Extracellular signal-regulated kinase (ERK) pathway control of CD8+ T cell differentiation

Quantitative analysis of how Myc controls T cell proteomes and metabolic pathways during T cell activation

(2020) Julia M Marchingo et al.   eLife

MEK inhibition reprograms CD8+ T lymphocytes into memory stem cells with potent antitumor effects

(2020) Vivek Verma et al.   NATURE IMMUNOLOGY

Antigen receptor control of methionine metabolism in T cells

(2019) Linda V Sinclair et al.   eLife

TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection

(2019) Francesca Alfei et al.   NATURE

TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion

(2019) Omar Khan et al.   NATURE

Quantitative analysis of T cell proteomes and environmental sensors during T cell differentiation

(2019) Andrew J. M. Howden et al.   NATURE IMMUNOLOGY

Targeting JAK2 reduces GVHD and xenograft rejection through regulation of T cell differentiation

(2018) Brian C. Betts et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interleukin-2 shapes the cytotoxic T cell proteome and immune environment–sensing programs

(2018) Christina M. Rollings et al.   Science Signaling

Interleukin-2 shapes the cytotoxic T cell proteome and immune environment–sensing programs

(2018) Christina M. Rollings et al.   Science Signaling

Integrative Proteomics and Phosphoproteomics Profiling Reveals Dynamic Signaling Networks and Bioenergetics Pathways Underlying T Cell Activation

(2017) Haiyan Tan et al.   IMMUNITY

Retinoic Acid and Retinoic Acid Receptors as Pleiotropic Modulators of the Immune System

(2016) Alexandre Larange et al.   Annual Review of Immunology

T Cell Factor 1-Expressing Memory-like CD8 + T Cells Sustain the Immune Response to Chronic Viral Infections

(2016) Daniel T. Utzschneider et al.   IMMUNITY

A Myc-dependent division timer complements a cell-death timer to regulate T cell and B cell responses

(2016) Susanne Heinzel et al.   NATURE IMMUNOLOGY

The Perseus computational platform for comprehensive analysis of (prote)omics data

(2016) Stefka Tyanova et al.   NATURE METHODS

T cell metabolism drives immunity

(2015) Michael D. Buck et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The cytotoxic T cell proteome and its shaping by the kinase mTOR

(2015) Jens L Hukelmann et al.   NATURE IMMUNOLOGY

Signaling in Lymphocyte Activation

(2015) Doreen Cantrell   Cold Spring Harbor Perspectives in Biology

The Erk2 MAPK Regulates CD8 T Cell Proliferation and Survival

(2014) W. N. D'Souza et al.   JOURNAL OF IMMUNOLOGY

A “Proteomic Ruler” for Protein Copy Number and Concentration Estimation without Spike-in Standards

(2014) Jacek R. Wiśniewski et al.   MOLECULAR & CELLULAR PROTEOMICS

Ultrasensitive proteome analysis using paramagnetic bead technology

(2014) C. S. Hughes et al.   Molecular Systems Biology

Serine-threonine kinases in TCR signaling

(2014) María N Navarro et al.   NATURE IMMUNOLOGY

Antigen affinity, costimulation, and cytokine inputs sum linearly to amplify T cell expansion

(2014) J. M. Marchingo et al.   SCIENCE

Protein kinase D2 is a digital amplifier of T cell receptor-stimulated diacylglycerol signaling in naive CD8+ T cells

(2014) M. N. Navarro et al.   Science Signaling

CHK2 kinase in the DNA damage response and beyond

(2014) L. Zannini et al.   Journal of Molecular Cell Biology

Metabolic Regulation of T Lymphocytes

(2013) Nancie J. MacIver et al.   Annual Review of Immunology

The Transcription Factors Egr2 and Egr3 Are Essential for the Control of Inflammation and Antigen-Induced Proliferation of B and T Cells

(2012) Suling Li et al.   IMMUNITY

Interferon regulatory factor 8 integrates T-cell receptor and cytokine-signaling pathways and drives effector differentiation of CD8 T cells

(2012) Fumi Miyagawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differentiation and Persistence of Memory CD8+ T Cells Depend on T Cell Factor 1

(2010) Xinyuan Zhou et al.   IMMUNITY

Essential role of the Wnt pathway effector Tcf-1 for the establishment of functional CD8 T cell memory

(2010) G. Jeannet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Digital Signaling and Hysteresis Characterize Ras Activation in Lymphoid Cells

(2009) Jayajit Das et al.   CELL

Critical role for Rsk2 in T-lymphocyte activation

(2007) J.-X. Lin et al.   BLOOD