A Carbonic Anhydrase IX (CAIX)‐Anchored Rhenium(I) Photosensitizer Evokes Pyroptosis for Enhanced Anti‐Tumor Immunity

Ferroptosis Photoinduced by New Cyclometalated Iridium(III) Complexes and Its Synergism with Apoptosis in Tumor Cell Inhibition

(2021) Hao Yuan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Activation of Pyroptosis by Membrane‐Anchoring AIE Photosensitizer Design: New Prospect for Photodynamic Cancer Cell Ablation

(2021) Min Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Immunogenic camptothesome nanovesicles comprising sphingomyelin-derived camptothecin bilayers for safe and synergistic cancer immunochemotherapy

(2021) Zhiren Wang et al.   Nature Nanotechnology

Metal–Organic Framework Nanoparticles Induce Pyroptosis in Cells Controlled by the Extracellular pH

(2020) Evelyn Ploetz et al.   ADVANCED MATERIALS

A Photocaged, Water-Oxidizing, and Nucleolus-Targeted Pt(IV) Complex with a Distinct Anticancer Mechanism

(2020) Zhiqin Deng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rationally Designed Long-Wavelength Absorbing Ru(II) Polypyridyl Complexes as Photosensitizers for Photodynamic Therapy

(2020) Johannes Karges et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Gasdermin E suppresses tumour growth by activating anti-tumour immunity

(2020) Zhibin Zhang et al.   NATURE

A bioorthogonal system reveals antitumour immune function of pyroptosis

(2020) Qinyang Wang et al.   NATURE

Plasma membrane damage causes NLRP3 activation and pyroptosis during Mycobacterium tuberculosis infection

(2020) Kai S. Beckwith et al.   Nature Communications

Multiple‐Color Platinum Complex with Super‐Large Stokes Shift for Super‐Resolution Imaging of Autolysosome Escape

(2020) Liu-Yi Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

CAIXplatins: Highly Potent Platinum(IV) Prodrugs Selective Against Carbonic Anhydrase IX for the Treatment of Hypoxic Tumors

(2020) Qian Cao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

PlatinER: a Highly Potent Anticancer Platinum(II) Complex that induces Endoplasmic Reticulum Stress‐driven Immunogenic Cell Death

(2020) Max Jing Rui Tham et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Multispecific Platinum(IV) Complex Deters Breast Cancer via Interposing Inflammation and Immunosuppression as an Inhibitor of COX‐2 and PD‐L1

(2020) Suxing Jin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Programming cell pyroptosis with biomimetic nanoparticles for solid tumor immunotherapy

(2020) Pengfei Zhao et al.   BIOMATERIALS

Endoplasmic reticulum targeted AIE bioprobe as a highly efficient inducer of immunogenic cell death

(2020) Jun Li et al.   Science China-Chemistry

Organic Photodynamic Nanoinhibitor for Synergistic Cancer Therapy

(2019) Yuyan Jiang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Targeted photoredox catalysis in cancer cells

(2019) Huaiyi Huang et al.   Nature Chemistry

New power of self-assembling carbonic anhydrase inhibitor: Short peptide–constructed nanofibers inspire hypoxic cancer therapy

(2019) Jiayang Li et al.   Science Advances

Enzyme-Driven Membrane-Targeted Chimeric Peptide for Enhanced Tumor Photodynamic Immunotherapy

(2019) Chi Zhang et al.   ACS Nano

Massively Evoking Immunogenic Cell Death by Focused Mitochondrial Oxidative Stress using an AIE Luminogen with a Twisted Molecular Structure

(2019) Chao Chen et al.   ADVANCED MATERIALS

Immunogenic cell death induced by a new photodynamic therapy based on photosens and photodithazine

(2019) Victoria D. Turubanova et al.   Journal for ImmunoTherapy of Cancer

Bioinspired Hybrid Protein Oxygen Nanocarrier Amplified Photodynamic Therapy for Eliciting Anti-tumor Immunity and Abscopal Effect

(2018) Zhikuan Chen et al.   ACS Nano

Lipid Peroxidation Drives Gasdermin D-Mediated Pyroptosis in Lethal Polymicrobial Sepsis

(2018) Rui Kang et al.   Cell Host & Microbe

Transition Metal Complexes and Photodynamic Therapy from a Tumor-Centered Approach: Challenges, Opportunities, and Highlights from the Development of TLD1433

(2018) Susan Monro et al.   CHEMICAL REVIEWS

Live-cell visualization of gasdermin D-driven pyroptotic cell death

(2017) Joseph K. Rathkey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Supramolecular Photoactivatable Anticancer Hydrogels

(2017) V. Venkatesh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Overcoming the Limits of Hypoxia in Photodynamic Therapy: A Carbonic Anhydrase IX-Targeted Approach

(2017) Hyo Sung Jung et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

Hollow MnO2 as a tumor-microenvironment-responsive biodegradable nano-platform for combination therapy favoring antitumor immune responses

(2017) Guangbao Yang et al.   Nature Communications

Chlorin-Based Nanoscale Metal–Organic Framework Systemically Rejects Colorectal Cancers via Synergistic Photodynamic Therapy and Checkpoint Blockade Immunotherapy

(2016) Kuangda Lu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Pore-forming activity and structural autoinhibition of the gasdermin family

(2016) Jingjin Ding et al.   NATURE

Carbonic anhydrase IX inhibitors in cancer therapy: an update

(2015) Claudiu T Supuran et al.   Future Medicinal Chemistry

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

The future of immune checkpoint therapy

(2015) P. Sharma et al.   SCIENCE

ER stress, autophagy and immunogenic cell death in photodynamic therapy-induced anti-cancer immune responses

(2014) Abhishek D. Garg et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

Photodynamic therapy: illuminating the road from cell death towards anti-tumour immunity

(2010) Abhishek D. Garg et al.   APOPTOSIS

Carbonic anhydrases: novel therapeutic applications for inhibitors and activators

(2008) Claudiu T. Supuran   NATURE REVIEWS DRUG DISCOVERY