The Role of KEAP1-NRF2 System in Atopic Dermatitis and Psoriasis

Interleukin 1α: a comprehensive review on the role of IL-1α in the pathogenesis and targeted treatment of autoimmune and inflammatory diseases

(2021) Giulio Cavalli et al.   AUTOIMMUNITY REVIEWS

Rapamycin Alleviates 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Induced Aggravated Dermatitis in Mice with Imiquimod-Induced Psoriasis-Like Dermatitis by Inducing Autophagy

(2021) Hye Ran Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Galangin ameliorates Imiquimod-Induced psoriasis-like skin inflammation in BALB/c mice via down regulating NF-κB and activation of Nrf2 signaling pathways

(2021) Rajendra Sangaraju et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Miquelianin Inhibits Allergic Responses in Mice by Suppressing CD4+ T Cell Proliferation

(2021) Dae Woon Choi et al.   Antioxidants

Perillyl alcohol inhibits keratinocyte proliferation and attenuates imiquimod-induced psoriasis like skin-inflammation by modulating NF-κB and STAT3 signaling pathways

(2021) Sai Sudha Yalamarthi et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Loricrin Protects against Chemical Carcinogenesis

(2021) Tatsuya Ogawa et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Host‐microbial interactions between PTGR2 and Bifidobacterium in the early life gut of atopic dermatitis children

(2021) Jeong‐Hyun Kim et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

Attenuation of experimentally induced atopic dermatitis in mice by sulforaphane: effect on inflammation and apoptosis

(2021) Abdullah Alyoussef   TOXICOLOGY MECHANISMS AND METHODS

The Epidermis: Redox Governor of Health and Diseases

(2021) Yosuke Ishitsuka et al.   Antioxidants

Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) Regulates Epidermal Keratinization under Psoriatic Skin Inflammation

(2020) Tatsuya Ogawa et al.   AMERICAN JOURNAL OF PATHOLOGY

Igalan from Inula helenium (L.) suppresses the atopic dermatitis-like response in stimulated HaCaT keratinocytes via JAK/STAT3 signaling

(2020) Thien T. P. Dao et al.   INFLAMMATION RESEARCH

Genetic activation of Nrf2 reduces cutaneous symptoms in a murine model of Netherton syndrome

(2020) Sukalp Muzumdar et al.   Disease Models & Mechanisms

Loricrin: Past, Present, and Future

(2020) Yosuke Ishitsuka et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pathophysiology, Clinical Presentation, and Treatment of Psoriasis

(2020) April W. Armstrong et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Changes in Proteome of Fibroblasts Isolated from Psoriatic Skin Lesions

(2020) Agnieszka Gęgotek et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

NRF2 Augments Epidermal Antioxidant Defenses and Promotes Atopy

(2020) Tatsuya Ogawa et al.   JOURNAL OF IMMUNOLOGY

Atopic dermatitis

(2020) Sinéad M Langan et al.   LANCET

Chijabyukpi-Tang Inhibits Pro-Inflammatory Cytokines and Chemokines via the Nrf2/HO-1 Signaling Pathway in TNF-α/IFN-γ-Stimulated HaCaT Cells and Ameliorates 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis-Like Skin Lesions in Mice

(2020) Ji-Hyun Lee et al.   Frontiers in Pharmacology

The KEAP1/NRF2 Signaling Pathway in Keratinization

(2020) Yosuke Ishitsuka et al.   Antioxidants

Cardamonin Inhibits Oxazolone-Induced Atopic Dermatitis by the Induction of NRF2 and the Inhibition of Th2 Cytokine Production

(2020) Ok-Kyung Yoo et al.   Antioxidants

Inhibitory Effects of a Novel Chrysin-Derivative, CPD 6, on Acute and Chronic Skin Inflammation

(2019) Chan-Hee Yu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sulforaphane has a therapeutic effect in an atopic dermatitis murine model and activates the Nrf2/HO‑1 axis

(2019) Wenqing Wu et al.   Molecular Medicine Reports

Activators and Inhibitors of NRF2: A Review of Their Potential for Clinical Development

(2019) Natalia Robledinos-Antón et al.   Oxidative Medicine and Cellular Longevity

Soshiho-Tang, a Traditional Herbal Medicine, Alleviates Atopic Dermatitis Symptoms via Regulation of Inflammatory Mediators

(2019) Ji-Hyun Lee et al.   Frontiers in Pharmacology

Effect of redox imbalance on protein modifications in lymphocytes of psoriatic patients

(2019) Piotr Wójcik et al.   JOURNAL OF BIOCHEMISTRY

Tussilagonone Ameliorates Psoriatic Features in Keratinocytes and Imiquimod-Induced Psoriasis-Like Lesions in Mice via NRF2 Activation

