STING nuclear partners contribute to innate immune signaling responses

MEN1 deficiency leads to neuroendocrine differentiation of lung cancer and disrupts the DNA damage response

(2020) Huan Qiu et al.   Nature Communications

Nucleoplasmic signals promote directed transmembrane protein import simultaneously via multiple channels of nuclear pores

(2020) Krishna C. Mudumbi et al.   Nature Communications

The N-Terminal Domain of cGAS Determines Preferential Association with Centromeric DNA and Innate Immune Activation in the Nucleus

(2019) Matteo Gentili et al.   Cell Reports

cGAS in action: Expanding roles in immunity and inflammation

(2019) Andrea Ablasser et al.   SCIENCE

Autophagy induction via STING trafficking is a primordial function of the cGAS pathway

(2019) Xiang Gui et al.   NATURE

The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death

(2019) Christian Zierhut et al.   CELL

DNA sensing by the cGAS–STING pathway in health and disease

(2019) Mona Motwani et al.   NATURE REVIEWS GENETICS

Viral Appropriation: Laying Claim to Host Nuclear Transport Machinery

(2019) Tanner M. Tessier et al.   Cells

Chromatin‐bound cGAS is an inhibitor of DNA repair and hence accelerates genome destabilization and cell death

(2019) Hui Jiang et al.   EMBO JOURNAL

DDX23, an Evolutionary Conserved dsRNA Sensor, Participates in Innate Antiviral Responses by Pairing With TRIF or MAVS

(2019) Jie Ruan et al.   Frontiers in Immunology

Casting a Wider Net: Differentiating between Inner Nuclear Envelope and Outer Nuclear Envelope Transmembrane Proteins

(2019) Mark Tingey et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Influenza A virus M2 protein triggers mitochondrial DNA-mediated antiviral immune responses

(2019) Miyu Moriyama et al.   Nature Communications

STING signaling and host defense against microbial infection

(2019) Jeonghyun Ahn et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Tight nuclear tethering of cGAS is essential for preventing autoreactivity

(2019) Hannah E Volkman et al.   eLife

DDX5 RNA Helicases: Emerging Roles in Viral Infection

(2018) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

STING-dependent translation inhibition restricts RNA virus replication

(2018) Kate M. Franz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Species-specific disruption of STING-dependent antiviral cellular defenses by the Zika virus NS2B3 protease

(2018) Qiang Ding et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

cGAS–STING and Cancer: Dichotomous Roles in Tumor Immunity and Development

(2018) Kevin W. Ng et al.   TRENDS IN IMMUNOLOGY

A Cell-Intrinsic Interferon-like Response Links Replication Stress to Cellular Aging Caused by Progerin

(2018) Ray Kreienkamp et al.   Cell Reports

Herpes Simplex Virus 1 γ134.5 Protein Inhibits STING Activation That Restricts Viral Replication

(2018) Shuang Pan et al.   JOURNAL OF VIROLOGY

Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage

(2018) Gillian Dunphy et al.   MOLECULAR CELL

Nuclear cGAS suppresses DNA repair and promotes tumorigenesis

(2018) Haipeng Liu et al.   NATURE

Global Interactomics Connect Nuclear Mitotic Apparatus Protein NUMA1 to Influenza Virus Maturation

(2018) Md Rahim et al.   Viruses-Basel

Collateral Damage during Dengue Virus Infection: Making Sense of DNA by cGAS

(2017) Sebastian Aguirre et al.   JOURNAL OF VIROLOGY

Influenza A Virus NS1 Protein Promotes Efficient Nuclear Export of Unspliced Viral M1 mRNA

(2017) Carina F. Pereira et al.   JOURNAL OF VIROLOGY

cGAS surveillance of micronuclei links genome instability to innate immunity

(2017) Karen J. Mackenzie et al.   NATURE

IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes

(2017) Jessica F. Almine et al.   Nature Communications

HSV‐1 ICP27 targets the TBK1‐activated STING signalsome to inhibit virus‐induced type I IFN expression

(2016) Maria H Christensen et al.   EMBO JOURNAL

Herpes Simplex Virus 1 Serine Protease VP24 Blocks the DNA-Sensing Signal Pathway by Abrogating Activation of Interferon Regulatory Factor 3

(2016) Dandan Zhang et al.   JOURNAL OF VIROLOGY

Single-point single-molecule FRAP distinguishes inner and outer nuclear membrane protein distribution

(2016) Krishna C Mudumbi et al.   Nature Communications

Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses

(2016) Christian K. Holm et al.   Nature Communications

Beyond receptors and signaling: epigenetic factors in the regulation of innate immunity

(2015) Stuti Mehta et al.   IMMUNOLOGY AND CELL BIOLOGY

Bipartite Nuclear Localization Signal Controls Nuclear Import and DNA-Binding Activity of IFN Regulatory Factor 3

(2015) Mingzhu Zhu et al.   JOURNAL OF IMMUNOLOGY

Hepatitis C Virus NS4B Can Suppress STING Accumulation To Evade Innate Immune Responses

(2015) Guanghui Yi et al.   JOURNAL OF VIROLOGY

Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

(2015) S. Liu et al.   SCIENCE

Message in a bottle: lessons learned from antagonism of STING signalling during RNA virus infection

(2014) Kevin Maringer et al.   CYTOKINE & GROWTH FACTOR REVIEWS

MITA/STING: A central and multifaceted mediator in innate immune response

(2014) Yong Ran et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Host Factors That Interact with the Pestivirus N-Terminal Protease, Npro, Are Components of the Ribonucleoprotein Complex

(2014) M. Jefferson et al.   JOURNAL OF VIROLOGY

The cGAS-cGAMP-STING Pathway of Cytosolic DNA Sensing and Signaling

(2014) Xin Cai et al.   MOLECULAR CELL

The Pestivirus N Terminal Protease Npro Redistributes to Mitochondria and Peroxisomes Suggesting New Sites for Regulation of IRF3 by Npro

(2014) Matthew Jefferson et al.   PLoS One

NET23/STING Promotes Chromatin Compaction from the Nuclear Envelope

(2014) Poonam Malik et al.   PLoS One

Understanding the interaction of hepatitis C virus with host DEAD-box RNA helicases

(2014) Megha Haridas Upadya   WORLD JOURNAL OF GASTROENTEROLOGY

The DEAD-box RNA helicase DDX5 acts as a positive regulator of Japanese encephalitis virus replication by binding to viral 3′ UTR

(2013) Chen Li et al.   ANTIVIRAL RESEARCH

The interferon response to intracellular DNA: Why so many receptors?

(2013) Leonie Unterholzner   IMMUNOBIOLOGY

MEN1 Is a Melanoma Tumor Suppressor That Preserves Genomic Integrity by Stimulating Transcription of Genes That Promote Homologous Recombination-Directed DNA Repair

(2013) M. Fang et al.   MOLECULAR AND CELLULAR BIOLOGY

STING Recognition of Cytoplasmic DNA Instigates Cellular Defense

(2013) Takayuki Abe et al.   MOLECULAR CELL

DDX5 Facilitates HIV-1 Replication as a Cellular Co-Factor of Rev

(2013) Xiuxia Zhou et al.   PLoS One

Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects

(2013) X.-D. Li et al.   SCIENCE

Viral Subversion of Nucleocytoplasmic Trafficking

(2013) Melanie L. Yarbrough et al.   TRAFFIC

Hepatitis C virus NS4B protein targets STING and abrogates RIG-I-mediated type I interferon-dependent innate immunity

(2012) Sayuri Nitta et al.   HEPATOLOGY

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

(2012) J. Wu et al.   SCIENCE

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

STING Specifies IRF3 Phosphorylation by TBK1 in the Cytosolic DNA Signaling Pathway

(2012) Y. Tanaka et al.   Science Signaling

Knockdown of menin affects pre-mRNA processing and promoter fidelity at the interferon-gamma inducible IRF1 gene

(2012) Lauren B Auriemma et al.   Epigenetics & Chromatin

STING Mediates Neuronal Innate Immune Response Following Japanese Encephalitis Virus Infection

(2012) Arshed Nazmi et al.   Scientific Reports

DENV Inhibits Type I IFN Production in Infected Cells by Cleaving Human STING

(2012) Sebastian Aguirre et al.   PLoS Pathogens

The essential adaptors of innate immune signaling

(2012) Huihui Chen et al.   Protein & Cell

Mapping a Dynamic Innate Immunity Protein Interaction Network Regulating Type I Interferon Production

(2011) Shitao Li et al.   IMMUNITY

System analysis shows distinct mechanisms and common principles of nuclear envelope protein dynamics

(2011) Nikolaj Zuleger et al.   JOURNAL OF CELL BIOLOGY

The HBx protein of hepatitis B virus regulates the expression, intracellular distribution and functions of ribosomal protein S27a

(2011) G. Fatima et al.   JOURNAL OF GENERAL VIROLOGY

STING is a direct innate immune sensor of cyclic di-GMP

(2011) Dara L. Burdette et al.   NATURE

The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells

(2011) Zhiqiang Zhang et al.   NATURE IMMUNOLOGY

Cytoscape Web: an interactive web-based network browser

(2010) Christian T. Lopes et al.   BIOINFORMATICS

Cell-specific and lamin-dependent targeting of novel transmembrane proteins in the nuclear envelope

(2010) Poonam Malik et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The Leukocyte Nuclear Envelope Proteome Varies with Cell Activation and Contains Novel Transmembrane Proteins That Affect Genome Architecture

(2010) Nadia Korfali et al.   MOLECULAR & CELLULAR PROTEOMICS

Several Novel Nuclear Envelope Transmembrane Proteins Identified in Skeletal Muscle Have Cytoskeletal Associations

(2010) Gavin S. Wilkie et al.   MOLECULAR & CELLULAR PROTEOMICS

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

(2009) Hiroki Ishikawa et al.   NATURE

Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response

(2009) T. Saitoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization

(2009) W. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SYNCRIP (synaptotagmin-binding, cytoplasmic RNA-interacting protein) is a host factor involved in hepatitis C virus RNA replication

(2009) Helene Minyi Liu et al.   VIROLOGY

The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation

(2008) Bo Zhong et al.   IMMUNITY

HIV-1 genome-encoded hiv1-mir-H1 impairs cellular responses to infection

(2008) Deepak Kaul et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

MPYS, a Novel Membrane Tetraspanner, Is Associated with Major Histocompatibility Complex Class II and Mediates Transduction of Apoptotic Signals

(2008) L. Jin et al.   MOLECULAR AND CELLULAR BIOLOGY

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE

Subdiffraction Multicolor Imaging of the Nuclear Periphery with 3D Structured Illumination Microscopy

(2008) L. Schermelleh et al.   SCIENCE