Increased ERK signalling promotes inflammatory signalling in primary airway epithelial cells expressing Z α1-antitrypsin

α1-Antitrypsin Modulates Lung Endothelial Cell Inflammatory Responses to TNF-α

(2013) Angelia D. Lockett et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Twenty Years of Polymers: A Personal Perspective on Alpha-1 Antitrypsin Deficiency

(2013) David A. Lomas   COPD-Journal of Chronic Obstructive Pulmonary Disease

Endoplasmic reticulum polymers impair luminal protein mobility and sensitize to cellular stress in alpha1-antitrypsin deficiency

(2012) Adriana Ordóñez et al.   HEPATOLOGY

Anti-Tumour Effects of a Specific Anti-ADAM17 Antibody in an Ovarian Cancer Model In Vivo

(2012) Frances M. Richards et al.   PLoS One

α1-Antitrypsin Production by Proinflammatory and Antiinflammatory Macrophages and Dendritic Cells

(2011) Emily F. A. van ‘t Wout et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

A quantitative method for detection of spliced X-box binding protein-1 (XBP1) mRNA as a measure of endoplasmic reticulum (ER) stress

(2011) Annemarie van Schadewijk et al.   CELL STRESS & CHAPERONES

CCL20/CCR6 Feedback Exaggerates Epidermal Growth Factor Receptor-Dependent MUC5AC Mucin Production in Human Airway Epithelial (NCI-H292) Cells

(2011) S. Kim et al.   JOURNAL OF IMMUNOLOGY

Cross-domain inhibition of TACE ectodomain

(2011) C. J. Tape et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxidation of Z α1-Antitrypsin by Cigarette Smoke Induces Polymerization

(2010) Sam Alam et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Thiol isomerases negatively regulate the cellular shedding activity of ADAM17

(2010) Sofie H. Willems et al.   BIOCHEMICAL JOURNAL

A novel monoclonal antibody to characterize pathogenic polymers in liver disease associated with α1-antitrypsin deficiency

(2010) Elena Miranda et al.   HEPATOLOGY

ADAM17 is regulated by a rapid and reversible mechanism that controls access to its catalytic site

(2010) S. M. Le Gall et al.   JOURNAL OF CELL SCIENCE

α-1 Antitrypsin regulates human neutrophil chemotaxis induced by soluble immune complexes and IL-8

(2010) David A. Bergin et al.   JOURNAL OF CLINICAL INVESTIGATION

Defining the mechanism of polymerization in the serpinopathies

(2010) U. I. Ekeowa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti-apoptotic effects of Z  1-antitrypsin in human bronchial epithelial cells

(2009) C. M. Greene et al.   EUROPEAN RESPIRATORY JOURNAL

Neuroserpin Polymers Activate NF-κB by a Calcium Signaling Pathway That Is Independent of the Unfolded Protein Response

(2009) Mark J. Davies et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endoplasmic Reticulum-associated Degradation (ERAD) and Autophagy Cooperate to Degrade Polymerogenic Mutant Serpins

(2009) Heike Kroeger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Macrophage Migration Inhibitory Factor and Interleukin-8 Produced by Gastric Epithelial Cells during Helicobacter pylori Exposure Induce Expression and Activation of the Epidermal Growth Factor Receptor

(2008) E. J. Beswick et al.   INFECTION AND IMMUNITY

Polymers and inflammation: disease mechanisms of the serpinopathies

(2008) Bibek Gooptu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TNF-α-induced self expression in human lung endothelial cells is inhibited by native and oxidized α1-antitrypsin

(2007) Devipriya Subramaniyam et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY