Utility of iPSC-Derived Cells for Disease Modeling, Drug Development, and Cell Therapy
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Title
Utility of iPSC-Derived Cells for Disease Modeling, Drug Development, and Cell Therapy
Authors
Keywords
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Journal
Cells
Volume 11, Issue 11, Pages 1853
Publisher
MDPI AG
Online
2022-06-07
DOI
10.3390/cells11111853
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Note: Only part of the references are listed.- Epicardial injection of allogeneic human-induced-pluripotent stem cell-derived cardiomyocytes in patients with advanced heart failure: protocol for a phase I/IIa dose-escalation clinical trial
- (2022) He Zhang et al. BMJ Open
- Population-based high-throughput toxicity screen of human iPSC-derived cardiomyocytes and neurons
- (2022) Ching Ying Huang et al. Cell Reports
- Antiarrhythmic Hit to Lead Refinement in a Dish Using Patient-Derived iPSC Cardiomyocytes
- (2021) John R. Cashman et al. JOURNAL OF MEDICINAL CHEMISTRY
- Evaluation of the Spanish population coverage of a prospective HLA haplobank of induced pluripotent stem cells
- (2021) Belén Álvarez-Palomo et al. Stem Cell Research & Therapy
- Generation of hypoimmunogenic T cells from genetically engineered allogeneic human induced pluripotent stem cells
- (2021) Bo Wang et al. Nature Biomedical Engineering
- Improved modeling of human AD with an automated culturing platform for iPSC neurons, astrocytes and microglia
- (2021) Reina Bassil et al. Nature Communications
- ERRγ enhances cardiac maturation with T-tubule formation in human iPSC-derived cardiomyocytes
- (2021) Kenji Miki et al. Nature Communications
- Human induced pluripotent stem cell-derived atrial cardiomyocytes carrying an SCN5A mutation identify nitric oxide signaling as a mediator of atrial fibrillation
- (2021) Liang Hong et al. Stem Cell Reports
- Transplantation of human induced pluripotent stem cell-derived cardiomyocytes improves myocardial function and reverses ventricular remodeling in infarcted rat hearts
- (2020) Xumin Guan et al. Stem Cell Research & Therapy
- hiPSC-Derived Cardiomyocyte Model of LQT2 Syndrome Derived from Asymptomatic and Symptomatic Mutation Carriers Reproduces Clinical Differences in Aggregates but Not in Single Cells
- (2020) Disheet Shah et al. Cells
- Modeling Cardiac Disease Mechanisms Using Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Progress, Promises and Challenges
- (2020) Elvira Immacolata Parrotta et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Pre-clinical study of induced pluripotent stem cell-derived dopaminergic progenitor cells for Parkinson’s disease
- (2020) Daisuke Doi et al. Nature Communications
- Genome engineering of induced pluripotent stem cells to manufacture natural killer cell therapies
- (2020) Keerthana Shankar et al. Stem Cell Research & Therapy
- HLA-Matched Allogeneic iPS Cells-Derived RPE Transplantation for Macular Degeneration
- (2020) Sunao Sugita et al. Journal of Clinical Medicine
- Reengineering an Antiarrhythmic Drug Using Patient hiPSC Cardiomyocytes to Improve Therapeutic Potential and Reduce Toxicity
- (2020) Wesley L. McKeithan et al. Cell Stem Cell
- Neuronal defects in a human cellular model of 22q11.2 deletion syndrome
- (2020) Themasap A. Khan et al. NATURE MEDICINE
- iPSC Modeling of RBM20-Deficient DCM Identifies Upregulation of RBM20 as a Therapeutic Strategy
- (2020) Francesca Briganti et al. Cell Reports
- Design of efficacious somatic cell genome editing strategies for recessive and polygenic diseases
- (2020) Jared Carlson-Stevermer et al. Nature Communications
- Cross-Comparison of Human iPSC Motor Neuron Models of Familial and Sporadic ALS Reveals Early and Convergent Transcriptomic Disease Signatures
- (2020) Ritchie Ho et al. Cell Systems
- Pathological priming causes developmental gene network heterochronicity in autistic subject-derived neurons
- (2019) Simon T. Schafer et al. NATURE NEUROSCIENCE
- SHANK2 mutations associated with autism spectrum disorder cause hyperconnectivity of human neurons
- (2019) Kirill Zaslavsky et al. NATURE NEUROSCIENCE
- Drug Screening in Human PSC-Cardiac Organoids Identifies Pro-proliferative Compounds Acting via the Mevalonate Pathway
- (2019) Richard J. Mills et al. Cell Stem Cell
- Targeted Disruption of HLA Genes via CRISPR-Cas9 Generates iPSCs with Enhanced Immune Compatibility
- (2019) Huaigeng Xu et al. Cell Stem Cell
- Identifying the Transcriptome Signatures of Calcium Channel Blockers in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes
- (2019) Chi Keung Lam et al. CIRCULATION RESEARCH
- Human iPSC-Derived Blood-Brain Barrier Chips Enable Disease Modeling and Personalized Medicine Applications
- (2019) Gad D. Vatine et al. Cell Stem Cell
- Functional cardiac fibroblasts derived from human pluripotent stem cells via second heart field progenitors
- (2019) Jianhua Zhang et al. Nature Communications
- The K219T-Lamin mutation induces conduction defects through epigenetic inhibition of SCN5A in human cardiac laminopathy
- (2019) Nicolò Salvarani et al. Nature Communications
- Modeling of LMNA-Related Dilated Cardiomyopathy Using Human Induced Pluripotent Stem Cells
- (2019) Disheet Shah et al. Cells
- Building a Safer and Faster CAR: Seatbelts, Airbags, and CRISPR
- (2018) Miguel-Angel Perales et al. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
- Generation of Hepatic Stellate Cells from Human Pluripotent Stem Cells Enables In Vitro Modeling of Liver Fibrosis
- (2018) Mar Coll et al. Cell Stem Cell
- Generation of spatial-patterned early-developing cardiac organoids using human pluripotent stem cells
- (2018) Plansky Hoang et al. Nature Protocols
- Patient-derived organoids model treatment response of metastatic gastrointestinal cancers
- (2018) Georgios Vlachogiannis et al. SCIENCE
- Repurposing the Cord Blood Bank for Haplobanking of HLA-Homozygous iPSCs and Their Usefulness to Multiple Populations
- (2018) Suji Lee et al. STEM CELLS
- Mitochondrial Dysfunctions Contribute to Hypertrophic Cardiomyopathy in Patient iPSC-Derived Cardiomyocytes with MT-RNR2 Mutation
- (2018) Shishi Li et al. Stem Cell Reports
- Maturation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes by Soluble Factors from Human Mesenchymal Stem Cells
- (2018) Shohei Yoshida et al. MOLECULAR THERAPY
- Modeling sporadic ALS in iPSC-derived motor neurons identifies a potential therapeutic agent
- (2018) Koki Fujimori et al. NATURE MEDICINE
- Mutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral Sclerosis
- (2018) Haibo Wang et al. Nature Communications
- Human iPS cell-derived dopaminergic neurons function in a primate Parkinson’s disease model
- (2017) Tetsuhiro Kikuchi et al. NATURE
- Common genetic variation drives molecular heterogeneity in human iPSCs
- (2017) Helena Kilpinen et al. NATURE
- Autologous Induced Stem-Cell–Derived Retinal Cells for Macular Degeneration
- (2017) Michiko Mandai et al. NEW ENGLAND JOURNAL OF MEDICINE
- Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest
- (2017) Richard J. Mills et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- High-throughput screening of tyrosine kinase inhibitor cardiotoxicity with human induced pluripotent stem cells
- (2017) Arun Sharma et al. Science Translational Medicine
- MHC matching improves engraftment of iPSC-derived neurons in non-human primates
- (2017) Asuka Morizane et al. Nature Communications
- iPSC-Based Compound Screening and In Vitro Trials Identify a Synergistic Anti-amyloid β Combination for Alzheimer’s Disease
- (2017) Takayuki Kondo et al. Cell Reports
- Cerebral organoids reveal early cortical maldevelopment in schizophrenia—computational anatomy and genomics, role of FGFR1
- (2017) E. K. Stachowiak et al. Translational Psychiatry
- NK Cell Alloreactivity against KIR-Ligand-Mismatched HLA-Haploidentical Tissue Derived from HLA Haplotype-Homozygous iPSCs
- (2017) Hiroshi Ichise et al. Stem Cell Reports
- FUS Mutant Human Motoneurons Display Altered Transcriptome and microRNA Pathways with Implications for ALS Pathogenesis
- (2017) Riccardo De Santis et al. Stem Cell Reports
- Transcriptome Profiling of Patient-Specific Human iPSC-Cardiomyocytes Predicts Individual Drug Safety and Efficacy Responses In Vitro
- (2016) Elena Matsa et al. Cell Stem Cell
- Evaluation of TCR Gene Editing Achieved by TALENs, CRISPR/Cas9, and megaTAL Nucleases
- (2016) Mark J Osborn et al. MOLECULAR THERAPY
- Allogeneic transplantation of iPS cell-derived cardiomyocytes regenerates primate hearts
- (2016) Yuji Shiba et al. NATURE
- High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects
- (2016) Benjamin P. Kleinstiver et al. NATURE
- An eye to the future: Researchers debate best path for stem cell–derived therapies
- (2016) Shraddha Chakradhar NATURE MEDICINE
- Making it personal: the prospects for autologous pluripotent stem cell-derived therapies
- (2016) Nicholas F Blair et al. Regenerative Medicine
- Cardiomyocytes Derived from MHC-Homozygous Induced Pluripotent Stem Cells Exhibit Reduced Allogeneic Immunogenicity in MHC-Matched Non-human Primates
- (2016) Takuji Kawamura et al. Stem Cell Reports
- Successful Transplantation of Retinal Pigment Epithelial Cells from MHC Homozygote iPSCs in MHC-Matched Models
- (2016) Sunao Sugita et al. Stem Cell Reports
- Autonomous and Non-autonomous Defects Underlie Hypertrophic Cardiomyopathy in BRAF-Mutant hiPSC-Derived Cardiomyocytes
- (2016) Rebecca Josowitz et al. Stem Cell Reports
- Modeling of lamin A/C mutation premature cardiac aging using patient-specific induced pluripotent stem cells
- (2016) Chung-Wah Siu et al. Aging-US
- Induction of Human iPSC-Derived Cardiomyocyte Proliferation Revealed by Combinatorial Screening in High Density Microbioreactor Arrays
- (2016) Drew M. Titmarsh et al. Scientific Reports
- FOXG1-Dependent Dysregulation of GABA/Glutamate Neuron Differentiation in Autism Spectrum Disorders
- (2015) Jessica Mariani et al. CELL
- New Cell Sources for T Cell Engineering and Adoptive Immunotherapy
- (2015) Maria Themeli et al. Cell Stem Cell
- Elucidating Molecular Phenotypes Caused by the SORL1 Alzheimer’s Disease Genetic Risk Factor Using Human Induced Pluripotent Stem Cells
- (2015) Jessica E. Young et al. Cell Stem Cell
- Functional Analysis and Transcriptomic Profiling of iPSC-Derived Macrophages and Their Application in Modeling Mendelian Disease
- (2015) H. Zhang et al. CIRCULATION RESEARCH
- Human embryonic stem cell-derived retinal pigment epithelium in patients with age-related macular degeneration and Stargardt's macular dystrophy: follow-up of two open-label phase 1/2 studies
- (2015) Steven D Schwartz et al. LANCET
- Engineered CRISPR-Cas9 nucleases with altered PAM specificities
- (2015) Benjamin P. Kleinstiver et al. NATURE
- Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy
- (2015) J. T. Hinson et al. SCIENCE
- Induced Pluripotent Stem Cell-Derived Natural Killer Cells for Treatment of Ovarian Cancer
- (2015) David L. Hermanson et al. STEM CELLS
- Defined MicroRNAs Induce Aspects of Maturation in Mouse and Human Embryonic-Stem-Cell-Derived Cardiomyocytes
- (2015) Desy S. Lee et al. Cell Reports
- APP Metabolism Regulates Tau Proteostasis in Human Cerebral Cortex Neurons
- (2015) Steven Moore et al. Cell Reports
- Proceedings: Human Leukocyte Antigen Haplo-Homozygous Induced Pluripotent Stem Cell Haplobank Modeled After the California Population: Evaluating Matching in a Multiethnic and Admixed Population
- (2015) Derek James Pappas et al. Stem Cells Translational Medicine
- Established Stem Cell Model of Spinal Muscular Atrophy Is Applicable in the Evaluation of the Efficacy of Thyrotropin-Releasing Hormone Analog
- (2015) Kazuki Ohuchi et al. Stem Cells Translational Medicine
- Treatment of Macular Degeneration Using Embryonic Stem Cell-Derived Retinal Pigment Epithelium: Preliminary Results in Asian Patients
- (2015) Won Kyung Song et al. Stem Cell Reports
- Modeling the Early Phenotype at the Neuromuscular Junction of Spinal Muscular Atrophy Using Patient-Derived iPSCs
- (2015) Michiko Yoshida et al. Stem Cell Reports
- Study familial hypertrophic cardiomyopathy using patient-specific induced pluripotent stem cells
- (2014) Lu Han et al. CARDIOVASCULAR RESEARCH
- Re-trafficking of hERG reverses long QT syndrome 2 phenotype in human iPS-derived cardiomyocytes
- (2014) Ashish Mehta et al. CARDIOVASCULAR RESEARCH
- Efficient Ablation of Genes in Human Hematopoietic Stem and Effector Cells using CRISPR/Cas9
- (2014) Pankaj K. Mandal et al. Cell Stem Cell
- Modeling ALS with iPSCs Reveals that Mutant SOD1 Misregulates Neurofilament Balance in Motor Neurons
- (2014) Hong Chen et al. Cell Stem Cell
- Pathways Disrupted in Human ALS Motor Neurons Identified through Genetic Correction of Mutant SOD1
- (2014) Evangelos Kiskinis et al. Cell Stem Cell
- Modeling non-syndromic autism and the impact of TRPC6 disruption in human neurons
- (2014) K Griesi-Oliveira et al. MOLECULAR PSYCHIATRY
- Improving CRISPR-Cas nuclease specificity using truncated guide RNAs
- (2014) Yanfang Fu et al. NATURE BIOTECHNOLOGY
- Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing
- (2014) Shengdar Q Tsai et al. NATURE BIOTECHNOLOGY
- Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification
- (2014) John P Guilinger et al. NATURE BIOTECHNOLOGY
- Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases
- (2014) Richard L Frock et al. NATURE BIOTECHNOLOGY
- CRISPR/Cas9 systems have off-target activity with insertions or deletions between target DNA and guide RNA sequences
- (2014) Y. Lin et al. NUCLEIC ACIDS RESEARCH
- Parkin Mutations Reduce the Complexity of Neuronal Processes in iPSC-Derived Human Neurons
- (2014) Yong Ren et al. STEM CELLS
- Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity
- (2013) F. Ann Ran et al. CELL
- Toward the Development of a Global Induced Pluripotent Stem Cell Library
- (2013) Marc Turner et al. Cell Stem Cell
- Lack of Immune Response to Differentiated Cells Derived from Syngeneic Induced Pluripotent Stem Cells
- (2013) Prajna Guha et al. Cell Stem Cell
- Modeling Alzheimer’s Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness
- (2013) Takayuki Kondo et al. Cell Stem Cell
- Abnormal Calcium Handling Properties Underlie Familial Hypertrophic Cardiomyopathy Pathology in Patient-Specific Induced Pluripotent Stem Cells
- (2013) Feng Lan et al. Cell Stem Cell
- Modeling of Arrhythmogenic Right Ventricular Cardiomyopathy With Human Induced Pluripotent Stem Cells
- (2013) Oren Caspi et al. Circulation-Cardiovascular Genetics
- HLA Engineering of Human Pluripotent Stem Cells
- (2013) Laura Riolobos et al. MOLECULAR THERAPY
- Cerebral organoids model human brain development and microcephaly
- (2013) Madeline A. Lancaster et al. NATURE
- Generation of tumor-targeted human T lymphocytes from induced pluripotent stem cells for cancer therapy
- (2013) Maria Themeli et al. NATURE BIOTECHNOLOGY
- DNA targeting specificity of RNA-guided Cas9 nucleases
- (2013) Patrick D Hsu et al. NATURE BIOTECHNOLOGY
- The Presenilin-1 ΔE9 Mutation Results in Reduced γ-Secretase Activity, but Not Total Loss of PS1 Function, in Isogenic Human Stem Cells
- (2013) Grace Woodruff et al. Cell Reports
- Disease characterization using LQTS-specific induced pluripotent stem cells
- (2012) Toru Egashira et al. CARDIOVASCULAR RESEARCH
- Generating an iPSC Bank for HLA-Matched Tissue Transplantation Based on Known Donor and Recipient HLA Types
- (2012) Craig J. Taylor et al. Cell Stem Cell
- Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability
- (2012) B. Bilican et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Modeling human cortical development in vitro using induced pluripotent stem cells
- (2012) J. Mariani et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Patient-Specific Induced Pluripotent Stem Cells as a Model for Familial Dilated Cardiomyopathy
- (2012) N. Sun et al. Science Translational Medicine
- Pharmacological Rescue of Mitochondrial Deficits in iPSC-Derived Neural Cells from Patients with Familial Parkinson's Disease
- (2012) O. Cooper et al. Science Translational Medicine
- Parkin controls dopamine utilization in human midbrain dopaminergic neurons derived from induced pluripotent stem cells
- (2012) Houbo Jiang et al. Nature Communications
- Drug evaluation in cardiomyocytes derived from human induced pluripotent stem cells carrying a long QT syndrome type 2 mutation
- (2011) Elena Matsa et al. EUROPEAN HEART JOURNAL
- Modelling the long QT syndrome with induced pluripotent stem cells
- (2011) Ilanit Itzhaki et al. NATURE
- A more efficient method to generate integration-free human iPS cells
- (2011) Keisuke Okita et al. NATURE METHODS
- Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus
- (2011) Michael J. Devine et al. Nature Communications
- NKAML: A Pilot Study to Determine the Safety and Feasibility of Haploidentical Natural Killer Cell Transplantation in Childhood Acute Myeloid Leukemia
- (2010) Jeffrey E. Rubnitz et al. JOURNAL OF CLINICAL ONCOLOGY
- Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome
- (2010) Xonia Carvajal-Vergara et al. NATURE
- Patient-Specific Induced Pluripotent Stem-Cell Models for Long-QT Syndrome
- (2010) Alessandra Moretti et al. NEW ENGLAND JOURNAL OF MEDICINE
- Induced pluripotent stem cells from a spinal muscular atrophy patient
- (2008) Allison D. Ebert et al. NATURE
- A European study of HLA-B in Stevens???Johnson syndrome and toxic epidermal necrolysis related to five high-risk drugs
- (2008) Christine Lonjou et al. Pharmacogenetics and Genomics
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