Fluoro-Hydroxylation of gem -Difluoroalkenes: Synthesis of 18 O-labeled α-CF3 Alcohols

Deuterium- and Tritium-Labelled Compounds: Applications in the Life Sciences

(2018) Jens Atzrodt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium(II)-Mediated C−H Tritiation of Complex Pharmaceuticals

(2018) Haifeng Yang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

C−H Functionalisation for Hydrogen Isotope Exchange

(2018) Jens Atzrodt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of α-CF3 and α-CF2H amines via the aminofluorination of fluorinated alkenes

(2018) Ling Yang et al.   CHEMICAL COMMUNICATIONS

Synthesis of 2,2-Difluorinated 4-Isoflavanols/4-Thioisoflavanols via a Base-Catalyzed [4 + 2] Annulation Reaction of gem-Difluoroolefins

(2017) Jiaheng Li et al.   JOURNAL OF ORGANIC CHEMISTRY

Copper-Catalyzed Regioselective Monodefluoroborylation of Polyfluoroalkenes en Route to Diverse Fluoroalkenes

(2017) Hironobu Sakaguchi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nickel-Catalyzed Defluorinative Reductive Cross-Coupling of gem-Difluoroalkenes with Unactivated Secondary and Tertiary Alkyl Halides

(2017) Xi Lu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Radical Deuteration with D2O: Catalysis and Mechanistic Insights

(2017) Valentin Soulard et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

First deuterated drug approved

(2017) Charles Schmidt   NATURE BIOTECHNOLOGY

Synthesis of N,N-disubstituted 2-aminothiophenes by the cyclization of gem-difluoroalkenes with β-keto thioamides

(2017) Xuxue Zhang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

N-Heterocyclic carbene-catalyzed stereoselective construction of olefinic carbon–sulfur bonds via cross-coupling reaction of gem-difluoroalkenes and thiols

(2017) Zi-Song Cong et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Base Catalysis Enables Access to α,α-Difluoroalkylthioethers

(2017) Douglas L. Orsi et al.   ORGANIC LETTERS

Cu-Catalyzed Stereoselective Borylation of gem-Difluoroalkenes with B2pin2

(2017) Juan Zhang et al.   ORGANIC LETTERS

Photoredox-catalyzed deuteration and tritiation of pharmaceutical compounds

(2017) Yong Yao Loh et al.   SCIENCE

China's flourishing synthetic organofluorine chemistry: innovations in the new millennium

(2017) Qinghe Liu et al.   National Science Review

Synthesis of Exocyclic Trisubstituted AlkenesviaNickel- Catalyzed Kumada-Type Cross-Coupling Reaction ofgem- Difluoroalkenes with Di-Grignard Reagents

(2016) Wenpeng Dai et al.   ADVANCED SYNTHESIS & CATALYSIS

Palladium-Catalyzed Defluorinative Coupling of 1-Aryl-2,2-Difluoroalkenes and Boronic Acids: Stereoselective Synthesis of Monofluorostilbenes

(2016) Richard T. Thornbury et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mild and Copper-Free Stereoselective Cyanation of gem -Difluoroalkenes by Using Benzyl Nitrile as a Cyanating Reagent

(2016) Juan Zhang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis of fluorovinyl pyrazolyl (thio)ethers by the reaction of gem -difluoroalkenes with pyrazolin-5-ones (thiones)

(2016) Tao Huang et al.   JOURNAL OF FLUORINE CHEMISTRY

F– Nucleophilic-Addition-Induced Allylic Alkylation

(2016) Panpan Tian et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Sterically Controlled Cu-Catalyzed or Transition-Metal-Free Cross-Coupling of gem-Difluoroalkenes with Tertiary, Secondary, and Primary Alkyl Grignard Reagents

(2016) Wenpeng Dai et al.   ORGANIC LETTERS

Cobalt(III)-Catalyzed Regio- and Stereoselective α-Fluoroalkenylation of Arenes with gem-Difluorostyrenes

(2016) Lingheng Kong et al.   ORGANIC LETTERS

Isotope chemistry; a useful tool in the drug discovery arsenal

(2015) Charles S. Elmore et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Nickel-catalyzed Suzuki–Miyaura type cross-coupling reactions of (2,2-difluorovinyl)benzene derivatives with arylboronic acids

(2015) Yang Xiong et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Copper-Catalyzed Coupling Cyclization of gem-Difluoroalkenes with Activated Methylene Carbonyl Compounds: Facile Domino Access to Polysubstituted Furans

(2015) Xuxue Zhang et al.   ORGANIC LETTERS

Mild and metal-free trifluoromethylation and pentafluoroethylation of gem-difluoroalkenes with TMSCF3 and TMSCF2CF3

(2015) Guanyi Jin et al.   TETRAHEDRON

Rhodium-catalysed C(sp2)–C(sp2) bond formation via C–H/C–F activation

(2015) Panpan Tian et al.   Nature Communications

Synthesis of fluorovinyl aryl ethers by a three-component reaction of gem-difluoroalkenes with arylboronic acids and oxygen

(2015) Mingjin Wang et al.   RSC Advances

Synthesis of monofluoroalkenes through selective hydrodefluorination of gem-difluoroalkenes with Red-Al®

(2015) Jingjing Wu et al.   RSC Advances

Base-mediated direct fluoroalkenylation of 2-phenyl-1,3,4-oxadiazole, benzothiazole and benzoxazole with gem-difluoroalkenes

(2015) Xuxue Zhang et al.   RSC Advances

Modern Carbon–Fluorine Bond Forming Reactions for Aryl Fluoride Synthesis

(2014) Michael G. Campbell et al.   CHEMICAL REVIEWS

Trifluoromethyltrimethylsilane: Nucleophilic Trifluoromethylation and Beyond

(2014) Xiao Liu et al.   CHEMICAL REVIEWS

Stereoselective synthesis of β-fluoroenyne by the reaction of gem -difluoroalkenes with terminal alkynes

(2014) Guanyi Jin et al.   JOURNAL OF FLUORINE CHEMISTRY

Palladium- and Nickel-Catalyzed Kumada Cross-Coupling Reactions of gem-Difluoroalkenes and Monofluoroalkenes with Grignard Reagents

(2014) Wenpeng Dai et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of N-(α-Fluorovinyl)azoles by the Reaction of Difluoroalkenes with Azoles

(2014) Yang Xiong et al.   JOURNAL OF ORGANIC CHEMISTRY

Two-Step Synthesis of Difluoromethyl-Substituted 2,3-Dihydrobenzoheteroles

(2014) Takeshi Fujita et al.   ORGANIC LETTERS

Synthesis of Deuterated Benzopyran Derivatives as Selective COX-2 Inhibitors with Improved Pharmacokinetic Properties

(2014) Yanmei Zhang et al.   ACS Medicinal Chemistry Letters

Domino Synthesis of Fluorine-Substituted Polycyclic Aromatic Hydrocarbons: 1,1-Difluoroallenes as Synthetic Platforms

(2013) Kohei Fuchibe et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Microwave assisted fluorofunctionalization of phenyl substituted alkenes using selectfluor™

(2013) Anil Kumar et al.   JOURNAL OF FLUORINE CHEMISTRY

AgF-Mediated Fluorinative Homocoupling of gem-Difluoroalkenes

(2013) Bing Gao et al.   ORGANIC LETTERS

Mechanism of electrophilic fluorination with Pd(iv): fluoride capture and subsequent oxidative fluoride transfer

(2013) Jochen R. Brandt et al.   Chemical Science

Deuterated Clopidogrel Analogues as a New Generation of Antiplatelet Agents

(2013) Yaoqiu Zhu et al.   ACS Medicinal Chemistry Letters

In Vitro Approach to Assess the Potential for Risk of Idiosyncratic Adverse Reactions Caused by Candidate Drugs

(2012) Richard A. Thompson et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Use of Radiolabeled Compounds in Drug Metabolism and Pharmacokinetic Studies

(2012) Emre M. Isin et al.   CHEMICAL RESEARCH IN TOXICOLOGY

A simple, rapid procedure for nucleophilic radiosynthesis of aliphatic [18F]trifluoromethyl groups

(2011) Patrick J. Riss et al.   CHEMICAL COMMUNICATIONS

Domino Friedel-Crafts-Type Cyclizations of Difluoroalkenes Promoted by the α-Cation-Stabilizing Effect of Fluorine: An Efficient Method for Synthesizing Angular PAHs

(2011) Kohei Fuchibe et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design

(2011) Nicholas A. Meanwell   JOURNAL OF MEDICINAL CHEMISTRY

Highly Enantioselective Addition of Dialkylzinc to Trifluoroacetophenones, Catalyzed by 1,2-Diamines. Synthesis of Key Fragments of Inhibitors of the Enzyme 11β-HSD1 and Kinetic Analysis of the Process†

(2010) Miroslav Genov et al.   ORGANOMETALLICS

Fluorinated high-performance polymers: Poly(arylene ether)s and aromatic polyimides containing trifluoromethyl groups

(2010) Mahua G. Dhara et al.   PROGRESS IN POLYMER SCIENCE

Nucleophilic (phenylsulfonyl)difluoromethylation of alkyl halides using PhSO2CF2SiMe3: preparation of gem-difluoroalkenes and trifluoromethyl compounds

(2010) Lingui Zhu et al.   TETRAHEDRON LETTERS

Fenofibric Acid

(2009) Lily P.H. Yang et al.   American Journal of Cardiovascular Drugs

C−F Bond Activation in Organic Synthesis

(2009) Hideki Amii et al.   CHEMICAL REVIEWS

Efficient Helicene Synthesis: Friedel–Crafts-type Cyclization of 1,1-Difluoro-1-alkenes

(2008) Junji Ichikawa et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Molecular Imaging with PET

(2008) Simon M. Ametamey et al.   CHEMICAL REVIEWS

Synthetic strategies to α-trifluoromethyl and α-difluoromethyl substituted α-amino acids

(2008) René Smits et al.   CHEMICAL SOCIETY REVIEWS

The Many Roles for Fluorine in Medicinal Chemistry

(2008) William K. Hagmann   JOURNAL OF MEDICINAL CHEMISTRY

Catalytic Enantioselective Addition of Diethylzinc to Trifluoromethyl Ketones

(2008) Kimberly Yearick et al.   ORGANIC LETTERS

Fluorination in Medicinal Chemistry: Methods, Strategies, and Recent Developments

(2008) Kenneth L. Kirk   ORGANIC PROCESS RESEARCH & DEVELOPMENT

InX3-catalyzed haloamidation of vinyl arenes: a facile synthesis of α-bromo- and α-fluoroamides

(2008) J.S. Yadav et al.   TETRAHEDRON LETTERS

Fluorine in medicinal chemistry

(2007) Sophie Purser et al.   CHEMICAL SOCIETY REVIEWS