Tunable alkoxy-nucleophilic addition under photochemical condition: Dioxidation of gem‑difluoroalkenes with O2

Acid-Catalyzed Hydrothiolation of gem-Difluorostyrenes to Access α,α-Difluoroalkylthioethers

(2021) Jacob P. Sorrentino et al.   JOURNAL OF ORGANIC CHEMISTRY

Solvent‐Switched Oxidation Selectivities with O2: Controlled Synthesis of α‐Difluoro(thio)methylated Alcohols and Ketones

(2021) Huanfeng Jiang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Pd/Cu‐Catalyzed Defluorinative Carbonylative Coupling of Aryl Iodides and gem ‐Difluoroalkenes: Efficient Synthesis of α‐Fluorochalcones

(2021) Fu‐Peng Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

[3 + 2]-Annulation of gem-Difluoroalkenes and Pyridinium Ylides: Access to Functionalized 2-Fluoroindolizines

(2021) Jun-Qi Zhang et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Monofluoroalkenes through Visible-Light-Promoted Defluorinative Alkylation of gem-Difluoroalkenes with 4-Alkyl-1,4-dihydropyridines

(2020) Hai-Wu Du et al.   ORGANIC LETTERS

Synthesis of difluoromethylated benzylborons via rhodium(I)-catalyzed fluorine-retainable hydroboration of gem-difluoroalkenes

(2020) Yuanhong Cai et al.   CHINESE CHEMICAL LETTERS

Recent Advances in Transition Metal‐Catalyzed Functionalization of gem ‐Difluoroalkenes

(2020) Suvajit Koley et al.   ISRAEL JOURNAL OF CHEMISTRY

Cobalt-Catalyzed Selective Unsymmetrical Dioxidation of gem-Difluoroalkenes

(2020) Douglas L. Orsi et al.   JOURNAL OF ORGANIC CHEMISTRY

Palladium-Catalyzed Stereoselective Hydrodefluorination of Tetrasubstituted gem-Difluoroalkenes

(2020) Qiao Ma et al.   ORGANIC LETTERS

Design and Synthesis of TY‐Phos and Application in Palladium‐Catalyzed Enantioselective Fluoroarylation of gem ‐Difluoroalkenes

(2020) Tao‐Yan Lin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Organic Dye-Catalyzed Intermolecular Radical Coupling of α-Bromocarbonyls with Olefins: Photocatalytic Synthesis of 1,4-Ketocarbonyls Using Air as an Oxidant

(2020) Soumyadeep Roy Chowdhury et al.   JOURNAL OF ORGANIC CHEMISTRY

Chalcogenide-Catalyzed Intermolecular Electrophilic Thio- and Halofunctionalization of gem-Difluoroalkenes: Construction of Diverse Difluoroalkyl Sulfides and Halides

(2020) Quanbin Jiang et al.   ORGANIC LETTERS

Catalytic AgF-Initiated Intramolecular 1,3-Sulfonyl Migration of gem-Difluorovinyl Sulfonates to α,α-Difluoro-β-ketosulfones

(2020) Baojian Xiong et al.   ORGANIC LETTERS

Photoredox-Coupled F-Nucleophilic Addition: Allylation of gem -Difluoroalkenes

(2019) Haidong Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Direct α-Monofluoroalkenylation of Heteroatomic Alkanes via a Combination of Photoredox Catalysis and Hydrogen-Atom-Transfer Catalysis

(2019) Hao Tian et al.   ORGANIC LETTERS

Selective Copper Complex-Catalyzed Hydrodefluorination of Fluoroalkenes and Allyl Fluorides: A Tale of Two Mechanisms

(2019) Nicholas O. Andrella et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Light-Mediated Dual Phosphine-/Copper-Catalyzed Atom Transfer Radical Addition Reaction

(2019) Oleg V. Fedorov et al.   JOURNAL OF ORGANIC CHEMISTRY

Radical Hydroboration and Hydrosilylation of gem-Difluoroalkenes: Synthesis of α-Difluorinated Alkylborons and Alkylsilanes

(2019) Xiaozu Liu et al.   ORGANIC LETTERS

Regioselective Radical Hydroboration of gem-Difluoroalkenes: Synthesis of α-Borylated Organofluorines

(2019) Ji-Kang Jin et al.   ORGANIC LETTERS

Visible-Light-Induced Selective Defluoroborylation of Polyfluoroarenes, gem -Difluoroalkenes, and Trifluoromethylalkenes

(2019) Wengang Xu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Fluorohalogenation of gem ‐Difluoroalkenes: Synthesis and Applications of α‐Trifluoromethyl Halides

(2019) Chi Liu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Difluorocarbene as a Building Block for Consecutive Bond-Forming Reactions

(2018) Alexander D. Dilman et al.   ACCOUNTS OF CHEMICAL RESEARCH

Visible-Light-Accelerated Copper(II)-Catalyzed Regio- and Chemoselective Oxo-Azidation of Vinyl Arenes

(2018) Asik Hossain et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Transition Metal-Mediated and -Catalyzed C-F Bond Activation via Fluorine Elimination

(2018) Takeshi Fujita et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of α-CF3 and α-CF2H amines via the aminofluorination of fluorinated alkenes

(2018) Ling Yang et al.   CHEMICAL COMMUNICATIONS

Transition-Metal (Cu, Pd, Ni)-Catalyzed Difluoroalkylation via Cross-Coupling with Difluoroalkyl Halides

(2018) Zhang Feng et al.   ACCOUNTS OF CHEMICAL RESEARCH

Visible Light-Mediated Photocatalytic Metal-Free Cross-Coupling Reaction of Alkenyl Carboxylic Acids with Diarylphosphine Oxides Leading to β-Ketophosphine Oxides

(2018) Hai-Feng Qian et al.   ORGANIC LETTERS

Fluoro-Hydroxylation of gem -Difluoroalkenes: Synthesis of 18 O-labeled α-CF3 Alcohols

(2018) Jingyu Hu et al.   CHINESE JOURNAL OF CHEMISTRY

Palladium-Catalyzed Synthesis of α-Trifluoromethyl Benzylic Amines via Fluoroarylation of gem-Difluoro-2-azadienes Enabled by Phosphine-Catalyzed Formation of an Azaallyl–Silver Intermediate

(2018) Paige E. Daniel et al.   ACS Catalysis

Mechanistic Insight into the Photocontrolled Cationic Polymerization of Vinyl Ethers

(2017) Quentin Michaudel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Base Catalysis Enables Access to α,α-Difluoroalkylthioethers

(2017) Douglas L. Orsi et al.   ORGANIC LETTERS

Silicon-Based Reagents for Difluoromethylation and Difluoromethylenation Reactions

(2017) G. Prakash et al.   SYNTHESIS-STUTTGART

Recent advances in the synthesis and CF functionalization of gem-difluoroalkenes

(2017) Xuxue Zhang et al.   TETRAHEDRON LETTERS

Controlled Fluoroalkylation Reactions by Visible-Light Photoredox Catalysis

(2016) Tanmay Chatterjee et al.   ACCOUNTS OF CHEMICAL RESEARCH

Photoredox-Catalyzed Dimerization of Arylalkenesviaan Oxidative [4+2] Cycloaddition Sequence: Synthesis of Naphthalene Derivatives

(2016) Donglei Wei et al.   ADVANCED SYNTHESIS & CATALYSIS

Monofluoroalkenylation of Dimethylamino Compounds through Radical-Radical Cross-Coupling

(2016) Jin Xie et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Oxidative trifluoromethylation and fluoroolefination of unactivated olefins

(2016) Ye-bin Wu et al.   CHEMICAL COMMUNICATIONS

Visible-light-initiated difluoromethylation of arene diazonium tetrafluoroborates

(2016) Ye-bin Wu et al.   CHEMICAL COMMUNICATIONS

Cobalt(III)-Catalyzed Regio- and Stereoselective α-Fluoroalkenylation of Arenes with gem-Difluorostyrenes

(2016) Lingheng Kong et al.   ORGANIC LETTERS

Site-selective arene C-H amination via photoredox catalysis

(2015) N. A. Romero et al.   SCIENCE

Mechanistic Insight into the Photoredox Catalysis of Anti-Markovnikov Alkene Hydrofunctionalization Reactions

(2014) Nathan A. Romero et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)

(2013) Jiang Wang et al.   CHEMICAL REVIEWS

Data-Mining for Sulfur and Fluorine: An Evaluation of Pharmaceuticals To Reveal Opportunities for Drug Design and Discovery

(2013) Elizabeth A. Ilardi et al.   JOURNAL OF MEDICINAL CHEMISTRY

AgF-Mediated Fluorinative Homocoupling of gem-Difluoroalkenes

(2013) Bing Gao et al.   ORGANIC LETTERS

Synthesis and Metal-Catalyzed Reactions of gem-Dihalovinyl Systems

(2011) Giorgio Chelucci   CHEMICAL REVIEWS

Synthetic approaches to monofluoroalkenes

(2011) Grégory Landelle et al.   CHEMICAL SOCIETY REVIEWS

Selective Nucleophilic Fluoroalkylations Facilitated by Removable Activation Groups

(2011) Jinbo Hu et al.   SYNLETT

C−F Bond Activation in Organic Synthesis

(2009) Hideki Amii et al.   CHEMICAL REVIEWS

Fluorine in medicinal chemistry

(2007) Sophie Purser et al.   CHEMICAL SOCIETY REVIEWS