Naringin and Naringenin: Their Mechanisms of Action and the Potential Anticancer Activities

Comprehensive review on naringenin and naringin polyphenols as a potent anticancer agent

(2022) Abdur Rauf et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Beneficial Effects of Citrus Flavanones Naringin and Naringenin and Their Food Sources on Lipid Metabolism: An Update on Bioavailability, Pharmacokinetics, and Mechanisms

(2022) Yang Yang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Naringenin Induces ROS-Mediated ER Stress, Autophagy, and Apoptosis in Human Osteosarcoma Cell Lines

(2022) Chiang-Wen Lee et al.   MOLECULES

Citrus fruits are rich in flavonoids for immunoregulation and potential targeting ACE2

(2022) Wenting Liu et al.   Natural Products and Bioprospecting

Naringin suppressed airway inflammation and ameliorated pulmonary endothelial hyperpermeability by upregulating Aquaporin1 in lipopolysaccharide/cigarette smoke-induced mice

(2022) Huan-huan Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

Dietary Polyphenols: Extraction, Identification, Bioavailability, and Role for Prevention and Treatment of Colorectal and Prostate Cancers

(2022) Naveed Ahmad et al.   MOLECULES

Inhibition of tumor invasion and metastasis by targeting TGF-β-Smad-MMP2 pathway with Asiatic acid and Naringenin

(2021) Guang-Yu Lian et al.   Molecular Therapy-Oncolytics

Autophagy: Mechanisms and Therapeutic Potential of Flavonoids in Cancer

(2021) Xuening Pang et al.   Biomolecules

Naringenin inhibits migration, invasion, induces apoptosis in human lung cancer cells and arrests tumour progression in vitro

(2021) Xingyuan Shi et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Synergic Fabrication of Naringin Molecule into Polymeric Nanoparticles for the Treatment and Nursing Care of Lung Cancer Therapy

(2021) Lingqiao Yan et al.   JOURNAL OF POLYMERS AND THE ENVIRONMENT

A Systematic Review of the Preventive and Therapeutic Effects of Naringin Against Human Malignancies

(2021) Maryam Ghanbari-Movahed et al.   Frontiers in Pharmacology

Natural-Derived Molecules as a Potential Adjuvant in Chemotherapy: Normal Cell Protectors and Cancer Cell Sensitizers

(2021) Rajib Hossain et al.   Anti-Cancer Agents in Medicinal Chemistry

Naringin prevents cyclophosphamide-induced hepatotoxicity in rats by attenuating oxidative stress, fibrosis, and inflammation

(2021) Adio J. Akamo et al.   FOOD AND CHEMICAL TOXICOLOGY

Naringin induces apoptosis of gastric carcinoma cells via blocking the PI3K/AKT pathway and activating pro‑death autophagy

(2021) Cuixiang Xu et al.   Molecular Medicine Reports

Effects of Citrus Fruit Juices and Their Bioactive Components on Inflammation and Immunity: A Narrative Review

(2021) Elizabeth A. Miles et al.   Frontiers in Immunology

Naringenin inhibits human breast cancer cells (MDA-MB-231) by inducing programmed cell death, caspase stimulation, G2/M phase cell cycle arrest and suppresses cancer metastasis

(2021) Zhaozhen Qi et al.   CELLULAR AND MOLECULAR BIOLOGY

Balancing the efficacy vs. the toxicity of promiscuous natural products: Paclitaxel-based acid-labile lipophilic prodrugs as promising chemotherapeutics

(2021) Saqlain Haider et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Citrus Genus and Its Waste Utilization: A Review on Health-Promoting Activities and Industrial Application

(2021) Usman Mir Khan et al.   Evidence-based Complementary and Alternative Medicine

Citrus flavonoids as potential therapeutic agents: A review

(2021) Fiaz Alam et al.   PHYTOTHERAPY RESEARCH

Flavonoids as Anticancer Agents

(2020) Dalia M. Kopustinskiene et al.   Nutrients

Naringin inhibits autophagy mediated by PI3K-Akt-mTOR pathway to ameliorate endothelial cell dysfunction induced by high glucose/high fat stress

(2020) Kun Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Naringin inhibits colorectal cancer cell growth by repressing the PI3K/AKT/mTOR signaling pathway

(2020) Hongyun Cheng et al.   Experimental and Therapeutic Medicine

Pharmacokinetics and Metabolism of Naringin and Active Metabolite Naringenin in Rats, Dogs, Humans, and the Differences Between Species

(2020) Yang Bai et al.   Frontiers in Pharmacology

Dietary polyphenols inhibit the cytochrome P450 monooxygenase branch of the arachidonic acid cascade with remarkable structure-dependent selectivity and potency

(2020) Nadja Kampschulte et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Natural dietary compound naringin inhibits glioblastoma cancer neoangiogenesis

(2020) Sonia Aroui et al.   BMC Pharmacology & Toxicology

Flavonoids Regulate Inflammation and Oxidative Stress in Cancer

(2020) Guangxing Li et al.   MOLECULES

Multi-Therapeutic Potential of Naringenin (4′,5,7-Trihydroxyflavonone): Experimental Evidence and Mechanisms

(2020) Azher Arafah et al.   Plants-Basel

Naringin and naringenin as anticancer agents and adjuvants in cancer combination therapy: Efficacy and molecular mechanisms of action, a comprehensive narrative review

(2020) Zahra Memariani et al.   PHARMACOLOGICAL RESEARCH

Pharmacokinetics, Tissue Distribution, Metabolism, and Excretion of Naringin in Aged Rats

(2019) Xuan Zeng et al.   Frontiers in Pharmacology

Beneficial Effects of Citrus Flavonoids on Cardiovascular and Metabolic Health

(2019) Ayman M. Mahmoud et al.   Oxidative Medicine and Cellular Longevity

In Vivo Anti-inflammatory and Antiallergic Activity of Pure Naringenin, Naringenin Chalcone, and Quercetin in Mice

(2019) Elvira Escribano-Ferrer et al.   JOURNAL OF NATURAL PRODUCTS

Naringenin inhibits migration of breast cancer cells via inflammatory and apoptosis cell signaling pathways

(2019) Zhenjiang Zhao et al.   INFLAMMOPHARMACOLOGY

Inflammation and Metabolism in Cancer Cell—Mitochondria Key Player

(2019) Monica Neagu et al.   Frontiers in Oncology

Modulating Oxidative Stress in Drug-Induced Injury and Metabolic Disorders: The Role of Natural and Synthetic Antioxidants

(2019) Ayman M. Mahmoud et al.   Oxidative Medicine and Cellular Longevity

Safety and pharmacokinetics of naringenin: A randomized, controlled, single‐ascending‐dose clinical trial

(2019) Candida J. Rebello et al.   DIABETES OBESITY & METABOLISM

Quercetin and naringenin abate diethylnitrosamine/acetylaminofluorene-induced hepatocarcinogenesis in Wistar rats: the roles of oxidative stress, inflammation and cell apoptosis

(2019) Osama M. Ahmed et al.   DRUG AND CHEMICAL TOXICOLOGY

Anti-inflammatory effects of flavonoids

(2019) Soheila J. Maleki et al.   FOOD CHEMISTRY

Flavonoid-mediated immunomodulation of human macrophages involves key metabolites and metabolic pathways

(2019) Luís F. Mendes et al.   Scientific Reports

Tissue distribution of naringin and derived metabolites in rats after a single oral administration

(2019) Xuan Zeng et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Research trends in flavonoids and health

(2018) Francisco Perez-Vizcaino et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Naringenin inhibits prostate cancer metastasis by blocking voltage-gated sodium channels

(2018) Hatice Gumushan Aktas et al.   BIOMEDICINE & PHARMACOTHERAPY

Naringenin (4,5,7-trihydroxyflavanone) suppresses the development of precancerous lesions via controlling hyperproliferation and inflammation in the colon of Wistar rats

(2018) Muneeb U. Rehman et al.   ENVIRONMENTAL TOXICOLOGY

Sensitization of tumor cells to chemotherapy by natural products: A systematic review of preclinical data and molecular mechanisms

(2018) Raimundo Gonçalves de Oliveira Júnior et al.   FITOTERAPIA

Flavonoids inhibit cell proliferation and induce apoptosis and autophagy through downregulation of PI3Kγ mediated PI3K/AKT/mTOR/p70S6K/ULK signaling pathway in human breast cancer cells

(2018) Hong-Wei Zhang et al.   Scientific Reports

Naringin targets Zeb1 to suppress osteosarcoma cell proliferation and metastasis

(2018) He Ming et al.   Aging-US

Naringenin inhibited migration and invasion of glioblastoma cells through multiple mechanisms

(2018) Yen-Yu Chen et al.   ENVIRONMENTAL TOXICOLOGY

Targeting Cancer with Phytochemicals via Their Fine Tuning of the Cell Survival Signaling Pathways

(2018) Salvatore Chirumbolo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pharmacokinetic, pharmacodynamic and formulations aspects of Naringenin: An update

(2018) Ruthvika Joshi et al.   LIFE SCIENCES

The Immunomodulatory and Anti-Inflammatory Role of Polyphenols

(2018) Nour Yahfoufi et al.   Nutrients

Flavonoids in Cancer and Apoptosis

(2018) Mariam Abotaleb et al.   Cancers

Inhibition of LPS induced pro-inflammatory responses in RAW 264.7 macrophage cells by PVP-coated naringenin nanoparticle via down regulation of NF-κB/P38MAPK mediated stress signaling

(2017) Pradeep Kumar R. et al.   Pharmacological Reports

One-Step Extraction and Hydrolysis of Flavonoid Glycosides in Rape Bee Pollen Based on Soxhlet-Assisted Matrix Solid Phase Dispersion

(2017) Xijuan Tu et al.   PHYTOCHEMICAL ANALYSIS

Naringenin Impairs Two-Pore Channel 2 Activity And Inhibits VEGF-Induced Angiogenesis

(2017) Irene Pafumi et al.   Scientific Reports

Targeting Inflammation in Cancer Prevention and Therapy

(2016) J. Todoric et al.   Cancer Prevention Research

Naringin suppresses cell metastasis and the expression of matrix metalloproteinases (MMP-2 and MMP-9) via the inhibition of ERK-P38-JNK signaling pathway in human glioblastoma

(2016) Sonia Aroui et al.   CHEMICO-BIOLOGICAL INTERACTIONS

JAK-STAT signaling in cancer: From cytokines to non-coding genome

(2016) Jan Pencik et al.   CYTOKINE

Naringenin exerts anti-angiogenic effects in human endothelial cells: Involvement of ERRα/VEGF/KDR signaling pathway

(2016) Qunyi Li et al.   FITOTERAPIA

Naringenin inhibits proliferation, migration, and invasion as well as induces apoptosis of gastric cancer SGC7901 cell line by downregulation of AKT pathway

(2016) Lei Bao et al.   TUMOR BIOLOGY

Naringenin inhibits migration of lung cancer cells via the inhibition of matrix metalloproteinases-2 and −9

(2016) Huai-Lu Chang et al.   Experimental and Therapeutic Medicine

Naringenin: an analgesic and anti-inflammatory citrus flavanone

(2016) Marília F. Manchope et al.   Oncotarget

Polyphenols as mitochondria-targeted anticancer drugs

(2015) Sylwia Gorlach et al.   CANCER LETTERS

Notch signaling: An emerging therapeutic target for cancer treatment

(2015) Xun Yuan et al.   CANCER LETTERS

Naringenin suppresses TPA-induced tumor invasion by suppressing multiple signal transduction pathways in human hepatocellular carcinoma cells

(2015) Hung-Rong Yen et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Naringin induces autophagy-mediated growth inhibition by downregulating the PI3K/Akt/mTOR cascade via activation of MAPK pathways in AGS cancer cells

(2015) SUCHISMITA RAHA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Naringenin modulates the metastasis of human prostate cancer cells by down regulating the matrix metalloproteinases -2/-9 via ROS/ERK1/2 pathways

(2014) Er-Jiang Lin et al.   Bangladesh Journal of Pharmacology

Naringin suppress chondrosarcoma migration through inhibition vascular adhesion molecule-1 expression by modulating miR-126

(2014) Tzu-Wei Tan et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Naringenin inhibits migration of bladder cancer cells through downregulation of AKT and MMP-2

(2014) ALEX CHIEN HWA LIAO et al.   Molecular Medicine Reports

Naringin administration inhibits platelet aggregation and release by reducing blood cholesterol levels and the cytosolic free calcium concentration in hyperlipidemic rabbits

(2014) YANG XIAO et al.   Experimental and Therapeutic Medicine

An Overview of Autophagy: Morphology, Mechanism, and Regulation

(2013) Katherine R. Parzych et al.   ANTIOXIDANTS & REDOX SIGNALING

Protective effect of naringenin against experimental colitis via suppression of Toll-like receptor 4/NF-κB signalling

(2013) Wei Dou et al.   BRITISH JOURNAL OF NUTRITION

6-C-(E-phenylethenyl)-Naringenin Suppresses Colorectal Cancer Growth by Inhibiting Cyclooxygenase-1

(2013) H. Li et al.   CANCER RESEARCH

Acute and 13weeks subchronic toxicological evaluation of naringin in Sprague-Dawley rats

(2013) Peibo Li et al.   FOOD AND CHEMICAL TOXICOLOGY

Naringin inhibits growth potential of human triple-negative breast cancer cells by targeting β-catenin signaling pathway

(2013) Hongzhong Li et al.   TOXICOLOGY LETTERS

Naringenin Decreases Invasiveness and Metastasis by Inhibiting TGF-β-Induced Epithelial to Mesenchymal Transition in Pancreatic Cancer Cells

(2012) Changjie Lou et al.   PLoS One

Modulation of the Pharmacological Activities of Secretory Phospholipase A2 from Crotalus durissus cascavella Induced by Naringin

(2011) Marcelo L. Santos et al.   MOLECULES

Tumor Cell Metabolism: Cancer's Achilles' Heel

(2008) Guido Kroemer et al.   CANCER CELL