Dasatinib mitigates renal fibrosis in a rat model of UUO via inhibition of Src/STAT-3/NF-κB signaling

Dasatinib plus quercetin prevents uterine age-related dysfunction and fibrosis in mice

(2020) Marcelo B. Cavalcante et al.   Aging-US

RIG-I aggravates interstitial fibrosis via c-Myc-mediated fibroblast activation in UUO mice

(2020) Zhuanli Zhou et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Global, regional, and national burden of chronic kidney disease, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

(2020) Boris Bikbov et al.   LANCET

Targeting the progression of chronic kidney disease

(2020) Marta Ruiz-Ortega et al.   Nature Reviews Nephrology

Dasatinib-induced nephrotic syndrome in a patient with chronic myelogenous leukemia: a case report

(2019) Shoko Ochiai et al.   BMC Nephrology

Assessment of chronic renal injury in patients with chronic myeloid leukemia in the chronic phase receiving tyrosine kinase inhibitors

(2019) Xin Ren et al.   ANNALS OF HEMATOLOGY

Unilateral Ureteral Obstruction as a Model to Investigate Fibrosis-Attenuating Treatments

(2019) Elena Martínez-Klimova et al.   Biomolecules

WISP3 prevents fibroblast–myofibroblast transdifferentiation in NRK-49F cells

(2018) Yang Yi et al.   BIOMEDICINE & PHARMACOTHERAPY

Dasatinib dose management for the treatment of chronic myeloid leukemia

(2018) Moshe Talpaz et al.   CANCER

Inflammation and renal fibrosis: Recent developments on key signaling molecules as potential therapeutic targets

(2018) Wenshan Lv et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Effects of Qingshen Granules on the Oxidative Stress-NF/kB Signal Pathway in Unilateral Ureteral Obstruction Rats

(2018) Hua Jin et al.   Evidence-based Complementary and Alternative Medicine

Dasatinib Suppresses TGFβ-Mediated Epithelial–Mesenchymal Transition in Alveolar Epithelial Cells and Inhibits Pulmonary Fibrosis

(2018) Ryota Kanemaru et al.   LUNG

PAX2 may induce ADAM10 expression in renal tubular epithelial cells and contribute to epithelial-to-mesenchymal transition

(2018) Ling Hou et al.   INTERNATIONAL UROLOGY AND NEPHROLOGY

Long-term efficacy and safety of dasatinib in patients with chronic myeloid leukemia in accelerated phase who are resistant to or intolerant of imatinib

(2018) Oliver Ottmann et al.   Blood Cancer Journal

Histone deacetylase inhibitor, CG200745 attenuates renal fibrosis in obstructive kidney disease

(2018) Hong Sang Choi et al.   Scientific Reports

Tamoxifen ameliorates obstructive nephropathy through Src and the PI3K/Akt/mTOR pathway

(2018) Chang Seong Kim et al.   BIOLOGY OF THE CELL

Thymoquinone ameliorates renal damage in unilateral ureteral obstruction in rats

(2017) Sara Hosseinian et al.   Pharmacological Reports

Arctigenin suppresses renal interstitial fibrosis in a rat model of obstructive nephropathy

(2017) Ao Li et al.   PHYTOMEDICINE

N-acetylcysteine alleviates angiotensin II-mediated renal fibrosis in mouse obstructed kidneys

(2016) Yang Shen et al.   ACTA PHARMACOLOGICA SINICA

Sorafenib Inhibits Renal Fibrosis Induced by Unilateral Ureteral Obstruction via Inhibition of Macrophage Infiltration

(2016) Wenting Ma et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Dasatinib prevent hepatic fibrosis induced by carbon tetrachloride (CCl4) via anti-inflammatory and antioxidant mechanism

(2016) Adel Mohammadalipour et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Genomic Analysis of Kidney Allograft Injury Identifies Hematopoietic Cell Kinase as a Key Driver of Renal Fibrosis

(2016) Chengguo Wei et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Stat3 Controls Tubulointerstitial Communication during CKD

(2016) F. Bienaime et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Src inhibition blocks renal interstitial fibroblast activation and ameliorates renal fibrosis

(2016) Yanli Yan et al.   KIDNEY INTERNATIONAL

Elsholtzia ciliata (Thunb.) Hylander attenuates renal inflammation and interstitial fibrosis via regulation of TGF-ß and Smad3 expression on unilateral ureteral obstruction rat model

(2016) Tae-Won Kim et al.   PHYTOMEDICINE

Dasatinib Reduces Lung Inflammation and Fibrosis in Acute Experimental Silicosis

(2016) Fernanda Ferreira Cruz et al.   PLoS One

Alpha1-Antitrypsin Attenuates Renal Fibrosis by Inhibiting TGF-β1-Induced Epithelial Mesenchymal Transition

(2016) Jang-Hee Cho et al.   PLoS One

Dasatinib attenuated bleomycin-induced pulmonary fibrosis in mice

(2015) Oznur Yilmaz et al.   GROWTH FACTORS

Evaluation of anti-asthmatic and antioxidant potential of Boerhavia procumbens in toluene diisocyanate (TDI) treated rats

(2015) Jasia Bokhari et al.   JOURNAL OF ETHNOPHARMACOLOGY

Origin of myofibroblasts and cellular events triggering fibrosis

(2015) Matthias Mack et al.   KIDNEY INTERNATIONAL

Dasatinib-induced nephrotic syndrome

(2015) Taichi Hirano et al.   LEUKEMIA & LYMPHOMA

Understanding the mechanisms of kidney fibrosis

(2015) Dong Zhou et al.   Nature Reviews Nephrology

Beneficial effects montelukast, cysteinyl-leukotriene receptor antagonist, on renal damage after unilateral ureteral obstruction in rats

(2015) Alper Otunctemur et al.   International Braz J Urol

Cellular and molecular mechanisms in kidney fibrosis

(2014) Jeremy S. Duffield   JOURNAL OF CLINICAL INVESTIGATION

Ulinastatin attenuates renal interstitial inflammation and inhibits fibrosis progression in rats under unilateral ureteral obstruction

(2014) GUO-TAO JIANG et al.   Molecular Medicine Reports

Prevention of Murine Lupus Nephritis by Targeting Multiple Signaling Axes and Oxidative Stress Using a Synthetic Triterpenoid

(2014) Tianfu Wu et al.   Arthritis & Rheumatology

Dasatinib-Induced Nephrotic-Range Proteinuria

(2013) Eric Wallace et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Cysteamine Modulates Oxidative Stress and Blocks Myofibroblast Activity in CKD

(2013) D. M. Okamura et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Epithelial Cell TGF  Signaling Induces Acute Tubular Injury and Interstitial Inflammation

(2013) M. E. Gentle et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Origin and function of myofibroblasts in kidney fibrosis

(2013) Valerie S LeBleu et al.   NATURE MEDICINE

Could problems with bardoxolone methyl have been predicted?

(2013) Peter Rossing   Nature Reviews Nephrology

Therapeutic Effects of Human Amniotic Fluid-Derived Stem Cells on Renal Interstitial Fibrosis in a Murine Model of Unilateral Ureteral Obstruction

(2013) Dong Sun et al.   PLoS One

Indoxyl sulfate, a uremic toxin, downregulates renal expression of Nrf2 through activation of NF-κB

(2013) Dilinaer Bolati et al.   BMC Nephrology

Curcumin attenuates lupus nephritis upon interaction with regulatory T cells in New Zealand Black/White mice

(2012) Hyojung Lee et al.   BRITISH JOURNAL OF NUTRITION

Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung fibrosis

(2012) Robert J. J. O'Donoghue et al.   EMBO Molecular Medicine

Nilotinib counteracts thioacetamide-induced hepatic oxidative stress and attenuates liver fibrosis progression

(2011) Mohamed E. Shaker et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Pirfenidone for Diabetic Nephropathy

(2011) K. Sharma et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Myofibroblast differentiation during fibrosis: role of NAD(P)H oxidases

(2011) Jeffrey L. Barnes et al.   KIDNEY INTERNATIONAL

The contribution of chronic kidney disease to the global burden of major noncommunicable diseases

(2011) William G. Couser et al.   KIDNEY INTERNATIONAL

Transforming Growth Factor-β1 Induces Smad3-Dependent β1 Integrin Gene Expression in Epithelial-to-Mesenchymal Transition during Chronic Tubulointerstitial Fibrosis

(2010) Yi-Chun Yeh et al.   AMERICAN JOURNAL OF PATHOLOGY

Role of inflammation in túbulo-interstitial damage associated to obstructive nephropathy

(2010) María T Grande et al.   Journal of Inflammation-London

Acute Renal Failure under Dasatinib Therapy

(2010) Sultan Ozkurt et al.   RENAL FAILURE

Phase I Dose-Escalation and Pharmacokinetic Study of Dasatinib in Patients with Advanced Solid Tumors

(2009) G. D. Demetri et al.   CLINICAL CANCER RESEARCH

New dosing schedules of dasatinib for CML and adverse event management

(2009) Siu-Fun Wong   Journal of Hematology & Oncology

Paricalcitol Inhibits Renal Inflammation by Promoting Vitamin D Receptor-Mediated Sequestration of NF- B Signaling

(2008) X. Tan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The Effect of N-Acetylcysteine on Proteinuria and Markers of Tubular Injury in Non-Diabetic Patients with Chronic Kidney Disease

(2008) Marcin Renke et al.   KIDNEY & BLOOD PRESSURE RESEARCH

Increased E-cadherin expression in the ligated kidney following unilateral ureteric obstruction

(2008) Neil G. Docherty et al.   KIDNEY INTERNATIONAL

Renal failure and recovery associated with second-generation Bcr-Abl kinase inhibitors in imatinib-resistant chronic myelogenous leukemia

(2008) Sarah A. Holstein et al.   LEUKEMIA RESEARCH

Testosterone exacerbates obstructive renal injury by stimulating TNF-α production and increasing proapoptotic and profibrotic signaling

(2007) Peter D. Metcalfe et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM