Genome engineering of induced pluripotent stem cells to manufacture natural killer cell therapies
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Title
Genome engineering of induced pluripotent stem cells to manufacture natural killer cell therapies
Authors
Keywords
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Journal
Stem Cell Research & Therapy
Volume 11, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2020-06-16
DOI
10.1186/s13287-020-01741-4
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Note: Only part of the references are listed.- Deletion of CISH in Human Pluripotent Stem Cell-Derived Natural Killer Cells Enhances Anti-Tumor Activity Via Metabolic Reprogramming
- (2020) Huang Zhu et al. BLOOD
- Use of CAR-Transduced Natural Killer Cells in CD19-Positive Lymphoid Tumors
- (2020) Enli Liu et al. NEW ENGLAND JOURNAL OF MEDICINE
- Potently Cytotoxic Natural Killer Cells Initially Emerge from Erythro-Myeloid Progenitors during Mammalian Development
- (2020) Carissa Dege et al. DEVELOPMENTAL CELL
- Programmed cell death protein 1 on natural killer cells: fact or fiction?
- (2020) Monica M. Cho et al. JOURNAL OF CLINICAL INVESTIGATION
- Analysis of ex vivo expanded and activated clinical-grade human NK cells after cryopreservation
- (2020) Sudarshawn N. Damodharan et al. CYTOTHERAPY
- Cancer statistics, 2019
- (2019) Rebecca L. Siegel et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Current Challenges in Cancer Immunotherapy: Multimodal Approaches to Improve Efficacy and Patient Response Rates
- (2019) Manpreet Sambi et al. Journal of Oncology
- Engineering the TGFβ receptor to Enhance the Therapeutic Potential of Natural Killer Cells as an Immunotherapy for Neuroblastoma
- (2019) Rachel A Burga et al. CLINICAL CANCER RESEARCH
- A gene signature predicting natural killer cell infiltration and improved survival in melanoma patients
- (2019) Joseph Cursons et al. Cancer Immunology Research
- Discovery of a novel natural killer cell line with distinct immunostimulatory and proliferative potential as an alternative platform for cancer immunotherapy
- (2019) Hyun Gul Yang et al. Journal for ImmunoTherapy of Cancer
- Medulloblastoma rendered susceptible to NK-cell attack by TGFβ neutralization
- (2019) Allison B. Powell et al. Journal of Translational Medicine
- Engineered T Cell Therapy for Cancer in the Clinic
- (2019) Lijun Zhao et al. Frontiers in Immunology
- Pluripotent stem cell–derived NK cells with high-affinity noncleavable CD16a mediate improved antitumor activity
- (2019) Huang Zhu et al. BLOOD
- Human iPSC-Derived Natural Killer Cells Engineered with Chimeric Antigen Receptors Enhance Anti-tumor Activity
- (2018) Ye Li et al. Cell Stem Cell
- Shedding of CD16 disassembles the NK cell immune synapse and boosts serial engagement of target cells
- (2018) Katja Srpan et al. JOURNAL OF CELL BIOLOGY
- Blockade of the checkpoint receptor TIGIT prevents NK cell exhaustion and elicits potent anti-tumor immunity
- (2018) Qing Zhang et al. NATURE IMMUNOLOGY
- Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia
- (2018) Shannon L. Maude et al. NEW ENGLAND JOURNAL OF MEDICINE
- An Uncoupling of Canonical Phenotypic Markers and Functional Potency of Ex Vivo-Expanded Natural Killer Cells
- (2018) Nicole A. P. Lieberman et al. Frontiers in Immunology
- Adoptive immunotherapy with haploidentical natural killer cells and Anti-GD2 monoclonal antibody m3F8 for resistant neuroblastoma: Results of a phase I study
- (2018) Shakeel Modak et al. OncoImmunology
- Enhancing T Cell Receptor Stability in Rejuvenated iPSC-Derived T Cells Improves Their Use in Cancer Immunotherapy
- (2018) Atsutaka Minagawa et al. Cell Stem Cell
- Long-term safety and activity of axicabtagene ciloleucel in refractory large B-cell lymphoma (ZUMA-1): a single-arm, multicentre, phase 1–2 trial
- (2018) Frederick L Locke et al. LANCET ONCOLOGY
- Tisagenlecleucel in Adult Relapsed or Refractory Diffuse Large B-Cell Lymphoma
- (2018) Stephen J. Schuster et al. NEW ENGLAND JOURNAL OF MEDICINE
- Analysis of Single-Cell RNA-Seq Identifies Cell-Cell Communication Associated with Tumor Characteristics
- (2018) Manu P. Kumar et al. Cell Reports
- Principles of Immunotherapy: Implications for Treatment Strategies in Cancer and Infectious Diseases
- (2018) Krupa Naran et al. Frontiers in Microbiology
- Expression of a Recombinant High Affinity IgG Fc Receptor by Engineered NK Cells as a Docking Platform for Therapeutic mAbs to Target Cancer Cells
- (2018) Kristin M. Snyder et al. Frontiers in Immunology
- Natural killer-92 cells maintain cytotoxic activity after long-term cryopreservation in novel DMSO-free media
- (2017) Shannon Pasley et al. IMMUNOLOGY LETTERS
- Cord blood NK cells engineered to express IL-15 and a CD19-targeted CAR show long-term persistence and potent antitumor activity
- (2017) E Liu et al. LEUKEMIA
- Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma
- (2017) Sattva S. Neelapu et al. NEW ENGLAND JOURNAL OF MEDICINE
- A phase I trial of NK-92 cells for refractory hematological malignancies relapsing after autologous hematopoietic cell transplantation shows safety and evidence of efficacy
- (2017) Brent A. Williams et al. Oncotarget
- Generation of “Off-the-Shelf” Natural Killer Cells from Peripheral Blood Cell-Derived Induced Pluripotent Stem Cells
- (2017) Jieming Zeng et al. Stem Cell Reports
- Phase II Study of Haploidentical Natural Killer Cell Infusion for Treatment of Relapsed or Persistent Myeloid Malignancies Following Allogeneic Hematopoietic Cell Transplantation
- (2016) Brian C. Shaffer et al. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
- Haploidentical Natural Killer Cells Infused before Allogeneic Stem Cell Transplantation for Myeloid Malignancies: A Phase I Trial
- (2016) Dean A. Lee et al. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
- CIS is a potent checkpoint in NK cell–mediated tumor immunity
- (2016) Rebecca B Delconte et al. NATURE IMMUNOLOGY
- Cytokine-induced memory-like natural killer cells exhibit enhanced responses against myeloid leukemia
- (2016) Rizwan Romee et al. Science Translational Medicine
- Natural Killer Cells for Immunotherapy – Advantages of the NK-92 Cell Line over Blood NK Cells
- (2016) Hans Klingemann et al. Frontiers in Immunology
- Clinical manufacturing of CAR T cells: foundation of a promising therapy
- (2016) Xiuyan Wang et al. Molecular Therapy-Oncolytics
- Efficient Killing of High Risk Neuroblastoma Using Natural Killer Cells Activated by Plasmacytoid Dendritic Cells
- (2016) Martine Cordeau et al. PLoS One
- CD16 is indispensable for antibody-dependent cellular cytotoxicity by human monocytes
- (2016) Wei Hseun Yeap et al. Scientific Reports
- Ex Vivo–expanded Natural Killer Cells Demonstrate Robust Proliferation In Vivo in High-risk Relapsed Multiple Myeloma Patients
- (2015) Susann Szmania et al. JOURNAL OF IMMUNOTHERAPY
- Induced Pluripotent Stem Cell-Derived Natural Killer Cells for Treatment of Ovarian Cancer
- (2015) David L. Hermanson et al. STEM CELLS
- Highly effective NK cells are associated with good prognosis in patients with metastatic prostate cancer
- (2015) Christine Pasero et al. Oncotarget
- Identification of an ADAM17 Cleavage Region in Human CD16 (FcγRIII) and the Engineering of a Non-Cleavable Version of the Receptor in NK Cells
- (2015) Yawu Jing et al. PLoS One
- CAR-Engineered NK Cells Targeting Wild-Type EGFR and EGFRvIII Enhance Killing of Glioblastoma and Patient-Derived Glioblastoma Stem Cells
- (2015) Jianfeng Han et al. Scientific Reports
- Clearance of acute myeloid leukemia by haploidentical natural killer cells is improved using IL-2 diphtheria toxin fusion protein
- (2014) V. Bachanova et al. BLOOD
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- (2014) Erik Wennerberg et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Seamless gene correction of β-thalassemia mutations in patient-specific iPSCs using CRISPR/Cas9 andpiggyBac
- (2014) Fei Xie et al. GENOME RESEARCH
- CD56brightPerforinlow Noncytotoxic Human NK Cells Are Abundant in Both Healthy and Neoplastic Solid Tissues and Recirculate to Secondary Lymphoid Organs via Afferent Lymph
- (2014) P. Carrega et al. JOURNAL OF IMMUNOLOGY
- T-Cell and NK-Cell Infiltration into Solid Tumors: A Key Limiting Factor for Efficacious Cancer Immunotherapy
- (2014) I. Melero et al. Cancer Discovery
- Platform for Induction and Maintenance of Transgene-free hiPSCs Resembling Ground State Pluripotent Stem Cells
- (2014) Bahram Valamehr et al. Stem Cell Reports
- Classification of human natural killer cells based on migration behavior and cytotoxic response
- (2013) B. Vanherberghen et al. BLOOD
- A Chimeric Receptor with NKG2D Specificity Enhances Natural Killer Cell Activation and Killing of Tumor Cells
- (2013) Y.-H. Chang et al. CANCER RESEARCH
- Regeneration of Human Tumor Antigen-Specific T Cells from iPSCs Derived from Mature CD8 + T Cells
- (2013) Raul Vizcardo et al. Cell Stem Cell
- Interaction between natural killer cells and regulatory T cells: perspectives for immunotherapy
- (2013) Isabela Pedroza-Pacheco et al. Cellular & Molecular Immunology
- Treatment of patients with advanced cancer with the natural killer cell line NK-92
- (2013) Torsten Tonn et al. CYTOTHERAPY
- CS1-specific chimeric antigen receptor (CAR)-engineered natural killer cells enhance in vitro and in vivo antitumor activity against human multiple myeloma
- (2013) J Chu et al. LEUKEMIA
- Generation of tumor-targeted human T lymphocytes from induced pluripotent stem cells for cancer therapy
- (2013) Maria Themeli et al. NATURE BIOTECHNOLOGY
- CD56negCD16+ NK cells are activated mature NK cells with impaired effector function during HIV-1 infection
- (2013) Jeffrey M Milush et al. Retrovirology
- Expression of Chimeric Receptor CD4ζ by Natural Killer Cells Derived from Human Pluripotent Stem Cells Improves In Vitro Activity but Does Not Enhance Suppression of HIV Infection In Vivo
- (2013) Zhenya Ni et al. STEM CELLS
- The Basic Principles of Chimeric Antigen Receptor Design
- (2013) Michel Sadelain et al. Cancer Discovery
- Clinical-Scale Derivation of Natural Killer Cells From Human Pluripotent Stem Cells for Cancer Therapy
- (2013) David A. Knorr et al. Stem Cells Translational Medicine
- Development, Expansion, and In vivo Monitoring of Human NK Cells from Human Embryonic Stem Cells (hESCs) and and Induced Pluripotent Stem Cells (iPSCs)
- (2013) Allison M. Bock et al. Jove-Journal of Visualized Experiments
- Human plasmacytoid dendritic cells are equipped with antigen-presenting and tumoricidal capacities
- (2012) J. Tel et al. BLOOD
- Expression of IL-15 in NK cells results in rapid enrichment and selective cytotoxicity of gene-modified effectors that carry a tumor-specific antigen receptor
- (2012) Christiane Sahm et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Generating an iPSC Bank for HLA-Matched Tissue Transplantation Based on Known Donor and Recipient HLA Types
- (2012) Craig J. Taylor et al. Cell Stem Cell
- Large-scale ex vivo expansion and characterization of natural killer cells for clinical applications
- (2012) Natalia Lapteva et al. CYTOTHERAPY
- A clinically adaptable method to enhance the cytotoxicity of natural killer cells against B-cell malignancies
- (2012) Noriko Shimasaki et al. CYTOTHERAPY
- The HOXB4 Homeoprotein Promotes the Ex Vivo Enrichment of Functional Human Embryonic Stem Cell-Derived NK Cells
- (2012) Aniya Larbi et al. PLoS One
- Natural killer cells: a review of manufacturing and clinical utility
- (2012) Scott A. Koepsell et al. TRANSFUSION
- Natural killer cell lines in tumor immunotherapy
- (2012) Min Cheng et al. Frontiers of Medicine
- Antitumor activity and long-term fate of chimeric antigen receptor-positive T cells in patients with neuroblastoma
- (2011) C. U. Louis et al. BLOOD
- The unique profile of cord blood natural killer cells balances incomplete maturation and effective killing function upon activation
- (2011) Martha Luevano et al. HUMAN IMMUNOLOGY
- Comparison of mRNA and lentiviral based transfection of natural killer cells with chimeric antigen receptors recognizing lymphoid antigens
- (2011) Laurent Boissel et al. LEUKEMIA & LYMPHOMA
- A more efficient method to generate integration-free human iPS cells
- (2011) Keisuke Okita et al. NATURE METHODS
- Natural Killer Cell-Enriched Donor Lymphocyte Infusions from A 3-6/6 HLA Matched Family Member following Nonmyeloablative Allogeneic Stem Cell Transplantation
- (2010) David A. Rizzieri et al. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
- NKAML: A Pilot Study to Determine the Safety and Feasibility of Haploidentical Natural Killer Cell Transplantation in Childhood Acute Myeloid Leukemia
- (2010) Jeffrey E. Rubnitz et al. JOURNAL OF CLINICAL ONCOLOGY
- Daratumumab, a Novel Therapeutic Human CD38 Monoclonal Antibody, Induces Killing of Multiple Myeloma and Other Hematological Tumors
- (2010) M. de Weers et al. JOURNAL OF IMMUNOLOGY
- Human Pluripotent Stem Cells Produce Natural Killer Cells That Mediate Anti-HIV-1 Activity by Utilizing Diverse Cellular Mechanisms
- (2010) Z. Ni et al. JOURNAL OF VIROLOGY
- Human embryonic stem cells differentiate into a homogeneous population of natural killer cells with potent in vivo antitumor activity
- (2009) P. S. Woll et al. BLOOD
- Control of CD56 expression and tumor cell cytotoxicity in human Vγ2Vδ2 T cells
- (2009) Elizabeth M Urban et al. BMC IMMUNOLOGY
- Generation of donor natural killer cells from CD34+ progenitor cells and subsequent infusion after HLA-mismatched allogeneic hematopoietic cell transplantation: a feasibility study
- (2009) S R Yoon et al. BONE MARROW TRANSPLANTATION
- Expression of chimeric antigen receptors in natural killer cells with a regulatory-compliant non-viral method
- (2009) L Li et al. CANCER GENE THERAPY
- Expansion of Highly Cytotoxic Human Natural Killer Cells for Cancer Cell Therapy
- (2009) H. Fujisaki et al. CANCER RESEARCH
- 2B4 (CD244) Signaling by Recombinant Antigen-specific Chimeric Receptors Costimulates Natural Killer Cell Activation to Leukemia and Neuroblastoma Cells
- (2009) B. Altvater et al. CLINICAL CANCER RESEARCH
- Transfection with mRNA for CD19 specific chimeric antigen receptor restores NK cell mediated killing of CLL cells
- (2009) Laurent Boissel et al. LEUKEMIA RESEARCH
- Graft-versus-host disease after donor leukocyte infusions: presentation and management
- (2008) Noelle V. Frey et al. BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY
- Infusion of the allogeneic cell line NK-92 in patients with advanced renal cell cancer or melanoma: a phase I trial
- (2008) S. Arai et al. CYTOTHERAPY
- Permanent silencing of NKG2A expression for cell-based therapeutics
- (2008) Constança Figueiredo et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Up on the tightrope: natural killer cell activation and inhibition
- (2008) Lewis L Lanier NATURE IMMUNOLOGY
- Engineering antigen-specific primary human NK cells against HER-2 positive carcinomas
- (2008) A. Kruschinski et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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