TLR4-Stimulated Macrophages

(2022) Louise Blair et al.   JOURNAL OF IMMUNOLOGY

Extracellular signal‐regulated kinase regulates microglial immune responses in Alzheimer’s disease

(2021) Michael J. Chen et al.   JOURNAL OF NEUROSCIENCE RESEARCH

SCIMP is a spatiotemporal transmembrane scaffold for Erk1/2 to direct pro-inflammatory signaling in TLR-activated macrophages

(2021) Richard M. Lucas et al.   Cell Reports

Unravelling the Impact of the Genetic Variant rs1042058 within the TPL2 Risk Gene Locus on Molecular and Clinical Disease Course Patients with Inflammatory Bowel Disease

(2021) Yasser Morsy et al.   Cells

Loss of Mef2D function enhances TLR induced IL-10 production in macrophages.

(2020) Micheal J Pattison et al.   BIOSCIENCE REPORTS

ERK signalling: a master regulator of cell behaviour, life and fate

(2020) Hugo Lavoie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Kinase inhibition in autoimmunity and inflammation

(2020) Ali A. Zarrin et al.   NATURE REVIEWS DRUG DISCOVERY

Extracellular signal-regulated kinase (ERK) pathway control of CD8+ T cell differentiation

(2020) Marcos P. Damasio et al.   BIOCHEMICAL JOURNAL

LRRK2 kinase plays a critical role in manganese-induced inflammation and apoptosis in microglia

(2019) Judong Kim et al.   PLoS One

Clinical genome sequencing uncovers potentially targetable truncations and fusions of MAP3K8 in spitzoid and other melanomas

(2019) Scott Newman et al.   NATURE MEDICINE

TREM2 Attenuates Aβ1-42-Mediated Neuroinflammation in BV-2 Cells by Downregulating TLR Signaling

(2019) Huiping Long et al.   NEUROCHEMICAL RESEARCH

Activation of Toll-like Receptor 2 (TLR2) induces Interleukin-6 trans-signaling

(2019) Charlotte M. Flynn et al.   Scientific Reports

SCIMP is a universal Toll‐like receptor adaptor in macrophages

(2019) Lin Luo et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The IκB-protein BCL-3 controls Toll-like receptor-induced MAPK activity by promoting TPL-2 degradation in the nucleus

(2019) Patricia E. Collins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting melanoma’s MCL1 bias unleashes the apoptotic potential of BRAF and ERK1/2 pathway inhibitors

(2019) Matthew J. Sale et al.   Nature Communications

Signalling, sorting and scaffolding adaptors for Toll-like receptors

(2019) Lin Luo et al.   JOURNAL OF CELL SCIENCE

pTRAPs: Transmembrane adaptors in innate immune signaling

(2018) James E.B. Curson et al.   JOURNAL OF LEUKOCYTE BIOLOGY

TPL2 kinase action and control of inflammation

(2018) Daqi Xu et al.   PHARMACOLOGICAL RESEARCH

Grb2 and GRAP connect the B cell antigen receptor to Erk MAP kinase activation in human B cells

(2018) Kanika Vanshylla et al.   Scientific Reports

Targeting ERK, an Achilles' Heel of the MAPK pathway, in cancer therapy

(2018) Feifei Liu et al.   Acta Pharmaceutica Sinica B

CNS inflammation and neurodegeneration

(2017) Tanuja Chitnis et al.   JOURNAL OF CLINICAL INVESTIGATION

Emerging functions of the EGFR in cancer

(2017) Sara Sigismund et al.   Molecular Oncology

The kinase TPL2 activates ERK and p38 signaling to promote neutrophilic inflammation

(2017) Kate Senger et al.   Science Signaling

SCIMP is a transmembrane non-TIR TLR adaptor that promotes proinflammatory cytokine production from macrophages

(2017) Lin Luo et al.   Nature Communications

Activation of ERK Signaling via TLR11 Induces IL-12p40 Production in Peritoneal Macrophages Challenged by Neospora caninum

(2017) Xiaoxia Jin et al.   Frontiers in Microbiology

The kinase TPL2 activates ERK and p38 signaling to promote neutrophilic inflammation

(2017) Kate Senger et al.   Science Signaling

TLR and TNF-R1 activation of the MKK3/MKK6-p38  axis in macrophages is mediated by TPL-2 kinase

(2016) M. J. Pattison et al.   BIOCHEMICAL JOURNAL

SRF Co-factors Control the Balance between Cell Proliferation and Contractility

(2016) Francesco Gualdrini et al.   MOLECULAR CELL

Innate Immune Pattern Recognition: A Cell Biological Perspective

(2015) Sky W. Brubaker et al.   Annual Review of Immunology

Compromised MAPK signaling in human diseases: an update

(2015) Eun Kyung Kim et al.   ARCHIVES OF TOXICOLOGY

Alike but Different: RAF Paralogs and Their Signaling Outputs

(2015) Enrico Desideri et al.   CELL

The IRAK-ERK-p67phox-Nox-2 axis mediates TLR4, 2-induced ROS production for IL-1β transcription and processing in monocytes

(2015) Ankita Singh et al.   Cellular & Molecular Immunology

ATPL2 (MAP3K8)disease-risk polymorphism increases TPL2 expression thereby leading to increased pattern recognition receptor-initiated caspase-1 and caspase-8 activation, signalling and cytokine secretion

(2015) Matija Hedl et al.   GUT

Tumor necrosis factor receptor- associated factor 6 (TRAF6) regulation of development, function, and homeostasis of the immune system

(2015) Matthew C. Walsh et al.   IMMUNOLOGICAL REVIEWS

IL-10 Production in Macrophages Is Regulated by a TLR-Driven CREB-Mediated Mechanism That Is Linked to Genes Involved in Cell Metabolism

(2015) David E. Sanin et al.   JOURNAL OF IMMUNOLOGY

NF-κB transcriptional activation by TNFα requires phospholipase C, extracellular signal-regulated kinase 2 and poly(ADP-ribose) polymerase-1

(2015) Billy Vuong et al.   Journal of Neuroinflammation

ERK1/2 has an essential role in B cell receptor- and CD40-induced signaling in an in vitro model of germinal center B cell selection

(2015) Jemal Adem et al.   MOLECULAR IMMUNOLOGY

Regulation of RAF protein kinases in ERK signalling

(2015) Hugo Lavoie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Phytic acid attenuates inflammatory responses and the levels of NF-κB and p-ERK in MPTP-induced Parkinson’s disease model of mice

(2015) Yuqiang Lv et al.   NEUROSCIENCE LETTERS

Functional Redundancy of ERK1 and ERK2 MAP Kinases during Development

(2015) Christophe Frémin et al.   Cell Reports

Klf2 Is an Essential Factor that Sustains Ground State Pluripotency

(2014) Jia-Chi Yeo et al.   Cell Stem Cell

TPL2 mediates autoimmune inflammation through activation of the TAK1 axis of IL-17 signaling

(2014) Yichuan Xiao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulation of Experimental Autoimmune Encephalomyelitis by TPL-2 Kinase

(2014) S. Sriskantharajah et al.   JOURNAL OF IMMUNOLOGY

ERK-mediated phosphorylation of TFAM downregulates mitochondrial transcription: Implications for Parkinson's disease

(2014) Kent Z.Q. Wang et al.   MITOCHONDRION

MURC/Cavin-4 facilitates recruitment of ERK to caveolae and concentric cardiac hypertrophy induced by  1-adrenergic receptors

(2014) T. Ogata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

I B kinase-induced interaction of TPL-2 kinase with 14-3-3 is essential for Toll-like receptor activation of ERK-1 and -2 MAP kinases

(2014) A. Ben-Addi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toll-Like Receptor Signaling Pathways

(2014) Takumi Kawasaki et al.   Frontiers in Immunology

Genetic Correction of a LRRK2 Mutation in Human iPSCs Links Parkinsonian Neurodegeneration to ERK-Dependent Changes in Gene Expression

(2013) Peter Reinhardt et al.   Cell Stem Cell

Increased ERK signalling promotes inflammatory signalling in primary airway epithelial cells expressing Z α1-antitrypsin

(2013) Emily F.A. van ‘t Wout et al.   HUMAN MOLECULAR GENETICS

PLC-  and PI3K Link Cytokines to ERK Activation in Hematopoietic Cells with Normal and Oncogenic Kras

(2013) E. Diaz-Flores et al.   Science Signaling

Serine 111 Phosphorylation Regulates OCT4A Protein Subcellular Distribution and Degradation

(2012) Renza Spelat et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

Synaptic Mitochondrial Pathology in Alzheimer's Disease

(2011) Heng Du et al.   ANTIOXIDANTS & REDOX SIGNALING

Ghrelin protects spinal cord motoneurons against chronic glutamate-induced excitotoxicity via ERK1/2 and phosphatidylinositol-3-kinase/Akt/glycogen synthase kinase-3β pathways

(2011) Eunjin Lim et al.   EXPERIMENTAL NEUROLOGY

Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases

(2011) M. Cargnello et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Regulation of Primary Response Genes

(2011) Trent Fowler et al.   MOLECULAR CELL

Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma

(2011) Sergey I Nikolaev et al.   NATURE GENETICS

Ras trafficking, localization and compartmentalized signalling

(2011) Ian A. Prior et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

What the Myddosome structure tells us about the initiation of innate immunity

(2011) Nicholas J. Gay et al.   TRENDS IN IMMUNOLOGY

Selective involvement of ERK and JNK MAP kinases in the synovial tissue of patients with early arthritis

(2010) D de Launay et al.   ANNALS OF THE RHEUMATIC DISEASES

Cell Signaling by Receptor Tyrosine Kinases

(2010) Mark A. Lemmon et al.   CELL

Regulation and function of TPL-2, an IκB kinase-regulated MAP kinase kinase kinase

(2010) Thorsten Gantke et al.   CELL RESEARCH

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Targeting mycobacterium protein tyrosine phosphatase B for antituberculosis agents

(2010) B. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Adaptive Immunity by the Innate Immune System

(2010) A. Iwasaki et al.   SCIENCE

ERK1/2, but not ERK5, is necessary and sufficient for phosphorylation and activation of c-Fos

(2009) Rebecca Gilley et al.   CELLULAR SIGNALLING

TPL-2 negatively regulates interferon-β production in macrophages and myeloid dendritic cells

(2009) Frank Kaiser et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Signalling pathways in alcohol-induced liver inflammation

(2009) Pranoti Mandrekar et al.   JOURNAL OF HEPATOLOGY

Inhibition of ERK MAPK Suppresses IL-23- and IL-1-Driven IL-17 Production and Attenuates Autoimmune Disease

(2009) C. F. Brereton et al.   JOURNAL OF IMMUNOLOGY

A Switch in Retrograde Signaling from Survival to Stress in Rapid-Onset Neurodegeneration

(2009) E. Perlson et al.   JOURNAL OF NEUROSCIENCE

Phosphoproteomics reveals new ERK MAP kinase targets and links ERK to nucleoporin-mediated nuclear transport

(2009) Hidetaka Kosako et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Tumour cell survival signalling by the ERK1/2 pathway

(2008) K Balmanno et al.   CELL DEATH AND DIFFERENTIATION

Oncogenic MAPK Signaling Stimulates mTORC1 Activity by Promoting RSK-Mediated Raptor Phosphorylation

(2008) Audrey Carrière et al.   CURRENT BIOLOGY

B Cell Development: Important Work for ERK

(2008) Michael R. Gold   IMMUNITY

TPL2-mediated activation of ERK1 and ERK2 regulates the processing of pre-TNF  in LPS-stimulated macrophages

(2008) S. Rousseau et al.   JOURNAL OF CELL SCIENCE