Journal
INTERNATIONAL IMMUNOPHARMACOLOGY
Volume 22, Issue 1, Pages 107-114Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.intimp.2014.06.029
Keywords
Naringin; Chondrosarcoma; miR-126; Migration; Vascular cell adhesion molecule-1
Categories
Funding
- National Science Council of Taiwan (NSC) [100-2320-B-039-028-MY3, 102-2632-B-039-001-MY3, 102-2320-B-039-030-MY3]
- Taichung Hospital, Ministry of Health and Welfare [10321]
- China Medical University Hospital [DMR103-059]
- CMU under the Aim for Top University Plan of the Ministry of Education, Taiwan
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Chondrosarcoma, a primary malignant bone cancer, has a potent capacity to invade locally and cause distant metastasis, especially to the lungs. Patients diagnosed with it have poor prognosis. Naringin, polymethoxylated flavonoid commonly found in citrus fruits, has anti-oxidant, anti-inflammatory and anti-tumor activity; whether naringin regulates migration of chondrosarcoma is largely unknown. Here we report that naringin does not expedite apoptosis in human chondrosarcoma. By contrast at noncytotoxic concentrations, naringin suppressed migration and invasion of chondrosarcoma cells. Vascular cell adhesion molecule-1 (VCAM-1) of the immunoglobulin superfamily is linked with metastasis; we found incubation of chondrosarcoma cells with naringin reducing mRNA transcription for, and cell surface expression of, VCAM-1. We also observed that naringin enhancing miR-126 expression, and miR-126 inhibitor reversed the naringin-inhibited cell motility and VCAM-1 expression. Therefore, naringin inhibits migration and invasion of human chondrosarcoma via down-regulation of VCAM-1 by increasing miR-126. Thus, naringin may be a novel anti-migration agent for the treatment of migration in chondrosarcoma (C) 2014 Elsevier B.V. All rights reserved.
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