(2019) Joohee Lee et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Epidemiology of atopic dermatitis in adults: Results from an international survey

(2018) S. Barbarot et al.   ALLERGY

Metformin Promotes HaCaT Cell Apoptosis through Generation of Reactive Oxygen Species via Raf-1-ERK1/2-Nrf2 Inactivation

(2018) Xiaoyan Wang et al.   INFLAMMATION

Transcription Factor NRF2 as a Therapeutic Target for Chronic Diseases: A Systems Medicine Approach

(2018) Antonio Cuadrado et al.   PHARMACOLOGICAL REVIEWS

The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis

(2018) Masayuki Yamamoto et al.   PHYSIOLOGICAL REVIEWS

The Nrf2 activator tBHQ inhibits the activation of primary murine natural killer cells

(2018) Allison P. Boss et al.   FOOD AND CHEMICAL TOXICOLOGY

Clinical use of dimethyl fumarate in moderate-to-severe plaque-type psoriasis: a European expert consensus

(2018) U. Mrowietz et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Gallic acid inhibits the expression of keratin 16 and keratin 17 through Nrf2 in psoriasis-like skin disease

(2018) Jinwei Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Three Constituents of Moringa oleifera Seeds Regulate Expression of Th17-Relevant Cytokines and Ameliorate TPA-Induced Psoriasis-Like Skin Lesions in Mice

(2018) Nuan Ma et al.   MOLECULES

Pathophysiological Alterations of Redox Signaling and Endocannabinoid System in Granulocytes and Plasma of Psoriatic Patients

(2018) Ewa Ambrożewicz et al.   Cells

Nrf2 Promotes Keratinocyte Proliferation in Psoriasis through Up-Regulation of Keratin 6, Keratin 16, and Keratin 17

(2017) Luting Yang et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Systemic Activation of NRF2 Alleviates Lethal Autoimmune Inflammation in Scurfy Mice

(2017) Takuma Suzuki et al.   MOLECULAR AND CELLULAR BIOLOGY

Lce1 Family Members Are Nrf2 -Target Genes that Are Induced to Compensate for the Loss of Loricrin

(2016) Yosuke Ishitsuka et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

6-Shogaol, an active compound of ginger, alleviates allergic dermatitis-like skin lesions via cytokine inhibition by activating the Nrf2 pathway

(2016) Gunhyuk Park et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

A newly synthesized macakurzin C-derivative attenuates acute and chronic skin inflammation: The Nrf2/heme oxygenase signaling as a potential target

(2016) Muhammad Akram et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Non-electrophilic modulators of the canonical Keap1/Nrf2 pathway

(2015) B.G. Richardson et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Nrf2 Activation Promotes Keratinocyte Survival during Early Skin Carcinogenesis via Metabolic Alterations

(2015) F. Rolfs et al.   CANCER RESEARCH

The Nrf2 activator tBHQ inhibits T cell activation of primary human CD4 T cells

(2015) Alexandra E. Turley et al.   CYTOKINE

Modulation of HMGB1 translocation and RAGE/NFκB cascade by quercetin treatment mitigates atopic dermatitis in NC/Nga transgenic mice

(2015) Vengadeshprabhu Karuppagounder et al.   EXPERIMENTAL DERMATOLOGY

Nrf2—A regulator of keratinocyte redox signaling

(2015) Matthias Schäfer et al.   FREE RADICAL BIOLOGY AND MEDICINE

The 3 major types of innate and adaptive cell-mediated effector immunity

(2015) Francesco Annunziato et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Dimethyl fumarate in the treatment of relapsing–remitting multiple sclerosis: an overview

(2015) Roberto Bomprezzi   Therapeutic Advances in Neurological Disorders

Activation of Nrf2 in keratinocytes causes chloracne (MADISH)-like skin disease in mice

(2014) M. Schafer et al.   EMBO Molecular Medicine

Application of moisturizer to neonates prevents development of atopic dermatitis

(2014) Kenta Horimukai et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Complexity of Danger: The Diverse Nature of Damage-associated Molecular Patterns

(2014) Liliana Schaefer   JOURNAL OF BIOLOGICAL CHEMISTRY

Dupilumab Treatment in Adults with Moderate-to-Severe Atopic Dermatitis

(2014) Lisa A. Beck et al.   NEW ENGLAND JOURNAL OF MEDICINE

Platycodon grandiflorum root-derived saponins attenuate atopic dermatitis-like skin lesions via suppression of NF-κB and STAT1 and activation of Nrf2/ARE-mediated heme oxygenase-1

(2014) Jae Ho Choi et al.   PHYTOMEDICINE

New insights into the epidemiology of childhood atopic dermatitis

(2013) C. Flohr et al.   ALLERGY

Cell death by cornification

(2013) Leopold Eckhart et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Nrf2/ARE-mediated antioxidant actions of pro-electrophilic drugs

(2013) Takumi Satoh et al.   FREE RADICAL BIOLOGY AND MEDICINE

Coal tar induces AHR-dependent skin barrier repair in atopic dermatitis

(2013) Ellen H. van den Bogaard et al.   JOURNAL OF CLINICAL INVESTIGATION

New concept of the pathogenesis of atopic dermatitis: Interplay among the barrier, allergy, and pruritus as a trinity

(2013) Kenji Kabashima   JOURNAL OF DERMATOLOGICAL SCIENCE

Nrf2 suppresses lupus nephritis through inhibition of oxidative injury and the NF-κB-mediated inflammatory response

(2013) Tao Jiang et al.   KIDNEY INTERNATIONAL

Amniotic Fluid Activates the Nrf2/Keap1 Pathway to Repair an Epidermal Barrier Defect In Utero

(2012) Aaron J. Huebner et al.   DEVELOPMENTAL CELL

Nrf2 links epidermal barrier function with antioxidant defense

(2012) Matthias Schäfer et al.   EMBO Molecular Medicine

Langerhans cells protect from allergic contact dermatitis in mice by tolerizing CD8+ T cells and activating Foxp3+ regulatory T cells

(2012) Mercedes Gomez de Agüero et al.   JOURNAL OF CLINICAL INVESTIGATION

Th2 Skewing by Activation of Nrf2 in CD4+ T Cells

(2012) C. E. Rockwell et al.   JOURNAL OF IMMUNOLOGY

The autophagy initiating kinase ULK1 is regulated via opposing phosphorylation by AMPK and mTOR

(2011) Dan Egan et al.   Autophagy

Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway

(2011) Ralf A. Linker et al.   BRAIN

Understanding the mechanism of IL-1β secretion

(2011) Gloria Lopez-Castejon et al.   CYTOKINE & GROWTH FACTOR REVIEWS

The ‘psoriatic march’: a concept of how severe psoriasis may drive cardiovascular comorbidity

(2011) Wolf-Henning Boehncke et al.   EXPERIMENTAL DERMATOLOGY

An Unexpected Role for Uric Acid as an Inducer of T Helper 2 Cell Immunity to Inhaled Antigens and Inflammatory Mediator of Allergic Asthma

(2011) Mirjam Kool et al.   IMMUNITY

The Danger Signal, Extracellular ATP, Is a Sensor for an Airborne Allergen and Triggers IL-33 Release and Innate Th2-Type Responses

(2011) Hideaki Kouzaki et al.   JOURNAL OF IMMUNOLOGY

Filaggrin Mutations Associated with Skin and Allergic Diseases

(2011) Alan D. Irvine et al.   NEW ENGLAND JOURNAL OF MEDICINE

Determinants of eczema: population-based cross-sectional study in Germany

(2010) C. J. Apfelbacher et al.   ALLERGY

Role of oxidative stress in rheumatoid arthritis: insights from the Nrf2-knockout mice

(2010) C. J. Wruck et al.   ANNALS OF THE RHEUMATIC DISEASES

Protective effect of sulforaphane against oxidative stress: Recent advances

(2010) Carlos Enrique Guerrero-Beltrán et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Nrf2 establishes a glutathione-mediated gradient of UVB cytoprotection in the epidermis

(2010) M. Schafer et al.   GENES & DEVELOPMENT

Autophagy Negatively Regulates Keratinocyte Inflammatory Responses via Scaffolding Protein p62/SQSTM1

(2010) H.-M. Lee et al.   JOURNAL OF IMMUNOLOGY

IL-1α Stimulation Restores Epidermal Permeability and Antimicrobial Barriers Compromised by Topical Tacrolimus

(2010) Ye-Jin Jung et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Oxidative stress in the pathogenesis of psoriasis

(2009) Qiang Zhou et al.   FREE RADICAL BIOLOGY AND MEDICINE

Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice Is Mediated via the IL-23/IL-17 Axis

(2009) L. van der Fits et al.   JOURNAL OF IMMUNOLOGY

The Cutaneous Biochemical Redox Barrier: A Component of the Innate Immune Defenses against Sensitization by Highly Reactive Environmental Xenobiotics

(2009) C. Pickard et al.   JOURNAL OF IMMUNOLOGY

Attenuation of UVB-Induced Sunburn Reaction and Oxidative DNA Damage with no Alterations in UVB-Induced Skin Carcinogenesis in Nrf2 Gene-Deficient Mice

(2008) Yasuhiro Kawachi et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Animal Models of Atopic Dermatitis

(2008) Haoli Jin et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Targeted deletion of the murine corneodesmosin gene delineates its essential role in skin and hair physiology

(2008) M. Matsumoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA