Sirolimus induces depletion of intracellular calcium stores and mitochondrial dysfunction in pancreatic beta cells

Interferon alpha impairs insulin production in human beta cells via endoplasmic reticulum stress

(2017) Angela Lombardi et al.   JOURNAL OF AUTOIMMUNITY

Game of TOR — The Target of Rapamycin Rules Four Kingdoms

(2017) Brendan D. Manning   NEW ENGLAND JOURNAL OF MEDICINE

Reduction of endoplasmic reticulum- mitochondria interactions in beta cells from patients with type 2 diabetes

(2017) Charles Thivolet et al.   PLoS One

The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging

(2016) Brian K. Kennedy et al.   Cell Metabolism

SERCA2 Deficiency Impairs Pancreatic β-Cell Function in Response to Diet-Induced Obesity

(2016) Xin Tong et al.   DIABETES

Post-Transplant Diabetes Mellitus: Causes, Treatment, and Impact on Outcomes

(2016) Vijay Shivaswamy et al.   ENDOCRINE REVIEWS

The expression of Lamin A mutant R321X leads to endoplasmic reticulum stress with aberrant Ca2+handling

(2016) Monica Carmosino et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Risk assessment and management of post-transplant diabetes mellitus

(2016) Eugene Han et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Rapamycin Attenuates Cardiac Fibrosis in Experimental Uremic Cardiomyopathy by Reducing Marinobufagenin Levels and Inhibiting Downstream Pro‐Fibrotic Signaling

(2016) Steven T. Haller et al.   Journal of the American Heart Association

Novel Observations From Next-Generation RNA Sequencing of Highly Purified Human Adult and Fetal Islet Cell Subsets

(2015) David M. Blodgett et al.   DIABETES

LKB1 couples glucose metabolism to insulin secretion in mice

(2015) Accalia Fu et al.   DIABETOLOGIA

Endoplasmic Reticulum Stress as a Novel Mechanism in Amiodarone-Induced Destructive Thyroiditis

(2015) Angela Lombardi et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Calcium release channel RyR2 regulates insulin release and glucose homeostasis

(2015) Gaetano Santulli et al.   JOURNAL OF CLINICAL INVESTIGATION

MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

(2015) Remi-Martin Laberge et al.   NATURE CELL BIOLOGY

Mitochondrial calcium overload is a key determinant in heart failure

(2015) Gaetano Santulli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging

(2015) Gaetano Santulli et al.   Current Molecular Pharmacology

Rapamycin attenuates mitochondrial dysfunction via activation of mitophagy in experimental ischemic stroke

(2014) Qiang Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Rapamycin: One Drug, Many Effects

(2014) Jing Li et al.   Cell Metabolism

Endocytic Cycling of Glucose Transporters and Insulin Resistance Due to Immunosuppressive Agents

(2014) Jonathan S. Bogan   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

A selective microRNA-based strategy inhibits restenosis while preserving endothelial function

(2014) Gaetano Santulli et al.   JOURNAL OF CLINICAL INVESTIGATION

Genetically enhancing mitochondrial antioxidant activity improves muscle function in aging

(2014) Alisa Umanskaya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Losartan, an angiotensin II type 1 receptor blocker, protects human islets from glucotoxicity through the phospholipase C pathway

(2013) Anne-Marie Madec et al.   FASEB JOURNAL

Rapalogs and mTOR inhibitors as anti-aging therapeutics

(2013) Dudley W. Lamming et al.   JOURNAL OF CLINICAL INVESTIGATION

Imaging atrial arrhythmic intracellular calcium in intact heart

(2013) Wenjun Xie et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Tailoring mTOR-based therapy: molecular evidence and clinical challenges

(2013) Gaetano Santulli et al.   PHARMACOGENOMICS

Intraislet SLIT-ROBO signaling is required for beta-cell survival and potentiates insulin secretion

(2013) Y. H. C. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Age-Related Impairment in Insulin Release: The Essential Role of  2-Adrenergic Receptor

(2012) G. Santulli et al.   DIABETES

Rapamycin toxicity in MIN6 cells and rat and human islets is mediated by the inhibition of mTOR complex 2 (mTORC2)

(2012) A. D. Barlow et al.   DIABETOLOGIA

Delineation of glutamate pathways and secretory responses in pancreatic islets with β-cell–specific abrogation of the glutamate dehydrogenase

(2012) Laurène Vetterli et al.   MOLECULAR BIOLOGY OF THE CELL

Rapamycin Ameliorates Age-Dependent Obesity Associated with Increased mTOR Signaling in Hypothalamic POMC Neurons

(2012) Shi-Bing Yang et al.   NEURON

Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

(2012) D. W. Lamming et al.   SCIENCE

Role of insulin resistance indices in predicting new-onset diabetes after kidney transplantation

(2012) Pramod Nagaraja et al.   TRANSPLANT INTERNATIONAL

Increased hexosamine biosynthetic pathway flux dedifferentiates INS-1E cells and murine islets by an extracellular signal-regulated kinase (ERK)1/2-mediated signal transmission pathway

(2011) A. Lombardi et al.   DIABETOLOGIA

Methylglyoxal impairs insulin signalling and insulin action on glucose-induced insulin secretion in the pancreatic beta cell line INS-1E

(2011) F. Fiory et al.   DIABETOLOGIA

Inositol 1,4,5-trisphosphate receptor 1 mutation perturbs glucose homeostasis and enhances susceptibility to diet-induced diabetes

(2011) Risheng Ye et al.   JOURNAL OF ENDOCRINOLOGY

Rapamycin induces glucose intolerance in mice by reducing islet mass, insulin content, and insulin sensitivity

(2011) Shi-Bing Yang et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Fighting neurodegeneration with rapamycin: mechanistic insights

(2011) Jordi Bové et al.   NATURE REVIEWS NEUROSCIENCE

mTOR links incretin signaling to HIF induction in pancreatic beta cells

(2011) S. Van de Velde et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chronic Rapamycin Treatment Causes Glucose Intolerance and Hyperlipidemia by Upregulating Hepatic Gluconeogenesis and Impairing Lipid Deposition in Adipose Tissue

(2010) V. P. Houde et al.   DIABETES

Mitochondrial matrix pH controls oxidative phosphorylation and metabolism-secretion coupling in INS-1E clonal β cells

(2010) Dmitry Akhmedov et al.   FASEB JOURNAL

Intracardiac Injection of AdGRK5-NT Reduces Left Ventricular Hypertrophy by Inhibiting NF-κB–Dependent Hypertrophic Gene Expression

(2010) Daniela Sorriento et al.   HYPERTENSION

Mitochondrial Ca2+ uptake and not mitochondrial motility is required for STIM1-Orai1-dependent store-operated Ca2+ entry

(2010) S. Naghdi et al.   JOURNAL OF CELL SCIENCE

MICU1 encodes a mitochondrial EF hand protein required for Ca2+ uptake

(2010) Fabiana Perocchi et al.   NATURE

Effects of palmitate on ER and cytosolic Ca2+ homeostasis in β-cells

(2009) Kamila S. Gwiazda et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Oral rapamycin attenuates inflammation and enhances stability of atherosclerotic plaques in rabbits independent of serum lipid levels

(2009) Wen Qiang Chen et al.   BRITISH JOURNAL OF PHARMACOLOGY

PDX1 Deficiency Causes Mitochondrial Dysfunction and Defective Insulin Secretion through TFAM Suppression

(2009) Benoit R. Gauthier et al.   Cell Metabolism

Inactivation of Mammalian Target of Rapamycin Increases STAT1 Nuclear Content and Transcriptional Activity in α4- and Protein Phosphatase 2A-dependent Fashion

(2009) Jill A. Fielhaber et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rapamycin Protects Against High Fat Diet–Induced Obesity in C57BL/6J Mice

(2009) Geng-Ruei Chang et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Roles of IP3R and RyR Ca2+ Channels in Endoplasmic Reticulum Stress and  -Cell Death

(2008) D. S. Luciani et al.   DIABETES

Metabolic syndrome in liver transplantation: Relation to etiology and immunosuppression

(2008) Giampaolo Bianchi et al.   LIVER TRANSPLANTATION

Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation

(2008) Riina M. Luik et al.   NATURE

Regulation of androgen receptor transcriptional activity by rapamycin in prostate cancer cell proliferation and survival

(2008) Y Wang et al.   ONCOGENE