Fructus Zanthoxyli extract improves glycolipid metabolism disorder of type 2 diabetes mellitus via activation of AMPK/PI3K/Akt pathway: Network pharmacology and experimental validation

Development and in vivo Evaluation of Hydroxy-α-Sanshool Intranasal Liposomes as a Potential Remedial Treatment for Alzheimer’s Disease

(2022) Ruolan Li et al.   International Journal of Nanomedicine

Determination of Volatile Terpenes in Coriander Cold Pressed Oil by Vacuum Assisted Sorbent Extraction (VASE)

(2021) Henryk H. Jeleń et al.   MOLECULES

Liraglutide Alleviates Hepatic Steatosis and Liver Injury in T2MD Rats via a GLP-1R Dependent AMPK Pathway

(2021) Rui Zhou et al.   Frontiers in Pharmacology

Perilla frutescens Leaf Extract and Fractions: Polyphenol Composition, Antioxidant, Enzymes (α-Glucosidase, Acetylcholinesterase, and Tyrosinase) Inhibitory, Anticancer, and Antidiabetic Activities

(2021) Zhenxing Wang et al.   Foods

Comparative Study on the Essential Oils from Five Wild Egyptian Centaurea Species: Effective Extraction Techniques, Antimicrobial Activity and In-Silico Analyses

(2021) Eman H. Reda et al.   Antibiotics-Basel

Essential Oils of New Lippia alba Genotypes Analyzed by Flow-Modulated Comprehensive Two-Dimensional Gas Chromatography (GC×GC) and Chemometric Analysis

(2021) Leila Gimenes et al.   MOLECULES

Cudrania tricuspidata Root Extract Prevents Methylglyoxal-Induced Inflammation and Oxidative Stress via Regulation of the PKC-NOX4 Pathway in Human Kidney Cells

(2021) Donghee Kim et al.   Oxidative Medicine and Cellular Longevity

Anti-biofilm Potential of Elletaria cardamomum Essential Oil Against Escherichia coli O157:H7 and Salmonella Typhimurium JSG 1748

(2021) Abdullah et al.   Frontiers in Microbiology

In Silico and In Vitro Evaluation of the Antimicrobial and Antioxidant Potential of Mentha × smithiana R. GRAHAM Essential Oil from Western Romania

(2021) Călin Jianu et al.   Foods

Laurus nobilis, Salvia sclarea and Salvia officinalis Essential Oils and Hydrolates: Evaluation of Liquid and Vapor Phase Chemical Composition and Biological Activities

(2021) Elisa Ovidi et al.   Plants-Basel

Chemical Characterization of Marrubium vulgare Volatiles from Serbia

(2021) Milica Aćimović et al.   Plants-Basel

Chemical Profiles, Anticancer, and Anti-Aging Activities of Essential Oils of Pluchea dioscoridis (L.) DC. and Erigeron bonariensis L.

(2021) Abdelbaset M. Elgamal et al.   Plants-Basel

Exercise and Urtica dioica extract ameliorate hippocampal insulin signaling, oxidative stress, neuroinflammation, and cognitive function in STZ-induced diabetic rats

(2021) Masoud Rahmati et al.   BIOMEDICINE & PHARMACOTHERAPY

Alkaloidal extract from Zanthoxylum zanthoxyloides stimulates insulin secretion in normoglycemic and nicotinamide/streptozotocin-induced diabetic rats

(2021) Isaac Kyei-Barffour et al.   Heliyon

Paeoniflorin is a promising natural monomer for neurodegenerative diseases via modulation of Ca2+ and ROS homeostasis

(2021) Wei Peng et al.   CURRENT OPINION IN PHARMACOLOGY

Dulaglutide: A Review in Type 2 Diabetes

(2020) Lesley J. Scott   DRUGS

Applications of Network Pharmacology in Traditional Chinese Medicine Research

(2020) Zhuchen Zhou et al.   Evidence-based Complementary and Alternative Medicine

Role of β-Caryophyllene in the Antinociceptive and Anti-Inflammatory Effects of Tagetes lucida Cav. Essential Oil

(2020) Alberto Hernandez-Leon et al.   MOLECULES

Prosthechea karwinskii, an orchid used as traditional medicine, exerts anti-inflammatory activity and inhibits ROS

(2020) Gabriela Soledad Barragán-Zarate et al.   JOURNAL OF ETHNOPHARMACOLOGY

Prevalence of diabetes recorded in mainland China using 2018 diagnostic criteria from the American Diabetes Association: national cross sectional study

(2020) Yongze Li et al.   BMJ-British Medical Journal

Banxia Xiexin Decoction Ameliorates t-BHP-Induced Apoptosis in Pancreatic Beta Cells by Activating the PI3K/AKT/FOXO1 Signaling Pathway

(2020) Li-juan Du et al.   Journal of Diabetes Research

DhHP-6 ameliorates hepatic oxidative stress and insulin resistance in type 2 diabetes mellitus through the PI3K/AKT and AMPK pathway

