Article
Multidisciplinary Sciences
AhmadReza Rezaeian, Fatemeh Khatami, Saeed Heidari Keshel, Mohammad Reza Akbari, Akram Mirzaei, Keykavos Gholami, Reza Mohammadi Farsani, Seyed Mohammad Kazem Aghamir
Summary: This study demonstrates that MSC-exosomes have certain anti-tumor effects on prostate, bladder, and kidney cancer cells. These effects are mainly achieved by inducing apoptosis and inhibiting cancer cell proliferation.
SCIENTIFIC REPORTS
(2022)
Article
Biotechnology & Applied Microbiology
Tiangang Ma, Yanbing Hu, Yinxue Guo, Qinghua Zhang
Summary: The study demonstrates that miR-203 carried by extracellular vesicles from endothelial cells can inhibit the malignant phenotypes of NSCLC cells and delay tumor growth by targeting DTL and promoting p21 protein stability.
CANCER GENE THERAPY
(2022)
Article
Cell Biology
Min Lin, Jianan Zhang, Hakim Bouamar, Zhiwei Wang, Lu-Zhe Sun, Xueqiong Zhu
Summary: This study reveals that high expression of FBXO22 is associated with clinicopathological characteristics and poor prognosis in cervical cancer patients. Overexpression of FBXO22 promotes cell viability and tumor growth, while knockdown of FBXO22 has opposite effects. Additionally, overexpression of FBXO22 promotes cell cycle progression and inhibits apoptosis in cervical cancer cells. FBXO22 promotes cervical cancer progression by regulating the ubiquitination and proteasomal degradation of the cyclin-dependent kinase inhibitor p57(Kip2).
CELL DEATH & DISEASE
(2022)
Article
Medicine, Research & Experimental
Ri Chen, Chunfan Zhang, Yuanda Cheng, Shaoqiang Wang, Hang Lin, Heng Zhang
Summary: The long non-coding RNA UCC acts as a competing endogenous RNA of miR-143-3p and upregulates SOX5 by absorbing miR-143-3p, resulting in proliferation and migration of non-small-cell lung cancer (NSCLC) cells both in vitro and in vivo. UCC enhances carcinogenesis of NSCLC cells via the miR-143-3p/SOX5 axis, which may function as a novel target for NSCLC treatment.
LABORATORY INVESTIGATION
(2021)
Review
Oncology
Jiaqi Liu, Chi Tim Leung, Luyun Liang, Yuqin Wang, Jian Chen, Keng Po Lai, William Ka Fai Tse
Summary: This review summarizes the current findings of DUBs in the most common cancers worldwide, including liver, breast, prostate, colorectal, pancreatic, and lung cancers, with regards to their roles in proliferation, metastasis, and apoptosis. The review provides an updated overview of the current findings and can serve as a quick guide for researchers in identifying target DUBs in cancer.
Article
Oncology
Shengjie Tang, Shuangjiang Li, Tao Liu, Yiwei He, Haiyang Hu, Yunhe Zhu, Shoujun Tang, Haining Zhou
Summary: MicroRNAs play pivotal roles in lung cancer development and progression, serving as potential biomarkers and therapeutic targets. Research has revealed the importance of microRNAs in regulating lung cancer cell growth, spread, and metastasis.
Article
Oncology
Joan Font-Diaz, Alba Jimenez-Panizo, Carme Caelles, Maria dM Vivanco, Paloma Perez, Ana Aranda, Eva Estebanez-Perpina, Antonio Castrillo, Mercedes Ricote, Annabel F. Valledor
Summary: Nuclear receptors are important transcription factors that regulate gene expression, influencing cell proliferation, differentiation, and apoptosis, and are significant for cancer intervention.
SEMINARS IN CANCER BIOLOGY
(2021)
Review
Cell Biology
Ijeoma Theresa Achi, Paromita Sarbadhikary, Blassan P. George, Heidi Abrahamse
Summary: Despite advancements in therapy, lung cancer remains the leading cause of cancer deaths worldwide. The high incidence of tumor recurrence, progression, and metastasis in lung cancer necessitate the exploration of novel treatments. Plant-derived compounds, particularly alkaloids like berberine, have shown promise as potential natural anticancer agents. Multiple studies have demonstrated the effectiveness of berberine in inhibiting cancer growth and progression through various mechanisms, including cell cycle arrest, apoptosis and autophagy-induced cell death, inhibition of proliferation and invasion, and regulation of microRNA expression, telomerase activity, and the tumor microenvironment. This review aims to provide a comprehensive understanding of the molecular insights into the antiproliferative and antimetastatic effects of berberine and its derivatives against lung cancer.
Article
Immunology
Yue-Wei Chen, Qiu-Rong Du, Yu-Juan He, Wen-Shu Chen, Wen-Yang Jiang, Qi Gui, Cheng-Cheng Xu, Wei Wang, Hong-Yun Cheng
Summary: This study reveals the significant role of the circ_0044516/miR-136/MAT2A axis in lung cancer progression, demonstrating that silencing circ_0044516 can inhibit processes such as cell proliferation, invasion, and stemness. These findings may provide novel targets for diagnosis and therapeutic intervention in lung cancer patients.
JOURNAL OF IMMUNOLOGY RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Heng Zhang, Shao-Qiang Wang, Jie-Bo Zhu, Li-Na Wang, Hang Lin, Lin-Feng Li, Yuan-Da Cheng, Chao-Jun Duan, Chun-Fang Zhang
Summary: CALML3-AS1 is upregulated while BTNL9 is downregulated in NSCLC. Depletion of CALML3-AS1 inhibits malignant phenotypes, tumor growth, and liver metastasis in NSCLC. Mechanistically, ALKBH5 enhances the stability of CALML3-AS1 through m6A demethylation, while YTHDC2 destabilizes CALML3-AS1. Additionally, CALML3-AS1 represses BTNL9 transcription and expression through the recruitment of EZH2. Downregulation of BTNL9 counteracts the antitumor effects mediated by CALML3-AS1 in NSCLC.
CANCER GENE THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Zhaozhen Qi, Shuangxi Kong, Shunyu Zhao, Qiu Tang
Summary: The study revealed significant anticancer potential of naringenin against breast cancer MDA-MB-231 cells, inhibiting cell proliferation, inducing apoptosis, causing cell cycle arrest, and reducing cell migration and invasion tendency.
CELLULAR AND MOLECULAR BIOLOGY
(2021)
Article
Integrative & Complementary Medicine
Peng Yu, Jingyang Li, Yanqing Luo, Jiayi Sun, Yingfan Hu, Bo Lin, Xianli Meng, Li Xiang
Summary: Breast cancer is a common and deadly malignancy in women. Traditional Chinese medicine, especially Scutellaria baicalensis, has shown promising activity against breast cancer through multiple mechanisms, including proliferation inhibition, apoptosis induction, and modulation of signaling pathways.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2023)
Article
Oncology
Yuxing Wang, Ru Wang, Xiaohe Liu, Menghao Liu, Lili Sun, Xiaohua Pan, Huili Hu, Baichun Jiang, Yongxin Zou, Qiao Liu, Yaoqin Gong, Molin Wang, Gongping Sun
Summary: Cancer relapse and metastasis pose challenges for effective treatment. Recent evidence suggests that cancer cells can survive even after executioner caspase activation, a key step in apoptosis, through a process called anastasis. In this study, breast cancer cells that experienced anastasis showed enhanced proliferation and migration, which was attributed to the persistent upregulation of CDH12. The activation of ERK and CREB by CDH12 promoted breast cancer malignancy. Additionally, executioner caspase activation led to increased CDH12 expression due to loss of DNA methylation and repressive histone modifications in the CDH12 promoter region. These findings provide insights into the mechanism underlying anastasis-induced enhancement in breast cancer malignancy and offer potential therapeutic targets for preventing post-chemotherapy cancer relapse and metastasis.
Review
Oncology
Bin Wang, Hanfei Guo, Hongquan Yu, Yong Chen, Haiyang Xu, Gang Zhao
Summary: EGR1, a transcription factor, plays a role in tissue injury, immune responses, and fibrosis. Recent studies suggest EGR1's involvement in cancer initiation and progression, potentially affecting tumor cell proliferation, invasion, metastasis, and angiogenesis. The specific mechanisms by which EGR1 modulates these processes are still under investigation.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yan Lv, Yin Wang, Yu Song, Shu-Sheng Wang, Kai-wen Cheng, Zhi-qing Zhang, Jin Yao, Li-na Zhou, Zhuo-yan Ling, Cong Cao
Summary: PINK1-AS promotes G alpha i1-driven gastric cancer progression by sponging miR-200a, while miR-200a directly silences G alpha i1 to induce anti-gastric cancer activity.