Loricrin: Past, Present, and Future

314 Loricrin protects against chemical carcinogenesis but affects cancer immunoediting

(2019) T. Ogawa et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Long‐term safety and efficacy of trifarotene 50μg/g cream, a first‐in‐class RAR ‐γ selective topical retinoid, in patients with moderate facial and truncal acne

(2019) Ulrike Blume‐Peytavi et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Loricrin confers photoprotective function against UVB in corneocytes

(2018) Yosuke Ishitsuka et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis

(2018) Masayuki Yamamoto et al.   PHYSIOLOGICAL REVIEWS

Staphylococcus aureus and Atopic Dermatitis: A Complex and Evolving Relationship

(2018) Joan A. Geoghegan et al.   TRENDS IN MICROBIOLOGY

Transient elevation of cytoplasmic calcium ion concentration at a single cell level precedes morphological changes of epidermal keratinocytes during cornification

(2018) Teruasa Murata et al.   Scientific Reports

Human and computational models of atopic dermatitis: A review and perspectives by an expert panel of the International Eczema Council

(2018) Kilian Eyerich et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The atopic march and atopic multimorbidity: Many trajectories, many pathways

(2018) Amy S. Paller et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The epithelial immune microenvironment (EIME) in atopic dermatitis and psoriasis

(2018) Teruki Dainichi et al.   NATURE IMMUNOLOGY

OMIM.org: leveraging knowledge across phenotype–gene relationships

(2018) Joanna S Amberger et al.   NUCLEIC ACIDS RESEARCH

Commensal-specific T cell plasticity promotes rapid tissue adaptation to injury

(2018) Oliver J. Harrison et al.   SCIENCE

Stem cells repurpose proliferation to contain a breach in their niche barrier

(2018) Kenneth Lay et al.   eLife

Intestinal dysbiosis and probiotic applications in autoimmune diseases

(2017) Gislane Lelis Vilela de Oliveira et al.   IMMUNOLOGY

Langerhans Cells – The Macrophage in Dendritic Cell Clothing

(2017) Thomas Doebel et al.   TRENDS IN IMMUNOLOGY

Retinoic Acid and Immune Homeostasis: A Balancing Act

(2017) Martje N. Erkelens et al.   TRENDS IN IMMUNOLOGY

Mutations in Three Genes Encoding Proteins Involved in Hair Shaft Formation Cause Uncombable Hair Syndrome

(2016) F. Buket Ü. Basmanav et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Bacterial and Viral Infections in Atopic Dermatitis: a Comprehensive Review

(2016) Peck Y. Ong et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

The Microbiome, Timing, and Barrier Function in the Context of Allergic Disease

(2016) Duane R. Wesemann et al.   IMMUNITY

Inherited ichthyosis: Non-syndromic forms

(2016) Takuya Takeichi et al.   JOURNAL OF DERMATOLOGY

Lce1 Family Members Are Nrf2 -Target Genes that Are Induced to Compensate for the Loss of Loricrin

(2016) Yosuke Ishitsuka et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Increased Bacterial Load and Expression of Antimicrobial Peptides in Skin of Barrier-Deficient Mice with Reduced Cancer Susceptibility

(2016) Ken Natsuga et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Proteomic Analysis of Loricrin Knockout Mouse Epidermis

(2016) Robert H. Rice et al.   JOURNAL OF PROTEOME RESEARCH

Epidermal cell turnover across tight junctions based on Kelvin's tetrakaidecahedron cell shape

(2016) Mariko Yokouchi et al.   eLife

Determinants of efficacy and safety in epicutaneous allergen immunotherapy: summary of three clinical trials

(2015) G. Senti et al.   ALLERGY

All hands on DE(T)C: Epithelial-resident γδ T cells respond to tissue injury

(2015) Kevin Ramirez et al.   CELLULAR IMMUNOLOGY

Gene loss in keratinization programs accompanies adaptation of cetacean skin to aquatic lifestyle

(2015) Ji Won Oh et al.   EXPERIMENTAL DERMATOLOGY

Comparative genomics reveals conservation of filaggrin and loss of caspase-14 in dolphins

