Endoplasmic Reticulum Stress and Dysregulated Autophagy in Human Pancreatic Beta Cells

An autophagy enhancer ameliorates diabetes of human IAPP-transgenic mice through clearance of amyloidogenic oligomer

(2021) Jinyoung Kim et al.   Nature Communications

Pancreatic beta cell autophagy is impaired in type 1 diabetes

(2021) Charanya Muralidharan et al.   DIABETOLOGIA

β-Cell autophagy in the pathogenesis of type 1 diabetes

(2021) Charanya Muralidharan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Engineering islets from stem cells for advanced therapies of diabetes

(2021) Johanna Siehler et al.   NATURE REVIEWS DRUG DISCOVERY

Therapeutic opportunities for pancreatic β-cell ER stress in diabetes mellitus

(2021) Jing Yong et al.   Nature Reviews Endocrinology

Altered islet prohormone processing: A cause or consequence of diabetes?

(2021) Adam Ramzy et al.   PHYSIOLOGICAL REVIEWS

Living Dangerously: Protective and Harmful ER Stress Responses in Pancreatic β-Cells

(2021) Rohit B. Sharma et al.   DIABETES

An accomplice more than a mere victim: The impact of β-cell ER stress on type 1 diabetes pathogenesis

(2021) Gulcan Semra Sahin et al.   Molecular Metabolism

Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles

(2020) Ren-Qi Yao et al.   Autophagy

Pancreatic β-cells in type 1 and type 2 diabetes mellitus: different pathways to failure

(2020) Décio L. Eizirik et al.   Nature Reviews Endocrinology

Mechanisms, regulation and functions of the unfolded protein response

(2020) Claudio Hetz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Autophagy as a modulator of cell death machinery

(2020) Masayuki Noguchi et al.   Cell Death & Disease

Pharmacological Targeting of Endoplasmic Reticulum Stress in Pancreatic Beta Cells

(2020) Sara Bilekova et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Specific PERK inhibitors enhanced glucose-stimulated insulin secretion in a mouse model of type 2 diabetes

(2019) Min Joo Kim et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Modulation of Autophagy Influences the Function and Survival of Human Pancreatic Beta Cells Under Endoplasmic Reticulum Stress Conditions and in Type 2 Diabetes

(2019) M. Bugliani et al.   Frontiers in Endocrinology

Type 2 diabetes is associated with suppression of autophagy and lipid accumulation in β‐cells

(2019) Jeff Ji et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Cells Deploy a Two-Pronged Strategy to Rectify Misfolded Proinsulin Aggregates

(2019) Corey N. Cunningham et al.   MOLECULAR CELL

Proinsulin misfolding is an early event in the progression to type 2 diabetes

(2019) Anoop Arunagiri et al.   eLife

Glucolipotoxicity Alters Insulin Secretion via Epigenetic Changes in Human Islets

(2019) Elin Hall et al.   DIABETES

Glucolipotoxicity, β-Cells, and Diabetes: The Emperor Has No Clothes

(2019) Gordon C. Weir   DIABETES

Breaking Bad and Breaking Good: β-Cell Autophagy Pathways in Diabetes

(2019) Kevin Vivot et al.   JOURNAL OF MOLECULAR BIOLOGY

Metabolically phenotyped pancreatectomized patients as living donors for the study of islets in health and diabetes

(2019) Marko Barovic et al.   Molecular Metabolism

β-cell autophagy: Mechanism and role in β-cell dysfunction

(2019) Yong-ho Lee et al.   Molecular Metabolism

Relationship Between Oxidative Stress, ER Stress, and Inflammation in Type 2 Diabetes: The Battle Continues

(2019) Burgos-Morón et al.   Journal of Clinical Medicine

Recent Insights Into Mechanisms of β-Cell Lipo- and Glucolipotoxicity in Type 2 Diabetes

(2019) Maria Lytrivi et al.   JOURNAL OF MOLECULAR BIOLOGY

De Novo Mutations in EIF2B1 Affecting eIF2 Signaling Cause Neonatal/Early-Onset Diabetes and Transient Hepatic Dysfunction

(2019) Elisa De Franco et al.   DIABETES

CCPG1 Is a Non-canonical Autophagy Cargo Receptor Essential for ER-Phagy and Pancreatic ER Proteostasis

(2018) Matthew D. Smith et al.   DEVELOPMENTAL CELL

The effects of high glucose exposure on global gene expression and DNA methylation in human pancreatic islets

(2018) Elin Hall et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

A novel autophagy enhancer as a therapeutic agent against metabolic syndrome and diabetes

(2018) Hyejin Lim et al.   Nature Communications

Identification of early biological changes in palmitate-treated isolated human islets

(2018) Ernest Sargsyan et al.   BMC GENOMICS

Complement Component C3 Is Highly Expressed in Human Pancreatic Islets and Prevents β Cell Death via ATG16L1 Interaction and Autophagy Regulation

(2018) Ben C. King et al.   Cell Metabolism

β Cell Replacement after Gene Editing of a Neonatal Diabetes-Causing Mutation at the Insulin Locus

(2018) Shuangyu Ma et al.   Stem Cell Reports

Addition of exogenous sodium palmitate increases the IAPP/insulin mRNA ratio via GPR40 in human EndoC-βH1 cells

(2017) Camilla Krizhanovskii et al.   UPSALA JOURNAL OF MEDICAL SCIENCES

Sirolimus induces depletion of intracellular calcium stores and mitochondrial dysfunction in pancreatic beta cells

(2017) Angela Lombardi et al.   Scientific Reports

Combined lipidomic and proteomic analysis of isolated human islets exposed to palmitate reveals time-dependent changes in insulin secretion and lipid metabolism

(2017) Kirsten Roomp et al.   PLoS One

Autophagy protects pancreatic beta cell mass and function in the setting of a high-fat and high-glucose diet

(2017) Qingfeng Sheng et al.   Scientific Reports

The role of ER stress in lipid metabolism and lipotoxicity

(2016) Jaeseok Han et al.   JOURNAL OF LIPID RESEARCH

The Role of Endoplasmic Reticulum Stress in Human Pathology

(2015) Scott A. Oakes et al.   Annual Review of Pathology-Mechanisms of Disease

Cytokines induce endoplasmic reticulum stress in human, rat and mouse beta cells via different mechanisms

(2015) Flora Brozzi et al.   DIABETOLOGIA

Insulin demand regulates β cell number via the unfolded protein response

(2015) Rohit B. Sharma et al.   JOURNAL OF CLINICAL INVESTIGATION

Allosteric Inhibition of the IRE1α RNase Preserves Cell Viability and Function during Endoplasmic Reticulum Stress

(2014) Rajarshi Ghosh et al.   CELL

Inhibition of Autophagic Turnover in β-Cells by Fatty Acids and Glucose Leads to Apoptotic Cell Death

(2014) Shakeel U. R. Mir et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloidogenic peptide oligomer accumulation in autophagy-deficient β cells induces diabetes

(2014) Jinyoung Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Human IAPP–induced pancreatic β cell toxicity and its regulation by autophagy

(2014) Nayumi Shigihara et al.   JOURNAL OF CLINICAL INVESTIGATION

Autophagy defends pancreatic β cells from human islet amyloid polypeptide-induced toxicity

(2014) Jacqueline F. Rivera et al.   JOURNAL OF CLINICAL INVESTIGATION

Clinical development success rates for investigational drugs

(2014) Michael Hay et al.   NATURE BIOTECHNOLOGY

Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress

(2014) Sumaira Z Hasnain et al.   NATURE MEDICINE

Lipotoxic endoplasmic reticulum stress, β cell failure, and type 2 diabetes mellitus

(2014) Trevor J. Biden et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

RNA Sequencing Identifies Dysregulation of the Human Pancreatic Islet Transcriptome by the Saturated Fatty Acid Palmitate

(2013) Miriam Cnop et al.   DIABETES

Exendin-4 Improves β-Cell Function in Autophagy-Deficient β-Cells

(2013) Hiroko Abe et al.   ENDOCRINOLOGY

Insulin Secretion and Ca2+Dynamics in β-Cells Are Regulated by PERK (EIF2AK3) in Concert with Calcineurin

(2013) Rong Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oral Treatment Targeting the Unfolded Protein Response Prevents Neurodegeneration and Clinical Disease in Prion-Infected Mice

(2013) J. A. Moreno et al.   Science Translational Medicine

The Pancreas Cancer Microenvironment

(2012) C. Feig et al.   CLINICAL CANCER RESEARCH

Expression of endoplasmic reticulum stress markers in the islets of patients with type 1 diabetes

(2012) I. Marhfour et al.   DIABETOLOGIA

Distinctions Between the Islets of Mice and Men: Implications for New Therapies for Type 1 and 2 Diabetes

(2012) Claresa Levetan et al.   Endocrine Practice

Uncoupling Proteostasis and Developmentin Vitrowith a Small Molecule Inhibitor of the Pancreatic Endoplasmic Reticulum Kinase, PERK

(2012) Heather P. Harding et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of 7-Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase (PERK)

(2012) Jeffrey M. Axten et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Novel Glucose-Regulated Proteins in Isolated Human Pancreatic Islets Using LC–MS/MS-Based Proteomics

(2012) Alexandra C. Schrimpe-Rutledge et al.   JOURNAL OF PROTEOME RESEARCH

Development and Functional Characterization of Insulin-releasing Human Pancreatic Beta Cell Lines Produced by Electrofusion

(2011) Jane T. McCluskey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A genetically engineered human pancreatic β cell line exhibiting glucose-inducible insulin secretion

(2011) Philippe Ravassard et al.   JOURNAL OF CLINICAL INVESTIGATION

Islet Amyloid Polypeptide, Islet Amyloid, and Diabetes Mellitus

(2011) Per Westermark et al.   PHYSIOLOGICAL REVIEWS

Proinsulin misfolding and diabetes: mutant INS gene-induced diabetes of youth

(2010) Ming Liu et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Pancreatic islet plasticity: Interspecies comparison of islet architecture and composition

(2010) Donald J. Steiner et al.   Islets

Autophagy in human type 2 diabetes pancreatic beta cells

(2009) M. Masini et al.   DIABETOLOGIA

β Cells Can Be Generated from Endogenous Progenitors in Injured Adult Mouse Pancreas

(2008) Xiaobo Xu et al.   CELL