Article
Reproductive Biology
Yinling Zhao, Donglan Yuan, Dandan Zhu, Tianhui Xu, Aihua Huang, Li Jiang, Chiwen Liu, Hua Qian, Xinhua Bu
Summary: In this study, it was found that MSC-AS1 and miR-425-5p were aberrantly expressed in ovarian cancer, with MSC-AS1 inhibiting ovarian cancer progression by modulating the levels of miR-425-5p. These findings may provide a promising therapeutic target for the treatment of ovarian cancer.
JOURNAL OF OVARIAN RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Zhang Aichen, Wang Kun, Sun Xiaochun, Tong Lingling
Summary: FGD5-AS1 is markedly up-regulated in ovarian cancer and its high expression is associated with positive local lymph node metastasis and higher T stage in patients. Mechanistically, FGD5-AS1 promotes the proliferation, migration, and invasion of OC cells by targeting miR-142-5p.
Article
Biotechnology & Applied Microbiology
Xinyu Tang, YiHe Wu, Jie Yang, Wenyu Zhu
Summary: The COX10-AS1/miR-142-5p/PAICS axis, identified as a ceRNA regulatory network, influences the apoptosis and proliferation of non-small cell lung cancer cells by activating the glycolysis pathway.
Article
Medicine, Research & Experimental
Tae Won Kim, Haein Ji, Nak Hyeon Yun, Chang Hoon Shin, Hyeon Ho Kim, Yong Beom Cho
Summary: This study identified AFAP1-AS1 and MLK7-AS1 as ceRNAs that promote the progression of colorectal cancer by reducing the levels of tumor-suppressing miRNAs miR-149-5p and miR-485-5p.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2023)
Article
Biochemistry & Molecular Biology
Yun Jiang, Kun Wang, Xiaoning Lu, Yongliang Wang, Jianle Chen
Summary: CAFs are key stromal cells in the tumor microenvironment, playing a crucial role in regulating lung cancer development. Through exosome-mediated miR-142-5p/ PD-L1 axis, CAFs promote tumor growth and suppress immune killing of lung cancer cells, providing potential opportunities for diagnosis and treatment of lung cancer.
MOLECULAR IMMUNOLOGY
(2021)
Article
Genetics & Heredity
Tamyres Mingorance Carvalho, Guillermo Ortiz Brasil, Tayana Schultz Jucoski, Douglas Adamoski, Rubens Silveira de Lima, Cleverton C. Spautz, Karina Furlan Anselmi, Patricia Midori Murobushi Ozawa, Iglenir Joao Cavalli, Jaqueline Carvalho de Oliveira, Daniela Fiori Gradia, Enilze Maria de Souza Fonseca Ribeiro
Summary: The study identified miR-320a and miR-4433b-5p as highly specific and sensitive biomarkers for distinguishing breast cancer from controls, regardless of sample source. In tissues, lower levels of miR-150-5p and higher levels of miR-142-5p were significant biomarkers. Combining these miRNAs in panels improved the ability to differentiate breast cancer patients from controls.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
TianWei Guo, Wei Wang, YueXia Ji, Min Zhang, GuoYing Xu, Sen Lin
Summary: The study revealed that PROX1-AS1 plays a role in gastric cancer progression through the miR-877-5p/PD-L1 axis, suggesting it may serve as a new therapeutic target for the diagnosis and treatment of GC patients.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Haixiao Wang, Guangli Sun, Penghui Xu, Jialun Lv, Xing Zhang, Lu Zhang, Sen Wang, Jiacheng Cao, Yiwen Xia, Zhe Xuan, Bowen Li, Xiaoxu Huang, Tianlu Jiang, Lang Fang, Zekuan Xu
Summary: Our study revealed that circTMEM87A is upregulated in GC tissues and cell lines, and its high expression is associated with poor prognosis in GC patients. CircTMEM87A functions as an oncogene by sponging miR-142-5p to regulate ULK1 expression and promote GC progression, indicating its potential as a prognostic biomarker and therapeutic target in GC.
JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Jiewen Su, Dawei Chen, Yi Ruan, Yuan Tian, Kaiji Lv, Xinhua Zhou, Dongjian Ying, Yeting Lu
Summary: Studies have shown that lncRNA MBNL1-AS1 participates in the progression of gastric cancer by regulating the miR-424-5p/Smad7 axis, thus activating the TGF-beta/EMT pathways. This finding may provide a potential marker for gastric cancer patients.
Article
Oncology
Xianguo Meng, Wei Li, Ziqi Meng, Yan Li
Summary: This study reveals the important role of a newly discovered circRNA, circBRWD3, in the tumorigenesis and progression of breast cancer. CircBRWD3 expression is upregulated in breast cancer tissues and is associated with poor prognosis. Mechanistically, circBRWD3 regulates the miR-142-3p, miR-142-5p, and RAC1/PAK1 signaling pathway to promote tumor formation and progression. Additionally, circBRWD3 expression is positively regulated by EIF4A3. These findings provide valuable scientific data for the early diagnosis and therapy of breast cancer patients.
Article
Biotechnology & Applied Microbiology
Zhien Zhou, Xingcheng Wu, Yi Zhou, Weigang Yan
Summary: The study showed that ADAMTS9-AS1 is down-regulated in prostate cancer, and its overexpression can suppress cell proliferation and induce apoptosis. Furthermore, miR-142-5p mimic and si-CCND1 can weaken the inhibitory effects of ADAMTS9-AS1 overexpression on prostate cancer cell growth.
JOURNAL OF GENE MEDICINE
(2021)
Article
Medicine, Research & Experimental
Feng Zhu, Rong Niu, Xiaoliang Shao, Xiaonan Shao
Summary: The study revealed that FGD5-AS1 increases resistance of LAD to DDP via the miR-142/PD-L1 axis, suggesting a novel treatment approach for patients with DDP-resistant LAD.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Medicine, Research & Experimental
Yuqin Ding, Yuting Huang, Fanrong Zhang, Lijie Gong, Chenlu Liang, Kaijing Ding, Xiangming He, Xiaowen Ding, Yiding Chen
Summary: Our study investigated the role of lncRNA TDRKH-AS1 in breast cancer (BC). We found that TDRKH-AS1 was upregulated in BC tissues and cell lines, and its high expression was associated with advanced stages and poor outcomes in BC patients. Knockdown of TDRKH-AS1 inhibited BC cell proliferation and invasion. Mechanistically, TDRKH-AS1 acted as a sponge for miR-134-5p, thereby promoting the expression of cAMP response element-binding protein 1 (CREB1), a downstream target of miR-134-5p. In vivo experiments confirmed the tumor-promoting role of TDRKH-AS1 in BC.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Delphine Garnier, Edward Ratcliffe, Josephine Briand, Pierre-Francois Cartron, Lisa Oliver, Francois M. Vallette
Summary: Glioblastoma stem cells (GSCs) can activate mesenchymal stem cells (MSCs) into cancer-associated fibroblasts (CAFs) via extracellular vesicles (EVs) and promote tumor progression through miRNA-mediated mechanisms.
Article
Medicine, Research & Experimental
Tingting Xu, Mengyan Xie, Xinming Jing, Huning Jiang, Xi Wu, Xinzhu Wang, Yongqian Shu
Summary: In this study, bioinformatic analysis and experimental validation revealed that miR-26b-5p was downregulated in Helicobacter pylori-infected gastric cancer (GC) cells and GC tissues. Low expression of miR-26b-5p promoted GC proliferation in vitro and in vivo and was associated with poor prognosis in GC patients. Mechanistically, miR-26b-5p directly targeted PDE4B and CDK8, leading to decreased phosphorylation and nuclear translocation of STAT3, which regulated GC proliferation. Importantly, miR-26b-5p was transcriptionally suppressed by STAT3, forming a miR-26b-5p-PDE4B/CDK8-STAT3 positive feedback loop. This newly identified feedback loop may serve as a promising therapeutic target for inflammation-related GC progression.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