(2020) Kai Wang et al.   BIOCHEMICAL JOURNAL

Attenuation of Free Fatty Acid (FFA)-Induced Skeletal Muscle Cell Insulin Resistance by Resveratrol is Linked to Activation of AMPK and Inhibition of mTOR and p70 S6K

(2020) Danja J. Den Hartogh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Antidiabetic Potency, Antioxidant Effects, and Mode of Actions of Citrus reticulata Fruit Peel Hydroethanolic Extract, Hesperidin, and Quercetin in Nicotinamide/Streptozotocin-Induced Wistar Diabetic Rats

(2020) Alaa M. Ali et al.   Oxidative Medicine and Cellular Longevity

Interactions Between Gut Microbiota, Host, and Herbal Medicines: A Review of New Insights Into the Pathogenesis and Treatment of Type 2 Diabetes

(2020) Yujiao Zheng et al.   Frontiers in Cellular and Infection Microbiology

Drug Delivery System in the Treatment of Diabetes Mellitus

(2020) Ruichen Zhao et al.   Frontiers in Bioengineering and Biotechnology

Medicinal Properties of Lilium candidum L. and Its Phytochemicals

(2020) Michele Zaccai et al.   Plants-Basel

Pathophysiology of Type 2 Diabetes Mellitus

(2020) Unai Galicia-Garcia et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Catalpol Ameliorates Insulin Sensitivity and Mitochondrial Respiration in Skeletal Muscle of Type-2 Diabetic Mice Through Insulin Signaling Pathway and AMPK/SIRT1/PGC-1α/PPAR-γ Activation

(2020) Kah Heng Yap et al.   Biomolecules

UHPLC-ESI-QTOF-MS/MS-Based Molecular Networking Guided Isolation and Dereplication of Antibacterial and Antifungal Constituents of Ventilago denticulata

(2020) Muhaiminatul Azizah et al.   Antibiotics-Basel

Mechanism of action of Imeglimin: A novel therapeutic agent for type 2 diabetes

(2020) Sophie Hallakou‐Bozec et al.   DIABETES OBESITY & METABOLISM

A Novel Chemical Profile of a Selective In Vitro Cholinergic Essential Oil from Clinopodium taxifolium (Kunth) Govaerts (Lamiaceae), a Native Andean Species of Ecuador

(2020) Sandra Espinosa et al.   MOLECULES

Liraglutide Alleviates Hepatic Steatosis by Activating the TFEB-Regulated Autophagy-Lysosomal Pathway

(2020) Yunyun Fang et al.   Frontiers in Cell and Developmental Biology

Simultaneous quantitative analysis of 11 flavonoid derivatives with a single marker in persimmon leaf extraction and evaluation of their myocardium protection activity

(2019) Zhi Zhou et al.   Journal of Natural Medicines

SwissTargetPrediction: updated data and new features for efficient prediction of protein targets of small molecules

(2019) Antoine Daina et al.   NUCLEIC ACIDS RESEARCH

Antiepileptic Effects of Protein-Rich Extract from Bombyx batryticatus on Mice and Its Protective Effects against H2O2-Induced Oxidative Damage in PC12 Cells via Regulating PI3K/Akt Signaling Pathways

(2019) Meibian Hu et al.   Oxidative Medicine and Cellular Longevity

Dapagliflozin: A Review in Type 2 Diabetes

(2019) Sohita Dhillon   DRUGS

Baicalein improves glucose metabolism in insulin resistant HepG2 cells

(2019) Zongchun Yang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Simultaneous identification of low-molecular weight phenolic and nitrogen compounds in craft beers by HPLC-ESI-MS/MS

(2019) Kamila P. Cheiran et al.   FOOD CHEMISTRY

Scutellariae radix and coptidis rhizoma ameliorate glycolipid metabolism of type 2 diabetic rats by modulating gut microbiota and its metabolites

(2019) Suwei Xiao et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Gymnemic Acid Ameliorates Hyperglycemia through PI3K/AKT- and AMPK-Mediated Signaling Pathways in Type 2 Diabetes Mellitus Rats

(2019) Yumeng Li et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Analysis of the Volatile Components in Selaginella doederleinii by Headspace Solid Phase Microextraction-Gas Chromatography-Mass Spectrometry

(2019) Xian-kui Ma et al.   MOLECULES

Resveratrol Attenuates Oxidative Stress-Induced Intestinal Barrier Injury through PI3K/Akt-Mediated Nrf2 Signaling Pathway

(2019) Yu Zhuang et al.   Oxidative Medicine and Cellular Longevity

Mechanisms of AMPK in the maintenance of ATP balance during energy metabolism

(2018) Rong Ke et al.   CELL BIOLOGY INTERNATIONAL

Comprehensive metabolite profiling of Solanum tuberosum L. (potato) leaves by HPLC-ESI-QTOF-MS

(2018) Celia Rodríguez-Pérez et al.   FOOD RESEARCH INTERNATIONAL

HPLC-MS/MS determination of flavonoids in Gleditsiae Spina for its quality assessment

(2018) Jing Li et al.   JOURNAL OF SEPARATION SCIENCE

Chemical composition, antimicrobial and antioxidant activities of the essential oils of three Uzbek Lamiaceae species

(2018) Nilufar Z. Mamadalieva et al.   NATURAL PRODUCT RESEARCH

Phytochemical screening and preliminary clinical trials of the aqueous extract mixture of Andrographis paniculata (Burm. f.) Wall. ex Nees and Syzygium polyanthum (Wight.) Walp leaves in metformin treated patients with type 2 diabetes

(2018) Elisabeth Catherina Widjajakusuma et al.   PHYTOMEDICINE

Palmitic and Oleic Acid: The Yin and Yang of Fatty Acids in Type 2 Diabetes Mellitus

(2018) Xavier Palomer et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The PI3K/AKT pathway in obesity and type 2 diabetes

(2018) Xingjun Huang et al.   International Journal of Biological Sciences

The relationship between alkymide compound content and pungency intensity of Zanthoxylum bungeanum based on sensory evaluation and ultra-performance liquid chromatography-mass spectrometry/ mass spectrometry (UPLC-MS/MS) analysis

(2018) Lu-Lu Zhang et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Simultaneous Determination of Chlorogenic Acid Isomers and Metabolites in Rat Plasma Using LC-MS/MS and Its Application to A Pharmacokinetic Study Following Oral Administration of Stauntonia Hexaphylla Leaf Extract (YRA-1909) to Rats

(2018) Won-Gu Choi et al.   Pharmaceutics

Dietary compounds and traditional Chinese medicine ameliorate type 2 diabetes by modulating gut microbiota

(2018) Qixing Nie et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

(2018) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Zanthoxylum bungeanum Maxim. (Rutaceae): A Systematic Review of Its Traditional Uses, Botany, Phytochemistry, Pharmacology, Pharmacokinetics, and Toxicology

(2017) Mengmeng Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Comparatively evaluating the pharmacokinetic of fifteen constituents in normal and blood deficiency rats after oral administration of Xin-Sheng-Hua Granule by UPLC–MS/MS

(2017) Han-Qing Pang et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Zanthoxylumalkylamides ameliorate protein metabolism disorder in STZ-induced diabetic rats

(2017) Tingyuan Ren et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Profiling and Distribution of Metabolites of Procyanidin B2 in Mice by UPLC-DAD-ESI-IT-TOF-MSn Technique

(2017) Ying Xiao et al.   Frontiers in Pharmacology

Characterization of isobutylhydroxyamides with NGF-potentiating activity from Zanthoxylum bungeanum

(2016) Jun-Mian Tian et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Hypoglycemic Activity of Aqueous Root Bark ExtractZanthoxylum chalybeumin Alloxan-Induced Diabetic Rats

(2016) Moses Solomon Agwaya et al.   Journal of Diabetes Research

Metabolic profiling of antioxidants constituents in Artemisia selengensis leaves

(2015) Lu Zhang et al.   FOOD CHEMISTRY

The effects of Zanthoxylum bungeanum extract on lipid metabolism induced by sterols

(2015) Tingting Wu et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Caulerpa lentillifera extract ameliorates insulin resistance and regulates glucose metabolism in C57BL/KsJ-db/db mice via PI3K/AKT signaling pathway in myocytes

(2015) Bhesh Sharma et al.   Journal of Translational Medicine

Hypoglycemic effects of Zanthoxylum alkylamides by enhancing glucose metabolism and ameliorating pancreatic dysfunction in streptozotocin-induced diabetic rats

(2015) Yuming You et al.   Food & Function

Inhibitory effects of Pericarpium zanthoxyli extract on adipocyte differentiation

(2014) HA-RIM KIM et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

All-trans-Configuration in Zanthoxylum Alkylamides Swaps the Tingling with a Numbing Sensation and Diminishes Salivation

(2014) Matthias Bader et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

AMP-activated protein kinase: a key regulator of energy balance with many roles in human disease

(2014) D. Grahame Hardie   JOURNAL OF INTERNAL MEDICINE

Polyphenolics Composition of the Leaves of Zanthoxylum bungeanum Maxim. Grown in Hebei, China, and Their Radical Scavenging Activities

(2013) Li-Chen Yang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

PI3K/AKT, MAPK and AMPK signalling: protein kinases in glucose homeostasis

(2012) Simon M. Schultze et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Effects of linalool on inflammation, matrix accumulation and podocyte loss in kidney of streptozotocin-induced diabetic rats

(2012) Balasubramaniam Deepa et al.   TOXICOLOGY MECHANISMS AND METHODS