(2015) Bettina Strasser et al.   EXPERIMENTAL DERMATOLOGY

A Wave of Regulatory T Cells into Neonatal Skin Mediates Tolerance to Commensal Microbes

(2015) Tiffany C. Scharschmidt et al.   IMMUNITY

Dissecting the formation, structure and barrier function of the stratum corneum

(2015) Takeshi Matsui et al.   INTERNATIONAL IMMUNOLOGY

A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity

(2015) Vinod Kumar et al.   JOURNAL OF CELL BIOLOGY

Control of adaptive immunity by the innate immune system

(2015) Akiko Iwasaki et al.   NATURE IMMUNOLOGY

Polymicrobial synergy and dysbiosis in inflammatory disease

(2015) Richard J. Lamont et al.   TRENDS IN MOLECULAR MEDICINE

Filaggrin loss-of-function mutations are associated with food allergy in childhood and adolescence

(2014) Devasmitha Venkataraman et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Evolutionary Origin and Diversification of Epidermal Barrier Proteins in Amniotes

(2014) Bettina Strasser et al.   MOLECULAR BIOLOGY AND EVOLUTION

The gut microbiota, bacterial metabolites and colorectal cancer

(2014) Petra Louis et al.   NATURE REVIEWS MICROBIOLOGY

Correction: A Mouse Model of Harlequin Ichthyosis Delineates a Key Role for Abca12 in Lipid Homeostasis

(2014) Ian Smyth et al.   PLoS Genetics

Resolution of inflammation: an integrated view

(2013) Almudena Ortega-Gómez et al.   EMBO Molecular Medicine

Nuclear Factor-erythroid 2 (NF-E2) p45-related Factor-2 (Nrf2) Modulates Dendritic Cell Immune Function through Regulation of p38 MAPK-cAMP-responsive Element Binding Protein/Activating Transcription Factor 1 Signaling

(2013) Laith M. A. Al-Huseini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dendritic cells of the oral mucosa

(2013) A-H Hovav   Mucosal Immunology

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

(2013) Nicholas Arpaia et al.   NATURE

Distinguishing Ichthyoses by Protein Profiling

(2013) Robert H. Rice et al.   PLoS One

Skin-specific expression of IL-33 activates group 2 innate lymphoid cells and elicits atopic dermatitis-like inflammation in mice

(2013) Yasutomo Imai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Filaggrin - revisited

(2013) C. R. Harding et al.   INTERNATIONAL JOURNAL OF COSMETIC SCIENCE

Amniotic Fluid Activates the Nrf2/Keap1 Pathway to Repair an Epidermal Barrier Defect In Utero

(2012) Aaron J. Huebner et al.   DEVELOPMENTAL CELL

Nrf2 links epidermal barrier function with antioxidant defense

(2012) Matthias Schäfer et al.   EMBO Molecular Medicine

Update on risk factors for food allergy

(2012) Gideon Lack   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Altered stratum corneum barrier and enhanced percutaneous immune responses in filaggrin-null mice

(2012) Hiroshi Kawasaki et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Deletion of K1/K10 does not impair epidermal stratification but affects desmosomal structure and nuclear integrity

(2012) L. Wallace et al.   JOURNAL OF CELL SCIENCE

Langerhans cells protect from allergic contact dermatitis in mice by tolerizing CD8+ T cells and activating Foxp3+ regulatory T cells

(2012) Mercedes Gomez de Agüero et al.   JOURNAL OF CLINICAL INVESTIGATION

Psoriasiform dermatitis is driven by IL-36–mediated DC-keratinocyte crosstalk

(2012) Luigi Tortola et al.   JOURNAL OF CLINICAL INVESTIGATION

Alcohol and aldehyde dehydrogenases: Retinoid metabolic effects in mouse knockout models

(2011) Sandeep Kumar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Nonlesional atopic dermatitis skin is characterized by broad terminal differentiation defects and variable immune abnormalities

(2011) Mayte Suárez-Fariñas et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Epicutaneous Immunotherapy Results in Rapid Allergen Uptake by Dendritic Cells through Intact Skin and Downregulates the Allergen-Specific Response in Sensitized Mice

(2011) V. Dioszeghy et al.   JOURNAL OF IMMUNOLOGY

ROS Quenching Potential of the Epidermal Cornified Cell Envelope

(2011) Wilbert P. Vermeij et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Caspase-14 Is Required for Filaggrin Degradation to Natural Moisturizing Factors in the Skin

(2011) Esther Hoste et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Response to self antigen imprints regulatory memory in tissues

(2011) Michael D. Rosenblum et al.   NATURE

Interleukin-36–Receptor Antagonist Deficiency and Generalized Pustular Psoriasis

(2011) Slaheddine Marrakchi et al.   NEW ENGLAND JOURNAL OF MEDICINE

How vitamin A metabolizing dendritic cells are generated in the gut mucosa

(2011) William W. Agace et al.   TRENDS IN IMMUNOLOGY

Aldehyde dehydrogenase 1A3 is transcriptionally activated by all-trans-retinoic acid in human epidermal keratinocytes

(2010) Ulrich Koenig et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Nrf2 establishes a glutathione-mediated gradient of UVB cytoprotection in the epidermis

(2010) M. Schafer et al.   GENES & DEVELOPMENT

Cow's milk epicutaneous immunotherapy in children: A pilot trial of safety, acceptability, and impact on allergic reactivity

(2010) Christophe Dupont et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Skin Cornification Proteins Provide Global Link between ROS Detoxification and Cell Migration during Wound Healing

(2010) Wilbert P. Vermeij et al.   PLoS One

Premature Terminal Differentiation and a Reduction in Specific Proteases Associated with Loss of ABCA12 in Harlequin Ichthyosis

(2009) Anna C. Thomas et al.   AMERICAN JOURNAL OF PATHOLOGY

External antigen uptake by Langerhans cells with reorganization of epidermal tight junction barriers

(2009) Akiharu Kubo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CD207+CD103+dermal dendritic cells cross-present keratinocyte-derived antigens irrespective of the presence of Langerhans cells

(2009) Sandrine Henri et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity

(2009) Caspar Ohnmacht et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Cutaneous Biochemical Redox Barrier: A Component of the Innate Immune Defenses against Sensitization by Highly Reactive Environmental Xenobiotics

(2009) C. Pickard et al.   JOURNAL OF IMMUNOLOGY

Deletion of the late cornified envelope LCE3B and LCE3C genes as a susceptibility factor for psoriasis

(2009) Rafael de Cid et al.   NATURE GENETICS

The involvement of cytochrome p450 (CYP) 26 in the retinoic acid metabolism of human epidermal keratinocytes

(2008) Elizabeth Pavez Loriè et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Plasmacytoid Dendritic Cells Mediate Oral Tolerance

(2008) Anne Goubier et al.   IMMUNITY

Filaggrin mutations, atopic eczema, hay fever, and asthma in children

(2008) Stephan Weidinger et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Nrf2 activation by sulforaphane restores the age-related decrease of TH1 immunity: Role of dendritic cells

(2008) Hyon-Jeen Kim et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

ABCA12 Maintains the Epidermal Lipid Permeability Barrier by Facilitating Formation of Ceramide Linoleic Esters

(2008) Ying Zuo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Toll-like receptor and IL-12 signaling control susceptibility to contact hypersensitivity

(2008) Stefan F. Martin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Attenuation of UVB-Induced Sunburn Reaction and Oxidative DNA Damage with no Alterations in UVB-Induced Skin Carcinogenesis in Nrf2 Gene-Deficient Mice

(2008) Yasuhiro Kawachi et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Environmental cues, dendritic cells and the programming of tissue-selective lymphocyte trafficking

(2008) Hekla Sigmundsdottir et al.   NATURE IMMUNOLOGY

The immune privilege of the oral mucosa

(2008) Natalija Novak et al.   TRENDS IN MOLECULAR MEDICINE