Filaggrin Mutations Associated with Skin and Allergic Diseases

Levels of filaggrin degradation products are influenced by both filaggrin genotype and atopic dermatitis severity

(2011) S. Kezic et al.   ALLERGY

Filaggrin Genotype in Ichthyosis Vulgaris Predicts Abnormalities in Epidermal Structure and Function

(2011) Robert Gruber et al.   AMERICAN JOURNAL OF PATHOLOGY

SASPase regulates stratum corneum hydration through profilaggrin-to-filaggrin processing

(2011) Takeshi Matsui et al.   EMBO Molecular Medicine

Loss-of-function variants in the filaggrin gene are a significant risk factor for peanut allergy

(2011) Sara J. Brown et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Stratum corneum lipids, skin barrier function and filaggrin mutations in patients with atopic eczema

(2010) J. M. Jungersted et al.   ALLERGY

Self-Improvement of Keratinocyte Differentiation Defects During Skin Maturation in ABCA12-Deficient Harlequin Ichthyosis Model Mice

(2010) Teruki Yanagi et al.   AMERICAN JOURNAL OF PATHOLOGY

Flaky Tail Mouse Denotes Human Atopic Dermatitis in the Steady State and by Topical Application with Dermatophagoides pteronyssinus Extract

(2010) Catharina Sagita Moniaga et al.   AMERICAN JOURNAL OF PATHOLOGY

A milieu of regulatory elements in the epidermal differentiation complex syntenic block: implications for atopic dermatitis and psoriasis

(2010) Cristina de Guzman Strong et al.   HUMAN MOLECULAR GENETICS

Raman profiles of the stratum corneum define 3 filaggrin genotype–determined atopic dermatitis endophenotypes

(2010) Gráinne M. O'Regan et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Recent insights into atopic dermatitis and implications for management of infectious complications

(2010) Mark Boguniewicz et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Tight junction defects in patients with atopic dermatitis

(2010) Anna De Benedetto et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Elastase 2 is expressed in human and mouse epidermis and impairs skin barrier function in Netherton syndrome through filaggrin and lipid misprocessing

(2010) Chrystelle Bonnart et al.   JOURNAL OF CLINICAL INVESTIGATION

IL-4 Regulates Skin Homeostasis and the Predisposition toward Allergic Skin Inflammation

(2010) S. Sehra et al.   JOURNAL OF IMMUNOLOGY

Knockdown of Filaggrin Impairs Diffusion Barrier Function and Increases UV Sensitivity in a Human Skin Model

(2010) Michael Mildner et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Eczema Prevalence in the United States: Data from the 2003 National Survey of Children's Health

(2010) Tatyana E. Shaw et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Increased Sensitivity of Histidinemic Mice to UVB Radiation Suggests a Crucial Role of Endogenous Urocanic Acid in Photoprotection

(2010) Caterina Barresi et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Sensing the outside world: TSLP regulates barrier immunity

(2010) Steven F Ziegler et al.   NATURE IMMUNOLOGY

Pharmaceuticals Targeting Nonsense Mutations in Genetic Diseases

(2009) Steven M. Rowe et al.   BIODRUGS

Increased pachyonychia congenita severity in patients with concurrent keratin and filaggrin mutations

(2009) R. Gruber et al.   BRITISH JOURNAL OF DERMATOLOGY

Filaggrin deficiency confers a paracellular barrier abnormality that reduces inflammatory thresholds to irritants and haptens

(2009) Tiffany C. Scharschmidt et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Different effects of pimecrolimus and betamethasone on the skin barrier in patients with atopic dermatitis

(2009) Jens-Michael Jensen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Filaggrin in atopic dermatitis

(2009) Grainne M. O'Regan et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Filaggrin-deficient mice exhibit TH17-dominated skin inflammation and permissiveness to epicutaneous sensitization with protein antigen

(2009) Michiko K. Oyoshi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Filaggrin mutations that confer risk of atopic dermatitis confer greater risk for eczema herpeticum

(2009) Pei-Song Gao et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Neutral Cysteine Protease Bleomycin Hydrolase Is Essential for the Breakdown of Deiminated Filaggrin into Amino Acids

(2009) Yayoi Kamata et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Filaggrin in the frontline: role in skin barrier function and disease

(2009) A. Sandilands et al.   JOURNAL OF CELL SCIENCE

Kallikrein 5 induces atopic dermatitis–like lesions through PAR2-mediated thymic stromal lymphopoietin expression in Netherton syndrome

(2009) Anaïs Briot et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Maintenance of an Acidic Stratum Corneum Prevents Emergence of Murine Atopic Dermatitis

(2009) Yutaka Hatano et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Development of an Ichthyosiform Phenotype in Alox12b-Deficient Mouse Skin Transplants

(2009) Silvia de Juanes et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Deletion of the late cornified envelope LCE3B and LCE3C genes as a susceptibility factor for psoriasis

(2009) Rafael de Cid et al.   NATURE GENETICS

Cytokine gene polymorphisms and susceptibility to chronic irritant contact dermatitis

(2008) Cindy M. de Jongh et al.   CONTACT DERMATITIS

Filaggrin variants confer susceptibility to asthma

(2008) W. H. Irwin McLean et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Th2 Cytokines Act on S100/A11 to Downregulate Keratinocyte Differentiation

(2008) Michael D. Howell et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Atopic Dermatitis

(2008) Thomas Bieber   NEW ENGLAND JOURNAL OF MEDICINE

The Socioeconomic Impact of Atopic Dermatitis in the United States: A Systematic Review

(2008) Anthony J. Mancini et al.   PEDIATRIC DERMATOLOGY

Filaggrin loss-of-function mutations and association with allergic diseases

(2008) Elke Rodríguez et al.   PHARMACOGENOMICS

Gene-Environment Interaction in the Onset of Eczema in Infancy: Filaggrin Loss-of-Function Mutations Enhanced by Neonatal Cat Exposure

(2008) Hans Bisgaard et al.   PLOS MEDICINE

Acute Modulations in Permeability Barrier Function Regulate Epidermal Cornification

(2007) Marianne Demerjian et al.   AMERICAN JOURNAL OF PATHOLOGY

Loss-of-Function Mutations in the Filaggrin Gene and Allergic Contact Sensitization to Nickel

(2007) Natalija Novak et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY