New Structural Perspectives in G Protein-Coupled Receptor-Mediated Src Family Kinase Activation

Anti-GPR56 monoclonal antibody potentiates GPR56-mediated Src-Fak signaling to modulate cell adhesion

(2021) Treena Chatterjee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adhesion GPCR Latrophilin-2 Specifies Cardiac Lineage Commitment through CDK5, Src, and P38MAPK

(2021) Choon-Soo Lee et al.   Stem Cell Reports

Structure of the neurotensin receptor 1 in complex with β-arrestin 1

(2020) Weijiao Huang et al.   NATURE

Structure of the M2 muscarinic receptor–β-arrestin complex in a lipid nanodisc

(2020) Dean P. Staus et al.   NATURE

Molecular basis of β-arrestin coupling to formoterol-bound β1-adrenoceptor

(2020) Yang Lee et al.   NATURE

Phosphorylation barcode-dependent signal bias of the dopamine D1 receptor

(2020) Ali I. Kaya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting SRC Kinase Signaling in Pancreatic Cancer Stem Cells

(2020) Sonia Alcalá et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Allosteric activation of proto-oncogene kinase Src by GPCR–beta-arrestin complexes

(2020) Natalia Pakharukova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ligand-induced activation of ERK1/2 signaling by constitutively active Gs-coupled 5-HT receptors

(2019) Ping Liu et al.   ACTA PHARMACOLOGICA SINICA

A Combined Approach Reveals a Regulatory Mechanism Coupling Src’s Kinase Activity, Localization, and Phosphotransferase-Independent Functions

(2019) Ethan Ahler et al.   MOLECULAR CELL

YES1 Drives Lung Cancer Growth and Progression and Predicts Sensitivity to Dasatinib

(2019) Irati Garmendia et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Expression of myeloid Src-family kinases is associated with poor prognosis in AML and influences Flt3-ITD kinase inhibitor acquired resistance

(2019) Ravi K. Patel et al.   PLoS One

CRF1 Receptor Signaling via the ERK1/2-MAP and Akt Kinase Cascades: Roles of Src, EGF Receptor, and PI3-Kinase Mechanisms

(2019) G. Karina Parra-Mercado et al.   Frontiers in Endocrinology

Muscarinic Acetylcholine Receptors Inhibit Fyn Activity in the Rat Striatum In Vivo

(2018) Li-Min Mao et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Structural Basis of Arrestin-Dependent Signal Transduction

(2018) Qiuyan Chen et al.   TRENDS IN BIOCHEMICAL SCIENCES

Lack of beta-arrestin signaling in the absence of active G proteins

(2018) Manuel Grundmann et al.   Nature Communications

Allosteric mechanisms underlie GPCR signaling to SH3-domain proteins through arrestin

(2018) Fan Yang et al.   Nature Chemical Biology

G protein subunit phosphorylation as a regulatory mechanism in heterotrimeric G protein signaling in mammals, yeast, and plants

(2018) David Chakravorty et al.   BIOCHEMICAL JOURNAL

The Two Isoforms of Lyn Display Different Intramolecular Fuzzy Complexes with the SH3 Domain

(2018) João Teixeira et al.   MOLECULES

Teaching an Old Drug New Tricks: Agonism, Antagonism, and Biased Signaling of Pilocarpine through M3 Muscarinic Acetylcholine Receptor

(2017) Alexey N. Pronin et al.   MOLECULAR PHARMACOLOGY

The Diverse Roles of Arrestin Scaffolds in G Protein–Coupled Receptor Signaling

(2017) Yuri K. Peterson et al.   PHARMACOLOGICAL REVIEWS

Distinct conformations of GPCR–β-arrestin complexes mediate desensitization, signaling, and endocytosis

(2017) Thomas J. Cahill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Unique Domain Forms a Fuzzy Intramolecular Complex in Src Family Kinases

(2017) Miguel Arbesú et al.   STRUCTURE

V1b vasopressin receptor trafficking and signaling: Role of arrestins, G proteins and Src kinase

(2017) Sanja Perkovska et al.   TRAFFIC

Structural basis of arrestin-3 activation and signaling

(2017) Qiuyan Chen et al.   Nature Communications

Src tyrosine kinase mediates endothelin-1-induced early growth response protein-1 expression via MAP kinase-dependent pathways in vascular smooth muscle cells

(2016) Estelle R. Simo-Cheyou et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Regulation, Signaling, and Physiological Functions of G-Proteins

(2016) Viktoriya Syrovatkina et al.   JOURNAL OF MOLECULAR BIOLOGY

STEP activation by Gαq coupled GPCRs opposes Src regulation of NMDA receptors containing the GluN2A subunit

(2016) Meng Tian et al.   Scientific Reports

Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser

(2015) Yanyong Kang et al.   NATURE

Dopaminergic and cholinergic regulation of Fyn tyrosine kinase phosphorylation in the rat striatum in vivo

(2015) Li-Min Mao et al.   NEUROPHARMACOLOGY

The Src family kinases Hck, Fgr, and Lyn are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment

(2014) Miklós Kovács et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Visualization of arrestin recruitment by a G-protein-coupled receptor

(2014) Arun K. Shukla et al.   NATURE

A graph kernel approach for alignment-free domain-peptide interaction prediction with an application to human SH3 domains

(2013) K. Kundu et al.   BIOINFORMATICS

Treatment-Related Toxicities in a Phase II Trial of Dasatinib in Patients with Squamous Cell Carcinoma of the Lung

(2013) Andrew M. Brunner et al.   Journal of Thoracic Oncology

Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide

(2013) Arun K. Shukla et al.   NATURE

S49G and R389G polymorphisms of the β1-adrenergic receptor influence signaling via the cAMP-PKA and ERK pathways

(2013) Fan Zhang et al.   PHYSIOLOGICAL GENOMICS

Bradykinin enhances cell migration in human prostate cancer cells through B2 receptor/PKCδ/c-Src dependent signaling pathway

(2012) Hsin-Shan Yu et al.   PROSTATE

Bradykinin-mediated cell proliferation depends on transactivation of EGF receptor in corneal fibroblasts

(2011) Ching-Yi Cheng et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Crystal Structure of Arrestin-3 Reveals the Basis of the Difference in Receptor Binding Between Two Non-visual Subtypes

(2011) Xuanzhi Zhan et al.   JOURNAL OF MOLECULAR BIOLOGY

Src signaling in cancer invasion

(2010) Marcello Guarino   JOURNAL OF CELLULAR PHYSIOLOGY

A novel pathway for receptor-mediated post-translational activation of inducible nitric oxide synthase

(2009) Viktor Brovkovych et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Structural Characterization of the Natively Unfolded N-Terminal Domain of Human c-Src Kinase: Insights into the Role of Phosphorylation of the Unique Domain

(2009) Yolanda Pérez et al.   JOURNAL OF MOLECULAR BIOLOGY