Src Family Kinases: A Potential Therapeutic Target for Acute Kidney Injury

Ferroptosis: A Potential Therapeutic Target in Acute Kidney Injury

(2022) Keiko Hosohata et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dasatinib mitigates renal fibrosis in a rat model of UUO via inhibition of Src/STAT-3/NF-κB signaling

(2021) Nabila M.E. Hassan et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

New Structural Perspectives in G Protein-Coupled Receptor-Mediated Src Family Kinase Activation

(2021) Sandra Berndt et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Non-Lyn Src Family Kinases Activate SIRPα–SHP-1 to Inhibit PI3K–Akt2 and Dampen Proinflammatory Macrophage Polarization

(2021) Lei Shi et al.   JOURNAL OF IMMUNOLOGY

Src/lck inhibitor dasatinib reversibly switches off cytokine release and T cell cytotoxicity following stimulation with T cell bispecific antibodies

(2021) Gabrielle Leclercq et al.   Journal for ImmunoTherapy of Cancer

Mitochondrial Redox Signaling and Oxidative Stress in Kidney Diseases

(2021) Ana Karina Aranda-Rivera et al.   Biomolecules

Tyrosine phosphorylation of NLRP3 by the Src family kinase Lyn suppresses the activity of the NLRP3 inflammasome

(2021) Juan Tang et al.   Science Signaling

PP121 suppresses RANKL-Induced osteoclast formation in vitro and LPS-Induced bone resorption in vivo

(2020) Zhihang Zhou et al.   EXPERIMENTAL CELL RESEARCH

Fyn Kinase: A Potential Therapeutic Target in Acute Kidney Injury

(2020) Md Jamal Uddin et al.   Biomolecules & Therapeutics

Calcitonin gene‐related peptide inhibits angiotensin II‐induced NADPH oxidase‐dependent ROS via the Src/STAT3 signalling pathway

(2020) Hong‐min Luo et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Src family kinases and pulmonary fibrosis: A review

(2020) Hang Li et al.   BIOMEDICINE & PHARMACOTHERAPY

KF-1607, A Novel Pan Src Kinase Inhibitor, Attenuates Obstruction-Induced Tubulointerstitial Fibrosis in Mice

(2020) Debra Dorotea et al.   Biomolecules & Therapeutics

Structure, Function, and Regulation of the SRMS Tyrosine Kinase

(2020) Chakia J. McClendon et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Phenylethanoid glycosides of Callicarpa kwangtungensis Chun exert cardioprotective effect by weakening Na+-K+-ATPase/Src/ERK1/2 pathway and inhibiting apoptosis mediated by oxidative stress and inflammation

(2020) Jing Sun et al.   JOURNAL OF ETHNOPHARMACOLOGY

AKI: an increasingly recognized risk factor for CKD development and progression

(2020) J. T. Kurzhagen et al.   JOURNAL OF NEPHROLOGY

Nomenclature for kidney function and disease: report of a Kidney Disease: Improving Global Outcomes (KDIGO) Consensus Conference

(2020) Andrew S. Levey et al.   KIDNEY INTERNATIONAL

Src Family Kinases as Therapeutic Targets in Advanced Solid Tumors: What We Have Learned So Far

(2020) Stefano Martellucci et al.   Cancers

Sulforaphane prevents type 2 diabetes-induced nephropathy via AMPK-mediated activation of lipid metabolic pathways and Nrf2 antioxidative function

(2020) Zhuo Li et al.   CLINICAL SCIENCE

Synergistic Inhibition of Renal Fibrosis by Nintedanib and Gefitinib in a Murine Model of Obstructive Nephropathy

(2020) Liu Feng et al.   Kidney Diseases

Triptolide induces oxidative damage in NRK-52E cells through facilitating Nrf2 degradation by ubiquitination via the GSK-3β/Fyn pathway

(2019) Ji Pan et al.   TOXICOLOGY IN VITRO

A Combined Approach Reveals a Regulatory Mechanism Coupling Src’s Kinase Activity, Localization, and Phosphotransferase-Independent Functions

(2019) Ethan Ahler et al.   MOLECULAR CELL

Src-mediated crosstalk between FXR and YAP protects against renal fibrosis

(2019) Dong-Hyun Kim et al.   FASEB JOURNAL

Green barley mitigates cytotoxicity in human lymphocytes undergoing aggressive oxidative stress, via activation of both the Lyn/PI3K/Akt and MAPK/ERK pathways

(2019) Blanca E. Ruiz-Medina et al.   Scientific Reports

Curcumin and its analogues protect from endoplasmic reticulum stress: Mechanisms and pathways

(2019) Abolfazl Shakeri et al.   PHARMACOLOGICAL RESEARCH

CD3 bispecific antibody–induced cytokine release is dispensable for cytotoxic T cell activity

(2019) Ji Li et al.   Science Translational Medicine

Inflammation in Renal Diseases: New and Old Players

(2019) Vinicius Andrade-Oliveira et al.   Frontiers in Pharmacology

Flavonoid fisetin alleviates kidney inflammation and apoptosis via inhibiting Src-mediated NF-κB p65 and MAPK signaling pathways in septic AKI mice

(2019) Qian Ren et al.   BIOMEDICINE & PHARMACOTHERAPY

CRF1 Receptor Signaling via the ERK1/2-MAP and Akt Kinase Cascades: Roles of Src, EGF Receptor, and PI3-Kinase Mechanisms

(2019) G. Karina Parra-Mercado et al.   Frontiers in Endocrinology

Hypoxia Activates Src and Promotes Endocytosis Which Decreases MMP-2 Activity and Aggravates Renal Interstitial Fibrosis

(2018) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Epithelial Cell Cycle Behaviour in the Injured Kidney

(2018) Lies Moonen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

pNaKtide ameliorates renal interstitial fibrosis through inhibition of sodium-potassium adenosine triphosphatase-mediated signaling pathways in unilateral ureteral obstruction mice

(2018) Xi Cheng et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Endoplasmic reticulum stress activates SRC, relocating chaperones to the cell surface where GRP78/CD109 blocks TGF-β signaling

(2018) Yuan-Li Tsai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hydrogen sulfide alleviates uranium-induced kidney cell apoptosis mediated by ER stress via 20S proteasome involving in Akt/GSK-3β/Fyn-Nrf2 signaling

(2018) Juan Yi et al.   FREE RADICAL RESEARCH

Global epidemiology and outcomes of acute kidney injury

(2018) Eric A. J. Hoste et al.   Nature Reviews Nephrology

Tamoxifen ameliorates obstructive nephropathy through Src and the PI3K/Akt/mTOR pathway

(2018) Chang Seong Kim et al.   BIOLOGY OF THE CELL

Src regulates amino acid-mediated mTORC1 activation by disrupting GATOR1-Rag GTPase interaction

(2018) Rituraj Pal et al.   Nature Communications

Inhibition of ROS-mediated activation Src-MAPK/AKT signaling by orientin alleviates H2O2-induced apoptosis in PC12 cells

(2018) Shimei Qi et al.   Drug Design Development and Therapy

mTORC1 as the main gateway to autophagy

(2017) Yoana Rabanal-Ruiz et al.   Essays in Biochemistry

Kidney and innate immunity

(2017) Ying-hui Wang et al.   IMMUNOLOGY LETTERS

MMP-2 and 9 in Chronic Kidney Disease

(2017) Zhengyuan Cheng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

AKI on CKD: heightened injury, suppressed repair, and the underlying mechanisms

(2017) Liyu He et al.   KIDNEY INTERNATIONAL

Na/K-ATPase/src complex mediates regulation of CD40 in renal parenchyma

(2017) Jeffrey X Xie et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Methylmercury augments Nrf2 activity by downregulation of the Src family kinase Fyn

(2017) Megan Culbreth et al.   NEUROTOXICOLOGY

Lyn and Fyn function as molecular switches that control immunoreceptors to direct homeostasis or inflammation

(2017) Sanae Ben Mkaddem et al.   Nature Communications

Pharmacological inhibition of Src kinase protects against acute kidney injury in a murine model of renal ischemia/reperfusion

(2017) Chongxiang Xiong et al.   Oncotarget

Lyn kinase represses mucus hypersecretion by regulating IL-13-induced endoplasmic reticulum stress in asthma

(2017) Xing Wang et al.   EBioMedicine

Acute Kidney Injury

(2016) Anna Zuk et al.   Annual Review of Medicine

Understanding the cellular roles of Fyn-related kinase (FRK): implications in cancer biology

(2016) Raghuveera Kumar Goel et al.   CANCER AND METASTASIS REVIEWS

Genomic Analysis of Kidney Allograft Injury Identifies Hematopoietic Cell Kinase as a Key Driver of Renal Fibrosis

(2016) Chengguo Wei et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Therapy for kidney fibrosis: is the Src kinase a potential target?

(2016) Dong Zhou et al.   KIDNEY INTERNATIONAL

Fyn deficiency attenuates renal fibrosis by inhibition of phospho-STAT3

(2016) Hye-Young Seo et al.   KIDNEY INTERNATIONAL

Src inhibition blocks renal interstitial fibroblast activation and ameliorates renal fibrosis

(2016) Yanli Yan et al.   KIDNEY INTERNATIONAL

Hydrogen sulfide suppresses endoplasmic reticulum stress-induced endothelial-to-mesenchymal transition through Src pathway

(2016) Ru Ying et al.   LIFE SCIENCES

Fyn phosphorylates AMPK to inhibit AMPK activity and AMP-dependent activation of autophagy

(2016) Eijiro Yamada et al.   Oncotarget

Lyn Delivers Bacteria to Lysosomes for Eradication through TLR2-Initiated Autophagy Related Phagocytosis

(2016) Xuefeng Li et al.   PLoS Pathogens

Deletion of Src family kinase Lyn aggravates endotoxin-induced lung inflammation

(2015) Rong Gao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

ER stress: Autophagy induction, inhibition and selection

(2015) Harun-Or Rashid et al.   Autophagy

Fisetin Suppresses Macrophage-Mediated Inflammatory Responses by Blockade of Src and Syk

(2015) Jun Ho Kim et al.   Biomolecules & Therapeutics

Fyn-phosphorylated PIKE-A binds and inhibits AMPK signaling, blocking its tumor suppressive activity

(2015) S Zhang et al.   CELL DEATH AND DIFFERENTIATION

Fyn Activation of mTORC1 Stimulates the IRE1α-JNK Pathway, Leading to Cell Death

(2015) Yichen Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fyn Kinase Regulates Microglial Neuroinflammatory Responses in Cell Culture and Animal Models of Parkinson's Disease

(2015) N. Panicker et al.   JOURNAL OF NEUROSCIENCE

Sulforaphane attenuation of experimental diabetic nephropathy involves GSK-3 beta/Fyn/Nrf2 signaling pathway

(2015) Guoguo Shang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

The complexity of the Nrf2 pathway: beyond the antioxidant response

(2015) Ying Huang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Inhibition of c-Src/p38 MAPK pathway ameliorates renal tubular epithelial cells apoptosis in db/db mice

(2015) Haijiang Wu et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Mechanisms of maladaptive repair after AKI leading to accelerated kidney ageing and CKD

(2015) David A. Ferenbach et al.   Nature Reviews Nephrology

Src protein-tyrosine kinase structure, mechanism, and small molecule inhibitors

(2015) Robert Roskoski   PHARMACOLOGICAL RESEARCH

TGF-β/Smad signaling in renal fibrosis

(2015) Xiao-Ming Meng et al.   Frontiers in Physiology

Src family kinases: at the forefront of platelet activation

(2014) Y. A. Senis et al.   BLOOD

Autophagy and the kidney: health and disease

(2014) Y. Takabatake et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Endoplasmic Reticulum Stress Induces Epithelial-Mesenchymal Transition through Autophagy via Activation of c-Src Kinase

(2014) Soo Young Moon et al.   NEPHRON EXPERIMENTAL NEPHROLOGY

Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release

(2014) Dmitry B. Zorov et al.   PHYSIOLOGICAL REVIEWS

Src-dependent impairment of autophagy by oxidative stress in a mouse model of Duchenne muscular dystrophy

(2014) Rituraj Pal et al.   Nature Communications

Stressed to death – mechanisms of ER stress-induced cell death

(2013) Natalia Sovolyova et al.   BIOLOGICAL CHEMISTRY

Inhibition of Src Kinase Blocks High Glucose-Induced EGFR Transactivation and Collagen Synthesis in Mesangial Cells and Prevents Diabetic Nephropathy in Mice

(2013) K. Taniguchi et al.   DIABETES

A Bioinformatics Approach Identifies Signal Transducer and Activator of Transcription-3 and Checkpoint Kinase 1 as Upstream Regulators of Kidney Injury Molecule-1 after Kidney Injury

(2013) A. K. Ajay et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

New Autophagy Reporter Mice Reveal Dynamics of Proximal Tubular Autophagy

(2013) L. Li et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Lyn Facilitates Glioblastoma Cell Survival under Conditions of Nutrient Deprivation by Promoting Autophagy

(2013) Wei Michael Liu et al.   PLoS One

ROS-induced mitochondrial depolarization initiates PARK2/PARKIN-dependent mitochondrial degradation by autophagy

(2012) Yuqing Wang et al.   Autophagy

Role of TLR4/NADPH oxidase/ROS-activated p38 MAPK in VCAM-1 expression induced by lipopolysaccharide in human renal mesangial cells

(2012) I-Ta Lee et al.   Cell Communication and Signaling

Deleting the TGF-  Receptor Attenuates Acute Proximal Tubule Injury

(2012) L. Gewin et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

(2012) Claudio Hetz   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mouse Skeletal Muscle Fiber-Type-Specific Macroautophagy and Muscle Wasting Are Regulated by a Fyn/STAT3/Vps34 Signaling Pathway

(2012) Eijiro Yamada et al.   Cell Reports

mTORC1 serves ER stress-triggered apoptosis via selective activation of the IRE1–JNK pathway

(2011) H Kato et al.   CELL DEATH AND DIFFERENTIATION

TGF-β1 Induces Podocyte Injury Through Smad3-ERK-NF-κB Pathway and Fyn-dependent TRPC6 phosphorylation

(2011) Lixia Yu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Inhibition of Src Family Kinases and Receptor Tyrosine Kinases by Dasatinib: Possible Combinations in Solid Tumors

(2011) J. C. Montero et al.   CLINICAL CANCER RESEARCH

Src family kinases in the nervous system

(2011) Xian-Min Yu et al.   FEBS Journal

Na/K-ATPase Mimetic pNaKtide Peptide Inhibits the Growth of Human Cancer Cells

(2011) Zhichuan Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of PKCδ reduces cisplatin-induced nephrotoxicity without blocking chemotherapeutic efficacy in mouse models of cancer

(2011) Navjotsingh Pabla et al.   JOURNAL OF CLINICAL INVESTIGATION

EGFR Signaling Promotes TGF -Dependent Renal Fibrosis

(2011) J. Chen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Chronic kidney disease after acute kidney injury: a systematic review and meta-analysis

(2011) Steven G. Coca et al.   KIDNEY INTERNATIONAL

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

(2011) Maria M. Mihaylova et al.   NATURE CELL BIOLOGY

Src family kinases: modulators of neurotransmitter receptor function and behavior

(2011) Hiroshi Ohnishi et al.   TRENDS IN NEUROSCIENCES

Building a better understanding of the intracellular tyrosine kinase PTK6 — BRK by BRK

(2010) Patrick M. Brauer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

RAKing in AKT: A tumor suppressor function for the intracellular tyrosine kinase FRK

(2010) Patrick M. Brauer et al.   CELL CYCLE

Fyn-Dependent Regulation of Energy Expenditure and Body Weight Is Mediated by Tyrosine Phosphorylation of LKB1

(2010) Eijiro Yamada et al.   Cell Metabolism

Endoplasmic reticulum stress as a progression factor for kidney injury

(2010) Reiko Inagi   CURRENT OPINION IN PHARMACOLOGY

Coordinated maintenance of muscle cell size control by AMP-activated protein kinase

(2010) Louise Lantier et al.   FASEB JOURNAL

Tyrosine phosphorylation controls nuclear export of Fyn, allowing Nrf2 activation of cytoprotective gene expression

(2010) James W. Kaspar et al.   FASEB JOURNAL

NF- B in Renal Inflammation

(2010) A. B. Sanz et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury

(2010) Li Yang et al.   NATURE MEDICINE

Involvement of Src Family Kinases in Substance P-Induced Chemokine Production in Mouse Pancreatic Acinar Cells and Its Significance in Acute Pancreatitis

(2009) R. D. Ramnath et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Endoplasmic Reticulum Stress in the Kidney as a Novel Mediator of Kidney Injury

(2009) Reiko Inagi   NEPHRON EXPERIMENTAL NEPHROLOGY

Activation of ROS/NF-κB and Ca2+/CaM kinase II are necessary for VCAM-1 induction in IL-1β-treated human tracheal smooth muscle cells

(2009) Shue-Fen Luo et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The innate immune response in ischemic acute kidney injury

(2008) Hye Ryoun Jang et al.   CLINICAL IMMUNOLOGY

Src family kinases: Regulation of their activities, levels and identification of new pathways

(2007) Evan Ingley   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS