Regeneration or Repair? The Role of Alveolar Epithelial Cells in the Pathogenesis of Idiopathic Pulmonary Fibrosis (IPF)

Idiopathic Pulmonary Fibrosis (an Update) and Progressive Pulmonary Fibrosis in Adults: An Official ATS/ERS/JRS/ALAT Clinical Practice Guideline

(2022) Ganesh Raghu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Human distal airways contain a multipotent secretory cell that can regenerate alveoli

(2022) Maria C. Basil et al.   NATURE

Loss of MT1-MMP in Alveolar Epithelial Cells Exacerbates Pulmonary Fibrosis

(2021) Luis Placido et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Novel insights into surfactant protein C trafficking revealed through the study of a pathogenic mutant

(2021) Jennifer A. Dickens et al.   EUROPEAN RESPIRATORY JOURNAL

Bidirectional epithelial–mesenchymal crosstalk provides self-sustaining profibrotic signals in pulmonary fibrosis

(2021) Liudi Yao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A proteomic atlas of senescence-associated secretomes for aging biomarker development

(2020) Nathan Basisty et al.   PLOS BIOLOGY

Cell senescence and fibrotic lung diseases

(2020) Rui-Ming Liu et al.   EXPERIMENTAL GERONTOLOGY

Cellular Senescence in the Lung: The Central Role of Senescent Epithelial Cells

(2020) Christine Hansel et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Conditional deletion of Nedd4-2 in lung epithelial cells causes progressive pulmonary fibrosis in adult mice

(2020) Julia Duerr et al.   Nature Communications

Circulating matrix metalloproteinases and tissue metalloproteinase inhibitors in patients with idiopathic pulmonary fibrosis in the multicenter IPF-PRO Registry cohort

(2020) Jamie L. Todd et al.   BMC Pulmonary Medicine

Inflammatory Signals Induce AT2 Cell-Derived Damage-Associated Transient Progenitors that Mediate Alveolar Regeneration

(2020) Jinwook Choi et al.   Cell Stem Cell

Induced pluripotent stem cell-derived lung alveolar epithelial type II cells reduce damage in bleomycin-induced lung fibrosis

(2020) Belén Alvarez-Palomo et al.   Stem Cell Research & Therapy

Convergence of therapy-induced senescence (TIS) and EMT in multistep carcinogenesis: current opinions and emerging perspectives

(2020) Mir Mohd Faheem et al.   Cell Death Discovery

Senescence of Alveolar Type 2 Cells Drives Progressive Pulmonary Fibrosis

(2020) Changfu Yao et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Epithelial-to-Mesenchymal Transition as a Possible Therapeutic Target in Fibrotic Disorders

(2020) Jacopo Di Gregorio et al.   Frontiers in Cell and Developmental Biology

Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study

(2019) Jamie N. Justice et al.   EBioMedicine

Cellular senescence and senescence-associated secretory phenotype: comparison of idiopathic pulmonary fibrosis, connective tissue disease-associated interstitial lung disease, and chronic obstructive pulmonary disease

(2019) Ryo Okuda et al.   Journal of Thoracic Disease

Early lineage specification defines alveolar epithelial ontogeny in the murine lung

(2019) David B. Frank et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epithelial–Mesenchymal Transition in the Pathogenesis of Idiopathic Pulmonary Fibrosis

(2019) Francesco Salton et al.   Medicina-Lithuania

Clinical characteristics of patients with familial idiopathic pulmonary fibrosis (f-IPF)

(2019) Ekaterina Krauss et al.   BMC Pulmonary Medicine

Cellular senescence and EMT crosstalk in bleomycin‐induced pathogenesis of pulmonary fibrosis—an in vitro analysis

(2019) Karthika Muthuramalingam et al.   CELL BIOLOGY INTERNATIONAL

Nintedanib with Add-on Pirfenidone in Idiopathic Pulmonary Fibrosis. Results of the INJOURNEY Trial

(2018) Carlo Vancheri et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Inhibition of Radiation-Induced Ccl2 Signaling Protects Lungs from Vascular Dysfunction and Endothelial Cell Loss

(2018) Alina Wiesemann et al.   ANTIOXIDANTS & REDOX SIGNALING

Safety of Nintedanib Added to Pirfenidone Treatment for Idiopathic Pulmonary Fibrosis

(2018) Kevin R. Flaherty et al.   EUROPEAN RESPIRATORY JOURNAL

Effect of Recombinant Human Pentraxin 2 vs Placebo on Change in Forced Vital Capacity in Patients With Idiopathic Pulmonary Fibrosis

(2018) Ganesh Raghu et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Idiopathic Pulmonary Fibrosis

(2018) David J. Lederer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Single-cell Wnt signaling niches maintain stemness of alveolar type 2 cells

(2018) Ahmad N. Nabhan et al.   SCIENCE

Occupational risk factors for idiopathic pulmonary fibrosis in Southern Europe: a case-control study

(2018) Giulia Paolocci et al.   BMC Pulmonary Medicine

Diagnosis of Idiopathic Pulmonary Fibrosis. An Official ATS/ERS/JRS/ALAT Clinical Practice Guideline

(2018) Ganesh Raghu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Paracrine signalling during ZEB1-mediated epithelial–mesenchymal transition augments local myofibroblast differentiation in lung fibrosis

(2018) Liudi Yao et al.   CELL DEATH AND DIFFERENTIATION

Regeneration of the lung alveolus by an evolutionarily conserved epithelial progenitor

(2018) William J. Zacharias et al.   NATURE

Idiopathic pulmonary fibrosis: lessons from clinical trials over the past 25 years

(2017) Ganesh Raghu   EUROPEAN RESPIRATORY JOURNAL

Prospective isolation of NKX2-1–expressing human lung progenitors derived from pluripotent stem cells

(2017) Finn Hawkins et al.   JOURNAL OF CLINICAL INVESTIGATION

Emerging therapies for idiopathic pulmonary fibrosis, a progressive age-related disease

(2017) Ana L. Mora et al.   NATURE REVIEWS DRUG DISCOVERY

Cellular senescence mediates fibrotic pulmonary disease

(2017) Marissa J. Schafer et al.   Nature Communications

Idiopathic pulmonary fibrosis

(2017) Fernando J. Martinez et al.   Nature Reviews Disease Primers

Cellular Senescence: A Translational Perspective

(2017) James L. Kirkland et al.   EBioMedicine

Surfactant dysfunction during overexpression of TGF-β1 precedes profibrotic lung remodeling in vivo

(2016) Elena Lopez-Rodriguez et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Safety and Tolerability of Alveolar Type II Cell Transplantation in Idiopathic Pulmonary Fibrosis

(2016) Anna Serrano-Mollar et al.   CHEST

Signal Transduction Pathways of EMT Induced by TGF-β, SHH, and WNT and Their Crosstalks

(2016) Jingyu Zhang et al.   Journal of Clinical Medicine

Lost after translation: insights from pulmonary surfactant for understanding the role of alveolar epithelial dysfunction and cellular quality control in fibrotic lung disease

(2015) Surafel Mulugeta et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

An Official ATS/ERS/JRS/ALAT Clinical Practice Guideline: Treatment of Idiopathic Pulmonary Fibrosis. An Update of the 2011 Clinical Practice Guideline

(2015) Ganesh Raghu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Matrix Metalloproteinases as Therapeutic Targets for Idiopathic Pulmonary Fibrosis

(2015) Vanessa J. Craig et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Loss of MT1-MMP causes cell senescence and nuclear defects which can be reversed by retinoic acid

(2015) A. Gutierrez-Fernandez et al.   EMBO JOURNAL

The genetic basis of idiopathic pulmonary fibrosis

(2015) Jonathan A. Kropski et al.   EUROPEAN RESPIRATORY JOURNAL

Hox5 Genes Regulate the Wnt2/2b-Bmp4-Signaling Axis during Lung Development

(2015) Steven M. Hrycaj et al.   Cell Reports

Molecular composition of the alveolar lining fluid in the aging lung

(2014) Juan I. Moliva et al.   AGE

Repair and Regeneration of the Respiratory System: Complexity, Plasticity, and Mechanisms of Lung Stem Cell Function

(2014) Brigid L.M. Hogan et al.   Cell Stem Cell

Wnt and FGF mediated epithelial-mesenchymal crosstalk during lung development

(2014) Thomas Volckaert et al.   DEVELOPMENTAL DYNAMICS

Alveolar Type II cell transplantation restores pulmonary surfactant protein levels in lung fibrosis

(2014) Raquel Guillamat-Prats et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Alveolar progenitor and stem cells in lung development, renewal and cancer

(2014) Tushar J. Desai et al.   NATURE

Reconstructing lineage hierarchies of the distal lung epithelium using single-cell RNA-seq

(2014) Barbara Treutlein et al.   NATURE

Lung regeneration: mechanisms, applications and emerging stem cell populations

(2014) Darrell N Kotton et al.   NATURE MEDICINE

A large kindred of pulmonary fibrosis associated with a novel ABCA3 gene variant

(2014) Ilaria Campo et al.   RESPIRATORY RESEARCH

Heterogeneous gene expression signatures correspond to distinct lung pathologies and biomarkers of disease severity in idiopathic pulmonary fibrosis

(2014) Daryle J DePianto et al.   THORAX

An Official American Thoracic Society/European Respiratory Society Statement: Update of the International Multidisciplinary Classification of the Idiopathic Interstitial Pneumonias

(2013) William D. Travis et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Fibrosis of two: Epithelial cell-fibroblast interactions in pulmonary fibrosis

(2013) Norihiko Sakai et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Senescence-associated secretory phenotype in a mouse model of bleomycin-induced lung injury

(2013) Kazutetsu Aoshiba et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Association Between the MUC5B Promoter Polymorphism and Survival in Patients With Idiopathic Pulmonary Fibrosis

(2013) Anna L. Peljto et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Type 2 alveolar cells are stem cells in adult lung

(2013) Christina E. Barkauskas et al.   JOURNAL OF CLINICAL INVESTIGATION

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

(2013) Juan Carlos Acosta et al.   NATURE CELL BIOLOGY

Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis

(2013) Tasha E Fingerlin et al.   NATURE GENETICS

Recombinant human serum amyloid P in healthy volunteers and patients with pulmonary fibrosis

(2013) M.R. Dillingh et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Epithelial–mesenchymal transition in lung development and disease: does it exist and is it important?

(2013) Domokos Bartis et al.   THORAX

Epidemiology of idiopathic pulmonary fibrosis

(2013) Brett Ley et al.   Clinical Epidemiology

Insufficient autophagy in idiopathic pulmonary fibrosis

(2012) Jun Araya et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Acellular Normal and Fibrotic Human Lung Matrices as a Culture System forIn VitroInvestigation

(2012) Adam J. Booth et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Pulmonary fibrosis: patterns and perpetrators

(2012) Paul W. Noble et al.   JOURNAL OF CLINICAL INVESTIGATION

Prednisone, Azathioprine, andN-Acetylcysteine for Pulmonary Fibrosis

(2012)   NEW ENGLAND JOURNAL OF MEDICINE

Signaling Networks Regulating Development of the Lower Respiratory Tract

(2012) D. M. Ornitz et al.   Cold Spring Harbor Perspectives in Biology

TGFβ signaling in lung epithelium regulates bleomycin-induced alveolar injury and fibroblast recruitment

(2011) Amber L. Degryse et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Regulation of alveolar epithelial cell apoptosis and pulmonary fibrosis by coordinate expression of components of the fibrinolytic system

(2011) Yashodhar P. Bhandary et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Telomere Dysfunction Causes Sustained Inflammation in Chronic Obstructive Pulmonary Disease

(2011) Valerie Amsellem et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

An Official ATS/ERS/JRS/ALAT Statement: Idiopathic Pulmonary Fibrosis: Evidence-based Guidelines for Diagnosis and Management

(2011) Ganesh Raghu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Epithelial Progenitor Cells in Lung Development, Maintenance, Repair, and Disease

(2011) Jason R. Rock et al.   Annual Review of Cell and Developmental Biology

Plasma CCN2 (connective tissue growth factor; CTGF) is a potential biomarker in idiopathic pulmonary fibrosis (IPF)

(2011) Masato Kono et al.   CLINICA CHIMICA ACTA

Integrating mechanisms of pulmonary fibrosis

(2011) Thomas A. Wynn   JOURNAL OF EXPERIMENTAL MEDICINE

Ligand-independent transforming growth factor-β type I receptor signalling mediates type I collagen-induced epithelial-mesenchymal transition

(2011) Lucas DeMaio et al.   JOURNAL OF PATHOLOGY

Idiopathic pulmonary fibrosis

(2011) Talmadge E King et al.   LANCET

The rising incidence of idiopathic pulmonary fibrosis in the UK

(2011) V. Navaratnam et al.   THORAX

Accelerated epithelial cell senescence in IPF and the inhibitory role of SIRT6 in TGF-β-induced senescence of human bronchial epithelial cells

(2010) Shunsuke Minagawa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Alveolar Surfactant Homeostasis and the Pathogenesis of Pulmonary Disease

(2010) Jeffrey A. Whitsett et al.   Annual Review of Medicine

Serum Amyloid P Therapeutically Attenuates Murine Bleomycin-Induced Pulmonary Fibrosis via Its Effects on Macrophages

(2010) Lynne A. Murray et al.   PLoS One

The basics of epithelial-mesenchymal transition

(2009) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

Short telomeres are a risk factor for idiopathic pulmonary fibrosis

(2008) J. K. Alder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA