The role of DEAD-box RNA helicase p68 (DDX5) in the development and treatment of breast cancer

TNF-related apoptosis-inducing ligand (TRAIL) as the potential therapeutic target in hematological malignancies

(2018) Adel Naimi et al.   BIOMEDICINE & PHARMACOTHERAPY

CD73 specific siRNA loaded chitosan lactate nanoparticles potentiate the antitumor effect of a dendritic cell vaccine in 4T1 breast cancer bearing mice

(2017) Farhad Jadidi-Niaragh et al.   JOURNAL OF CONTROLLED RELEASE

DDX5/p68 associated lncRNA LOC284454 is differentially expressed in human cancers and modulates gene expression

(2017) Monalisa Das et al.   RNA Biology

Inhibition of HIF-1α enhances anti-tumor effects of dendritic cell-based vaccination in a mouse model of breast cancer

(2016) Nasim Kheshtchin et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

LMTK3 escapes tumour suppressor miRNAs via sequestration of DDX5

(2016) Jimmy Jacob et al.   CANCER LETTERS

DEAD box RNA helicases crucial regulators of gene expression and oncogenesis

(2016) Mrinal Kanti Ghosh   Frontiers in Bioscience-Landmark

The DEAD box protein p68: a novel coactivator of Stat3 in mediating oncogenesis

(2016) M Sarkar et al.   ONCOGENE

Mechanisms of tumor cell resistance to the current targeted-therapy agents

(2016) Gholamreza Khamisipour et al.   TUMOR BIOLOGY

Constitutive activation of STAT3 in breast cancer cells: A review

(2015) Kasturi Banerjee et al.   INTERNATIONAL JOURNAL OF CANCER

A Novel Anti-Cancer Agent, 1-(3,5-Dimethoxyphenyl)-4-[(6-Fluoro-2-Methoxyquinoxalin-3-yl)Aminocarbonyl] Piperazine (RX-5902), Interferes With β-Catenin Function Through Y593 Phospho-p68 RNA Helicase

(2015) Gina Chun Kost et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

DDX5/p68 RNA helicase expression is essential for initiating adipogenesis

(2015) Nardev Ramanathan et al.   Lipids in Health and Disease

Beyond β-catenin: prospects for a larger catenin network in the nucleus

(2015) Pierre D. McCrea et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The DEAD box protein p68: a crucial regulator of AKT/FOXO3a signaling axis in oncogenesis

(2015) M Sarkar et al.   ONCOGENE

The RNA helicase/transcriptional co-regulator, p68 (DDX5), stimulates expression of oncogenic protein kinase, Polo-like kinase-1 (PLK1), and is associated with elevated PLK1 levels in human breast cancers

(2014) R Sumanth Iyer et al.   CELL CYCLE

P68 RNA helicase as a molecular target for cancer therapy

(2014) Ting-Yu Dai et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

STAT3 Target Genes Relevant to Human Cancers

(2014) Richard Carpenter et al.   Cancers

Looking back on the birth of DEAD-box RNA helicases

(2013) Patrick Linder et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Downregulation of the microRNA biogenesis components and its association with poor prognosis in hepatocellular carcinoma

(2013) Noriyuki Kitagawa et al.   CANCER SCIENCE

Pharmacological modulation of beta-catenin and its applications in cancer therapy

(2013) Ravi Thakur et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The Ddx5 and Ddx17 RNA helicases are cornerstones in the complex regulatory array of steroid hormone-signaling pathways

(2013) Samaan Samaan et al.   NUCLEIC ACIDS RESEARCH

DEAD box RNA helicase functions in cancer

(2013) Frances V. Fuller-Pace   RNA Biology

Role of STAT3 in Cancer Metastasis and Translational Advances

(2013) Mohammad Zahid Kamran et al.   Biomed Research International

Histone deacetylase inhibitor induction of epithelial–mesenchymal transitions via up-regulation of Snail facilitates cancer progression

(2012) Guan-Min Jiang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Overexpression of RNA helicase p68 protein in cutaneous squamous cell carcinoma

(2012) S. J. Wang et al.   CLINICAL AND EXPERIMENTAL DERMATOLOGY

Structural basis for RNA-duplex recognition and unwinding by the DEAD-box helicase Mss116p

(2012) Anna L. Mallam et al.   NATURE

Splicing switch of an epigenetic regulator by RNA helicases promotes tumor-cell invasiveness

(2012) Etienne Dardenne et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Direct regulation of microRNA biogenesis and expression by estrogen receptor beta in hormone-responsive breast cancer

(2012) O Paris et al.   ONCOGENE

DDX5 is a positive regulator of oncogenic NOTCH1 signaling in T cell acute lymphoblastic leukemia

(2012) S Lin et al.   ONCOGENE

The RNA helicase p68 (DDX5) is selectively required for the induction of p53-dependent p21 expression and cell-cycle arrest after DNA damage

(2012) S M Nicol et al.   ONCOGENE

DDX5 Regulates DNA Replication and Is Required for Cell Proliferation in a Subset of Breast Cancer Cells

(2012) Anthony Mazurek et al.   Cancer Discovery

RNA helicases p68 and p72: multifunctional proteins with important implications for cancer development

(2011) Frances V Fuller-Pace et al.   Future Oncology

RNA Helicase DDX5 Regulates MicroRNA Expression and Contributes to Cytoskeletal Reorganization in Basal Breast Cancer Cells

(2011) Daojing Wang et al.   MOLECULAR & CELLULAR PROTEOMICS

Enhancement of Canonical Wnt/β-Catenin Signaling Activity by HCV Core Protein Promotes Cell Growth of Hepatocellular Carcinoma Cells

(2011) Jiao Liu et al.   PLoS One

Mediation of CTCF transcriptional insulation by DEAD-box RNA-binding protein p68 and steroid receptor RNA activator SRA

(2010) H. Yao et al.   GENES & DEVELOPMENT

Pleiotropic Effects of p300-mediated Acetylation on p68 and p72 RNA Helicase

(2010) Steven M. Mooney et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylated p68 RNA helicase activates snail1 transcription by promoting HDAC1 dissociation from the snail1 promoter

(2010) C L Carter et al.   ONCOGENE

The RNA helicase p68 modulates expression and function of the Δ133 isoform(s) of p53 and is inversely associated with Δ133p53 expression in breast cancer

(2010) H C Moore et al.   ONCOGENE

Human DEAD-box protein 3 has multiple functions in gene regulation and cell cycle control and is a prime target for viral manipulation

(2009) Martina Schröder   BIOCHEMICAL PHARMACOLOGY

Regulation of bone development and extracellular matrix protein genes by RUNX2

(2009) Toshihisa Komori   CELL AND TISSUE RESEARCH

P68 RNA helicase is a nucleocytoplasmic shuttling protein

(2009) Haizhen Wang et al.   CELL RESEARCH

Motif III in Superfamily 2 “Helicases” Helps Convert the Binding Energy of ATP into a High-Affinity RNA Binding Site in the Yeast DEAD-Box Protein Ded1

(2009) Josette Banroques et al.   JOURNAL OF MOLECULAR BIOLOGY

The DEAD-box protein p72 regulates ERα-/oestrogen-dependent transcription and cell growth and is associated with improved survival in ERα-positive breast cancer

(2009) N C Wortham et al.   ONCOGENE

The RNA Helicase p68 Is a Novel Androgen Receptor Coactivator Involved in Splicing and Is Overexpressed in Prostate Cancer

(2008) E. L. Clark et al.   CANCER RESEARCH

A Conserved Phenylalanine of Motif IV in Superfamily 2 Helicases Is Required for Cooperative, ATP-Dependent Binding of RNA Substrates in DEAD-Box Proteins

(2008) J. Banroques et al.   MOLECULAR AND CELLULAR BIOLOGY

p68 (Ddx5) interacts with Runx2 and regulates osteoblast differentiation

(2007) Eric D. Jensen et al.   JOURNAL OF CELLULAR BIOCHEMISTRY