DDX5 and DDX17—multifaceted proteins in the regulation of tumorigenesis and tumor progression

LNCcation: lncRNA localization and function

(2021) Mary Catherine Bridges et al.   JOURNAL OF CELL BIOLOGY

BRCA2 promotes R‐loop resolution by DDX5 helicase at DNA breaks to facilitate their repair by homologous recombination

(2021) Gaetana Sessa et al.   EMBO JOURNAL

Simvastatin suppresses renal cell carcinoma cells by regulating DDX5/DUSP5

(2021) Yu Qiu et al.   Scandinavian Journal of Urology

MSC-AS1 induced cell growth and inflammatory mediators secretion through sponging miR-142-5p/DDX5 in gastric carcinoma

(2021) Yan Liu et al.   Aging-US

LINC01207 is up-regulated in gastric cancer tissues and promotes disease progression by regulating miR-671-5p/DDX5 axis

(2021) Hongquan Liu et al.   JOURNAL OF BIOCHEMISTRY

Identification of gene signatures and potential therapeutic targets for acquired chemotherapy resistance in gastric cancer patients

(2021) Jie Sun et al.   Journal of Gastrointestinal Oncology

DDX17 is involved in DNA damage repair and modifies FUS toxicity in an RGG-domain dependent manner

(2021) Tyler R. Fortuna et al.   ACTA NEUROPATHOLOGICA

Estrogen receptor-α signaling in post-natal mammary development and breast cancers

(2021) Mariam Rusidzé et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Long Noncoding RNA Cardiac Physiological Hypertrophy–Associated Regulator Induces Cardiac Physiological Hypertrophy and Promotes Functional Recovery After Myocardial Ischemia-Reperfusion Injury

(2021) Rongrong Gao et al.   CIRCULATION

LncPSCA in the 8q24.3 risk locus drives gastric cancer through destabilizing DDX5

(2021) Yan Zheng et al.   EMBO REPORTS

Ribosome Biogenesis and Cancer: Overview on Ribosomal Proteins

(2021) Annalisa Pecoraro et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Molecular Insights into the Recruiting Between UCP2 and DDX5/UBAP2L in the Metabolic Plasticity of Non-Small-Cell Lung Cancer

(2021) Zhiwei Yang et al.   Journal of Chemical Information and Modeling

Thrap3 promotes R-loop resolution via interaction with methylated DDX5

(2021) Hyun Je Kang et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

DDX17‐regulated alternative splicing that produced an oncogenic isoform of PXN‐AS1 to promote HCC metastasis

(2021) Hong‐Zhong Zhou et al.   HEPATOLOGY

Upregulated expression of DDX5 predicts recurrence and poor prognosis in breast cancer

(2021) Kai Li et al.   PATHOLOGY RESEARCH AND PRACTICE

PAK5 promotes RNA helicase DDX5 sumoylation and miRNA-10b processing in a kinase-dependent manner in breast cancer

(2021) Yang Li et al.   Cell Reports

Wnt/β-catenin signaling and p68 conjointly regulate CHIP in colorectal carcinoma

(2021) Satadeepa Kal et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

LncRNA CPhar mediates exercise-induced cardioprotection by promoting eNOS phosphorylation at Ser1177 via DDX17/PI3K/Akt pathway after MI/RI

(2021) Jingyi Wu et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

p53, cancer and the immune response

(2020) Julianna Blagih et al.   JOURNAL OF CELL SCIENCE

Knockdown of terminal differentiation induced ncRNA (TINCR) suppresses proliferation and invasion in hepatocellular carcinoma by targeting the miR‐218‐5p/DEAD‐box helicase 5 (DDX5) axis

(2020) Huibo Zhao et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Long Noncoding RNA NHEG1 Drives β-Catenin Transactivation and Neuroblastoma Progression through Interacting with DDX5

(2020) Xiang Zhao et al.   MOLECULAR THERAPY

Upregulation of DEAD box helicase 5 and 17 are correlated with the progression and poor prognosis in gliomas

(2020) Qisheng Luo et al.   PATHOLOGY RESEARCH AND PRACTICE

The RNA helicase DDX5 supports mitochondrial function in small cell lung cancer

(2020) Zheng Xing et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Roles and mechanisms of alternative splicing in cancer — implications for care

(2020) Sophie C. Bonnal et al.   Nature Reviews Clinical Oncology

LINC01116 promotes tumor proliferation and neutrophil recruitment via DDX5-mediated regulation of IL-1β in glioma cell

(2020) Teng Wang et al.   Cell Death & Disease

The role of miRNA biogenesis and DDX17 in tumorigenesis and cancer stemness

(2020) Kou-Juey Wu   Biomedical Journal

snoRNPs: Functions in Ribosome Biogenesis

(2020) Sandeep Ojha et al.   Biomolecules

Integration of Hippo-YAP Signaling with Metabolism

(2020) Consuelo Ibar et al.   DEVELOPMENTAL CELL

ATAD5 restricts R-loop formation through PCNA unloading and RNA helicase maintenance at the replication fork

(2020) Sangin Kim et al.   NUCLEIC ACIDS RESEARCH

DDX5-targeting fully human monoclonal autoantibody inhibits proliferation and promotes differentiation of acute promyelocytic leukemia cells by increasing ROS production

(2020) Jing Wu et al.   Cell Death & Disease

Intragenic recruitment of NF-κB drives splicing modifications upon activation by the oncogene Tax of HTLV-1

(2020) Lamya Ben Ameur et al.   Nature Communications

The Promising Role of miR-21 as a Cancer Biomarker and Its Importance in RNA-Based Therapeutics

(2020) Diana Bautista-Sánchez et al.   Molecular Therapy-Nucleic Acids

R-loops coordinate with SOX2 in regulating reprogramming to pluripotency

(2020) Yaoyi Li et al.   Science Advances

Decreased expression of DEAD-Box helicase 5 inhibits esophageal squamous cell carcinomas by regulating endoplasmic reticulum stress and autophagy

(2020) Lin Ma et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Camptothecin induced DDX5 degradation increased the camptothecin resistance of osteosarcoma

(2020) Xingkai Zhao et al.   EXPERIMENTAL CELL RESEARCH

The expression analyses of RMRP, DDX5, and RORC in RRMS patients treated with different drugs versus naïve patients and healthy controls

(2020) Shima Rahmani et al.   GENE

Low expression of DDX5 is associated with poor prognosis in patients with pancreatic ductal adenocarcinoma

(2020) Masashi Morimachi et al.   JOURNAL OF CLINICAL PATHOLOGY

LncRNA SLC26A4-AS1 suppresses the MRN complex-mediated DNA repair signaling and thyroid cancer metastasis by destabilizing DDX5

(2020) Jupeng Yuan et al.   ONCOGENE

LncRNA Platr22 promotes super-enhancer activity and stem cell pluripotency

(2020) Pixi Yan et al.   Journal of Molecular Cell Biology

Endoxifen and fulvestrant regulate estrogen-receptor α and related DEAD-box proteins

(2020) Jasmin Asberger et al.   Endocrine Connections

DDX5 promotes oncogene C3 and FABP1 expressions and drives intestinal inflammation and tumorigenesis

(2020) Nazia Abbasi et al.   Life Science Alliance

Essential functions of miR‐125b in cancer

(2020) Boya Peng et al.   CELL PROLIFERATION

Targeting the Wnt/β-catenin signaling pathway in cancer

(2020) Ya Zhang et al.   Journal of Hematology & Oncology

Androgen Receptor Signaling Pathway in Prostate Cancer: From Genetics to Clinical Applications

(2020) Gaetano Aurilio et al.   Cells

R-Loops as Cellular Regulators and Genomic Threats

(2019) Madzia P. Crossley et al.   MOLECULAR CELL

Regulation of miRNA biogenesis and histone modification by K63-polyubiquitinated DDX17 controls cancer stem-like features

(2019) Shih-Han Kao et al.   CANCER RESEARCH

DDX5 plays essential transcriptional and post-transcriptional roles in the maintenance and function of spermatogonia

(2019) Julien M. D. Legrand et al.   Nature Communications

Hepatoma-Derived Growth Factor and DDX5 Promote Carcinogenesis and Progression of Endometrial Cancer by Activating β-Catenin

(2019) Chunhua Liu et al.   Frontiers in Oncology

Arginine methylation of the DDX 5 helicase RGG / RG motif by PRMT 5 regulates resolution of RNA:DNA hybrids

(2019) Sofiane Y Mersaoui et al.   EMBO JOURNAL

RNA helicase p68 deploys β-catenin in regulating RelA/p65 gene expression: implications in colon cancer

(2019) Veenita Khare et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

MicroRNA Biogenesis Pathway Genes Are Deregulated in Colorectal Cancer

(2019) Petra Vychytilova-Faltejskova et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

First-in-Class Phosphorylated-p68 Inhibitor RX-5902 Inhibits β-Catenin Signaling and Demonstrates Antitumor Activity in Triple-Negative Breast Cancer

(2019) Anna Capasso et al.   MOLECULAR CANCER THERAPEUTICS

LncRNA CCAT1 promotes prostate cancer cell proliferation by interacting with DDX5 and miR-28-5p

(2019) Zonghao You et al.   MOLECULAR CANCER THERAPEUTICS

DDX5 helicase resolves G-quadruplex and is involved in MYC gene transcriptional activation

(2019) Guanhui Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DDX17 promotes hepatocellular carcinoma progression via inhibiting Klf4 transcriptional activity

(2019) Ying Xue et al.   Cell Death & Disease

Knockdown of DEAD-box RNA helicase DDX5 selectively attenuates serine 311 phosphorylation of NF-κB p65 subunit and expression level of anti-apoptotic factor Bcl-2

(2019) Ken Tanaka et al.   CELLULAR SIGNALLING

Precision medicine for human cancers with Notch signaling dysregulation (Review)

(2019) Masuko Katoh et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

RNA Specificity and Autoregulation of DDX17, a Modulator of MicroRNA Biogenesis

(2019) Tri D. Ngo et al.   Cell Reports

miR-5590-3p inhibited tumor growth in gastric cancer by targeting DDX5/AKT/m-TOR pathway

(2018) Nan Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Long non-coding RNA MIAT promotes gastric cancer growth and metastasis through regulation of miR-141/DDX5 pathway

(2018) Min Sha et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA

(2018) Tamer Sallam et al.   NATURE MEDICINE

The RNA helicase DDX17 controls the transcriptional activity of REST and the expression of proneural microRNAs in neuronal differentiation

(2018) Marie-Pierre Lambert et al.   NUCLEIC ACIDS RESEARCH

Structural characterization of β-catenin and RX-5902 binding to phospho-p68 RNA helicase by molecular dynamics simulation

(2018) Waqar Ali et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

High expression of ALDOA and DDX5 are associated with poor prognosis in human colorectal cancer

(2018) Ling Dai et al.   Cancer Management and Research

DDX5 promotes hepatocellular carcinoma tumorigenesis via Akt signaling pathway

(2018) Ying Xue et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification of lncRNAs and Their Functional Network Associated with Chemoresistance in SW1990/GZ Pancreatic Cancer Cells by RNA Sequencing

(2018) Duguang Li et al.   DNA AND CELL BIOLOGY

The lncRNA NEAT1 activates Wnt/β-catenin signaling and promotes colorectal cancer progression via interacting with DDX5

(2018) Meng Zhang et al.   Journal of Hematology & Oncology

P68 RNA helicase promotes invasion of glioma cells through negatively regulating DUSP5

(2018) Rui Wang et al.   CANCER SCIENCE

DEAD Box Protein 5 Inhibits Liver Tumorigenesis by Stimulating Autophagy via Interaction with p62/SQSTM1

(2018) Hao Zhang et al.   HEPATOLOGY

O-GlcNAcylation promotes colorectal cancer progression by regulating protein stability and potential catcinogenic function of DDX5

(2018) Nan Wu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

An overview of microRNAs: Biology, functions, therapeutics, and analysis methods

(2018) Kioomars Saliminejad et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The role of DEAD-box RNA helicase p68 (DDX5) in the development and treatment of breast cancer

(2018) Vida Hashemi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Post-transcriptional control of miRNA biogenesis

(2018) Gracjan Michlewski et al.   RNA

The DDX5/Dbp2 subfamily of DEAD-box RNA helicases

(2018) Zheng Xing et al.   Wiley Interdisciplinary Reviews-RNA

Knockdown of DDX5 Inhibits the Proliferation and Tumorigenesis in Esophageal Cancer

(2017) Zhenchuan Ma et al.   ONCOLOGY RESEARCH

MiR-132 promotes the proliferation, invasion and migration of human pancreatic carcinoma by inhibition of the tumor suppressor gene PTEN

(2017) Hui Zhang et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

DDX5/p68 associated lncRNA LOC284454 is differentially expressed in human cancers and modulates gene expression

(2017) Monalisa Das et al.   RNA Biology

Proteomic identification of potential biomarkers for cervical squamous cell carcinoma and human papillomavirus infection

(2017) Song Qing et al.   TUMOR BIOLOGY

p68 prompts the epithelial‑mesenchymal transition in cervical cancer cells by transcriptionally activating the TGF‑β1 signaling pathway

(2017) Ming‑Yi Li et al.   Oncology Letters

DDX5 promotes gastric cancer cell proliferation in vitro and in vivo through mTOR signaling pathway

(2017) Cheng Du et al.   Scientific Reports

Upregulation of p72 enhances malignant migration and invasion of glioma cells by repressing Beclin1 expression

(2016) Zhenxing Zhang et al.   BIOCHEMISTRY-MOSCOW

The miRNA biogenesis factors, p72/DDX17 and KHSRP regulate the protein level of Ago2 in human cells

(2016) Patrick Connerty et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

DDX17 (P72), a Sox2 binding partner, promotes stem-like features conferred by Sox2 in a small cell population in estrogen receptor-positive breast cancer

(2016) H. Alqahtani et al.   CELLULAR SIGNALLING

The DEAD box protein p68: a novel coactivator of Stat3 in mediating oncogenesis

(2016) M Sarkar et al.   ONCOGENE

Resveratrol directly targets DDX5 resulting in suppression of the mTORC1 pathway in prostate cancer

(2016) T Taniguchi et al.   Cell Death & Disease

The loop structure and the RNA helicase p72/DDX17 influence the processing efficiency of the mice miR-132

(2016) Judit Remenyi et al.   Scientific Reports

DDX5 promotes proliferation and tumorigenesis of non-small-cell lung cancer cells by activating β-catenin signaling pathway

(2015) Zhendong Wang et al.   CANCER SCIENCE

Oncogenic c-Myc-induced lymphomagenesis is inhibited non-redundantly by the p19Arf–Mdm2–p53 and RP–Mdm2–p53 pathways

(2015) X Meng et al.   ONCOGENE

The DEAD box protein p68: a crucial regulator of AKT/FOXO3a signaling axis in oncogenesis

(2015) M Sarkar et al.   ONCOGENE

Association of the Long Non-coding RNA Steroid Receptor RNA Activator (SRA) with TrxG and PRC2 Complexes

(2015) Patompon Wongtrakoongate et al.   PLoS Genetics

Hippo Signaling Regulates Microprocessor and Links Cell-Density-Dependent miRNA Biogenesis to Cancer

(2014) Masaki Mori et al.   CELL

Arf tumor suppressor disrupts the oncogenic positive feedback loop including c-Myc and DDX5

(2014) K Tago et al.   ONCOGENE

RNA Helicases DDX5 and DDX17 Dynamically Orchestrate Transcription, miRNA, and Splicing Programs in Cell Differentiation

(2014) Etienne Dardenne et al.   Cell Reports

Acquired Dependence of Acute Myeloid Leukemia on the DEAD-Box RNA Helicase DDX5

(2014) Anthony Mazurek et al.   Cell Reports

The DEAD box proteins DDX5 (p68) and DDX17 (p72): Multi-tasking transcriptional regulators

(2013) Frances V. Fuller-Pace   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

RNA helicase Ddx5 and the noncoding RNA SRA act as coactivators in the Notch signaling pathway

(2013) Claudia Jung et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The RNA helicase Ddx5/p68 binds to hUpf3 and enhances NMD of Ddx17/p72 and Smg5 mRNA

(2013) Verena Geißler et al.   NUCLEIC ACIDS RESEARCH

The Ddx5 and Ddx17 RNA helicases are cornerstones in the complex regulatory array of steroid hormone-signaling pathways

(2013) Samaan Samaan et al.   NUCLEIC ACIDS RESEARCH

Phosphorylation of P68 RNA Helicase by P38 MAP kinase contributes to colon cancer cells apoptosis induced by oxaliplatin

(2012) Heena Dey et al.   BMC CELL BIOLOGY

mrhl RNA, a Long Noncoding RNA, Negatively Regulates Wnt Signaling through Its Protein Partner Ddx5/p68 in Mouse Spermatogonial Cells

(2012) G. Arun et al.   MOLECULAR AND CELLULAR BIOLOGY

DDX5 is a multifunctional co-activator of steroid hormone receptors

(2012) Martin Wagner et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Splicing switch of an epigenetic regulator by RNA helicases promotes tumor-cell invasiveness

(2012) Etienne Dardenne et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

p68 RNA helicase promotes glioma cell proliferation in vitro and in vivo via direct regulation of NF- B transcription factor p50

(2012) R. Wang et al.   NEURO-ONCOLOGY

DDX5 is a positive regulator of oncogenic NOTCH1 signaling in T cell acute lymphoblastic leukemia

(2012) S Lin et al.   ONCOGENE

The RNA helicase p68 (DDX5) is selectively required for the induction of p53-dependent p21 expression and cell-cycle arrest after DNA damage

(2012) S M Nicol et al.   ONCOGENE

Dual role of the ddx5/ddx17 RNA helicases in the control of the pro-migratory NFAT5 transcription factor

(2012) S Germann et al.   ONCOGENE

DDX5 Regulates DNA Replication and Is Required for Cell Proliferation in a Subset of Breast Cancer Cells

(2012) Anthony Mazurek et al.   Cancer Discovery

RNA Helicase DDX5 Is a p53-Independent Target of ARF That Participates in Ribosome Biogenesis

(2011) A. J. Saporita et al.   CANCER RESEARCH

RNA helicases p68 and p72: multifunctional proteins with important implications for cancer development

(2011) Frances V Fuller-Pace et al.   Future Oncology

Pleiotropic Effects of p300-mediated Acetylation on p68 and p72 RNA Helicase

(2010) Steven M. Mooney et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylated p68 RNA helicase activates snail1 transcription by promoting HDAC1 dissociation from the snail1 promoter

(2010) C L Carter et al.   ONCOGENE

The RNA helicase p68 modulates expression and function of the Δ133 isoform(s) of p53 and is inversely associated with Δ133p53 expression in breast cancer

(2010) H C Moore et al.   ONCOGENE

Sumoylation of p68 and p72 RNA Helicases Affects Protein Stability and Transactivation Potential

(2009) Steven M. Mooney et al.   BIOCHEMISTRY

P68 RNA helicase is a nucleocytoplasmic shuttling protein

(2009) Haizhen Wang et al.   CELL RESEARCH

The DEAD-box protein p72 regulates ERα-/oestrogen-dependent transcription and cell growth and is associated with improved survival in ERα-positive breast cancer

(2009) N C Wortham et al.   ONCOGENE

The RNA Helicase p68 Is a Novel Androgen Receptor Coactivator Involved in Splicing and Is Overexpressed in Prostate Cancer

(2008) E. L. Clark et al.   CANCER RESEARCH

SMAD proteins control DROSHA-mediated microRNA maturation

(2008) Brandi N. Davis et al.   NATURE

P68 RNA Helicase (DDX5) Alters Activity of Cis- and Trans-Acting Factors of the Alternative Splicing of H-Ras

(2008) Maria Camats et al.   PLoS One

The let-7 family of microRNAs

(2008) Sarah Roush et al.   TRENDS IN CELL BIOLOGY

p68 (Ddx5) interacts with Runx2 and regulates osteoblast differentiation

(2007) Eric D. Jensen et al.   JOURNAL OF CELLULAR BIOCHEMISTRY